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D. Lecca · SciRah

Researcher profile · Semantic Scholar

D. Lecca

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D. Lecca — researcher profile on SciRah

h-index: 14
Works: 32
Citations: 978

Most-cited papers

Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease.
A. Pisanu, D. Lecca, G. Mulas, J. Wardas +3 more
2014Neurobiology of Disease253 citations Open access
Semantic Scholar
Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis
D. Lecca, Y. Jung, Michael T. Scerba, I. Hwang +15 more
2022Alzheimer's & Dementia202 citations Open access
Semantic Scholar
Differential induction of dyskinesia and neuroinflammation by pulsatile versus continuous l-DOPA delivery in the 6-OHDA model of Parkinson's disease.
G. Mulas, E. Espa, S. Fenu, S. Spiga +11 more
2016Experimental Neurology91 citations
Semantic Scholar
Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson’s disease
Shuchun Chen, Seong-Jin Yu, Ya-Zhou Li, D. Lecca +7 more
2018Scientific Reports64 citations Open access
Semantic Scholar
Boosting phagocytosis and anti‐inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease models
D. Lecca, E. Janda, G. Mulas, Andrea Diana +9 more
2018British Journal of Pharmacology59 citations Open access
Semantic Scholar
(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer’s disease challenged mice
D. Lecca, M. Bader, D. Tweedie, Alexander F. Hoffman +7 more
2019Neurobiology of Disease43 citations Open access
Semantic Scholar
Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice.
D. Lecca, D. K. Nevin, G. Mulas, M. Casu +5 more
2015Neuroscience42 citations
Semantic Scholar
3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation
Chih-Tung Lin, D. Lecca, Ling-Yu Yang, Weiming Luo +9 more
2020eLife33 citations Open access
Semantic Scholar
Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury
M. Bader, Ya-Zhou Li, D. Lecca, V. Rubovitch +9 more
2018Neurobiology of Disease33 citations Open access
Semantic Scholar
Microglia Drive Pockets of Neuroinflammation in Middle Age
Eric N. Moca, D. Lecca, Keenan Hope, F. Etienne +12 more
2021Journal of Neuroscience32 citations Open access
Semantic Scholar
Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
M. Indrigo, I. Morella, Daniel I. Orellana, Raffaele d’Isa +21 more
2023EMBO Molecular Medicine29 citations Open access
Semantic Scholar
3,6′-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Brain Injury
Pen-Sen Huang, Ping-Yen Tsai, Ling-Yu Yang, D. Lecca +6 more
2021International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury
D. Lecca, Shih-Chang Hsueh, Weiming Luo, D. Tweedie +9 more
2023Journal of Biomedical Sciences15 citations Open access
Semantic Scholar
(−)‐Phenserine tartrate (PhenT) as a treatment for traumatic brain injury
N. Greig, D. Lecca, Shih-Chang Hsueh, Carlos J Nogueras-Ortiz +6 more
2019CNS Neuroscience & Therapeutics15 citations Open access
Semantic Scholar
(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice
Shih-Chang Hsueh, D. Lecca, N. Greig, Jia-Yi Wang +4 more
2019Cell Transplantation14 citations Open access
Semantic Scholar
Chronic inflammation with microglia senescence at basal forebrain: impact on cholinergic deficit in Alzheimer’s brain haemodynamics
Dong Liu, Shih-Chang Hsueh, D. Tweedie, Nathan L. Price +6 more
2024Brain Communications8 citations Open access
Semantic Scholar
3,6′- and 1,6′-Dithiopomalidomide Mitigate Ischemic Stroke in Rats and Blunt Inflammation
Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen +15 more
2022Pharmaceutics8 citations Open access
Semantic Scholar
Activity of a Novel Anti-Inflammatory Agent F-3,6′-dithiopomalidomide as a Treatment for Traumatic Brain Injury
Shih-Chang Hsueh, Michael T. Scerba, D. Tweedie, D. Lecca +8 more
2022Biomedicines8 citations Open access
Semantic Scholar
Author Correction: Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson’s disease
Shuchun Chen, Seong-Jin Yu, Ya-Zhou Li, D. Lecca +7 more
2018Scientific Reports5 citations Open access
Semantic Scholar
Targeting neuroinflammation reduces synaptic, neuronal and cognitive loss in 5xFAD Alzheimer mice.
D. Lecca, Jin Yung Yoo, Michael T. Scerba, D. Tweedie +5 more
2022Alzheimer's & Dementia3 citations
Semantic Scholar
Mitigating chronic neuroinflammation in Alzheimer mice by novel immunomodulatory imide drugs (IMiDs) conserves neuroplasticity and cognitive function and also alleviates neurodegeneration‐behavioral impairments in TBI‐challenged mice
Nigel H. Greig, D. Lecca, Shih-Chang Hsueh, D. Tweedie +6 more
2023Alzheimer's & Dementia2 citations Open access
Semantic Scholar
Thionated aminofluorophthalimides reduce classical markers of cellular inflammation in LPS-challenged RAW 264.7 cells
Michael T. Scerba, D. Tweedie, D. Lecca, M. Siegler +2 more
2022Bioorganic & Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
γ-radiation reduces phosphorylated-tau in rhesus macaque brains: potential implications for Alzheimer’s disease and other tauopathies
E. K. Murphy, Kathleen Hatch, S. Y. Wise, O. Fatanmi +7 more
2026Alzheimer's Research & Therapy1 citations Open access
Semantic Scholar
Modulation of ERK1/MAPK3 potentiates ERK nuclear signalling, facilitates neuronal cell survival and improves memory in mouse models of neurodegenerative disorders
M. Indrigo, I. Morella, Daniel I. Orellana, Raffaele d’Isa +16 more
20181 citations Open access
Semantic Scholar
γ-Radiation Reduces phosphorylated-Tau in RhesusMacaque Brains: Potential Implications forAlzheimer’s Disease and other Tauopathies
E. K. Murphy, Kathleen Hatch, S. Y. Wise, O. Fatanmi +7 more
2026Research Square0 citations
Semantic Scholar
Corrigendum to "Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury" [Neurobiology of Disease Volume 124 (2019) 439-453 /YNBDI_4338].
M. Bader, Ya-Zhou Li, D. Lecca, V. Rubovitch +9 more
2024Neurobiology of Disease0 citations Open access
Semantic Scholar
Author response: 3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation
Chih-Tung Lin, D. Lecca, Ling-Yu Yang, Weiming Luo +9 more
20200 citations Open access
Semantic Scholar
P3-056: PROTECTIVE EFFECTS OF (-)-PHENSERINE (PHEN) IN ALZHEIMER'S DISEASE (AD) AND MILD TRAUMATIC BRAIN INJURY (MTBI) MURINE MODELS
D. Lecca, M. Bader, D. Tweedie, D. Lahiri +5 more
2019Alzheimer's & Dementia0 citations Open access
Semantic Scholar
GLUCAGON-LIKE PEPTIDE-1 (GLP-1) RECEPTOR AGONISTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
N. Greig, D. Tweedie, Ya-Zhou Li, D. Lecca +5 more
20180 citations Open access
Semantic Scholar
P3‐053: (‐)‐PHENSERINE (PHEN) AND THE PREVENTION OF PRE‐PROGRAMMED CELL DEATH IN ALZHEIMER'S DISEASE (AD) AND MILD TRAUMATIC BRAIN INJURY (MTBI)
D. Lecca, M. Bader, D. Tweedie, D. Lahiri +3 more
20180 citations
Semantic Scholar
Differential induction of dyskinesia and inflammatory responses by intermittent versus continuous L-DOPA delivery in the 6-OHDA model of Parkinson's disease
A. Carta, G. Mulas, S. Spiga, D. Lecca +1 more
20160 citations
Semantic Scholar
Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
D. Lecca
20160 citations
Semantic Scholar

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