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Yun C. Chang · SciRah

Researcher profile · Semantic Scholar

Yun C. Chang

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Yun C. Chang — researcher profile on SciRah

h-index: 47
Works: 92
Citations: 6,548

Most-cited papers

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes
E. Sionov, Hyeseung Lee, Yun C. Chang, K. Kwon-Chung
2010PLoS Pathogens427 citations Open access
Semantic Scholar
A Developmentally Regulated Gene Cluster Involved in Conidial Pigment Biosynthesis in Aspergillus fumigatus
H. Tsai, M. H. Wheeler, Yun C. Chang, K. Kwon-Chung
1999Journal of Bacteriology388 citations Open access
Semantic Scholar
The Developmentally Regulated alb1 Gene ofAspergillus fumigatus: Its Role in Modulation of Conidial Morphology and Virulence
H. Tsai, Yun C. Chang, R. Washburn, M. H. Wheeler +1 more
1998Journal of Bacteriology364 citations Open access
Semantic Scholar
The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis
K. Kwon-Chung, J. Bennett, B. Wickes, W. Meyer +29 more
2017Msphere349 citations Open access
Semantic Scholar
Cryptococcal Yeast Cells Invade the Central Nervous System via Transcellular Penetration of the Blood-Brain Barrier
Yun C. Chang, M. Stins, Michael J. McCaffery, G. Miller +5 more
2004Infection and Immunity276 citations Open access
Semantic Scholar
Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone
J. Sugui, J. Pardo, Yun C. Chang, Kol A. Zarember +6 more
2007Eukaryotic Cell240 citations Open access
Semantic Scholar
Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans
Yun C. Chang, Clara M. Bien, Hyeseung Lee, P. Espenshade +1 more
2007Molecular Microbiology213 citations Open access
Semantic Scholar
Human Polymorphonuclear Leukocytes Inhibit Aspergillus fumigatus Conidial Growth by Lactoferrin-Mediated Iron Depletion1
Kol A. Zarember, J. Sugui, Yun C. Chang, K. Kwon-Chung +1 more
2007Journal of Immunology202 citations
Semantic Scholar
Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells.
Steven H. M. Chen, M. Stins, Sheng-He Huang, Yu-Hua Chen +5 more
2003Journal of Medical Microbiology185 citations Open access
Semantic Scholar
Heteroresistance to Fluconazole in Cryptococcus neoformans Is Intrinsic and Associated with Virulence
E. Sionov, Yun C. Chang, H. Garraffo, K. Kwon-Chung
2009Antimicrobial Agents and Chemotherapy181 citations Open access
Semantic Scholar
Isolation, Characterization, and Localization of a Capsule-Associated Gene, CAP10, of Cryptococcus neoformans
Yun C. Chang, K. Kwon-Chung
1999Journal of Bacteriology168 citations Open access
Semantic Scholar
The Primary Target Organ of Cryptococcus gattii Is Different from That of Cryptococcus neoformans in a Murine Model
P. Ngamskulrungroj, Yun C. Chang, E. Sionov, K. Kwon-Chung
2012mBio159 citations Open access
Semantic Scholar
Identification of Aspergillus brlA response elements (BREs) by genetic selection in yeast.
Yun C. Chang, W. Timberlake
1993Genetics157 citations
Semantic Scholar
Pentaketide Melanin Biosynthesis in Aspergillus fumigatus Requires Chain-length Shortening of a Heptaketide Precursor*
H. Tsai, I. Fujii, A. Watanabe, M. H. Wheeler +4 more
2001Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Aspergillus fumigatus arp1 modulates conidial pigmentation and complement deposition
H. Tsai, R. Washburn, Yun C. Chang, K. J. Kwon-Chung
1997Molecular Microbiology130 citations Open access
Semantic Scholar
Genes Differentially Expressed in Conidia and Hyphae of Aspergillus fumigatus upon Exposure to Human Neutrophils
J. Sugui, H. Kim, Kol A. Zarember, Yun C. Chang +3 more
2008PLoS ONE120 citations Open access
Semantic Scholar
Cryptococcus neoformans CAP59 (or Cap59p) Is Involved in the Extracellular Trafficking of Capsular Glucuronoxylomannan
J. García-Rivera, Yun C. Chang, K. Kwon-Chung, A. Casadevall
2004Eukaryotic Cell115 citations Open access
Semantic Scholar
Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells
Ambrose Y. Jong, Chun-Hua Wu, G. Shackleford, K. J. Kwon-Chung +4 more
2008Cellular Microbiology114 citations Open access
Semantic Scholar
Azole Heteroresistance in Cryptococcus neoformans: Emergence of Resistant Clones with Chromosomal Disomy in the Mouse Brain during Fluconazole Treatment
E. Sionov, Yun C. Chang, K. Kwon-Chung
2013Antimicrobial Agents and Chemotherapy113 citations Open access
Semantic Scholar
Cryptococcus neoformans-Derived Microvesicles Enhance the Pathogenesis of Fungal Brain Infection
Sheng-He Huang, Chun-Hua Wu, Yun C. Chang, K. Kwon-Chung +2 more
2012PLoS ONE106 citations Open access
Semantic Scholar
Role of laeA in the Regulation of alb1, gliP, Conidial Morphology, and Virulence in Aspergillus fumigatus
J. Sugui, J. Pardo, Yun C. Chang, A. Müllbacher +7 more
2007Eukaryotic Cell103 citations Open access
Semantic Scholar
Identification and Characterization of CPS1 as a Hyaluronic Acid Synthase Contributing to the Pathogenesis of Cryptococcus neoformans Infection
Ambrose Y. Jong, Chun-Hua Wu, Han-Min Chen, F. Luo +5 more
2007Eukaryotic Cell102 citations Open access
Semantic Scholar
Hydrolytic Polyketide Shortening by Ayg1p, a Novel Enzyme Involved in Fungal Melanin Biosynthesis*
I. Fujii, Y. Yasuoka, H. Tsai, Yun C. Chang +2 more
2004Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Hyaluronic Acid Receptor CD44 Deficiency Is Associated with Decreased Cryptococcus neoformans Brain Infection*
Ambrose Y. Jong, Chun-Hua Wu, I. Gonzales-Gomez, K. Kwon-Chung +4 more
2012Journal of Biological Chemistry94 citations Open access
Semantic Scholar
Cobalt chloride, a hypoxia‐mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans
Hyeseung Lee, Clara M. Bien, Adam L. Hughes, P. Espenshade +2 more
2007Molecular Microbiology90 citations
Semantic Scholar
Factors Required for Activation of Urease as a Virulence Determinant in Cryptococcus neoformans
Arpita Singh, R. J. Panting, A. Varma, Tomomi Saijo +6 more
2013mBio87 citations Open access
Semantic Scholar
TUP1 disruption in Cryptococcus neoformans uncovers a peptide‐mediated density‐dependent growth phenomenon that mimics quorum sensing
Hyeseung Lee, Yun C. Chang, G. Nardone, K. J. Kwon-Chung
2007Molecular Microbiology81 citations Open access
Semantic Scholar
A New Lineage of Cryptococcus gattii (VGV) Discovered in the Central Zambezian Miombo Woodlands
R. Farrer, Miwha Chang, Michael J. Davis, L. van Dorp +13 more
2019mBio78 citations Open access
Semantic Scholar
Aneuploidy and Drug Resistance in Pathogenic Fungi
K. Kwon-Chung, Yun C. Chang
2012PLoS Pathogens78 citations Open access
Semantic Scholar
CPS1, a Homolog of the Streptococcus pneumoniae Type 3 Polysaccharide Synthase Gene, Is Important for the Pathobiology of Cryptococcus neoformans
Yun C. Chang, Ambrose Y. Jong, Sheng-He Huang, P. Zerfas +1 more
2006Infection and Immunity78 citations
Semantic Scholar
Importance of Mitochondria in Survival of Cryptococcus neoformans Under Low Oxygen Conditions and Tolerance to Cobalt Chloride
S. Ingavale, Yun C. Chang, Hyeseung Lee, C. M. McClelland +2 more
2008PLoS Pathogens77 citations Open access
Semantic Scholar
Invasion of Cryptococcus neoformans into Human Brain Microvascular Endothelial Cells Is Mediated through the Lipid Rafts-Endocytic Pathway via the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 3 (DYRK3)*
Sheng-He Huang, M. Long, Chun-Hua Wu, K. Kwon-Chung +4 more
2011Journal of Biological Chemistry75 citations Open access
Semantic Scholar
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C‐α activation
Ambrose Y. Jong, Chun-Hua Wu, N. Prasadarao, K. J. Kwon-Chung +4 more
2008Cellular Microbiology71 citations Open access
Semantic Scholar
Cas3p Belongs to a Seven-Member Family of Capsule Structure Designer Proteins
Frédérique Moyrand, Yun C. Chang, U. Himmelreich, K. Kwon-Chung +1 more
2004Eukaryotic Cell67 citations Open access
Semantic Scholar
THTA, a thermotolerance gene of Aspergillus fumigatus.
Yun C. Chang, H. Tsai, M. Karos, K. Kwon-Chung
2004Fungal Genetics and Biology65 citations
Semantic Scholar
High frequency transformation of Cryptococcus neoformans and Cryptococcus gattii by Agrobacterium tumefaciens.
C. M. McClelland, Yun C. Chang, K. Kwon-Chung
2005Fungal Genetics and Biology62 citations
Semantic Scholar
Identification and Characterization of an Aspergillus fumigatus “Supermater” Pair
J. Sugui, L. Losada, Wei Wang, J. Varga +8 more
2011mBio60 citations Open access
Semantic Scholar
Characterization of the Chromosome 4 Genes That Affect Fluconazole-Induced Disomy Formation in Cryptococcus neoformans
P. Ngamskulrungroj, Yun C. Chang, B. Hansen, Cliff Bugge +2 more
2012PLoS ONE59 citations Open access
Semantic Scholar
Importance of a Developmentally Regulated Pheromone Receptor of Cryptococcus neoformans for Virulence
Yun C. Chang, G. Miller, K. Kwon-Chung
2003Infection and Immunity58 citations Open access
Semantic Scholar
Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
Yun C. Chang, S. Ingavale, Clara M. Bien, P. Espenshade +1 more
2009Eukaryotic Cell56 citations Open access
Semantic Scholar
Roles of Three Cryptococcus neoformans and Cryptococcus gattii Efflux Pump-Coding Genes in Response to Drug Treatment
Miwha Chang, E. Sionov, Ami Khanal Lamichhane, K. Kwon-Chung +1 more
2018Antimicrobial Agents and Chemotherapy52 citations Open access
Semantic Scholar
Regulatory Diversity of TUP1 in Cryptococcus neoformans
Hyeseung Lee, Yun C. Chang, A. Varma, K. Kwon-Chung
2009Eukaryotic Cell52 citations Open access
Semantic Scholar
Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence
L. Losada, J. Sugui, M. Eckhaus, Yun C. Chang +9 more
2015PLoS Pathogens51 citations Open access
Semantic Scholar
Involvement of PDK1, PKC and TOR signaling pathways in basal fluconazole tolerance in Cryptococcus neoformans
Hyeseung Lee, Ami Khanal Lamichhane, H. Garraffo, K. J. Kwon-Chung +1 more
2012Molecular Microbiology50 citations Open access
Semantic Scholar
Cryptococcus neoformans Activates RhoGTPase Proteins Followed by Protein Kinase C, Focal Adhesion Kinase, and Ezrin to Promote Traversal across the Blood-Brain Barrier*
Jong-Chul Kim, B. Crary, Yun C. Chang, K. Kwon-Chung +1 more
2012Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Efficacy of Olorofim (F901318) against Aspergillus fumigatus, A. nidulans, and A. tanneri in Murine Models of Profound Neutropenia and Chronic Granulomatous Disease
S. Seyedmousavi, Yun C. Chang, D. Law, M. Birch +2 more
2019Antimicrobial Agents and Chemotherapy47 citations Open access
Semantic Scholar
Molecular Analysis of CPRα, a MATα-Specific Pheromone Receptor Gene of Cryptococcus neoformans
Se-Yung S. Chung, M. Karos, Yun C. Chang, J. Lukszo +2 more
2002Eukaryotic Cell47 citations Open access
Semantic Scholar
Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
Yun C. Chang, Ami Khanal Lamichhane, Hong-Yi Cai, P. Walter +2 more
2021Nature Communications44 citations Open access
Semantic Scholar
Complementation of a capsule deficient Cryptococcus neoformans with CAP64 restores virulence in a murine lung infection.
J. Wilder, G. K. Olson, Yun C. Chang, K. Kwon-Chung +1 more
2002American Journal of Respiratory Cell and Molecular Biology42 citations
Semantic Scholar
Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection
Dong-Hoon Yang, M. England, Hélène Salvator, Seher H. Anjum +19 more
2021mBio36 citations Open access
Semantic Scholar

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