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Brian J. McHugh · SciRah

Researcher profile · Semantic Scholar

Brian J. McHugh

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Brian J. McHugh — researcher profile on SciRah

h-index: 20
Works: 41
Citations: 2,174

Most-cited papers

Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis.
J. Chalmers, Maeve P. Smith, Brian J. McHugh, C. Doherty +2 more
2012American Journal of Respiratory and Critical Care Medicine382 citations
Semantic Scholar
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum
Brian J. McHugh, R. Buttery, Yatish Lad, S. Banks +2 more
2010Journal of Cell Science201 citations Open access
Semantic Scholar
The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus
Silke M. Currie, E. Findlay, Brian J. McHugh, A. Mackellar +6 more
2013PLoS ONE172 citations Open access
Semantic Scholar
Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration
Brian J. McHugh, A. Murdoch, C. Haslett, T. Sethi
2012PLoS ONE155 citations Open access
Semantic Scholar
Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis
J. Chalmers, Brian J. McHugh, C. Docherty, J. Govan +1 more
2012Thorax154 citations Open access
Semantic Scholar
An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.
Lynda Vuong, E. Kouverianou, C. Rooney, Brian J. McHugh +14 more
2019Cancer Research110 citations Open access
Semantic Scholar
Mammalian NOTCH-1 Activates β1 Integrins via the Small GTPase R-Ras*
P. Hodkinson, P. A. Elliott, Yatish Lad, Brian J. McHugh +3 more
2007Journal of Biological Chemistry107 citations Open access
Semantic Scholar
the Onset
Sara R. van Boeckel, Lenka Hrabálková, Tina L. Baker, H. Macpherson +8 more
2019104 citations
Semantic Scholar
Blood Neutrophils Are Reprogrammed in Bronchiectasis
P. Bedi, D. Davidson, Brian J. McHugh, A. G. Rossi +1 more
2018American Journal of Respiratory and Critical Care Medicine92 citations Open access
Semantic Scholar
Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo
Paula E. Beaumont, Brian J. McHugh, Emily Gwyer Findlay, A. Mackellar +5 more
2014PLoS ONE91 citations Open access
Semantic Scholar
Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study.
J. Chalmers, Brian J. McHugh, C. Doherty, Maeve P. Smith +3 more
2013The Lancet Respiratory Medicine90 citations Open access
Semantic Scholar
NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD
Eilíse M. Ryan, P. Sadiku, P. Coelho, E. Watts +24 more
2023American Journal of Respiratory and Critical Care Medicine75 citations Open access
Semantic Scholar
IL-1β–Induced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human β-Defensin 2
Bing-Jie Wang, Brian J. McHugh, A. Qureshi, D. Campopiano +5 more
2017Journal of Investigative Dermatology55 citations Open access
Semantic Scholar
Microbial Host Interactions and Impaired Wound Healing in Mice and Humans: Defining a Role for BD14 and NOD2.
H. Williams, L. Campbell, R. Crompton, Gurdeep Singh +5 more
2018Journal of Investigative Dermatology49 citations Open access
Semantic Scholar
Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration.
Brian J. McHugh, Sue A. Krause, Bin Yu, Anne-Marie Deans +3 more
2004Journal of Cell Biology48 citations Open access
Semantic Scholar
Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa
Brian J. McHugh, Rong-Ling Wang, Hsin-Ni Li, Paula E. Beaumont +9 more
2019PLoS Pathogens45 citations Open access
Semantic Scholar
Human Cathelicidin Production by the Cervix
L. Frew, S. Makieva, Andrew T. M. McKinlay, Brian J. McHugh +4 more
2014PLoS ONE44 citations Open access
Semantic Scholar
Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy
E. Findlay, A. Currie, Ai-Liang Zhang, Jana Ovciarikova +10 more
2019Oncoimmunology30 citations Open access
Semantic Scholar
Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
Duncan C. Humphries, R. Mills, C. Boz, Brian J. McHugh +10 more
2022Frontiers in Pharmacology27 citations Open access
Semantic Scholar
Mammalian Antimicrobial Peptides; Defensins and Cathelicidins
J. Dorin, Brian J. McHugh, S. Cox, D. Davidson
201526 citations
Semantic Scholar
Regulation of chromosome condensation and segregation.
Brian J. McHugh, Margarete M. S. Heck
2003Current Opinion in Genetics and Development15 citations
Semantic Scholar
The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation
K. Smith, Danielle Minns, Brian J. McHugh, Rebecca K. Holloway +7 more
2022PLoS Biology12 citations Open access
Semantic Scholar
Inhibition of Cyclin-Dependent Kinase 9 Downregulates Cytokine Production Without Detrimentally Affecting Human Monocyte-Derived Macrophage Viability
Brian J. McHugh, J. Stephen, C. Robb, Sarah Fox +6 more
2022Frontiers in Cell and Developmental Biology11 citations Open access
Semantic Scholar
Cathelicidins and the Onset of Labour
Sara R. van Boeckel, Lenka Hrabálková, Tina L. Baker, H. Macpherson +8 more
2019Scientific Reports11 citations Open access
Semantic Scholar
IL-1 beta-induced protection of keratinocytes against Staphylococcus aureus-secreted proteases is mediated by human beta defensin 2
Bing-Jie Wang, Brian J. McHugh, A. Qureshi, D. Campopiano +5 more
201611 citations
Semantic Scholar
Phospholipase Cϵ Suppresses Integrin Activation*
Yatish Lad, Brian J. McHugh, P. Hodkinson, A. Mackinnon +3 more
2006Journal of Biological Chemistry11 citations Open access
Semantic Scholar
Differential response to bacteria, and TOLLIP expression, in the human respiratory tract
O. L. Moncayo-Nieto, Thomas S. Wilkinson, M. Brittan, Brian J. McHugh +5 more
2014BMJ Open Respiratory Research10 citations Open access
Semantic Scholar
A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro
Jennifer Shelley, Brian J. McHugh, J. Wills, J. Dorin +3 more
2023Scientific Reports9 citations Open access
Semantic Scholar
Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19?
D. Dockrell, C. Russell, Brian J. McHugh, R. Fraser
2022European Respiratory Journal9 citations Open access
Semantic Scholar
Molecular Medical Microbiology - 2nd edition
J. Dorin, Brian J. McHugh, S. Cox, D. Davidson
20146 citations
Semantic Scholar
IL-1beInduced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human b-Defensin 2
Bing-jie Wang, Brian J. McHugh, A. Qureshi, D. Campopiano +5 more
20164 citations
Semantic Scholar
Invadolysin
Brian J. McHugh, Sue A. Krause, Bin Yu, Anne-Marie Deans +3 more
2004Journal of Cell Biology3 citations Open access
Semantic Scholar
The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease
K. Smith, Danielle Minns, Brian J. McHugh, Rebecca K. Holloway +7 more
2022bioRxiv2 citations Open access
Semantic Scholar
Classical macrophage polarisation is limited by human β-defensin-3 via an autocrine IL-4 dependent process
M. E. Candela, D. Allsop, Roderick N. Carter, Fiona Semple +11 more
2021bioRxiv2 citations Open access
Semantic Scholar
The relationship between airway bacterial load and airways inflammation in stable non-cystic fibrosis bronchiectasis
J. Chalmers, P. Mandal, Brian J. McHugh, Maeve P. Smith +3 more
20112 citations
Semantic Scholar
Dysregulation of lipid mediators in clinically stable bronchiectasis
P. Bedi, D. Davidson, Brian J. McHugh, A. G. Rossi +1 more
2018Respiratory infections1 citations
Semantic Scholar
S106 Peripheral blood neutrophils are primed and activated in bronchiectasis and are attenuated by the pro-resolving mediator lipoxin a4
P. Bedi, Brian J. McHugh, D. Davidson, Adriano G. Rossi +1 more
2016Thorax1 citations Open access
Semantic Scholar
Edinburgh IL-1beta-induced protection of keratinocytes against Staphylococcus aureus-secreted proteases is mediated by human beta defensin 2
Bingjie Wang, Brian J. McHugh, A. Qureshi, D. Campopiano +5 more
20180 citations
Semantic Scholar
Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis
J. Chalmers, Brian J. McHugh, C. Doherty, J. Govan +1 more
20170 citations
Semantic Scholar
Mannose binding lectin deficiency is associated with disease severity in patients with non-cystic fibrosis bronchiectasis
J. Chalmers, D. Kilpatrick, Brian J. McHugh, P. Mandal +4 more
2011European Respiratory Journal0 citations
Semantic Scholar
Characterisation of l(3)IX-14, a novel mitotic mutant in Drosophila melanogaster
Brian J. McHugh
20010 citations
Semantic Scholar

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