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F. Ashcroft · SciRah

Researcher profile · Semantic Scholar

F. Ashcroft

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F. Ashcroft — researcher profile on SciRah

h-index: 89
Works: 458
Citations: 33K

Most-cited papers

Pancreatic β-Cell Electrical Activity and Insulin Secretion: of Mice and Men
P. Rorsman, F. Ashcroft
2017Physiological Reviews681 citations Open access
Semantic Scholar
Control of Pancreatic β Cell Regeneration by Glucose Metabolism
S. Porat, N. Weinberg-Corem, Sharona Tornovsky-Babaey, R. Schyr-Ben-Haroush +15 more
2011Cell Metabolism325 citations Open access
Semantic Scholar
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Elizabeth Haythorne, M. Rohm, M. van de Bunt, M. Brereton +12 more
2019Nature Communications298 citations Open access
Semantic Scholar
KATP channels and islet hormone secretion: new insights and controversies
F. Ashcroft, P. Rorsman
2013Nature Reviews Endocrinology268 citations Open access
Semantic Scholar
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
M. Brereton, M. Iberl, K. Shimomura, Quan Zhang +11 more
2014Nature Communications256 citations Open access
Semantic Scholar
FTO influences adipogenesis by regulating mitotic clonal expansion
M. Merkestein, Samantha Laber, Fiona Mcmurray, D. Andrew +7 more
2015Nature Communications224 citations Open access
Semantic Scholar
Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes
Quan Zhang, R. Ramracheya, C. Lahmann, A. Tarasov +18 more
2013Cell Metabolism221 citations Open access
Semantic Scholar
Role for the obesity-related FTO gene in the cellular sensing of amino acids
P. Gulati, M. Cheung, R. Antrobus, C. Church +11 more
2013Proceedings of the National Academy of Sciences of the United States of America172 citations Open access
Semantic Scholar
Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
J. Cantley, F. Ashcroft
2015BMC Biology159 citations Open access
Semantic Scholar
Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse
Fiona Mcmurray, C. Church, R. Larder, G. Nicholson +11 more
2013PLoS Genetics154 citations Open access
Semantic Scholar
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
E. Vergari, J. G. Knudsen, R. Ramracheya, A. Salehi +16 more
2019Nature Communications144 citations Open access
Semantic Scholar
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.
Sharona Tornovsky-Babeay, D. Dadon, Oren Ziv, Elhanan Tzipilevich +17 more
2014Cell Metabolism137 citations Open access
Semantic Scholar
Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 2006;55:2153–2156
H. Freeman, Alison J. Hugill, N. Dear, F. Ashcroft +1 more
2014Diabetes122 citations
Semantic Scholar
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
M. Brereton, M. Rohm, K. Shimomura, Christian H. Holland +10 more
2016Nature Communications121 citations Open access
Semantic Scholar
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells
Elizabeth Haythorne, M. Lloyd, John Walsby-Tickle, A. Tarasov +9 more
2022Nature Communications106 citations Open access
Semantic Scholar
New insights into KATP channel gene mutations and neonatal diabetes mellitus
Tanadet Pipatpolkai, S. Usher, P. Stansfeld, F. Ashcroft
2020Nature Reviews Endocrinology101 citations
Semantic Scholar
Neonatal Diabetes and the KATP Channel: From Mutation to Therapy
F. Ashcroft, Michael C. Puljung, Natascia Vedovato
2017Trends in endocrinology and metabolism97 citations Open access
Semantic Scholar
Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents
C. Lahmann, H. Kramer, F. Ashcroft
2015PLoS ONE92 citations Open access
Semantic Scholar
Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression
Quan Zhang, M. Chibalina, M. Bengtsson, Lukas N. Groschner +11 more
2014Journal of Physiology89 citations Open access
Semantic Scholar
Is Type-2 Diabetes a Glycogen Storage Disease of Pancreatic β-Cells?
F. Ashcroft, M. Rohm, A. Clark, M. Brereton
2017Cell Metabolism88 citations Open access
Semantic Scholar
FTO Is Expressed in Neurones throughout the Brain and Its Expression Is Unaltered by Fasting
J. McTaggart, Sheena Lee, M. Iberl, C. Church +2 more
2011PLoS ONE85 citations Open access
Semantic Scholar
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
J. G. Knudsen, A. Hamilton, R. Ramracheya, A. Tarasov +9 more
2019Cell Metabolism78 citations Open access
Semantic Scholar
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes
Julie Adam, R. Ramracheya, M. Chibalina, N. Ternette +24 more
2017Cell Reports65 citations Open access
Semantic Scholar
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate
John N. Koberstein, Melissa L. Stewart, Chadwick B. Smith, A. Tarasov +3 more
2022Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
Semantic Scholar
Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo
N. Ved, Angela Curran, F. Ashcroft, D. Sparrow
2019Laboratory Animals. Journal of the Laboratory Animal Science Association60 citations Open access
Semantic Scholar
Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
T. Dahan, Oren Ziv, Elad Horwitz, Hai Zemmour +7 more
2016Diabetes59 citations Open access
Semantic Scholar
Functional identification of islet cell types by electrophysiological fingerprinting
L. Briant, Quan Zhang, E. Vergari, Joely A. Kellard +3 more
2017Journal of the Royal Society Interface53 citations Open access
Semantic Scholar
Glucokinase activity in diabetes: too much of a good thing?
F. Ashcroft, M. Lloyd, Elizabeth Haythorne
2022Trends in endocrinology and metabolism50 citations Open access
Semantic Scholar
Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules
Michael B. Hoppa, S. Collins, R. Ramracheya, L. Hodson +5 more
2011Cell Metabolism47 citations Open access
Semantic Scholar
Molecular Mechanism of Sulphonylurea Block of KATP Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes
P. Proks, H. de Wet, F. Ashcroft
2013Diabetes45 citations Open access
Semantic Scholar
A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1
K. Shimomura, Maija Tusa, M. Iberl, M. Brereton +10 more
2013Diabetes38 citations Open access
Semantic Scholar
Autosomal Dominant Hypercalciuria in a Mouse Model Due to a Mutation of the Epithelial Calcium Channel, TRPV5
N. Loh, L. Bentley, H. Dimke, S. Verkaart +16 more
2013PLoS ONE38 citations Open access
Semantic Scholar
KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture
F. Ashcroft
2023Diabetes37 citations Open access
Semantic Scholar
Pharmacological Inhibition of FTO
Fiona Mcmurray, M. Demetriades, W. Aik, M. Merkestein +9 more
2015PLoS ONE37 citations Open access
Semantic Scholar
Changes in Gene Expression Associated with FTO Overexpression in Mice
M. Merkestein, J. McTaggart, Sheena Lee, H. Kramer +5 more
2014PLoS ONE36 citations Open access
Semantic Scholar
Switching to Sulphonylureas in Children With iDEND Syndrome Caused by KCNJ11 Mutations Results in Improved Cerebellar Perfusion
W. Fendler, I. Pietrzak, M. Brereton, C. Lahmann +7 more
2013Diabetes Care36 citations Open access
Semantic Scholar
FTO demethylase activity is essential for normal bone growth and bone mineralization in mice
G. Sachse, C. Church, Michelle E. Stewart, Heather L. Cater +3 more
2018Biochimica et Biophysica Acta - Molecular Basis of Disease28 citations Open access
Semantic Scholar
The Nucleotide-Binding Sites of SUR1: A Mechanistic Model
Natascia Vedovato, F. Ashcroft, Michael C. Puljung
2015Biophysical Journal28 citations Open access
Semantic Scholar
Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk
Natascia Vedovato, E. Cliff, P. Proks, V. Poovazhagi +4 more
2016Diabetologia27 citations Open access
Semantic Scholar
Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the KATP Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes
R. Männikkö, S. Flanagan, X. Sim, D. Segal +4 more
2011Diabetes26 citations Open access
Semantic Scholar
Binding of sulphonylureas to plasma proteins – A KATP channel perspective
P. Proks, H. Kramer, Elizabeth Haythorne, F. Ashcroft
2018PLoS ONE25 citations Open access
Semantic Scholar
Low extracellular magnesium does not impair glucose-stimulated insulin secretion
Lisanne M. M. Gommers, T. Hill, F. Ashcroft, J. de Baaij
2019PLoS ONE24 citations Open access
Semantic Scholar
Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: A mechanistic study
P. Proks, H. de Wet, F. Ashcroft
2014The Journal of General Physiology24 citations Open access
Semantic Scholar
Magnesium deficiency prevents high-fat-diet-induced obesity in mice
Steef Kurstjens, J. V. van Diepen, Caro Overmars-Bos, W. Alkema +5 more
2018Diabetologia22 citations Open access
Semantic Scholar
Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry
S. Usher, F. Ashcroft, Michael C. Puljung
2019bioRxiv21 citations Open access
Semantic Scholar
Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated with Transplacental Transfer of Sulfonylurea in a Mother with KCNJ11-Related Neonatal Diabetes
N. Myngheer, K. Allegaert, A. Hattersley, T. Mcdonald +5 more
2014Diabetes Care21 citations Open access
Semantic Scholar
Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+
Steef Kurstjens, J. de Baaij, Caro Overmars-Bos, I. V. D. van den Munckhof +12 more
2018Diabetologia19 citations Open access
Semantic Scholar
Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease
Tanadet Pipatpolkai, R. Corey, P. Proks, F. Ashcroft +1 more
2020bioRxiv18 citations Open access
Semantic Scholar
A mutation causing increased KATP channel activity leads to reduced anxiety in mice
C. Lahmann, R. Clark, M. Iberl, F. Ashcroft
2014Physiology and Behavior17 citations Open access
Semantic Scholar
Monitoring the real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis
A. Tarasov, J. Galvanovskis, Olof Rorsman, A. Hamilton +5 more
2018Lab on a Chip16 citations Open access
Semantic Scholar

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