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A. Simonetti · SciRah

Researcher profile · Semantic Scholar

A. Simonetti

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A. Simonetti — researcher profile on SciRah

h-index: 19
Works: 46
Citations: 1,393

Most-cited papers

Structure of the 30S translation initiation complex
A. Simonetti, S. Marzi, A. Myasnikov, A. Fabbretti +3 more
2008Nature228 citations
Semantic Scholar
A structural view of translation initiation in bacteria
A. Simonetti, S. Marzi, L. Jenner, Alexander G. Myasnikov +4 more
2009Cellular and Molecular Life Sciences154 citations
Semantic Scholar
Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome
A. Myasnikov, S. Marzi, A. Simonetti, A. Giuliodori +4 more
2005Nature Structural &Molecular Biology136 citations
Semantic Scholar
eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
A. Simonetti, Jailson Brito Querido, A. Myasnikov, Eder Mancera-Martínez +3 more
2016Molecules and Cells107 citations Open access
Semantic Scholar
Structure-function insights into prokaryotic and eukaryotic translation initiation.
A. Myasnikov, A. Simonetti, S. Marzi, B. Klaholz
2009Current Opinion in Structural Biology93 citations
Semantic Scholar
Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF
I. Khusainov, Q. Vicens, R. Ayupov, K. Usachev +7 more
2017EMBO Journal82 citations Open access
Semantic Scholar
ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation
Eder Mancera-Martínez, Jailson Brito Querido, L. Valášek, A. Simonetti +1 more
2017RNA Biology71 citations Open access
Semantic Scholar
Structural Insights into the Mammalian Late-Stage Initiation Complexes
A. Simonetti, E. Guca, A. Bochler, L. Kuhn +1 more
2020Cell Reports69 citations Open access
Semantic Scholar
Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor
A. Simonetti, S. Marzi, I. Billas, A. Tsai +10 more
2013Proceedings of the National Academy of Sciences of the United States of America64 citations Open access
Semantic Scholar
Multiple ways to regulate translation initiation in bacteria: Mechanisms, regulatory circuits, dynamics.
Mélodie Duval, A. Simonetti, I. Caldelari, S. Marzi
2015Biochimie63 citations
Semantic Scholar
Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
S. Pellegrino, N. Demeshkina, Eder Mancera-Martínez, S. Melnikov +5 more
2018Journal of Molecular Biology52 citations Open access
Semantic Scholar
Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation
Franck Martin, J. Ménétret, A. Simonetti, Alexander G. Myasnikov +5 more
2016Nature Communications48 citations Open access
Semantic Scholar
Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases
D. Eiler, Jinzhong Lin, A. Simonetti, B. Klaholz +1 more
2013Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism
I. Abaeva, Q. Vicens, A. Bochler, H. Soufari +4 more
2020bioRxiv29 citations Open access
Semantic Scholar
Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts
A. Bochler, J. B. Querido, Terezie Prilepskaja, H. Soufari +6 more
2019bioRxiv29 citations Open access
Semantic Scholar
Biological Crystallography Structure of the Protein Core of Translation Initiation Factor 2 in Apo, Gtp-bound and Gdp-bound Forms
A. Simonetti, I. Hazemann, Jenner, G. C +1 more
26 citations
Semantic Scholar
Purification of mRNA‐programmed translation initiation complexes suitable for mass spectrometry analysis
J. Chicher, A. Simonetti, L. Kuhn, L. Schaeffer +3 more
2015Proteomics23 citations
Semantic Scholar
The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.
Jailson Brito Querido, Eder Mancera-Martínez, Q. Vicens, A. Bochler +3 more
2017Structure20 citations Open access
Semantic Scholar
Quantifying resolution limiting factors in subtomogram averaged cryo-electron tomography using simulations.
L. Voortman, M. Vulovic, M. Maletta, A. Voigt +5 more
2014Journal of Structural Biology20 citations
Semantic Scholar
Rapid purification of ribosomal particles assembled on histone H4 mRNA: a new method based on mRNA-DNA chimaeras.
Lydia Prongidi-Fix, L. Schaeffer, A. Simonetti, S. Barends +4 more
2013Biochemical Journal14 citations
Semantic Scholar
Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism.
Mattia D'Agostino, A. Simonetti, Stefano Motta, Philippe Wolff +6 more
2024Structure8 citations
Semantic Scholar
Internal ribosome entry sites enhance translation in trans in antisense non-coding SINEUP and circular RNAs
Sabrina D’Agostino, Abraham Tettey-Matey, Massimiliano Volpe, Bianca Pierattini +25 more
2025Nucleic Acids Research7 citations Open access
Semantic Scholar
Grad-cryo-EM: Tool to Isolate Translation Initiation Complexes from Rabbit Reticulocyte Lysate Suitable for Structural Studies.
Javier Rol-Moreno, L. Kuhn, S. Marzi, A. Simonetti
2020Methods in molecular biology5 citations Open access
Semantic Scholar
10 Integrative structure-function analysis of large nucleoprotein complexes
J. Ménétret, H. Khatter, A. Simonetti, Igor N. Orlov +9 more
20134 citations
Semantic Scholar
Insights into translation initiation and termination complexes and into the polysome architecture
A. Simonetti, S. Marzi, A. Myasnikov, J. Ménétret +1 more
20114 citations
Semantic Scholar
A structural element within the 5′UTR of β-catenin mRNA modulates its translation under hypoxia
Mattia D'Agostino, Javier Rol-Moreno, Guillaume Bec, Lauriane Kuhn +2 more
2025Nucleic Acids Research2 citations Open access
Semantic Scholar
Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma
Alexandre Haller, G. Gambi, Mattia D'Agostino, G. Davidson +8 more
2025bioRxiv2 citations Open access
Semantic Scholar
Mammalian 48S late-stage initiation complex with beta-globin mRNA
A. Bochler, A. Simonetti, E. Guca, Y. Hashem
20200 citations
Semantic Scholar
Mammalian 48S late-stage translation initiation complex with histone 4 mRNA
A. Bochler, A. Simonetti, E. Guca, Y. Hashem
20200 citations
Semantic Scholar
Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA
A. Bochler, A. Simonetti, E. Guca, Y. Hashem
20200 citations
Semantic Scholar
Structural insights into the Kozak sequence interactions within the mammalian late-stage initiation complexes
A. Simonetti, E. Guca, A. Bochler, L. Kuhn +1 more
2019bioRxiv0 citations Open access
Semantic Scholar
Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin)
S. Pellegrino, N. Demeshkina, Eder Mancera-Martínez, S. Melnikov +5 more
20180 citations
Semantic Scholar
Structure of KSRP in context of Leishmania donovani 80S
J. B. Querido, Eder Mancera-Martínez, Q. Vicens, A. Bochler +3 more
20170 citations
Semantic Scholar
Structure of KSRP in context of Trypanosoma cruzi 40S
J. B. Querido, Eder Mancera-Martínez, Q. Vicens, A. Bochler +3 more
20170 citations
Semantic Scholar
Hibernating ribosome from Staphylococcus aureus (Unrotated state)
I. Khusainov, Q. Vicens, R. Ayupov, K. Usachev +7 more
20170 citations
Semantic Scholar
eIF3b relocated to the intersubunit face to interact with eIF1 and below the eIF2 ternary-complex. from the structure of a partial yeast 48S preinitiation complex in closed conformation.
A. Simonetti, J. B. Querido, A. Myasnikov, Eder Mancera-Martínez +3 more
20160 citations
Semantic Scholar
m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face
A. Simonetti, J. B. Querido, A. Myasnikov, E. Mancera-Martinez +3 more
20160 citations
Semantic Scholar
Bacterial translation initiation factor IF2 (1-363), apo form, double mutant K86L H130A
A. Simonetti, A. Urzhumtsev, B. Klaholz
20130 citations
Semantic Scholar
Bacterial translation initiation factor IF2 (1-363), complex with GTP
A. Simonetti, A. Urzhumtsev, B. Klaholz
20130 citations
Semantic Scholar
Bacterial translation initiation factor IF2 (1-363), complex with GDP at pH8.0
A. Simonetti, A. Urzhumtsev, B. Klaholz
20130 citations
Semantic Scholar
Bacterial translation initiation factor IF2 (1-363), complex with GDP at pH6.5
A. Simonetti, A. Urzhumtsev, B. Klaholz
20130 citations
Semantic Scholar
Bacterial translation initiation factor IF2 (1-363), apo form
A. Simonetti, A. Urzhumtsev, B. Klaholz
20130 citations
Semantic Scholar
Model of full-length T. thermophilus Translation Initiation Factor 2 refined against its cryo-EM density from a 30S Initiation Complex map
A. Simonetti, S. Marzi, I. Billas, A. Tsai +10 more
20130 citations
Semantic Scholar
Investigation of the protein synthesis machinery at different levels of organization through integrative cryo-EM
A. Myasnikov, Z. Afonina, A. Simonetti, S. Marzi +1 more
20100 citations Open access
Semantic Scholar
Structure-function study of bacterial translation initiation complexes
A. Simonetti
20080 citations
Semantic Scholar
Purification of T. thermophilus translation initiation factors and characterization of the corresponding ribosome complexes by filter-binding assays
A. Simonetti, S. Marzi, A. Myasnikov, A. Fabbretti +3 more
20080 citations Open access
Semantic Scholar

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B. Klaholz×19
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Y. Hashem×18
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A. Myasnikov×16
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S. Marzi×11
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A. Bochler — researcher profile on SciRah

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