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Y. Le · SciRah

Researcher profile · Semantic Scholar

Y. Le

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Y. Le — researcher profile on SciRah

h-index: 34
Works: 129
Citations: 4,027

Most-cited papers

Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage
Juanjuan Wang, Xue-Lian Xu, Michael H. Elliott, Mei-Li Zhu +1 more
2010Diabetes393 citations Open access
Semantic Scholar
Transcriptional code and disease map for adult retinal cell types
S. Siegert, E. Cabuy, B. G. Scherf, H. Kohler +6 more
2012Nature Neuroscience255 citations
Semantic Scholar
Müller cell‐derived VEGF is a significant contributor to retinal neovascularization
Yanyan Bai, Jian-Xing Ma, Junjing Guo, Juanjuan Wang +3 more
2009Journal of Pathology244 citations
Semantic Scholar
Significance of outer blood-retina barrier breakdown in diabetes and ischemia.
Hui-Zhuo Xu, Y. Le
2011Investigative Ophthalmology and Visual Science187 citations Open access
Semantic Scholar
Autophagy Protects the Retina from Light-induced Degeneration*
Yu Chen, Osamu Sawada, H. Kohno, Y. Le +3 more
2013Journal of Biological Chemistry144 citations Open access
Semantic Scholar
Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.
Aditya Venkatesh, Shan Ma, Y. Le, M. Hall +2 more
2015Journal of Clinical Investigation143 citations Open access
Semantic Scholar
Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells
M. Lin, Y. Chen, J. Jin, Y. Hu +6 more
2011Diabetologia134 citations Open access
Semantic Scholar
IFT20 is required for opsin trafficking and photoreceptor outer segment development
Brian T. Keady, Y. Le, G. Pazour
2011Molecular Biology of the Cell134 citations Open access
Semantic Scholar
Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration.
H. Mao, S. Seo, M. Biswal, Hong Li +5 more
2014Investigative Ophthalmology and Visual Science113 citations Open access
Semantic Scholar
VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases
Y. Le
2017Vision Research109 citations Open access
Semantic Scholar
7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B.
Chao-Yong He, Huaiping Zhu, Wen-Cheng Zhang, I. Okon +4 more
2013American Journal of Pathology106 citations Open access
Semantic Scholar
Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes
Shu-Hua Fu, Shuqian Dong, Mei-Li Zhu, D. M. Sherry +4 more
2015Diabetes99 citations Open access
Semantic Scholar
RPE barrier breakdown in diabetic retinopathy: seeing is believing
Hui-Zhuo Xu, Zhi-Ming Song, Shu-Hua Fu, Mei-Li Zhu +1 more
2011Journal of Ocular Biology Diseases and Informatics96 citations Open access
Semantic Scholar
Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis
I. Nasonkin, S. Merbs, K. Lazo, V. F. Oliver +12 more
2013Development87 citations Open access
Semantic Scholar
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
Ling Luo, H. Uehara, Xiao-Hui Zhang, Subrata K. Das +31 more
2013eLife86 citations Open access
Semantic Scholar
Trafficking of Membrane Proteins to Cone but not Rod Outer Segments is Dependent on Heterotrimeric Kinesin-II
P. Avasthi, C. Watt, David S. Williams, Y. Le +5 more
2009Journal of Neuroscience73 citations Open access
Semantic Scholar
Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization.
Mingkai Lin, Yang Hu, Ying Chen, Kevin K. Zhou +5 more
2012Investigative Ophthalmology and Visual Science71 citations Open access
Semantic Scholar
Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function
M. Haruta, R. Bush, Sten Kjellstrom, C. Vijayasarathy +3 more
2009Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
Semantic Scholar
Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy.
Juanjuan Wang, Mei-Li Zhu, Y. Le
2015World Journal of Diabetes61 citations Open access
Semantic Scholar
X-Box Binding Protein 1 Is Essential for the Anti-Oxidant Defense and Cell Survival in the Retinal Pigment Epithelium
Yimin Zhong, Jingming Li, J. Wang, Cheng Chen +7 more
2012PLoS ONE61 citations Open access
Semantic Scholar
Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7
You-Wen Zhang, Samuel D. Cross, J. Stanton, A. Marmorstein +2 more
2017Molecular Vision52 citations
Semantic Scholar
Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.
I. Ivanović, R. E. Anderson, Y. Le, S. Fliesler +2 more
2011Investigative Ophthalmology and Visual Science52 citations Open access
Semantic Scholar
Temporal requirement of RPE-derived VEGF in the development of choroidal vasculature
Y. Le, Yanyan Bai, Mei-Li Zhu, Li-Xin Zheng
2010Journal of Neurochemistry51 citations Open access
Semantic Scholar
RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors
C. Grabner, M. Gandini, Renata Rehak, Y. Le +2 more
2015Journal of Neuroscience47 citations Open access
Semantic Scholar
Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors
Y. Ueki, Y. Le, S. Chollangi, Werner Müller +1 more
2009Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in a mouse model of diabetes
Jing Yang, Chen Chen, Todd McLaughlin, Ya-Qin Wang +3 more
2019Diabetologia44 citations Open access
Semantic Scholar
Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium*
L. Perusek, Bhubanananda Sahu, Tanu Parmar, H. Maeno +6 more
2015Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Expression of Cre recombinase in retinal Müller cells
Y. Ueki, J. Ash, Mei-Li Zhu, Li-Xin Zheng +1 more
2009Vision Research35 citations Open access
Semantic Scholar
VEGF Mediates Retinal Müller Cell Viability and Neuroprotection through BDNF in Diabetes
Y. Le, Bei Xu, A. J. Chucair-Elliott, Huiru Zhang +1 more
2021Biomolecules34 citations Open access
Semantic Scholar
Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival
Shan Ma, Aditya Venkatesh, Fernanda Langellotto, Y. Le +3 more
2015Experimental Eye Research32 citations Open access
Semantic Scholar
Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency
Michael R. Butler, Hong-Wei Ma, Fan Yang, Josh Belcher +7 more
2017Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Interruption of Wnt Signaling in Müller Cells Ameliorates Ischemia-Induced Retinal Neovascularization
Ke-Lu Zhou, S. Benyajati, Y. Le, R. Cheng +2 more
2014PLoS ONE31 citations Open access
Semantic Scholar
Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.
C. Lange, S. Heynen, N. Tanimoto, M. Thiersch +6 more
2011Investigative Ophthalmology and Visual Science29 citations Open access
Semantic Scholar
Phosphoinositide 3-kinase signaling in retinal rod photoreceptors.
I. Ivanović, D. Allen, Radhika Dighe, Y. Le +2 more
2011Investigative Ophthalmology and Visual Science28 citations Open access
Semantic Scholar
The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity
C. DeVera, Jendayi A. Dixon, M. Chrenek, Kenkichi Baba +3 more
2020bioRxiv24 citations Open access
Semantic Scholar
Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats.
J. Kusari, E. Padillo, Sheila X. Zhou, Yanyan Bai +5 more
2011Investigative Ophthalmology and Visual Science24 citations Open access
Semantic Scholar
Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.
M. Biswal, Cristhian J. Ildefonso, H. Mao, S. Seo +4 more
2016Advances in Experimental Medicine and Biology23 citations
Semantic Scholar
protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases
Jian-Yan Hu, Ting-Ting Li, Xin-hua Du, Qiang Wu +1 more
201721 citations
Semantic Scholar
Suppression of Retinal Neovascularization by Lentivirus-Mediated Netrin-1 Small Hairpin RNA
Hui-Zhuo Xu, Jiaolian Liu, Si-Qi Xiong, Y. Le +1 more
2011Ophthalmic Research21 citations Open access
Semantic Scholar
Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice*
Bhubanananda Sahu, Wen-Yu Sun, L. Perusek, Vipul M. Parmar +4 more
2015Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II
Derek J. Royer, Michael H. Elliott, Y. Le, D. Carr
2018Investigative Ophthalmology and Visual Science19 citations Open access
Semantic Scholar
Numb Regulates the Polarized Delivery of Cyclic Nucleotide-Gated Ion Channels in Rod Photoreceptor Cilia
V. Ramamurthy, C. Jolicoeur, Demetra Koutroumbas, Johanna Mühlhans +4 more
2014Journal of Neuroscience17 citations Open access
Semantic Scholar
Unexpected transcriptional activity of the human VMD2 promoter in retinal development.
Mei-Li Zhu, Li-Xin Zheng, Y. Ueki, J. Ash +1 more
2010Advances in Experimental Medicine and Biology16 citations
Semantic Scholar
Conditional Gene Targeting: Dissecting the Cellular Mechanisms of Retinal Degenerations
Y. Le
2010Journal of Ophthalmology13 citations Open access
Semantic Scholar
Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency
Hong-Wei Ma, Fan Yang, Michael R. Butler, Jacob Rapp +2 more
2019eNeuro12 citations Open access
Semantic Scholar
Intravitreous High Expression Level of Netrin-1 in Patients with Proliferative Diabetic Retinopathy
Jiaolian Liu, Xiao-Bo Xia, Si-Qi Xiong, Y. Le +1 more
2011Yan ke xue bao = Eye science12 citations
Semantic Scholar
Critical Role of Trophic Factors in Protecting Müller Glia: Implications to Neuroprotection in Age-Related Macular Degeneration, Diabetic Retinopathy, and Anti-VEGF Therapies.
Bei Xu, Huiru Zhang, Mei-Li Zhu, Y. Le
2019Advances in Experimental Medicine and Biology11 citations
Semantic Scholar
Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration
Aswin Pyakurel, D. Balmer, Marc K. Saba-El-Leil, C. Kizilyaprak +7 more
2017Molecular and Cellular Biology11 citations Open access
Semantic Scholar
Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis
Yi-Da Jiang, Li-Juan Duan, J. Pi, Y. Le +1 more
2022Investigative Ophthalmology and Visual Science10 citations Open access
Semantic Scholar
Effects of Cone Connexin-36 Disruption on Light Adaptation and Circadian Regulation of the Photopic ERG
Shuo Zhang, P. Lyuboslavsky, Jendayi A. Dixon, M. Chrenek +6 more
2020Investigative Ophthalmology and Visual Science10 citations Open access
Semantic Scholar

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