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Jacob T. Cain · SciRah

Researcher profile · Semantic Scholar

Jacob T. Cain

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Jacob T. Cain — researcher profile on SciRah

h-index: 15
Works: 33
Citations: 894

Most-cited papers

Cancer exosomes induce tumor innervation
Marianna Madeo, P. Colbert, Daniel W Vermeer, Christopher T. Lucido +12 more
2018Nature Communications275 citations Open access
Semantic Scholar
Therapeutic landscape for Batten disease: current treatments and future prospects
Tyler B. Johnson, Jacob T. Cain, K. White, D. Ramirez-Montealegre +2 more
2019Nature Reviews Neurology161 citations Open access
Semantic Scholar
A porcine model of neurofibromatosis type 1 that mimics the human disease.
K. White, Vicki J. Swier, Jacob T. Cain, Jordan L Kohlmeyer +24 more
2018JCI Insight54 citations Open access
Semantic Scholar
Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease
Jacob T. Cain, S. Likhite, K. White, Derek J. Timm +13 more
2019Molecular Therapy45 citations Open access
Semantic Scholar
A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies
R. Geraets, Logan M Langin, Jacob T. Cain, Camille Parker +4 more
2017PLoS ONE43 citations Open access
Semantic Scholar
Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development.
D. Darland, Jacob T. Cain, Matthew A. Berosik, M. Saint-Geniez +6 more
2011Developmental Biology42 citations Open access
Semantic Scholar
AAV9 gene therapy restores lifespan and treats pathological and behavioral abnormalities in a mouse model of CLN8-Batten disease
Tyler B. Johnson, K. White, Jon J. Brudvig, Jacob T. Cain +9 more
2020bioRxiv34 citations Open access
Semantic Scholar
Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance from Pro- to Anti-stress Signaling and Behavior
Jazmine D. W. Yaeger, K. Krupp, B. Jacobs, Benard O. Onserio +6 more
2022Biological Psychiatry33 citations Open access
Semantic Scholar
Nonsense Pathogenic Variants in Exon One of PHOX2B Lead to Translational Reinitiation in Congenital Central Hypoventilation Syndrome
Jacob T. Cain, D. I. Kim, M. Quast, W. Shivega +8 more
2017American Journal of Medical Genetics. Part A24 citations Open access
Semantic Scholar
Early postnatal administration of an AAV9 gene therapy is safe and efficacious in CLN3 disease
Tyler B. Johnson, Jon J. Brudvig, S. Likhite, Melissa A. Pratt +11 more
2023Frontiers in Genetics19 citations Open access
Semantic Scholar
Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum
Chung-Ling Lu, Steven B. Ortmeier, J. Brudvig, Tamara S. Moretti +4 more
2021bioRxiv19 citations Open access
Semantic Scholar
MARCKS is necessary for Netrin-DCC signaling and corpus callosum formation
Jon J. Brudvig, Jacob T. Cain, G. G. Schmidt-Grimminger, D. Stumpo +3 more
2018Molecular Neurobiology19 citations Open access
Semantic Scholar
Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity
Eli J. Louwagie, T. Larsen, Angela L. Wachal, Tyler C. T. Gandy +7 more
2020iScience17 citations Open access
Semantic Scholar
Tracking sex-dependent differences in a mouse model of CLN6-Batten disease
McKayla Poppens, Jacob T. Cain, Tyler B. Johnson, K. White +4 more
2019Orphanet Journal of Rare Diseases17 citations Open access
Semantic Scholar
Shifts in the Vascular endothelial growth factor (Vegf) isoforms result in transcriptome changes correlated with early neural stem cell proliferation and differentiation in mouse forebrain
Jacob T. Cain, Matthew A. Berosik, Stephanie D. Snyder, N. F. Crawford +3 more
2013Developmental Neurobiology16 citations Open access
Semantic Scholar
MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network
Jon J. Brudvig, Jacob T. Cain, R. M. Sears, G. Schmidt-Grimminger +4 more
2018Scientific Reports14 citations Open access
Semantic Scholar
Germs within Worms: Localization of Neorickettsia sp. within Life Cycle Stages of the Digenean Plagiorchis elegans
S. Greiman, Y. Rikihisa, Jacob T. Cain, J. A. Vaughan +1 more
2016Applied and Environmental Microbiology12 citations Open access
Semantic Scholar
Searching for novel biomarkers using a mouse model of CLN3-Batten disease
Derek J. Timm, Jacob T. Cain, R. Geraets, K. White +5 more
2018PLoS ONE11 citations Open access
Semantic Scholar
Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance
A. Kovács, Daniel W Vermeer, Marianna Madeo, Hunter Reavis +24 more
2020bioRxiv10 citations Open access
Semantic Scholar
A multimodal approach to identify clinically relevant biomarkers to comprehensively monitor disease progression in a mouse model of pediatric neurodegenerative disease.
Tyler B. Johnson, Jon J. Brudvig, K. Lehtimäki, Jacob T. Cain +10 more
2020Progress in neurobiology9 citations
Semantic Scholar
Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1
Tyler B. Johnson, Keegan B. Mechels, Ruth Ellen Anderson, Jacob T. Cain +7 more
2018Scientific Reports9 citations Open access
Semantic Scholar
Transmembrane Batten Disease Proteins Interact With a Shared Network of Vesicle Sorting Proteins, Impacting Their Synaptic Enrichment
M. Rechtzigel, B. Meyerink, H. Leppert, Tyler B. Johnson +6 more
2022Frontiers in Neuroscience7 citations Open access
Semantic Scholar
Transmembrane Batten disease proteins interact with a shared network of vesicle sorting proteins to regulate synaptic composition and function
M. Rechtzigel, B. Meyerink, H. Leppert, Tyler B. Johnson +6 more
2021bioRxiv2 citations Open access
Semantic Scholar
Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease
K. White, Jacob T. Cain, H. Magee, Seul Ki Yeon +3 more
2019Health Psychology and Behavioral Medicine2 citations Open access
Semantic Scholar
Promise of AAV9 gene therapy in the treatment of Batten disease: Systematic approach in therapy design reduces pathological and behavioral deficits and prolongs survival in mouse models of CLN3-, CLN6-, and CLN8-Batten disease
J. Weimer, Jacob T. Cain, Tyler B. Johnson, K. White +2 more
2019Molecular Genetics and Metabolism1 citations
Semantic Scholar
A multimodal approach to identify clinically relevant parameters to monitor disease progression in a preclinical model of neuropediatric disease
Tyler B. Johnson, Jon J. Brudvig, K. Lehtimäki, Jacob T. Cain +9 more
2019bioRxiv1 citations Open access
Semantic Scholar
From Bench to Bedside: Gene Therapy for Batten (CLN6) Disease
S. Likhite, Derek J. Timm, K. White, Jacob T. Cain +7 more
20181 citations
Semantic Scholar
Cancer exosomes induce tumor neo-neurogenesis potentiating tumor growth
Marianna Madeo, P. Colbert, Daniel W Vermeer, Christopher T. Lucido +10 more
2018bioRxiv1 citations Open access
Semantic Scholar
Principal component analysis (PCA) based data fusion approach for a mouse model of CLN8 Batten disease
J. Oksman, K. Lehtimäki, T. Bragge, Jussi Rytkönen +7 more
20200 citations
Semantic Scholar
Longitudinal characterization of the mouse model of CLN8 Batten disease fine motor performance, retinal degeneration, brain pathology, and metabolic changes
K. Lehtimäki, T. Bragge, Jussi Rytkönen, Jukka T. Puoliväli +8 more
20200 citations
Semantic Scholar
Author Correction: Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1
Tyler B. Johnson, Keegan B. Mechels, Ruthellen H. Anderson, Jacob T. Cain +7 more
2020Scientific Reports0 citations Open access
Semantic Scholar
Identifying a biomarker signature for Batten disease
Jacob T. Cain, Tyler B. Johnson, K. White, B. Meyerink +10 more
2019Molecular Genetics and Metabolism0 citations
Semantic Scholar
KIS: Synaptic Plasticity's Missing Molecular Link?
J. Brudvig, Jacob T. Cain
2015Journal of Neuroscience0 citations Open access
Semantic Scholar

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J. Weimer×26
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J. Weimer — researcher profile on SciRah
Tyler B. Johnson×15
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Tyler B. Johnson — researcher profile on SciRah
K. White×12
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Jon J. Brudvig×9
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Derek J. Timm — researcher profile on SciRah

Samantha S. Davis×7

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S. Likhite — researcher profile on SciRah

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