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C. Schéele · SciRah

Researcher profile · Semantic Scholar

C. Schéele

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C. Schéele — researcher profile on SciRah

h-index: 43
Works: 108
Citations: 8,266

Most-cited papers

Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
P. Muñoz-Cánoves, C. Schéele, B. Pedersen, A. Serrano
2013The FEBS Journal720 citations Open access
Semantic Scholar
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.
N. Jespersen, T. J. Larsen, Lone Peijs, S. Daugaard +9 more
2013Cell Metabolism543 citations Open access
Semantic Scholar
Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
E. Nilsson, P. Jansson, A. Perfilyev, P. Volkov +12 more
2014Diabetes370 citations
Semantic Scholar
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
Thorsten Gnad, Saskia Scheibler, I. von Kügelgen, C. Schéele +17 more
2014Nature366 citations
Semantic Scholar
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
J. Timmons, S. Knudsen, T. Rankinen, L. Koch +17 more
2010Journal of applied physiology343 citations Open access
Semantic Scholar
Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle
S. Nielsen, C. Schéele, C. Yfanti, T. Åkerström +3 more
2010Journal of Physiology321 citations Open access
Semantic Scholar
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
E. Mottillo, Eric M. Desjardins, J. Crane, Brennan K. Smith +12 more
2016Cell Metabolism315 citations Open access
Semantic Scholar
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation.
Denis P. Blondin, S. Nielsen, E. N. Kuipers, M. C. Severinsen +16 more
2020Cell Metabolism290 citations Open access
Semantic Scholar
The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training
S. Nielsen, T. Åkerström, A. Rinnov, C. Yfanti +3 more
2014PLoS ONE290 citations Open access
Semantic Scholar
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
I. Gallagher, C. Schéele, Pernille Keller, A. R. Nielsen +8 more
2010Genome Medicine270 citations Open access
Semantic Scholar
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans.
Susanna Søberg, C. Sandholt, N. Jespersen, U. Toft +14 more
2017Cell Metabolism204 citations Open access
Semantic Scholar
Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis
A. Rauch, A. Haakonsson, J. G. Madsen, Mette Larsen +13 more
2019Nature Genetics201 citations
Semantic Scholar
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
C. Schéele, C. Wolfrum
2019Endocrine reviews179 citations Open access
Semantic Scholar
Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis
J. Sanchez-Gurmaches, Yuefeng Tang, N. Jespersen, M. Wallace +9 more
2017Cell Metabolism175 citations Open access
Semantic Scholar
Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure
K. Fredriksson, I. Tjäder, Pernille Keller, N. Petrovic +5 more
2008PLoS ONE175 citations Open access
Semantic Scholar
ROS and myokines promote muscle adaptation to exercise.
C. Schéele, S. Nielsen, B. Pedersen
2009Trends in endocrinology and metabolism164 citations
Semantic Scholar
LIF is a contraction-induced myokine stimulating human myocyte proliferation.
C. Broholm, M. Laye, Claus Brandt, Radhika Vadalasetty +3 more
2011Journal of applied physiology162 citations
Semantic Scholar
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
E. G. Sustarsic, Tao Ma, M. Lynes, M. Larsen +40 more
2018Cell Metabolism160 citations Open access
Semantic Scholar
Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
A. Deshmukh, D. E. Steenberg, M. Hostrup, J. Birk +10 more
2021Nature Communications150 citations Open access
Semantic Scholar
Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine.
A. Deshmukh, Lone Peijs, Jacqueline L Beaudry, N. Jespersen +20 more
2019Cell Metabolism147 citations Open access
Semantic Scholar
Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells
S. Min, Anand Desai, Zinger Yang, Agastya Sharma +9 more
2019Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
C. Schéele, N. Petrovic, M. Faghihi, T. Lassmann +5 more
2007BMC Genomics132 citations Open access
Semantic Scholar
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Olivia Sveidahl Johansen, Tao Ma, J. Hansen, Lasse K. Markussen +47 more
2021Cell121 citations Open access
Semantic Scholar
Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice
J. D. de Jong, Wenfei Sun, Nuno D. Pires, A. Frontini +16 more
2019Nature Metabolism120 citations
Semantic Scholar
Adenosine/A2B receptor signaling ameliorates the effects of ageing and counteracts obesity
Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa +27 more
2020Cell Metabolism114 citations Open access
Semantic Scholar
Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473
Khanh-Van Tran, E. Brown, Tiffany DeSouza, N. Jespersen +20 more
2020Nature Metabolism107 citations Open access
Semantic Scholar
Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase
C. Green, M. Pedersen, B. Pedersen, C. Schéele
2011Diabetes106 citations Open access
Semantic Scholar
Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells
N. Jespersen, A. Feizi, Eline S. Andersen, S. Heywood +12 more
2019Molecular Metabolism99 citations Open access
Semantic Scholar
NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program
Yuta Hiraike, H. Waki, Jingjun Yu, Masahiro Nakamura +22 more
2017Nature Cell Biology91 citations Open access
Semantic Scholar
Metabolic regulation and the anti-obesity perspectives of human brown fat
C. Schéele, S. Nielsen
2017Redox Biology86 citations Open access
Semantic Scholar
Proteome- and transcriptome-driven reconstruction of the human myocyte metabolic network and its use for identification of markers for diabetes.
Leif Väremo, C. Schéele, C. Broholm, A. Mardinoğlu +6 more
2015Cell Reports83 citations Open access
Semantic Scholar
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application
Mona C. Löffler, M. Betz, Denis P. Blondin, R. Augustin +10 more
2021Molecular Metabolism73 citations Open access
Semantic Scholar
Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
Cajsa Davegårdh, Elin Hall Wedin, C. Broholm, T. Henriksen +4 more
2019Stem cell research & therapeutics73 citations Open access
Semantic Scholar
Satellite Cells Derived from Obese Humans with Type 2 Diabetes and Differentiated into Myocytes In Vitro Exhibit Abnormal Response to IL-6
C. Schéele, Søren Nielsen, M. Kelly, C. Broholm +5 more
2012PLoS ONE68 citations Open access
Semantic Scholar
Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes.
Leif Väremo, C. Schéele, C. Broholm, A. Mardinoğlu +6 more
2016Cell Reports65 citations Open access
Semantic Scholar
Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men
Susanna Søberg, J. Löfgren, Frederik E. Philipsen, Michal Jensen +14 more
2021Cell Reports Medicine59 citations Open access
Semantic Scholar
Impaired Leptin Gene Expression and Release in Cultured Preadipocytes Isolated From Individuals Born With Low Birth Weight
Ninna S Schultz, C. Broholm, L. Gillberg, B. Mortensen +6 more
2013Diabetes57 citations Open access
Semantic Scholar
Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
Cajsa Davegårdh, C. Broholm, A. Perfilyev, T. Henriksen +16 more
2017BMC Medicine51 citations Open access
Semantic Scholar
Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots
Nagendra P. Palani, Carla Horvath, P. Timshel, Pytrik Folkertsma +10 more
2023Nature Metabolism50 citations Open access
Semantic Scholar
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
C. Schlein, Alexander W. Fischer, F. Sass, A. Worthmann +17 more
2021Cell Reports50 citations Open access
Semantic Scholar
Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity.
Ryutaro Ikegami, Ippei Shimizu, Takeshi Sato, Y. Yoshida +13 more
2018Cell Reports47 citations Open access
Semantic Scholar
Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes
Leif Väremo, T. Henriksen, C. Schéele, C. Broholm +4 more
2017Genome Medicine43 citations Open access
Semantic Scholar
Muscle specific miRNAs are induced by testosterone and independently upregulated by age
S. Nielsen, Thine Hvid, M. Kelly, B. Lindegaard +6 more
2014Frontiers in Physiology39 citations Open access
Semantic Scholar
MultiPep: a hierarchical deep learning approach for multi-label classification of peptide bioactivities
Alexander G. B. Grønning, T. Kacprowski, C. Schéele
2021Biology Methods and Protocols38 citations Open access
Semantic Scholar
Lifelong Physical Activity Prevents Aging-Associated Insulin Resistance in Human Skeletal Muscle Myotubes via Increased Glucose Transporter Expression
T. Bunprajun, T. Henriksen, C. Schéele, B. Pedersen +1 more
2013PLoS ONE38 citations Open access
Semantic Scholar
Deficient leukemia inhibitory factor signaling in muscle precursor cells from patients with type 2 diabetes.
C. Broholm, Claus Brandt, Ninna S Schultz, A. R. Nielsen +2 more
2012American Journal of Physiology. Endocrinology and Metabolism38 citations
Semantic Scholar
Exercise and browning of white adipose tissue - a translational perspective.
M. C. Severinsen, C. Schéele, B. Pedersen
2020Current opinion in pharmacology (Print)36 citations
Semantic Scholar
Epigenetic programming of adipose-derived stem cells in low birthweight individuals
C. Broholm, A. Olsson, A. Perfilyev, N. S. Hansen +8 more
2016Diabetologia36 citations Open access
Semantic Scholar
Angiogenic and inflammatory biomarkers for screening and follow-up in patients with pulmonary arterial hypertension
D. Kylhammar, R. Hesselstrand, Susan Nielsen, C. Schéele +1 more
2018Scandinavian Journal of Rheumatology35 citations Open access
Semantic Scholar
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
Cajsa Davegårdh, Johanna Säll, A. Benrick, C. Broholm +16 more
2021Nature Communications31 citations Open access
Semantic Scholar

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