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L. B. Epling · SciRah

Researcher profile · Semantic Scholar

L. B. Epling

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L. B. Epling — researcher profile on SciRah

h-index: 8
Works: 20
Citations: 376

Most-cited papers

Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis
L. B. Epling, C. Grace, B. Lowe, J. Partridge +1 more
2015Journal of Molecular Biology86 citations Open access
Semantic Scholar
DNA translocation mechanism of the MCM complex and implications for replication initiation
M. Meagher, L. B. Epling, E. Enemark
2019Nature Communications78 citations Open access
Semantic Scholar
A conserved MCM single-stranded DNA binding element is essential for replication initiation
C. A. Froelich, Sukhyun Kang, L. B. Epling, S. Bell +1 more
2014eLife77 citations Open access
Semantic Scholar
Analysis of the crystal structure of an active MCM hexamer
Justin M. Miller, Buenafe T. Arachea, L. B. Epling, E. Enemark
2014eLife62 citations Open access
Semantic Scholar
Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
Artem Shvartsbart, Jeremy J. Roach, Michael R. Witten, H. Koblish +22 more
2022Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
Joshua R. Hummel, Kaijiong Xiao, Jeffrey Yang, L. B. Epling +23 more
2024Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor.
Qin-Da Ye, Artem Shvartsbart, Zhenwu Li, Pei Gan +30 more
2025Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Abstract 5900: INCB161734: A novel, potent, and orally bioavailable KRAS G12D selective inhibitor demonstrates antitumor activity in KRAS G12D mutant tumors
M. R. Farren, Valerie Roman, Alexandra Gallion, A. Allali‐Hassani +23 more
2024Cancer Research13 citations
Semantic Scholar
Crystal structure of minichromosome maintenance protein MCM/DNA complex
M. Meagher, L. B. Epling, E. Enemark
20197 citations
Semantic Scholar
Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases.
J. Zhuo, Yun-Long Li, Ding-Quan Qian, David M. Burns +26 more
2026Journal of Medicinal Chemistry2 citations
Semantic Scholar
Discovery of a Selective and Potent Inhibitor of Cyclin-Dependent Kinase 12/13 Employing a Noncovalent Mechanism.
Robert A. Swyka, Evan D. Styduhar, Anlai Wang, Xin Li +25 more
2026ACS Medicinal Chemistry Letters1 citations
Semantic Scholar
Discovery of INCB127443: A Potent and Orally Available Inhibitor of Cyclin-Dependent Kinase 2
Ken Mukai, Brandon R. Smith, Qin-Da Ye, L. B. Epling +26 more
2026Journal of Medicinal Chemistry0 citations
Semantic Scholar
DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V
L. B. Epling, C. Grace, B. Lowe, J. Partridge +1 more
20150 citations
Semantic Scholar
DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop
L. B. Epling, C. Grace, B. Lowe, J. Partridge +1 more
20150 citations
Semantic Scholar
Author response: Analysis of the crystal structure of an active MCM hexamer
Justin M. Miller, Buenafe T. Arachea, L. B. Epling, E. Enemark
20140 citations Open access
Semantic Scholar
PfMCM N-terminal domain without DNA
C. A. Froelich, Sukhyun Kang, L. B. Epling, S. Bell +1 more
20140 citations
Semantic Scholar
Crystal structure of an active MCM hexamer
Justin M. Miller, Buenafe T. Arachea, L. B. Epling, E. Enemark
20140 citations
Semantic Scholar
Author response: A conserved MCM single-stranded DNA binding element is essential for replication initiation
C. A. Froelich, Sukhyun Kang, L. B. Epling, S. Bell +1 more
20140 citations Open access
Semantic Scholar
PfMCM-AAA double-octamer
Justin M. Miller, Buenafe T. Arachea, L. B. Epling, Eric J. Enemark
20140 citations
Semantic Scholar
MCM-ssDNA co-crystal structure
C. A. Froelich, Sukhyun Kang, L. B. Epling, S. Bell +1 more
20140 citations
Semantic Scholar

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Maryanne B. Covington×5
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