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W. Backes · SciRah

Researcher profile · Semantic Scholar

W. Backes

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W. Backes — researcher profile on SciRah

h-index: 29
Works: 126
Citations: 3,735

Most-cited papers

Origin and Health Impacts of Emissions of Toxic By-Products and Fine Particles from Combustion and Thermal Treatment of Hazardous Wastes and Materials
S. Cormier, S. Lomnicki, W. Backes, B. Dellinger
2006Environmental Health Perspectives207 citations Open access
Semantic Scholar
Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes.
W. Backes, R. W. Kelley
2003Pharmacology and Therapeutics151 citations
Semantic Scholar
Formation of P450•P450 Complexes and Their Effect on P450 Function
J. Reed, W. Backes
2011Pharmacology and Therapeutics110 citations Open access
Semantic Scholar
Interactions among P450 enzymes when combined in reconstituted systems: formation of a 2B4-1A2 complex with a high affinity for NADPH-cytochrome P450 reductase.
W. Backes, C. Batie, George F. Cawley
1998Biochemistry94 citations
Semantic Scholar
Substrate-dependent competition of different P450 isozymes for limiting NADPH-cytochrome P450 reductase.
George F. Cawley, C. Batie, W. Backes
1995Biochemistry72 citations
Semantic Scholar
Evidence supporting the interaction of CYP2B4 and CYP1A2 in microsomal preparations.
George F. Cawley, Shuxin Zhang, Russell W. Kelley, W. Backes
2001Drug Metabolism And Disposition64 citations
Semantic Scholar
Ethylbenzene induces microsomal oxygen free radical generation: antibody-directed characterization of the responsible cytochrome P450 enzymes.
Sonia C. Serron, Neelam Dwivedi, W. Backes
2000Toxicology and Applied Pharmacology62 citations
Semantic Scholar
Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity
Lauren M. Brignac-Huber, J. W. Park, J. Reed, W. Backes
2016Drug Metabolism And Disposition58 citations Open access
Semantic Scholar
Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells
A. Harmon, Valeria Y. Hebert, S. Cormier, Balamurugan Subramanian +3 more
2018PLoS ONE55 citations Open access
Semantic Scholar
Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2.
R. W. Kelley, J. Reed, W. Backes
2005Biochemistry54 citations Open access
Semantic Scholar
Heteromeric complex formation between CYP2E1 and CYP1A2: evidence for the involvement of electrostatic interactions.
R. W. Kelley, Dongmei Cheng, W. Backes
2006Biochemistry52 citations Open access
Semantic Scholar
Cytochrome P450 System Proteins Reside in Different Regions of the Endoplasmic Reticulum
J. W. Park, J. Reed, Lauren M. Brignac-Huber, W. Backes
2014Biochemical Journal51 citations Open access
Semantic Scholar
Inhibition of Cytochrome P450 1A2-Mediated Metabolism and Production of Reactive Oxygen Species by Heme Oxygenase-1 in Rat Liver Microsomes
J. Reed, George F. Cawley, W. Backes
2011Drug Metabolism Letters46 citations Open access
Semantic Scholar
Organization of NADPH-Cytochrome P450 Reductase and CYP1A2 in the Endoplasmic Reticulum—Microdomain Localization Affects Monooxygenase Function
Lauren M. Brignac-Huber, J. Reed, W. Backes
2011Molecular Pharmacology44 citations Open access
Semantic Scholar
The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function
E. Scott, C. Wolf, M. Otyepka, Sara C. Humphreys +15 more
2016Drug Metabolism And Disposition43 citations Open access
Semantic Scholar
Differences in KRAS mutation spectrum in lung cancer cases between African Americans and Caucasians after occupational or environmental exposure to known carcinogens.
J. D. Hunt, A. Strimas, Julie E. Martin, Marilyn K. Eyer +6 more
2002Cancer Epidemiology, Biomarkers and Prevention38 citations
Semantic Scholar
Physical Studies of P450–P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures
J. Reed, W. Backes
2017Frontiers in Pharmacology33 citations Open access
Semantic Scholar
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase.
Warren J. Huber, W. Backes
2007Biochemistry32 citations Open access
Semantic Scholar
The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in vivo
J. Reed, W. Backes
2016Drug metabolism reviews (Softcover ed.)30 citations Open access
Semantic Scholar
Measurement of Membrane-Bound Human Heme Oxygenase-1 Activity Using a Chemically Defined Assay System
Warren J. Huber, C. Marohnic, Michelle L Peters, J. Alam +3 more
2009Drug Metabolism And Disposition30 citations Open access
Semantic Scholar
Effect of Homomeric P450•P450 Complexes on P450 Function
J. Reed, John Patrick Connick, Dongmei Cheng, George F. Cawley +1 more
2012Biochemical Journal29 citations Open access
Semantic Scholar
Functional Interactions between Cytochromes P450 1A2 and 2B4 Require Both Enzymes to Reside in the Same Phospholipid Vesicle
J. Reed, Marilyn K. Eyer, W. Backes
2010Journal of Biological Chemistry29 citations Open access
Semantic Scholar
AN EVALUATION OF METHODS FOR THE RECONSTITUTION OF CYTOCHROMES P450 AND NADPH P450 REDUCTASE INTO LIPID VESICLES
J. Reed, R. W. Kelley, W. Backes
2006Drug Metabolism And Disposition29 citations Open access
Semantic Scholar
Environmentally Persistent Free Radicals Inhibit Cytochromes P450 Activity in Rat Liver Microsomes
J. Reed, George F. Cawley, Taylor G Ardoin, B. Dellinger +4 more
2014Toxicology and Applied Pharmacology28 citations Open access
Semantic Scholar
C-Terminal Membrane Spanning Region of Human Heme Oxygenase-1 Mediates a Time Dependent Complex Formation with Cytochrome P450 Reductase
Warren J. Huber, Brittni A Scruggs, W. Backes
2008Biochemistry27 citations Open access
Semantic Scholar
High-level expression of recombinant rabbit cytochrome P450 2E1 in Escherichia coli C41 and its purification.
Dongmei Cheng, R. W. Kelley, George F. Cawley, W. Backes
2004Protein Expression and Purification27 citations
Semantic Scholar
Mutations of Human Cytochrome P450 Reductase Differentially Modulate Heme Oxygenase-I Activity and Oligomerization
C. Marohnic, Warren J. Huber, John Patrick Connick, J. Reed +5 more
2011Archives of Biochemistry and Biophysics25 citations Open access
Semantic Scholar
Correlating Structure and Function of Drug-Metabolizing Enzymes: Progress and Ongoing Challenges
E. F. Johnson, John Patrick Connick, J. Reed, W. Backes +5 more
2014Drug Metabolism And Disposition24 citations Open access
Semantic Scholar
Relationship between CYP1A2 Localization and Lipid Microdomain Formation as a Function of Lipid Composition
Lauren M. Brignac-Huber, J. Reed, Marilyn K. Eyer, W. Backes
2013Drug Metabolism And Disposition24 citations Open access
Semantic Scholar
Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter
J. Reed, Alberto Dela Cruz, S. Lomnicki, W. Backes
2015Biochemical Pharmacology23 citations Open access
Semantic Scholar
The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions*
J. W. Park, J. Reed, W. Backes
2015Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Time course for the modulation of hepatic cytochrome P450 after administration of ethylbenzene and its correlation with toluene metabolism.
Wei Yuan, D. Sequeira, George F. Cawley, Charles S. Eyer +1 more
1997Archives of Biochemistry and Biophysics22 citations
Semantic Scholar
Temporal changes in P-450 2E1 expression with continued ethylbenzene exposure.
D. Sequeira, George F. Cawley, Charles S. Eyer, W. Backes
1994Biochimica et Biophysica Acta22 citations
Semantic Scholar
Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2
J. Reed, Alberto Dela Cruz, S. Lomnicki, W. Backes
2015Toxicology and Applied Pharmacology21 citations Open access
Semantic Scholar
Physical Incorporation of NADPH-Cytochrome P450 Reductase and Cytochrome P450 into Phospholipid Vesicles Using Glycocholate and Bio-Beads
J. Reed, Lauren M. Brignac-Huber, W. Backes
2008Drug Metabolism And Disposition18 citations Open access
Semantic Scholar
Prough Formation of P 450 · P 450 complexes and their effect on P 450 function
J. Reed, W. Backes
201215 citations
Semantic Scholar
Ethylbenzene modulates the expression of different cytochrome P-450 isozymes by discrete multistep processes.
W. Yuan, Sonia C. Serron, Monica M. Haddican, George F. Cawley +2 more
1997Biochimica et Biophysica Acta15 citations
Semantic Scholar
Interactions between Cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) Lead to Alterations in Toluene Disposition and P450 Uncoupling
J. Reed, George F. Cawley, W. Backes
2013Biochemistry14 citations Open access
Semantic Scholar
Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes
John Patrick Connick, J. Reed, W. Backes
2018Drug Metabolism And Disposition13 citations Open access
Semantic Scholar
Changes in the expression of cytochrome P450s 2B1, 2B2, 2E1, and 2C11 in response to daily aromatic hydrocarbon treatment.
R. M. Bergeron, Кетан К. Десай, Sonia C. Serron, George F. Cawley +2 more
1999Toxicology and Applied Pharmacology13 citations
Semantic Scholar
Pituitary component of the aromatic hydrocarbon-mediated expression of CYP2B and CYP2C11.
R. M. Bergeron, S. C. Serron, J. Rinehart, George F. Cawley +1 more
1998Xenobiotica; the fate of foreign compounds in biological systems13 citations
Semantic Scholar
Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1
John Patrick Connick, J. Reed, George F. Cawley, W. Backes
2021Biochemical Journal10 citations Open access
Semantic Scholar
Human Heme Oxygenase-1 Efficiently Catabolizes Heme in the Absence of Biliverdin Reductase
J. Reed, Warren J. Huber, W. Backes
2010Drug Metabolism And Disposition9 citations Open access
Semantic Scholar
Quantitation of heme oxygenase 1: heme titration increases yield of purified protein.
Warren J. Huber, W. Backes
2008Analytical Biochemistry9 citations Open access
Semantic Scholar
Effect of hypophysectomy and growth hormone replacement on the modulation of p450 expression after treatment with the aromatic hydrocarbon ethylbenzene.
S. C. Serron, Shuxin Zhang, R. M. Bergeron, W. Backes
2001Toxicology and Applied Pharmacology8 citations
Semantic Scholar
Relationship between hydrocarbon structure and induction of P450: effect on RNA levels.
W. Yuan, T. B. White, J. W. White, H. Strobel +1 more
1995Xenobiotica; the fate of foreign compounds in biological systems8 citations
Semantic Scholar
Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1
John Patrick Connick, J. Reed, George F. Cawley, W. Backes
2020Journal of Biological Chemistry7 citations Open access
Semantic Scholar
Altered ethylbenzene-mediated hepatic CYP2E1 expression in growth hormone-deficient dwarf rats.
Shuxin Zhang, George F. Cawley, C. S. Eyer, W. Backes
2002Toxicology and Applied Pharmacology7 citations
Semantic Scholar
Functional Characterization of CYP1 Enzymes: Complex formation, membrane localization and function
John Patrick Connick, J. Reed, George F. Cawley, Aratrika Saha +1 more
2023Journal of Inorganic Biochemistry6 citations Open access
Semantic Scholar
Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1
John Patrick Connick, J. Reed, George F. Cawley, W. Backes
2020bioRxiv6 citations Open access
Semantic Scholar

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