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S. Akiyama · SciRah

Researcher profile · Semantic Scholar

S. Akiyama

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S. Akiyama — researcher profile on SciRah

h-index: 47
Works: 87
Citations: 10K

Most-cited papers

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules
S. Miyamoto, H. Teramoto, O. Coso, J. Gutkind +3 more
1995Journal of Cell Biology1,280 citations Open access
Semantic Scholar
Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
S. Miyamoto, S. Akiyama, Kenneth M. Yamada
1995Science958 citations
Semantic Scholar
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization
S. Akiyama, S. Yamada, Wen-Tien Chen, K. M. Yamada
1989Journal of Cell Biology642 citations Open access
Semantic Scholar
Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion.
M. Humphries, A. Komoriya, S. Akiyama, K. Olden +1 more
1987Journal of Biological Chemistry321 citations Open access
Semantic Scholar
Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.
A. Mould, S. Akiyama, M. Humphries
1995Journal of Biological Chemistry309 citations Open access
Semantic Scholar
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex
T. Matsuyama, A. Yamada, Jonathan Kay, K. M. Yamada +3 more
1989Journal of Experimental Medicine291 citations Open access
Semantic Scholar
Novel function for beta 1 integrins in keratinocyte cell-cell interactions
H. Larjava, J. Peltonen, S. Akiyama, S. Yamada +3 more
1990Journal of Cell Biology288 citations Open access
Semantic Scholar
Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.
C. J. Roberts, Thomas M. Birkenmeier, J. McQuillan, S. Akiyama +4 more
1988Journal of Biological Chemistry283 citations Open access
Semantic Scholar
Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]
S. LaFlamme, S. Akiyama, Kenneth M. Yamada
1992Journal of Cell Biology261 citations Open access
Semantic Scholar
Aberrant N-Glycosylation of β1 Integrin Causes Reduced α5β1 Integrin Clustering and Stimulates Cell Migration
Hua-Bei Guo, Intaek Lee, M. Kamar, S. Akiyama +1 more
2002253 citations
Semantic Scholar
A Novel Protease-docking Function of Integrin at Invadopodia*
S. Mueller, G. Ghersi, S. Akiyama, Q. Sang +5 more
1999Journal of Biological Chemistry252 citations Open access
Semantic Scholar
Integrins in cell adhesion and signaling.
S. Akiyama
1996Human Cell245 citations
Semantic Scholar
Fibronectin and integrins in invasion and metastasis
S. Akiyama, K. Olden, Kenneth M. Yamada
1995Cancer Metastasis Review242 citations
Semantic Scholar
Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas.
J. Peltonen, H. Larjava, S. Jaakkola, H. Gralnick +4 more
1989Journal of Clinical Investigation238 citations Open access
Semantic Scholar
Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.
J. Mcdonald, B. J. Quade, T. Broekelmann, R. M. LaChance +3 more
1987Journal of Biological Chemistry238 citations Open access
Semantic Scholar
Regulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates.
M. Yamagata, Sakaru Suzuki, S. Akiyama, K. M. Yamada +1 more
1989Journal of Biological Chemistry218 citations Open access
Semantic Scholar
Inhibition of binding of fibronectin to matrix assembly sites by anti- integrin (alpha 5 beta 1) antibodies
F. J. Fogerty, S. Akiyama, K. M. Yamada, Deane E. Mosher
1990Journal of Cell Biology215 citations Open access
Semantic Scholar
Vinexin: A Novel Vinculin-binding Protein with Multiple SH3 Domains Enhances Actin Cytoskeletal Organization
N. Kioka, S. Sakata, Takeshi Kawauchi, T. Amachi +5 more
1999Journal of Cell Biology198 citations Open access
Semantic Scholar
Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras.
S. Akiyama, S. Yamada, K. M. Yamada, S. LaFlamme
1994Journal of Biological Chemistry185 citations Open access
Semantic Scholar
Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration.
K. M. Yamada, D. W. Kennedy, S. Yamada, H. Gralnick +2 more
1990Cancer Research182 citations
Semantic Scholar
Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly
T. Nagai, N. Yamakawa, S. Aota, S. Yamada +3 more
1991Journal of Cell Biology159 citations Open access
Semantic Scholar
Identification of a novel anti‐integrin monoclonal antibody that recognises a ligand‐induced binding site epitope on the β1 subunit
A. Mould, A. Garratt, J. Askari, S. Akiyama +1 more
1995FEBS Letters158 citations Open access
Semantic Scholar
Analysis of the role of glycosylation of the human fibronectin receptor.
S. Akiyama, S. Yamada, K. M. Yamada
1989Journal of Biological Chemistry146 citations
Semantic Scholar
Synthetic peptides competitively inhibit both direct binding to fibroblasts and functional biological assays for the purified cell-binding domain of fibronectin.
S. Akiyama, K. M. Yamada
1985Journal of Biological Chemistry135 citations
Semantic Scholar
The inhibitory anti-beta1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy. Evidence for allosteric inhibition of integrin function.
A. Mould, S. Akiyama, M. Humphries
1996Journal of Biological Chemistry130 citations Open access
Semantic Scholar
Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure.
Valérie é, Y. Tomita, S. Akiyama, S. Aota +5 more
1998Journal of Molecular Biology122 citations
Semantic Scholar
Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment
M. Humphries, S. Akiyama, A. Komoriya, K. Olden +1 more
1988Journal of Cell Biology122 citations Open access
Semantic Scholar
Aberrant N-glycosylation of beta1 integrin causes reduced alpha5beta1 integrin clustering and stimulates cell migration.
Hua-Bei Guo, Intaek Lee, M. Kamar, S. Akiyama +1 more
2002Cancer Research119 citations
Semantic Scholar
A Mechanism for Regulation of Melanoma Invasion
H. Nakahara, M. Nomizu, S. Akiyama, Y. Yamada +2 more
1996Journal of Biological Chemistry117 citations Open access
Semantic Scholar
TNF-alpha binds to the N-terminal domain of fibronectin and augments the beta 1-integrin-mediated adhesion of CD4+ T lymphocytes to the glycoprotein.
R. Alon, L. Cahalon, R. Hershkoviz, D. Elbaz +5 more
1994Journal of Immunology112 citations
Semantic Scholar
A two‐domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix.
V. Ozeri, A. Tovi, I. Burstein, S. Natanson-Yaron +5 more
1996EMBO Journal109 citations Open access
Semantic Scholar
Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells.
E. Merit Reyes-Reyes, S. Akiyama
2008Experimental Cell Research95 citations Open access
Semantic Scholar
Arachidonic Acid Activates Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase 2 and Mediates Adhesion of a Human Breast Carcinoma Cell Line to Collagen Type IV through a p38 MAP Kinase-dependent Pathway*
E. Paine, R. Palmantier, S. Akiyama, K. Olden +1 more
2000Journal of Biological Chemistry90 citations Open access
Semantic Scholar
The structure of fibronectin and its role in cellular adhesion.
S. Akiyama, K. M. Yamada, M. Hayashi
1981Journal of Supramolecular Structure and Cellular Biochemistry86 citations
Semantic Scholar
STRUCTURE AND FUNCTION OF FIBRONECTIN
Kenneth M. Yamada, M. Hayashi, S. Akiyama
198284 citations
Semantic Scholar
Regulation of Integrin α5β1-Fibronectin Interactions by Divalent Cations
A. Mould, S. Akiyama, Martin J. Humphries
1995Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Latex beads as probes of cell surface-extracellular matrix interactions during chondrogenesis: evidence for a role for amino-terminal heparin-binding domain of fibronectin.
D. Frenz, S. Akiyama, D. Paulsen, S. Newman
1989Developmental Biology78 citations
Semantic Scholar
Differences in the biosynthesis and localization of the fibronectin receptor in normal and transformed cultured human cells.
S. Akiyama, H. Larjava, K. M. Yamada
1990Cancer Research74 citations
Semantic Scholar
Substrate-specific binding of the amino terminus of fibronectin to an integrin complex in focal adhesions.
B. Dzamba, H. Bultmann, S. Akiyama, Donna M. Peters
1994Journal of Biological Chemistry72 citations
Semantic Scholar
CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways
Heng-Ning Ke, C. Augustine, Vineela Gandham, Jane Y. Jin +4 more
2012Journal of Investigative Dermatology63 citations Open access
Semantic Scholar
Matrix-driven translocation: dependence on interaction of amino-terminal domain of fibronectin with heparin-like surface components of cells or particles.
Stuart A. Newman, Dorothy A. Frenz, E. Hasegawa, S. Akiyama
1987Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Altered glycosylation and cell surface expression of beta 1 integrin receptors during keratinocyte activation.
L. Kim, Shuichi Ishihara, Chong-Chou Lee, S. Akiyama +2 more
1992Journal of Cell Science55 citations
Semantic Scholar
Mechanisms of fibronectin and integrin function during cell adhesion and migration.
Kenneth M. Yamada, S. Aota, S. Akiyama, S. LaFlamme
1992Cold Spring Harbor Symposia on Quantitative Biology50 citations
Semantic Scholar
Activation of β1 Integrins Induces Cell–Cell Adhesion
J. Whittard, S. Akiyama
200149 citations
Semantic Scholar
A mechanism for regulation of melanoma invasion. Ligation of alpha6beta1 integrin by laminin G peptides.
H. Nakahara, M. Nomizu, S. Akiyama, Y. Yamada +2 more
1996Journal of Biological Chemistry47 citations
Semantic Scholar
BCL2 inhibits Cell Adhesion, Spreading, and Motility by Enhancing Actin Polymerization
Heng-Ning Ke, Vandy I. Parron, J. Reece, Jennifer Y. Zhang +2 more
2010Cell Research46 citations Open access
Semantic Scholar
Vinexin Forms a Signaling Complex with Sos and Modulates Epidermal Growth Factor-induced c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activities*
Masahiko Akamatsu, S. Aota, A. Suwa, K. Ueda +4 more
1999Journal of Biological Chemistry46 citations Open access
Semantic Scholar
P-selectin activates integrin-mediated colon carcinoma cell adhesion to fibronectin.
M. Reyes-Reyes, M. George, John D. Roberts, S. Akiyama
2006Experimental Cell Research38 citations Open access
Semantic Scholar
Fibroblast‐mediated collagen gel contraction does not require fibronectin‐α5β1 integrin interaction
J. Tomasek, S. Akiyama
199234 citations
Semantic Scholar
Fibronectin in evolution: presence in invertebrates and isolation from Microciona prolifera.
S. Akiyama, Molly D. Johnson
1983Comparative biochemistry and physiology. B, Comparative biochemistry34 citations
Semantic Scholar

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M. Humphries — researcher profile on SciRah

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A. Mould — researcher profile on SciRah

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H. Larjava — researcher profile on SciRah

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H. Gralnick — researcher profile on SciRah

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S. LaFlamme — researcher profile on SciRah

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H. Nakahara — researcher profile on SciRah