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G. Lui · SciRah

Researcher profile · Semantic Scholar

G. Lui

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G. Lui — researcher profile on SciRah

h-index: 13
Works: 31
Citations: 1,170

Most-cited papers

The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways
Z. Kovacevic, Sherin Chikhani, G. Lui, Sutharshani Sivagurunathan +1 more
2013Antioxidants and Redox Signaling167 citations
Semantic Scholar
Targeting cancer by binding iron: Dissecting cellular signaling pathways
G. Lui, Z. Kovacevic, V. Richardson, A. Merlot +2 more
2015OncoTarget156 citations Open access
Semantic Scholar
The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action
G. Lui, Peyman Obeidy, S. Ford, C. Tselepis +6 more
2013Molecular Pharmacology126 citations
Semantic Scholar
CDK12: An emerging therapeutic target for cancer
G. Lui, C. Grandori, C. Kemp
2018Journal of Clinical Pathology116 citations Open access
Semantic Scholar
Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells
K. Dixon, G. Lui, Z. Kovacevic, D. Zhang +5 more
2013British Journal of Cancer115 citations Open access
Semantic Scholar
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomes
D. Guo, G. Lui, Siew-Li Lai, J. Wilmott +18 more
2019International Journal of Cancer107 citations
Semantic Scholar
Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo
S. J. Ford, P. Obeidy, D. Lovejoy, M. Bedford +10 more
2013British Journal of Pharmacology78 citations Open access
Semantic Scholar
The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1
Wensheng Liu, F. Yue, Minhua Zheng, A. Merlot +10 more
2015OncoTarget73 citations Open access
Semantic Scholar
Cell Cycle Phase-Specific Drug Resistance as an Escape Mechanism of Melanoma Cells.
K. Beaumont, D. Hill, S. Daignault, G. Lui +4 more
2016Journal of Investigative Dermatology63 citations Open access
Semantic Scholar
Novel Thiosemicarbazones Regulate the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway: Inhibition of Constitutive and Interleukin 6–Induced Activation by Iron Depletion
G. Lui, Z. Kovacevic, Sharleen V. Menezes, D. Kalinowski +3 more
2015Molecular Pharmacology43 citations Open access
Semantic Scholar
Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer
Joan Q. Cao, Zhou Zhu, Hui Wang, T. Nichols +7 more
2019Oncogene39 citations
Semantic Scholar
BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer
G. Lui, R. Shaw, F. Schaub, Isabella N. Stork +12 more
2020EBioMedicine33 citations Open access
Semantic Scholar
Targeting BET proteins BRD2 and BRD3 in combination with PI3K-AKT inhibition as a therapeutic strategy for ovarian clear cell carcinoma
S. Shigeta, G. Lui, R. Shaw, Russell D. Moser +8 more
2021Molecular Cancer Therapeutics26 citations Open access
Semantic Scholar
Abrogation of RAB27A expression transiently affects melanoma cell proliferation
D. Guo, K. Beaumont, D. Sharp, G. Lui +3 more
2019bioRxiv11 citations Open access
Semantic Scholar
Development of a ZBTB7A and Wiz Dual Degrading, HbF-Activating CELMoD™ for the Treatment of Sickle Cell Disease
E. Rychak, G. Lui, Cristhian Fimbres, C. Kang +30 more
2024Blood6 citations
Semantic Scholar
A new strategy for the treatment of pancreatic cancer: Novel thiosemicarbazone iron chelators that up-regulate the iron-regulated metastasis suppressor, NDRG1
Z. Kovacevic, Sutharshani Sivagurunathan, Sherin Chikhani, G. Lui +2 more
20125 citations
Semantic Scholar
Abstract 534: Functional drug screening of organoids from ovarian cancer patients demonstrates clinical and genomic concordance and identifies novel therapeutic vulnerabilities
G. Lui, A. Richardson, P. Chatterjee, M. Pollastro +21 more
2021Clinical research3 citations
Semantic Scholar
Abstract 764: Rational combination of PF-06463922 (next-generation ALK inhibitor) with PI3K pathway inhibitors overcomes ALKi resistance in EML4-ALK+ NSCLC models
P. Wei, Ming Qiu, N. Lee, Joan Q. Cao +11 more
20153 citations
Semantic Scholar
1243 High Rab27a expression is associated with poor melanoma prognosis and promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes
D. Guo, G. Lui, Shweta Tikoo, W. Weninger +2 more
20182 citations Open access
Semantic Scholar
Rab27a, a novel marker for melanoma metastasis and poor prognosis
D. Guo, G. Lui, W. Weninger, K. Beaumont +1 more
20181 citations
Semantic Scholar
379 The Anti-tumor Agent, Dp44mT, Differentially Targets the AKT, TGF-beta and ERK Pathways Via the Metastasis Suppressor NDRG1 in Normal Prostate Epithelial Cells and Prostate Cancer Cells
G. Lui, K. Dixon, Z. Kovacevic, M. Yao +4 more
20121 citations
Semantic Scholar
Correction to: Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.
K. M. Dixon, G. Lui, Ž. Kovačević, D. Zhang +5 more
2026British Journal of Cancer0 citations
Semantic Scholar
Abstract NT-108: TARGETING BROMODOMAIN PROTEINS AS A THERAPEUTIC STRATEGY FOR CLEAR CELL CARCINOMA OF THE OVARY
S. Shigeta, R. Shaw, Russell D. Moser, K. Gurley +3 more
20190 citations Open access
Semantic Scholar
Abstract 5167: Rab27a promotes melanoma cell invasion and metastasis via the regulation of exosome secretion
D. Guo, G. Lui, D. Sharp, Siew-Li Lai +7 more
2018Tumor Biology0 citations
Semantic Scholar
Abstract A28: Casein kinase 1ϵ (CSNK1ϵ) is a synthetic lethal target in MYC-driven ovarian cancer
G. Lui, F. Schaub, Shaifali Agrawal, K. Kitatani +3 more
20170 citations
Semantic Scholar
Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells. Supp Mov 2.
K. Beaumont, D. S. Hill, S. Daignault, G. Lui +4 more
20160 citations
Semantic Scholar
Rab27a regulates invadopodia activity and invasion in melanoma
N. Haass, G. Lui, D. Sharp, S. Y. Tan +2 more
20160 citations
Semantic Scholar
Novel and clinically available iron chelators for cancer treatment: elucidation of molecular mechanisms underlying anti-tumour activity
G. Lui
20150 citations
Semantic Scholar
Abstract A43: RB pathway disruption by the CDK4/6 inhibitor palbociclib enhances responses to chemotherapy in squamous cell lung cancer
P. Wei, Joan Q. Cao, G. Lui, Hui Wang +6 more
20150 citations
Semantic Scholar
Abstract A232: Novel thiosemicarbazones with potent antitumor and antimetastatic activity inhibit the signal transducer and activator of transcription (STAT) pathway.
G. Lui, Z. Kovacevic, D. Richardson
20130 citations
Semantic Scholar
Targeting the Metastasis Suppressor NDRG1: A New Strategy for the Treatment of Pancreatic Cancer
Des R. Richardson, Sherin Chikhani, G. Lui, Sutharshani Sivagurunathan +1 more
20120 citations
Semantic Scholar

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