Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

I. Karl · SciRah

Researcher profile · Semantic Scholar

I. Karl

Share profile

I. Karl — researcher profile on SciRah

h-index: 45
Works: 124
Citations: 12K

Most-cited papers

The pathophysiology and treatment of sepsis.
R. Hotchkiss, I. Karl
2003New England Journal of Medicine4,167 citations
Semantic Scholar
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte
R. Hotchkiss, Kathy C Chang, P. Swanson, Kevin W. Tinsley +10 more
2000Nature Immunology575 citations
Semantic Scholar
Prevention of lymphocyte cell death in sepsis improves survival in mice.
R. Hotchkiss, Kevin W. Tinsley, P. Swanson, Katherine C. Chang +4 more
1999Proceedings of the National Academy of Sciences of the United States of America492 citations Open access
Semantic Scholar
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis.
R. Hotchkiss, P. Swanson, C. Knudson, Katherine C. Chang +6 more
1999Journal of Immunology414 citations Open access
Semantic Scholar
Depletion of Dendritic Cells, But Not Macrophages, in Patients with Sepsis
R. Hotchkiss, Kevin W. Tinsley, P. Swanson, M. Grayson +5 more
2002Journal of Immunology411 citations Open access
Semantic Scholar
Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis.
R. Hotchkiss, I. Karl
1992Journal of the American Medical Association (JAMA)383 citations
Semantic Scholar
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis.
C. Coopersmith, P. Stromberg, W. Dunne, C. Davis +4 more
2002Journal of the American Medical Association (JAMA)314 citations
Semantic Scholar
CECAL LIGATION AND PUNCTURE (CLP) INDUCES APOPTOSIS IN THYMUS, SPLEEN, LUNG, AND GUT BY AN ENDOTOXIN AND TNF‐INDEPENDENT PATHWAY
M. Hiramatsu, R. Hotchkiss, I. Karl, T. Buchman
1997Shock215 citations Open access
Semantic Scholar
Hyperthermia protects mice against the lethal effects of endotoxin.
R. Hotchkiss, I. Nunnally, S. Lindquist, J. Taulien +2 more
1993American Journal of Physiology213 citations
Semantic Scholar
Follicular Dendritic Cells Depletion of Splenic Interdigitating and Sepsis Induces Apoptosis and Profound
Kevin W. Tinsley, M. Grayson, P. Swanson, A. Drewry +3 more
2003186 citations
Semantic Scholar
Role of arginine in health and in renal disease.
A. A. Reyes, I. Karl, S. Klahr
1994American Journal of Physiology181 citations
Semantic Scholar
Role of Apoptotic Cell Death in Sepsis
R. Hotchkiss, Kevin W. Tinsley, I. Karl
2003Scandinavian Journal of Infectious Diseases172 citations
Semantic Scholar
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice
C. Coopersmith, Katherine C. Chang, P. Swanson, Kevin W. Tinsley +4 more
2002Critical Care Medicine156 citations
Semantic Scholar
Prevention of lymphocyte apoptosis--a potential treatment of sepsis?
R. Hotchkiss, C. Coopersmith, I. Karl
2005Clinical Infectious Diseases146 citations Open access
Semantic Scholar
Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?
Sheng-Kwei Song, I. Karl, J. Ackerman, R. Hotchkiss
1993Proceedings of the National Academy of Sciences of the United States of America143 citations Open access
Semantic Scholar
Akt Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis1
U. Bommhardt, Katherine C. Chang, P. Swanson, T. H. Wagner +3 more
2004Journal of Immunology142 citations Open access
Semantic Scholar
Endothelial cell apoptosis in sepsis
R. Hotchkiss, Kevin W. Tinsley, P. Swanson, I. Karl
2002Critical Care Medicine135 citations
Semantic Scholar
Dietary supplementation with L-arginine ameliorates the progression of renal disease in rats with subtotal nephrectomy.
A. A. Reyes, M. Purkerson, I. Karl, S. Klahr
1992American Journal of Kidney Diseases129 citations
Semantic Scholar
Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.
Isaiah R. Turnbull, Katherine C. Chang, M. Grayson, K. W. Tinsely +6 more
2003Proceedings of the National Academy of Sciences of the United States of America126 citations
Semantic Scholar
TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo1
R. Hotchkiss, K. McConnell, Kristin E. Bullok, C. Davis +11 more
2006Journal of Immunology120 citations Open access
Semantic Scholar
Abnormal calcium homeostasis and mitochondrial polarization in a human encephalomyopathy.
A. Moudy, S. Handran, M. Goldberg, Natasha Ruffin +4 more
1995Proceedings of the National Academy of Sciences of the United States of America119 citations Open access
Semantic Scholar
Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole.
R. Hotchkiss, R. Rust, C. Dence, T. Wasserman +4 more
1991American Journal of Physiology112 citations
Semantic Scholar
Antibiotics Improve Survival in Sepsis Independent of Injury Severity but do not Change Mortality in Mice with Markedly Elevated Interleukin 6 Levels
Isaiah R. Turnbull, P. Javadi, T. Buchman, R. Hotchkiss +2 more
2004Shock108 citations Open access
Semantic Scholar
L-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats.
A. A. Reyes, I. Karl, J. Kissane, S. Klahr
1993Journal of the American Society of Nephrology104 citations
Semantic Scholar
Sepsis does not impair tricarboxylic acid cycle in the heart.
R. Hotchkiss, Sheng-Kwei Song, J. Neil, R.-D. Chen +4 more
1991American Journal of Physiology99 citations
Semantic Scholar
Induction of Chondrocyte Apoptosis Following Impact Load
J. Borrelli, Kevin W. Tinsley, W. Ricci, M. Burns +2 more
2003Journal of Orthopaedics and Trauma96 citations
Semantic Scholar
Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis
R. Hotchkiss, Katherine C. Chang, M. Grayson, Kevin W. Tinsley +4 more
2003Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
Semantic Scholar
Heat Shock Induces IκB-α and Prevents Stress-Induced Endothelial Cell Apoptosis
S. L. Demeester, T. Buchman, Yu-Yu Qiu, Ammini K. Jacob +7 more
199766 citations
Semantic Scholar
Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.
R. Hotchkiss, I. Karl
1994Proceedings of the National Academy of Sciences of the United States of America61 citations Open access
Semantic Scholar
p53-Dependent and -Independent Pathways of Apoptotic Cell Death in Sepsis1
R. Hotchkiss, Kevin W. Tinsley, Jia J. Hui, Katherine C. Chang +4 more
2000Journal of Immunology54 citations Open access
Semantic Scholar
Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.
M. Grayson, R. Hotchkiss, I. Karl, M. Holtzman +1 more
2003American Journal of Physiology. Heart and Circulatory Physiology48 citations
Semantic Scholar
PYRROLIDINE DITHIOCARBAMATE ACTIVATES THE HEAT SHOCK RESPONSE AND THEREBY INDUCES APOPTOSIS IN PRIMED ENDOTHELIAL CELLS
S. L. Demeester, T. Buchman, Yu-Yu Qiu, K. Dunnigan +3 more
1998Shock46 citations Open access
Semantic Scholar
CALCIUM ANTAGONISTS INHIBIT OXIDATIVE BURST AND NITRITE FORMATION IN LIPOPOLYSACCHARIDE‐STIMULATED RAT PERITONEAL MACROPHAGES
R. Hotchkiss, W. Bowling, I. Karl, D. Osborne +1 more
1997Shock46 citations Open access
Semantic Scholar
Calcium: a regulator of the inflammatory response in endotoxemia and sepsis.
R. Hotchkiss, I. Karl
1996New Horizons45 citations
Semantic Scholar
INJURY IN THE ERA OF GENOMICS
P. Cobb, B. Brownstein, M. Watson, W. Shannon +7 more
2001Shock44 citations
Semantic Scholar
Molecular Diagnostics in Sepsis: From Bedside to Bench
T. Chung, J. Laramie, Donald J. Meyer, Thomas J. Downey +7 more
2006Journal of the American College of Surgeons42 citations Open access
Semantic Scholar
AGE DISPROPORTIONATELY INCREASES SEPSIS-INDUCED APOPTOSIS IN THE SPLEEN AND GUT EPITHELIUM
Isaiah R. Turnbull, T. Buchman, P. Javadi, C. Woolsey +3 more
2004Shock41 citations Open access
Semantic Scholar
EFFECT OF ETHANOL AND SODIUM ARSENITE ON HSP‐72 FORMATION AND ON SURVIVAL IN A MURINE ENDOTOXIN MODEL
George D. Lappas, I. Karl, R. Hotchkiss
1994Shock37 citations Open access
Semantic Scholar
BCL-2 Inhibits Gut Epithelial Apoptosis Induced by Acute Lung Injury in Mice but Has No Effect On Survival
K. D. Husain, P. Stromberg, P. Javadi, T. Buchman +3 more
2003Shock35 citations Open access
Semantic Scholar
Growth hormone directly stimulates gluconeogenesis in canine renal proximal tubule.
S. Rogers, I. Karl, M. R. Hammerman
1989American Journal of Physiology33 citations
Semantic Scholar
Glutamine interferes with glucocorticoid-induced expression of glutamine synthetase in skeletal muscle.
R. C. Hickson, L. Wegrzyn, D. Osborne, I. Karl
1996American Journal of Physiology31 citations Open access
Semantic Scholar
Alanyl-glutamine prevents muscle atrophy and glutamine synthetase induction by glucocorticoids.
R. C. Hickson, L. Wegrzyn, D. Osborne, I. Karl
1996American Journal of Physiology30 citations
Semantic Scholar
Reversal of hypocalcemia and decreased afterload in sepsis. Effect on myocardial systolic and diastolic function.
A. Kovács, M. Courtois, B. Barzilai, I. Karl +2 more
1998American Journal of Respiratory and Critical Care Medicine29 citations
Semantic Scholar
Confocal fluorescent intravital microscopy of the murine spleen.
M. Grayson, D. Chaplin, I. Karl, R. Hotchkiss
2001JIM - Journal of Immunological Methods26 citations
Semantic Scholar
Hormonal regulation of gluconeogenesis in cultured proximal tubular cells: role of cytosolic calcium.
M. Goligorsky, D. Osborne, T. Howard, K. Hruska +1 more
1987American Journal of Physiology26 citations
Semantic Scholar
Resistance of protein and glucose metabolism to insulin in denervated rat muscle.
Teresa A. Davis, I. Karl
1988Biochemical Journal25 citations Open access
Semantic Scholar
Glucose metabolism in epitrochlearis muscle of acutely exercised and trained rats.
Teresa A. Davis, S. Klahr, E. Tegtmeyer, D. Osborne +2 more
1986American Journal of Physiology25 citations
Semantic Scholar
Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis
B. Freeman, A. Reaume, P. Swanson, C. Epstein +4 more
2000Critical Care Medicine22 citations
Semantic Scholar
Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo.
T. H. Wagner, A. Drewry, Sandra Macmillan, W. Dunne +4 more
2007American Journal of Physiology. Regulatory Integrative and Comparative Physiology21 citations
Semantic Scholar
Effects of food restriction and insulin treatment on (Ca2+ + Mg2+)-ATPase response to insulin in kidney basolateral membranes of noninsulin-dependent diabetic rats.
J. Levy, G. Grunberger, I. Karl, J. R. Gavin
1990Metabolism: Clinical and Experimental21 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

R. Hotchkiss×39
Invite
R. Hotchkiss — researcher profile on SciRah
T. Buchman×14
Invite
T. Buchman — researcher profile on SciRah
Kevin W. Tinsley×11
Invite
Kevin W. Tinsley — researcher profile on SciRah
P. Swanson×10
Invite
P. Swanson — researcher profile on SciRah

Katherine C. Chang

×10

Invite

Katherine C. Chang — researcher profile on SciRah

Invite

D. Osborne — researcher profile on SciRah

C. Coopersmith×8

Invite

C. Coopersmith — researcher profile on SciRah

Invite

J. Cobb — researcher profile on SciRah

Invite

M. Grayson — researcher profile on SciRah

T. H. Wagner×4

Invite

T. H. Wagner — researcher profile on SciRah

Invite

C. Davis — researcher profile on SciRah

P. Stromberg×3

Invite

P. Stromberg — researcher profile on SciRah