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H. Broughton · SciRah

Researcher profile · Semantic Scholar

H. Broughton

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H. Broughton — researcher profile on SciRah

h-index: 28
Works: 109
Citations: 2,655

Most-cited papers

Molecular modeling.
H. Broughton
2020Current Opinion in Chemical Biology267 citations Open access
Semantic Scholar
Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition
M. Chambers, J. Atack, H. Broughton, N. Collinson +8 more
2003137 citations Open access
Semantic Scholar
Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.
M. B. Van Niel, I. Collins, M. Beer, H. Broughton +17 more
1999Journal of Medicinal Chemistry135 citations Open access
Semantic Scholar
The chemical basis of serine palmitoyltransferase inhibition by myriocin.
J. M. Wadsworth, D. Clarke, S. McMahon, J. Lowther +6 more
2013Journal of the American Chemical Society124 citations Open access
Semantic Scholar
Selection of heterocycles for drug design.
H. Broughton, Ian A. Watson
2004Journal of Molecular Graphics and Modelling104 citations
Semantic Scholar
Mechanism of inositol monophosphatase, the putative target of lithium therapy.
S. Pollack, J. Atack, Michael R. Knowles, G. Mcallister +5 more
1994Proceedings of the National Academy of Sciences of the United States of America100 citations Open access
Semantic Scholar
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.
M. Rowley, H. Broughton, I. Collins, R. Baker +6 more
1996Journal of Medicinal Chemistry90 citations Open access
Semantic Scholar
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.
M. G. Russell, Robert J. Baker, Laura Barden, M. Beer +6 more
2001Journal of Medicinal Chemistry87 citations Open access
Semantic Scholar
A method for including protein flexibility in protein-ligand docking: improving tools for database mining and virtual screening.
H. Broughton
2000Journal of Molecular Graphics and Modelling75 citations
Semantic Scholar
A Residue Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions
Daniel J. Saltzberg, H. Broughton, R. Pellarin, Michael J. Chalmers +6 more
2016Journal of Physical Chemistry B62 citations Open access
Semantic Scholar
Structural analysis of inositol monophosphatase complexes with substrates.
R. Bone, L. Frank, J. P. Springer, S. Pollack +6 more
1995Biochemistry62 citations
Semantic Scholar
Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.
J. L. Castro, R. Ball, H. Broughton, M. G. Russell +10 more
1996Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
lnositol monophosphatase-a putative target for Li ’ in the treatment of bipolar disorder
J. Atack, H. Broughton, S. Pollack
201855 citations
Semantic Scholar
The synthesis of azadirachtin: a potent insect antifeedant.
S. Ley, A. Abad-Somovilla, James C. Anderson, C. Ayats +42 more
2008Chemistry49 citations
Semantic Scholar
Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
M. Chambers, J. Atack, H. Broughton, N. Collinson +8 more
2003Journal of Medicinal Chemistry49 citations
Semantic Scholar
Preparation and cytotoxicity of podophyllotoxin derivatives lacking the lactone ring
M. Gordaliza, M. Castro, J. D. del Corral, M. López-Vázquez +4 more
199735 citations
Semantic Scholar
A new class of chiral pyrrolidine for asymmetric Michael addition reactions. New mechanism via simple 4+2 type attack of the enamine on the trans-nitrostyrene
D. Díez, M. Gil, R. Moro, I. Marcos +5 more
200734 citations
Semantic Scholar
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
M. Rowley, I. Collins, H. Broughton, W. Davey +8 more
1997Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
S. Gharbi, L. Pelletier, Alfonso Espada, Jesus A. Gutierrez +19 more
2022npj Breast Cancer33 citations Open access
Semantic Scholar
The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage.
Najia Jin, W. Matter, Laura F. Michael, Yuewei Qian +6 more
2021ACS Chemical Biology33 citations
Semantic Scholar
New selective cytotoxic diterpenylquinones and diterpenylhydroquinones.
J. D. del Corral, M. Gordaliza, M. Castro, M. M. Mahiques +5 more
2001Journal of Medicinal Chemistry33 citations
Semantic Scholar
Chemistry of insect antifeedants from azadirachta indica (part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment
S. Ley, A. A. Somovilla, H. Broughton, D. Craig +3 more
198933 citations
Semantic Scholar
Synthesis of bioactive sesterterpenolides from ent-halimic acid. 15-epi-ent-Cladocoran A and B.
I. Marcos, A. Pedrero, M. Sexmero, D. Díez +6 more
2003Journal of Organic Chemistry32 citations
Semantic Scholar
Organocatalytic Synthesis of an Alkyltetrahydropyran
D. Díez, Marta G. Núñez, A. Benéitez, R. Moro +4 more
200928 citations Open access
Semantic Scholar
A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry.
A. Espada, H. Broughton, S. Jones, Michael J. Chalmers +1 more
2016Journal of Medicinal Chemistry27 citations
Semantic Scholar
Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.
I. Rojo, Jose-Alfredo Martin, H. Broughton, D. Timm +3 more
2006Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.
M. Chambers, J. Atack, F. Bromidge, H. Broughton +8 more
2002Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery
J. Ting, F. Tung, S. Antonysamy, S. Wasserman +14 more
2018PLoS ONE26 citations Open access
Semantic Scholar
Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.
D. Cummins, A. Espada, S. Novick, M. Molina-Martin +8 more
2016Analytical Chemistry26 citations Open access
Semantic Scholar
Chemistry of sulfones: synthesis of a new chiral nucleophilic catalyst
D. Díez, M. Gil, R. Moro, N. M. Garrido +5 more
200525 citations
Semantic Scholar
3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.
M. G. Russell, Victor G. Matassa, Roy R. Pengilley, M. B. Van Niel +7 more
1999Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Synthesis and Absolute Configuration of the Supposed Structure of Cladocoran A and B
I. Marcos, A. Pedrero, M. Sexmero, D. Díez +4 more
200222 citations
Semantic Scholar
5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.
J. L. Castro, H. Broughton, M. G. Russell, D. Rathbone +7 more
1997Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Bioactive isoxazoline and oxime derivatives from 7-ketolignans
J. D. del Corral, M. Gordaliza, M. Castro, M. López-Vázquez +3 more
199720 citations
Semantic Scholar
Stereocontrolled synthesis of cyclopropanol amino acids from allylic sulfones: conformationally restricted building blocks.
D. Díez, P. García, I. Marcos, N. M. Garrido +3 more
2003Organic Letters19 citations
Semantic Scholar
Molecular Binding Interactions: Their Estimation and Rationalization in QSARs in Terms of Theoretically Derived Parameters
D. Lewis, H. Broughton
2002TheScientificWorldJournal19 citations Open access
Semantic Scholar
A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments
A. Espada, Rubén Haro, J. Castanon, C. Sayago +10 more
2019Journal of the American Society for Mass Spectrometry18 citations
Semantic Scholar
Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists.
C. Low, J. Black, H. Broughton, I. Buck +8 more
2000Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Chemistry of labdanediol from Cistus ladaniferus, L. synthesis of 12-Nor-ambreinolide and α and β-levantenolides
J. G. Urones, P. Basabe, I. Marcos, David Diez Martin +3 more
199218 citations
Semantic Scholar
Electrostatic vs. orbital control in π-facial diasteroselection: a PM3 SCF-MO study of electrophilic reactivity in 7-methylenenorbornanes
H. Broughton, S. Green, H. Rzepa
199216 citations
Semantic Scholar
Synthesis of 2 -Amino -5 -arylthiazoles by Palladium-Catalyzed Arylation at the C5 Position with Aryl Iodides
Julián Priego, Sonia Gutiérrez, R. Ferritto, H. Broughton
200715 citations
Semantic Scholar
Preparation of β-ketomacrolactones and β-ketodiolides using S-t-butyl 3-oxobutanethioate and S-t-butyl 4-diethylphosphono-3-oxobutanethioate
P. M. Booth, H. Broughton, M. Ford, Christina M. J. Fox +4 more
198915 citations
Semantic Scholar
Conformational features of secondary N-cyclopropyl amides.
Angela Gonzalez‐de‐Castro, H. Broughton, J. Martínez-Pérez, J. Espinosa
2015Journal of Organic Chemistry14 citations
Semantic Scholar
Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis
L. Hosseini-Gerami, I. Higgins, D. Collier, E. Laing +3 more
2022BMC Bioinformatics13 citations Open access
Semantic Scholar
Chemistry of vinyl sulfones. Approach to novel conformationally restricted analogues of glutamic acid
D. Díez, P. García, I. Marcos, N. M. Garrido +3 more
200513 citations
Semantic Scholar
The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogues: Potent and selective agonists for 5-HT1D receptors
F. Sternfeld, R. Baker, H. Broughton, A. Guiblin +12 more
199613 citations
Semantic Scholar
Deciphering Binding Interactions of IL-23R with HDX-MS: Mapping Protein and Macrocyclic Dodecapeptide Ligands.
C. Sayago, Isabel C. Gonzalez Valcarcel, Yuewei Qian, J. Lee +8 more
2018ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Assignment of absolute configuration on the basis of the conformational effects induced by chiral derivatizing agents: the 2-arylpyrrolidine case.
Paloma Vidal, C. Pedregal, Nuria Díaz, H. Broughton +3 more
2007Organic Letters11 citations
Semantic Scholar
Labdanolic Acid: Synthetic Precursor of Tricyclic Diterpenes
J. G. Urones, M. Sexmero, A. Lithgow, P. Basabe +6 more
199511 citations
Semantic Scholar
Synthesis of tri- and tetracyclic diterpenes. Cyclisations promoted by SmI2
I. Marcos, M. A. Cubillo, R. Moro, S. Carballares +7 more
200510 citations
Semantic Scholar

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