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R. Ramsay · SciRah

Researcher profile · Semantic Scholar

R. Ramsay

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R. Ramsay — researcher profile on SciRah

h-index: 37
Works: 124
Citations: 5,039

Most-cited papers

A perspective on multi-target drug discovery and design for complex diseases
R. Ramsay, M. Popović-Nikolić, Katarina M. Nikolic, Elisa Uliassi +1 more
2018Clinical and Translational Medicine650 citations Open access
Semantic Scholar
Molecular enzymology of carnitine transfer and transport.
R. Ramsay, R. Gandour, F. R. van der Leij
2001Biochimica et Biophysica Acta410 citations
Semantic Scholar
Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A.
F. Reck, Feiyu Zhou, Marc Girardot, Gunther H. Kern +4 more
2005Journal of Medicinal Chemistry266 citations Open access
Semantic Scholar
Inhibition of Monoamine Oxidase A by β-Carboline Derivatives
Hoon Kim, S. Sablin, R. Ramsay
1997230 citations
Semantic Scholar
Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs
R. Ramsay, K. Tipton
2017Molecules223 citations Open access
Semantic Scholar
Carnitine acyltransferases and their influence on CoA pools in health and disease.
R. Ramsay, V. Zammit
2004Molecular Aspects of Medicine164 citations
Semantic Scholar
Carnitine, mitochondrial function and therapy.
V. Zammit, R. Ramsay, M. Bonomini, A. Arduini
2009Advanced Drug Delivery Reviews146 citations
Semantic Scholar
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
M. Unzeta, Gerard Esteban, Irene Bolea, W. A. Fogel +4 more
2016Frontiers in Neuroscience134 citations Open access
Semantic Scholar
Monoamine oxidases: the biochemistry of the proteins as targets in medicinal chemistry and drug discovery.
R. Ramsay
2012Current Topics in Medicinal Chemistry110 citations
Semantic Scholar
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.
Óscar M. Bautista-Aguilera, S. Hagenow, A. Palomino-Antolin, Víctor Farré-Alins +17 more
2017Angewandte Chemie93 citations
Semantic Scholar
The carnitine acyltransferases: modulators of acyl-CoA-dependent reactions.
R. Ramsay
2000Biochemical Society Transactions92 citations
Semantic Scholar
Kinetics, mechanism, and inhibition of monoamine oxidase
R. Ramsay, Alen Albreht
2018Journal of neural transmission90 citations
Semantic Scholar
Molecular aspects of monoamine oxidase B.
R. Ramsay
2016Progress in Neuro-psychopharmacology and Biological Psychiatry86 citations Open access
Semantic Scholar
Characterization of the inhibitory mechanism of 1-methyl-4-phenylpyridinium and 4-phenylpyridine analogs in inner membrane preparations.
M. Gluck, M. Krueger, R. Ramsay, S. O. Sablin +2 more
1994Journal of Biological Chemistry85 citations Open access
Semantic Scholar
One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug
Rebecca E. Hughes, Katarina M. Nikolic, R. Ramsay
2016Frontiers in Neuroscience83 citations Open access
Semantic Scholar
ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy
J. Marco-Contelles, M. Unzeta, Irene Bolea, Gerard Esteban +5 more
2016Frontiers in Neuroscience69 citations Open access
Semantic Scholar
Inhibition of monoamine oxidase A by beta-carboline derivatives.
H. Kim, S. O. Sablin, R. Ramsay
1997Archives of Biochemistry and Biophysics69 citations
Semantic Scholar
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration
R. Ramsay, M. Májeková, M. Medina, M. Valoti
2016Frontiers in Neuroscience66 citations Open access
Semantic Scholar
Inhibitor design for monoamine oxidases.
R. Ramsay
2013Current pharmaceutical design65 citations
Semantic Scholar
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
Óscar M. Bautista-Aguilera, Abdelouahid Samadi, M. Chioua, Katarina M. Nikolic +10 more
2014Journal of Medicinal Chemistry63 citations Open access
Semantic Scholar
L-carnitine acyltransferase in intact peroxisomes is inhibited by malonyl-CoA.
J. Derrick, R. Ramsay
1989Biochemical Journal61 citations Open access
Semantic Scholar
Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.
Gerard Esteban, J. Allan, Abdelouahid Samadi, A. Mattevi +4 more
2014Biochimica et Biophysica Acta57 citations Open access
Semantic Scholar
Electron carriers and energy conservation in mitochondrial respiration
R. Ramsay
2019ChemTexts54 citations Open access
Semantic Scholar
Dietary inhibitors of monoamine oxidase A
Sarah E. Dixon Clarke, R. Ramsay
2011Journal of neural transmission50 citations
Semantic Scholar
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.
L. Hroch, Patrick Guest, O. Benek, O. Soukup +9 more
2017Bioorganic & Medicinal Chemistry46 citations Open access
Semantic Scholar
Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines.
A. P. Vintém, N. Price, R. Silverman, R. Ramsay
2005Bioorganic & Medicinal Chemistry45 citations
Semantic Scholar
A Stable Tyrosyl Radical in Monoamine Oxidase A*
S. E. Rigby, R. Hynson, R. Ramsay, A. Munro +1 more
2005Journal of Biological Chemistry44 citations Open access
Semantic Scholar
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.
Susan Lühr, M. Vilches-Herrera, A. Fierro, R. Ramsay +4 more
2010Bioorganic & Medicinal Chemistry42 citations Open access
Semantic Scholar
Characterization of the covalently bound anionic flavin radical in monoamine oxidase a by electron paramagnetic resonance.
Christopher W. M. Kay, H. El Mkami, G. Molla, L. Pollegioni +1 more
2007Journal of the American Chemical Society41 citations Open access
Semantic Scholar
A snapshot of carnitine acetyltransferase.
R. Ramsay, J. Naismith
2003TIBS -Trends in Biochemical Sciences. Regular ed40 citations
Semantic Scholar
Inhibitor Probes of the Quinone Binding Sites of Mammalian Complex II and Escherichia coli Fumarate Reductase*
V. Yankovskaya, S. O. Sablin, R. Ramsay, T. Singer +3 more
1996Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Comparison of the active sites of the purified carnitine acyltransferases from peroxisomes and mitochondria by using a reaction-intermediate analogue.
N. Nic A' Bháird, G. Kumaravel, R. Gandour, M. Krueger +1 more
1993Biochemical Journal37 citations Open access
Semantic Scholar
The effect of dithiocarbamates on neurotoxic action of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) and on mitochondrial respiration chain.
S. Bachurin, E. P. Shevtzova, N. Lermontova, T. Serkova +1 more
1996Neurotoxicology31 citations
Semantic Scholar
Tacrine-allyl/propargylcysteine–benzothiazole trihybrids as potential anti-Alzheimer's drug candidates
Asha Hiremathad, K. Chand, A. R. Esteves, S. Cardoso +4 more
201630 citations Open access
Semantic Scholar
Live cell interactome of the human voltage dependent anion channel 3 (VDAC3) revealed in HeLa cells by affinity purification tag technique.
A. Messina, S. Reina, F. Guarino, A. Magrì +4 more
2014Molecular Biosystems27 citations
Semantic Scholar
Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine.
P. De Deurwaerdère, C. Binda, R. Corne, Cosima Leone +5 more
2017ACS Chemical Neuroscience25 citations Open access
Semantic Scholar
Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism
Alen Albreht, I. Vovk, J. Mavri, J. Marco-Contelles +1 more
2018Frontiers in Chemistry24 citations Open access
Semantic Scholar
Inhibitors alter the spectrum and redox properties of monoamine oxidase A.
R. Ramsay, Dominic J. B. Hunter
2002Biochimica et Biophysica Acta23 citations
Semantic Scholar
Predicting targets of compounds against neurological diseases using cheminformatic methodology
Katarina M. Nikolic, L. Mavridis, Óscar M. Bautista-Aguilera, J. Marco-Contelles +7 more
2015Journal of Computer-Aided Molecular Design22 citations Open access
Semantic Scholar
The soluble carnitine palmitoyltransferase from bovine liver. A comparison with the enzymes from peroxisomes and from the mitochondrial inner membrane.
R. Ramsay
1988Biochemical Journal22 citations Open access
Semantic Scholar
Parameters for Irreversible Inactivation of Monoamine Oxidase
R. Ramsay, L. Basile, Antonin Maniquet, S. Hagenow +5 more
2020Molecules21 citations Open access
Semantic Scholar
An improved approach to steady-state analysis of monoamine oxidases
R. Ramsay, Aldo Olivieri, A. Holt
2011Journal of neural transmission21 citations
Semantic Scholar
Conformational changes in monoamine oxidase A in response to ligand binding or reduction.
R. Hynson, S. Kelly, N. C. Price, R. Ramsay
2004Biochimica et Biophysica Acta21 citations
Semantic Scholar
Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function
Ying Cheng, Matthew Buchan, K. Vitanova, L. Aitken +3 more
2020Journal of Neurochemistry20 citations Open access
Semantic Scholar
Orientation of oxazolidinones in the active site of monoamine oxidase.
Tadeusz Z. E. Jones, P. Fleming, C. Eyermann, M. Gravestock +1 more
2005Biochemical Pharmacology19 citations
Semantic Scholar
Monoamine Oxidase Contains a Redox-active Disulfide*
S. Sablin, R. Ramsay
1998Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Syntheses, Structures, and Enzymic Evaluations of Conformationally Constrained, Analog Inhibitors of Carnitine Acetyltransferase: (2R,6R)-, (2S,6S)-, (2R,6S)-, and (2S,6R)-6-(Carboxylatomethyl)-2-(hydroxymethyl)-2,4,4-trimethylmorpholinium
Guobin Sun, P. S. Savle, R. Gandour, N. N. Bhaird +2 more
199519 citations
Semantic Scholar
Mechanism-based inactivation of monoamine oxidases A and B by tetrahydropyridines and dihydropyridines.
M. Krueger, K. McKeown, R. Ramsay, S. Youngster +1 more
1990Biochemical Journal18 citations Open access
Semantic Scholar
Biochemical mechanisms underlying MPTP-induced and idiopathic parkinsonism. New vistas.
T. Singer, R. Ramsay, P. Sonsalla, W. Nicklas +1 more
1993Advances in neurology17 citations
Semantic Scholar
Substrate regulation of monoamine oxidases.
R. Ramsay
1998Journal of neural transmission. Supplementum15 citations
Semantic Scholar

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J. Marco-Contelles×8
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Katarina M. Nikolic×4
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T. Singer×4
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R. Gandour×3
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Gerard Esteban×3

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S. O. Sablin×3

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M. Gravestock×2

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