Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

C. Whitehead · SciRah

Researcher profile · Semantic Scholar

C. Whitehead

Share profile

C. Whitehead — researcher profile on SciRah

h-index: 13
Works: 34
Citations: 1,267

Most-cited papers

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
J. Ohren, Hui-Fen Chen, A. Pavlovsky, C. Whitehead +18 more
2004Nature Structural &Molecular Biology609 citations
Semantic Scholar
KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.
Shirish Shukla, U. Allam, Aarif Ahsan, Guo-An Chen +14 more
2014Neoplasia95 citations Open access
Semantic Scholar
Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors.
Aarif Ahsan, S. Ramanand, C. Whitehead, S. M. Hiniker +9 more
2012Neoplasia93 citations Open access
Semantic Scholar
Cisplatin Induces Bmi1 and Enhances the Stem Cell Fraction in Head and Neck Cancer
Aarif Ahsan, S. Ramanand, I. Bergin, Lillian Zhao +19 more
201575 citations
Semantic Scholar
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).
J. Warmus, C. Flamme, Lu-Yan Zhang, Stephen D. Barrett +14 more
2008Bioorganic & Medicinal Chemistry Letters66 citations
Semantic Scholar
Dual Inhibition of Allosteric Mitogen-Activated Protein Kinase (MEK) and Phosphatidylinositol 3-Kinase (PI3K) Oncogenic Targets with a Bifunctional Inhibitor
M. V. Van Dort, S. Galban, Hanxiao Wang, J. Sebolt-Leopold +4 more
2015Bioorganic & Medicinal Chemistry46 citations Open access
Semantic Scholar
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
J. Spicer, G. Rewcastle, M. Kaufman, S. L. Black +21 more
2007Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Destabilization of the Epidermal Growth Factor Receptor (EGFR) by a Peptide That Inhibits EGFR Binding to Heat Shock Protein 90 and Receptor Dimerization*♦
Aarif Ahsan, D. Ray, S. Ramanand, A. Hegde +7 more
2013Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts.
Aarif Ahsan, S. Ramanand, I. Bergin, Lillian Zhao +6 more
2014Neoplasia31 citations Open access
Semantic Scholar
Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide
W. Rodrigueza, Michael J. Woolliscroft, A. Ebrahim, R. Forgey +21 more
2014Cancer Chemotherapy and Pharmacology29 citations Open access
Semantic Scholar
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
M. Plummer, J. Cornicelli, H. Roark, Donald J. Skalitzky +22 more
2013Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.
M. Plummer, J. Cornicelli, H. Roark, Donald J. Skalitzky +22 more
2013Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Loss of NF1 in melanoma confers sensitivity to SYK kinase inhibition
Cara Abecunas, C. Whitehead, Elizabeth K. Ziemke, Douglas G. Baumann +3 more
2022Cancer Research8 citations Open access
Semantic Scholar
Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
J. Ohren, Hui-Fen Chen, A. Pavlovsky, C. Whitehead +18 more
2005Nature Structural &Molecular Biology7 citations Open access
Semantic Scholar
Oncogenic Mutants of MEK1: A Trilogy Unfolds.
J. Maust, C. Whitehead, J. Sebolt-Leopold
2018Cancer Discovery4 citations
Semantic Scholar
Erratum to “2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)” [Bioorg. Med. Chem. Lett. 18 (2008) 6171]
J. Warmus, C. Flamme, Lu-Yan Zhang, Stephen D. Barrett +14 more
20094 citations
Semantic Scholar
THER-29. NOVEL DUAL EGFR/PI3-KINASE INHIBITORS SHOW ENHANCED POTENCY, STRONGER PATHWAY SUPPRESSION AND TARGETING OF METABOLIC PROPERTIES IN PEDIATRIC AND ADULT HIGH GRADE GLIOMA MODELS THAN SINGLE KINASE INHIBITORS
Yu-Sha Sun, Cavan P. Bailey, C. Whitehead, J. Sebolt-Leopold +1 more
2019Neuro-Oncology2 citations Open access
Semantic Scholar
Abstract 2931: MTX-211, a dual and selective inhibitor of EGFR and PI3 kinase, shows promising activity in combination with MEK inhibition in preclinical models of pancreatic cancer
Christy L. Frankowski-McGregor, J. Maust, Elizabeth K. Ziemke, Rachel Mumby +4 more
2018Experimental and Molecular Therapeutics2 citations
Semantic Scholar
Abstract 148: A dual and selective small molecule inhibitor of EGFR and PI3 kinase shows promising preclinical activity against KRAS and BRAF mutant colorectal tumors
J. Maust, Elizabeth K. Ziemke, Christy L. Frankowski-McGregor, Jun Beom Ku +4 more
20172 citations
Semantic Scholar
Abstract 2764: Effect of PNT2258 combinations with docetaxel, dacarbazine, or vemurafenib on the A375 melanoma xenograft
W. Rodrigueza, C. Whitehead, R. Mohammad, J. P. Mcgovern +4 more
20122 citations
Semantic Scholar
Synthesis and SAR development of PD 0325901, a potent and highly bioavailable MEK inhibitor.
M. Kaufman, Stephen D. Barrett, C. Flamme, J. Warmus +15 more
20042 citations
Semantic Scholar
DDDR-25. CO-INHIBITION OF KINASE SIGNALING PATHWAYS AND EPIGENETIC REGULATORS OVERCOMES COMPENSATORY EFFECTS IN PEDIATRIC HIGH-GRADE GLIOMAS
Jack Adams, Lea M. Stitzlein, Melissa M. Singh, Xiaoping Su +6 more
2022Neuro-Oncology1 citations Open access
Semantic Scholar
Deciphering the Complexity of MEK Mutations in the Clinic
C. Whitehead, J. Sebolt-Leopold
2020Cancer Research1 citations
Semantic Scholar
Abstract 3966: Targeting DNA repair and survival signaling in diffuse intrinsic pontine gliomas to prevent tumor recurrence
Monika Sharma, Rachel Mumby, Varunkumar Krishnamoorthy, Brian Magnuson +4 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 3329: Efficacy of EGFR/PI3K signaling inhibition is enhanced with LSD1 inhibition in glioblastoma stem cell (GSC) models
Lea M. Stitzlein, Matthew A. Luetzen, Caitlin McCabe, M. Khosla +8 more
2022Cancer Research0 citations
Semantic Scholar
Systematic analysis uncovers SYK dependency in NF1LoF melanoma cells
Cara Abecunas, C. Whitehead, Elizabeth K. Ziemke, Douglas G. Baumann +3 more
2022bioRxiv0 citations Open access
Semantic Scholar
DDRE-31. EVALUATION OF HIGHLY POTENT AND SELECTIVE SINGLE-MOLECULE DUAL EGFR/PI3K INHIBITORS IN ADULT AND PEDIATRIC HIGH-GRADE GLIOMA
Achintyan Gangadharan, Yu-Sha Sun, Cavan P. Bailey, Trever R. Carter +4 more
20200 citations Open access
Semantic Scholar
Abstract 625: Selective inhibition of NF1 loss-of-function driven oncogenic signaling in melanomas
Cara Abecunas, M. Fallahi-Sichani, J. Leopold, C. Whitehead +1 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 3089: Evaluation of highly potent and selective single-molecule dual EGFR/PI3K inhibitors in preclinical models of adult and pediatric high-grade glioma
Yu-Sha Sun, Cavan P. Bailey, Trever R. Carter, C. Whitehead +2 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
PI3K/AKT/mTOR pathway inhibition sensitizes ovarian cancer cells to anti-estrogen therapy
C. McIlwain, V. Prince, L. Tan, C. Whitehead +2 more
2018Gynecologic Oncology0 citations
Semantic Scholar
Abstract 5871: Efficacy and selectivity of novel dually targeted kinase inhibitors for therapy of adult and pediatric high-grade glioma
Trever R. Carter, Cavan P. Bailey, Yu-Sha Sun, Alexsandra B. Espejo +3 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
SMALL MOLECULE DUAL INHIBITORS OF EGFR/PI3K AND USES THEREOF
C. Whitehead, Elizabeth K. Ziemke, J. Sebolt-Leopold
20170 citations
Semantic Scholar
Novel non-ATP competitive inhibitors of MEK
J. Spicer, S. L. Black, Kaufmann, D. Ortwine +8 more
20060 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

J. Sebolt-Leopold×19
Invite
J. Sebolt-Leopold — researcher profile on SciRah
Stephen D. Barrett×7
Invite
Stephen D. Barrett — researcher profile on SciRah
H. Tecle×7
Invite
H. Tecle — researcher profile on SciRah
A. Rehemtulla×7
Invite
A. Rehemtulla — researcher profile on SciRah

×6

Invite

J. Ohren — researcher profile on SciRah

Invite

C. Flamme — researcher profile on SciRah

Invite

J. Warmus — researcher profile on SciRah

Invite

M. Kaufman — researcher profile on SciRah

Richard Gowan×6

Invite

Richard Gowan — researcher profile on SciRah

Elizabeth K. Ziemke×6

Invite

Elizabeth K. Ziemke — researcher profile on SciRah

Invite

J. Chandra — researcher profile on SciRah

A. Pavlovsky×5

Invite

A. Pavlovsky — researcher profile on SciRah