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Keiichi Koizumi · SciRah

Researcher profile · Semantic Scholar

Keiichi Koizumi

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Keiichi Koizumi — researcher profile on SciRah

h-index: 34
Works: 110
Citations: 4,242

Most-cited papers

Chemokine receptors in cancer metastasis and cancer cell‐derived chemokines in host immune response
Keiichi Koizumi, S. Hojo, T. Akashi, K. Yasumoto +1 more
2007Cancer Science245 citations Open access
Semantic Scholar
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
K. Yasumoto, Keiichi Koizumi, A. Kawashima, Y. Saitoh +8 more
2006Cancer Research228 citations Open access
Semantic Scholar
Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia
A. Nakashima, Mikiko Yamanaka-Tatematsu, N. Fujita, Keiichi Koizumi +6 more
2013Autophagy203 citations Open access
Semantic Scholar
High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.
S. Hojo, Keiichi Koizumi, K. Tsuneyama, Y. Arita +10 more
2007Cancer Research177 citations Open access
Semantic Scholar
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer
T. Akashi, Keiichi Koizumi, K. Tsuneyama, I. Saiki +2 more
2008Cancer Science172 citations Open access
Semantic Scholar
Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells.
Isaya Hashimoto, Keiichi Koizumi, M. Tatematsu, Takayuki Minami +7 more
2008European Journal of Cancer150 citations
Semantic Scholar
Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption1
Keiichi Koizumi, Y. Saitoh, Takayuki Minami, Nobuhiro Takeno +9 more
2009Journal of Immunology147 citations Open access
Semantic Scholar
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2
Yue Zhou, Naoki Yamada, Tomohiro Tanaka, T. Hori +7 more
2017139 citations
Semantic Scholar
Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis.
Kazuteru Fukasawa, H. Fujii, Y. Saitoh, Keiichi Koizumi +5 more
2006Cancer Letters136 citations
Semantic Scholar
HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance
A. Takikawa, A. Mahmood, A. Nawaz, Tomonobu Kado +20 more
2016Diabetes118 citations Open access
Semantic Scholar
RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4
E. S. Nakamura, Keiichi Koizumi, M. Kobayashi, Y. Saitoh +5 more
2006Clinical and Experimental Metastasis102 citations
Semantic Scholar
TAK1-Mediated Serine/Threonine Phosphorylation of Epidermal Growth Factor Receptor via p38/Extracellular Signal-Regulated Kinase: NF-κB-Independent Survival Pathways in Tumor Necrosis Factor Alpha Signaling
M. Nishimura, M. Shin, Pattama Singhirunnusorn, Shunsuke Suzuki +4 more
2009Molecular and Cellular Biology85 citations Open access
Semantic Scholar
Dynamical Network Biomarkers: Theory and Applications.
K. Aihara, Rui Liu, Keiichi Koizumi, Xiaoping Liu +1 more
2021Gene84 citations Open access
Semantic Scholar
Heregulin‐induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
Y. Ueno, H. Sakurai, S. Tsunoda, M. Choo +3 more
2008International Journal of Cancer77 citations
Semantic Scholar
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Yasushi Aozuka, Keiichi Koizumi, Y. Saitoh, Y. Ueda +2 more
2004Cancer Letters77 citations
Semantic Scholar
A Proteomic Approach for the Diagnosis of ‘Oketsu’ (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine
Chinami Matsumoto, T. Kojima, Kazuo Ogawa, S. Kamegai +16 more
2007Evidence-Based Complementary and Alternative Medicine66 citations Open access
Semantic Scholar
Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer
Y. Kudo, S. Iizuka, Maki Yoshida, P. Nguyen +11 more
2012PLoS ONE64 citations Open access
Semantic Scholar
Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells.
M. Matsuo, Sanae Yamada, Keiichi Koizumi, H. Sakurai +1 more
2007European Journal of Cancer64 citations
Semantic Scholar
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers
Keiichi Koizumi, M. Oku, S. Hayashi, A. Inujima +7 more
2019Scientific Reports58 citations Open access
Semantic Scholar
Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-kappaB activation.
K. Lirdprapamongkol, H. Sakurai, Shunsuke Suzuki, Keiichi Koizumi +5 more
2010In Vivo55 citations
Semantic Scholar
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages
Ji-Ye Kee, Aya Ito, S. Hojo, Isaya Hashimoto +12 more
2014BMC Cancer54 citations Open access
Semantic Scholar
Severe pulmonary metastasis in obese and diabetic mice
A. Mori, H. Sakurai, M. Choo, Ryosuke Obi +4 more
2006International Journal of Cancer54 citations Open access
Semantic Scholar
Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade
M. Choo, Noritaka Kawasaki, Pattama Singhirunnusorn, Keiichi Koizumi +4 more
2006Molecular Cancer Therapeutics52 citations Open access
Semantic Scholar
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model.
Ji-Ye Kee, Aya Ito, S. Hojo, Isaya Hashimoto +9 more
2013Oncology Report50 citations Open access
Semantic Scholar
TAK1‐mediated stress signaling pathways are essential for TNF‐α‐promoted pulmonary metastasis of murine colon cancer cells
M. Choo, H. Sakurai, Keiichi Koizumi, I. Saiki
2006International Journal of Cancer50 citations
Semantic Scholar
CCL21 promotes the migration and adhesion of highly lymph node metastatic human non-small cell lung cancer Lu-99 in vitro.
Keiichi Koizumi, Yoko Kozawa, Yasukata Ohashi, E. S. Nakamura +6 more
2007Oncology Report47 citations Open access
Semantic Scholar
Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in prostate cancer DU-145.
T. Akashi, Keiichi Koizumi, O. Nagakawa, H. Fuse +1 more
2006Oncology Report44 citations Open access
Semantic Scholar
Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages.
Atsushi Chino, H. Sakurai, M. Choo, Keiichi Koizumi +3 more
2005International Immunopharmacology39 citations
Semantic Scholar
Human T Cell Lymphotropic Virus 1 Manipulates Interferon Regulatory Signals by Controlling the TAK1-IRF3 and IRF4 Pathways*
Shunsuke Suzuki, Yue Zhou, Alaa Refaat, Ichiro Takasaki +5 more
2009Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway.
M. Choo, H. Sakurai, Keiichi Koizumi, I. Saiki
2005Cancer Letters35 citations
Semantic Scholar
Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.
M. Matsuo, H. Sakurai, Keiichi Koizumi, I. Saiki
2007Cancer Letters34 citations
Semantic Scholar
Inverse correlation between Thr‐669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation
Kanae Sato, M. Shin, Ayaka Sakimura, Yue Zhou +7 more
2013Cancer Science33 citations Open access
Semantic Scholar
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Yoshiko Igarashi, A. Nawaz, Tomonobu Kado, M. Bilal +11 more
2018Scientific Reports32 citations Open access
Semantic Scholar
Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.
M. Shin, Pattama Shinghirunnusorn, Yumiko Sugishima, M. Nishimura +4 more
2009Biochimica et Biophysica Acta32 citations Open access
Semantic Scholar
Differential expression of integrin subunits in DU-145/AR prostate cancer cells.
O. Nagakawa, T. Akashi, Y. Hayakawa, A. Junicho +6 more
2004Oncology Report32 citations
Semantic Scholar
RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells.
Y. Saitoh, Keiichi Koizumi, H. Sakurai, Takayuki Minami +1 more
2007Biochemical and Biophysical Research Communications - BBRC30 citations
Semantic Scholar
Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells.
Y. Fuke, S. Shinoda, Ikuko Nagata, S. Sawaki +5 more
2006Cancer Detection and Prevention30 citations
Semantic Scholar
Distinct Roles of Transforming Growth Factor-β-activated Kinase 1 (TAK1)-c-Rel and Interferon Regulatory Factor 4 (IRF4) Pathways in Human T Cell Lymphotropic Virus 1-transformed T helper 17 Cells Producing Interleukin-9*
Alaa Refaat, Yue Zhou, Shunsuke Suzuki, Ichiro Takasaki +5 more
2011Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Selective inhibition of TNF-α-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib
Y. Ueno, H. Sakurai, M. Matsuo, M. Choo +2 more
2005British Journal of Cancer29 citations Open access
Semantic Scholar
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
Y. Saitoh, Keiichi Koizumi, Takayuki Minami, K. Sekine +2 more
2006Biological and Pharmaceutical Bulletin27 citations Open access
Semantic Scholar
Effects of keishibukuryogan on vascular function in adjuvant-induced arthritis rats.
Kazuya Nozaki, H. Goto, T. Nakagawa, H. Hikiami +3 more
2007Biological and Pharmaceutical Bulletin26 citations Open access
Semantic Scholar
Antitumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo.
Ji-Ye Kee, Y. Arita, Kanna Shinohara, Yasukata Ohashi +3 more
2013Molecular and clinical oncology25 citations Open access
Semantic Scholar
Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways
Pornthip Waiwut, M. Shin, A. Inujima, Yue Zhou +3 more
2011Molecular and Cellular Biochemistry24 citations
Semantic Scholar
Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.
Akinori Wada, Aya Ito, Hirofumi Iitsuka, K. Tsuneyama +9 more
2015Oncology Report23 citations Open access
Semantic Scholar
Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats
M. Matsuo, Keiichi Koizumi, Sanae Yamada, M. Tomi +7 more
2006Cell and Tissue Research23 citations
Semantic Scholar
Shikonin induces an anti‑tumor effect on murine mammary cancer via p38‑dependent apoptosis.
Jiuxiang Xu, Keiichi Koizumi, Mengxin Liu, Yusuke Mizuno +6 more
2019Oncology Report21 citations Open access
Semantic Scholar
Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect
Hirofumi Iitsuka, Keiichi Koizumi, A. Inujima, Mikiko Suzaki +13 more
2018Biochemistry and Biophysics Reports21 citations Open access
Semantic Scholar
Structure, synthesis, and biological activity of a C-20 bisacetylenic alcohol from a marine sponge Callyspongia sp.
Takayuki Shirouzu, Kousuke Watari, M. Ono, Keiichi Koizumi +4 more
2013Journal of Natural Products21 citations
Semantic Scholar
The Long-Term Effects of a Kampo Medicine, Juzentaihoto, on Maintenance of Antibody Titer in Elderly People after Influenza Vaccination
I. Saiki, Keiichi Koizumi, H. Goto, A. Inujima +13 more
2013Evidence-Based Complementary and Alternative Medicine21 citations Open access
Semantic Scholar
Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition.
Orawin Prangsaengtong, Phatcharida Jantaree, K. Lirdprapamongkol, Jisnuson Svasti +1 more
2018Biological and Pharmaceutical Bulletin20 citations Open access
Semantic Scholar

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