Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

D. Smith · SciRah

Researcher profile · Semantic Scholar

D. Smith

Share profile

D. Smith — researcher profile on SciRah

h-index: 20
Works: 60
Citations: 1,338

Most-cited papers

The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture*
K. Klumpp, V. Leveque, S. Le Pogam, Han Ma +16 more
2006Journal of Biological Chemistry220 citations Open access
Semantic Scholar
Characterization of the Metabolic Activation of Hepatitis C Virus Nucleoside Inhibitor β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and Identification of a Novel Active 5′-Triphosphate Species*
Han Ma, Wenjing Jiang, Nicole L Robledo, V. Leveque +7 more
2007Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
D. Smith, J. A. Martin, K. Klumpp, S. Baker +20 more
2007Bioorganic & Medicinal Chemistry Letters94 citations
Semantic Scholar
2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups*
K. Klumpp, G. Kalayanov, Han Ma, S. Le Pogam +20 more
2007Journal of Biological Chemistry90 citations Open access
Semantic Scholar
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
D. Smith, G. Kalayanov, C. Sund, A. Winqvist +15 more
2009Journal of Medicinal Chemistry88 citations
Semantic Scholar
Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
Plinio Perrone, G. Luoni, M. R. Kelleher, F. Daverio +11 more
2007Journal of Medicinal Chemistry86 citations
Semantic Scholar
First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
Plinio Perrone, F. Daverio, Rocco Valente, S. Rajyaguru +7 more
2007Journal of Medicinal Chemistry68 citations
Semantic Scholar
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
C. Mcguigan, M. R. Kelleher, Plinio Perrone, Sinead Mulready +8 more
2009Bioorganic & Medicinal Chemistry Letters54 citations
Semantic Scholar
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
G. Phillips, B. Buckman, D. Davey, Keith A. Eagen +21 more
1998Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid.
Peter H. Nelson, S. Carr, B. Devens, E. Eugui +15 more
1996Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
D. Smith, G. Kalayanov, C. Sund, A. Winqvist +16 more
2009Journal of Medicinal Chemistry46 citations
Semantic Scholar
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
Javier de Vicente, R. Hendricks, D. Smith, Jay B. Fell +31 more
2009Bioorganic & Medicinal Chemistry Letters33 citations
Semantic Scholar
Organic reactions at high pressure. The preparative scale synthesis of cantharidin
W. Dauben, J. M. Gerdes, D. Smith
198533 citations
Semantic Scholar
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Javier de Vicente, R. Hendricks, D. Smith, Jay B. Fell +26 more
2009Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Intramolecular Hydrogen-Bonding Effects on the Fluorescence of PRODAN Derivatives.
Isaac G Alty, Douglas W Cheek, Tao Chen, D. Smith +2 more
2016Journal of Physical Chemistry A31 citations Open access
Semantic Scholar
SOLID PHASE SYNTHESIS OF N-ALKYL SULFONAMIDES
S. M. Dankwardt, D. Smith, J. Porco, Cindy Nguyen
199726 citations
Semantic Scholar
The Florisil® catalyzed [1,3]-sigmatropic shift of allyl phenyl ethers — An entryway into novel mycophenolic acid analogues
F. Talamas, D. Smith, A. Cervantes, Fidencio Franco +4 more
199725 citations
Semantic Scholar
Physicochemical Properties of the Nucleoside Prodrug R1626 Leading to High Oral Bioavailability
M. Brandl, Xiaoyang Wu, M. Holper, L. Hong +11 more
200823 citations
Semantic Scholar
Asymmetric Synthesis and Stereochemical Assignment of RS-97613, a Potent Immunosuppressive and Antiinflammatory Agent†
D. Smith, Ann Marie Waltos, David G. Loughhead, R. Weikert +4 more
199623 citations
Semantic Scholar
The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
C. Mcguigan, F. Daverio, I. Nájera, J. A. Martin +2 more
2009Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Magnus Nilsson, G. Kalayanov, A. Winqvist, P. Pinho +26 more
2012Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization.
T. Elworthy, D. Kertesz, Woongki Kim, M. G. Roepel +10 more
2004Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Javier de Vicente, R. Hendricks, D. Smith, Jay B. Fell +30 more
2009Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. Part 2: Solution phase synthesis of tetrasubstituted purines†
L. Hammarström, M. Meyer, D. Smith, F. Talamas
200315 citations
Semantic Scholar
Physicochemical properties of the nucleoside prodrug R1626 leading to high oral bioavailability.
M. Brandl, Xiaoyang Wu, M. Holper, L. Hong +11 more
2008Drug Development and Industrial Pharmacy12 citations
Semantic Scholar
Discovery and Clinical Evaluation of the Nucleoside Analog Balapiravir (R1626) for the Treatment of HCV Infection
K. Klumpp, D. Smith
201111 citations
Semantic Scholar
Design and Characterization of R1626, A Prodrug of the HCV Replication Inhibitor R1479 (4′-Azidocytidine) With Enhanced Oral Bioavailability
K. Klumpp, D. Smith, M. Brandl, T. Alfredson +28 more
20079 citations
Semantic Scholar
On the utility of α-heteroatom substituted orthoesters in the Johnson Claisen rearrangement☆
T. Elworthy, D. Morgans, W. Palmer, D. B. Repke +2 more
19949 citations
Semantic Scholar
Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine
L. Hammarström, D. Smith, F. Talamas, S. Labadie +1 more
20028 citations
Semantic Scholar
Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. Part 3: Regioselective solid-phase synthesis of a 2,6,8,9-tetrasubstituted purine library☆
L. Hammarström, D. Smith, F. Talamas
20077 citations
Semantic Scholar
INVESTIGATION OF AN UNUSUAL REARRANGEMENT
D. Smith, T. Elworthy, D. Morgans, J. T. Nelson +3 more
19965 citations
Semantic Scholar
Synthesis of N-allylhydroxamic acids via [3,3]-sigmatropic rearrangement☆
J. A. de la Torre, M. Fernández, D. Morgans, D. Smith +2 more
19944 citations
Semantic Scholar
Novel 4′-Azido-2′-Deoxy-Nucleoside Analogs are Potent Inhibitors of NS5B-Dependent HCV Replication
D. Smith, Han Ma, S. Le Pogam, V. Leveque +12 more
20073 citations
Semantic Scholar
2’-deoxy-4’-azido nucleoside analogs are highly potent inhibitors of HCV replication despite the lack of 2’-alpha hydroxyl groups
K. Klumpp, G. Kalayanov, Han Ma, S. Le Pogam +21 more
20072 citations
Semantic Scholar
Asymmetric Synthesis and Stereochemical Assignment of RS-97613, a Potent Immunosuppressive and Antiinflammatory Agent.
D. Smith, A. Waltos, D. G. Loughhead, R. Weikert +4 more
19962 citations
Semantic Scholar
Different Incorporation Efficiencies for Nucleotide Analogs During HCV Polymerase RNA Synthesis Initiation and Elongation Phases
Han Ma, N. Inocencio, V. Leveque, G. Kalayanov +4 more
20081 citations
Semantic Scholar
A potent inhibitor of Hepatitis C virus replication
Magnus Nilsson, G. Kalayanov, A. Winqvist, P. Pinho +25 more
20120 citations
Semantic Scholar
Investigation of an Unusual Rearrangement.
D. Smith, T. Elworthy, D. J. Jun. Morgans, J. T. Nelson +3 more
20100 citations
Semantic Scholar
2′-Deoxy-nucleoside Analogs can be Potent Dual Inhibitors of HCV and HIV Replication with Selectivity against Human Polymerases
K. Klumpp, Guoping Su, V. Leveque, J. Deval +12 more
20090 citations
Semantic Scholar
Synthesis of a 2,6,8,9-Tetrasubstituted Purine Library
L. Hammarström, D. Smith, F. Talamas
20070 citations
Semantic Scholar
Sub Micromolar Inhibitors of HCV Generated from Inactive Nucleosides by Application of ProTide Technology
C. Mcguigan, Plinio Perrone, G. Luoni, M. R. Kelleher +11 more
20070 citations
Semantic Scholar
Decreased Plasma Gelsolin Levels in Patients With Plasmodiumfalciparum
D. Smith, P. Janmey, J. Sherwood, R. J. Howard +1 more
20050 citations
Semantic Scholar
Utility of 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine. Part 2. Solution Phase Synthesis of Tetrasubstituted Purines.
L. Hammarstroem, M. Meyer, D. Smith, F. Talamas
20040 citations
Semantic Scholar
Piperidine quaternary salt CCR-3 receptor antagonists
D. Hirschfeld, D. Kertesz, D. Smith
19990 citations
Semantic Scholar
Derivatives of 4-aroylpiperidine receptor antagonists CCR3
Le-Yi Gong, D. Kertesz, D. Smith, R. Wilhelm
19990 citations
Semantic Scholar
Ccr-3 receptor antagonist 4-aroylpiperidines, pharmaceutical compositions containing same, process for their use and preparation thereof
Le-Yi Gong, D. Kertesz, D. Smith, R. Wilhelm
19990 citations
Semantic Scholar
4-aroylpiperidines receptor antagonists of CCR-3, pharmaceutical compositions containing them, process for preparing them and the use
Le-Yi Gong, D. Kertesz, D. Smith, R. Wilhelm
19990 citations
Semantic Scholar
Piperidine CCR-3 receptor inhibitor
D. Hirschfeld, D. Kertesz, D. Smith
19990 citations
Semantic Scholar
quaternary compounds of piperidine antagonists of CCR-3 receptor, pharmaceutical composition containing them, their use and preparation
D. Hirschfeld, D. Kertesz, D. Smith
19990 citations
Semantic Scholar
6-benzyl-2H-pyridazin-3-one derivatives and the manufacture and the use thereof as inhibitors of prostaglandin G / H synthase I and II (COX I and COX II)
D. Allen, J. Dunn, E. Sjogren, D. Smith
19970 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

K. Klumpp×19
Invite
K. Klumpp — researcher profile on SciRah
V. Leveque×17
Invite
V. Leveque — researcher profile on SciRah
I. Nájera×17
Invite
I. Nájera — researcher profile on SciRah
S. Le Pogam×15
Invite
S. Le Pogam — researcher profile on SciRah

×15

Invite

J. A. Martin — researcher profile on SciRah

S. Rajyaguru×12

Invite

S. Rajyaguru — researcher profile on SciRah

Invite

N. Cammack — researcher profile on SciRah

Invite

Han Ma — researcher profile on SciRah

G. Kalayanov×9

Invite

G. Kalayanov — researcher profile on SciRah

N. Johansson×9

Invite

N. Johansson — researcher profile on SciRah

Invite

F. Talamas — researcher profile on SciRah

Invite

C. Sund — researcher profile on SciRah