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Yang Sun · SciRah

Researcher profile · Semantic Scholar

Yang Sun

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Yang Sun — researcher profile on SciRah

h-index: 55
Works: 205
Citations: 8,724

Most-cited papers

New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
Yu-Yu Zhu, Zi-Jun Ouyang, Haojie Du, Meijing Wang +6 more
2022Acta Pharmaceutica Sinica B364 citations Open access
Semantic Scholar
Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
Jian Gao, Shuang Peng, Xinni Shan, Guoliang Deng +12 more
2019Cell Death and Disease177 citations Open access
Semantic Scholar
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade
Mingxia Zhao, Wen-Jie Guo, Yuanyuan Wu, Chenxi Yang +10 more
2018Acta Pharmaceutica Sinica B166 citations Open access
Semantic Scholar
Targeting SHP2 as a promising strategy for cancer immunotherapy.
Qianqian Liu, Jiao Qu, Mingxia Zhao, Qiang Xu +1 more
2019Pharmacological Research144 citations
Semantic Scholar
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
Wen-Jie Guo, Wen Liu, Zhen Chen, Yan-Hong Gu +7 more
2017Nature Communications135 citations Open access
Semantic Scholar
Andrographolide alleviates Parkinsonism in MPTP‐PD mice via targeting mitochondrial fission mediated by dynamin‐related protein 1
Ji Geng, Wen Liu, Jian Gao, Chun-Hong Jiang +6 more
2019British Journal of Pharmacology131 citations Open access
Semantic Scholar
Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms.
Mu-Yang Huang, Xiao-Ming Jiang, Binglin Wang, Yang Sun +1 more
2020Pharmacology and Therapeutics127 citations
Semantic Scholar
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies
Zhen-Dong Song, Meijing Wang, Yang Ge, Xue-Ping Chen +3 more
2020Acta Pharmaceutica Sinica B113 citations Open access
Semantic Scholar
CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell
Binglin Wang, Yi Wang, Xiao-Fan Sun, Guoliang Deng +8 more
2021Journal for ImmunoTherapy of Cancer107 citations Open access
Semantic Scholar
Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation
Guoliang Deng, Li-Sha Zhou, Binglin Wang, Xiao-Fan Sun +8 more
2022Journal for ImmunoTherapy of Cancer104 citations Open access
Semantic Scholar
Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin
Lu Chen, Jie Wang, Q. You, Shuai He +7 more
2018Frontiers in Pharmacology101 citations Open access
Semantic Scholar
Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement.
Hang Zhou, Lili Feng, Fang Xu, Yi Sun +9 more
2017Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie97 citations
Semantic Scholar
Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy
Jie Pan, Li-Sha Zhou, Chenyang Zhang, Qiang Xu +1 more
2022Signal Transduction and Targeted Therapy96 citations Open access
Semantic Scholar
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Guoliang Deng, Wen-Jun Chen, Peng Wang, Tianying Zhan +5 more
2019International Immunopharmacology85 citations
Semantic Scholar
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice
Yu-Yu Zhu, Ning Wan, Xinni Shan, Guoliang Deng +3 more
2020Acta Pharmaceutica Sinica B79 citations Open access
Semantic Scholar
Mitochondrial Dysfunction in Chronic Respiratory Diseases: Implications for the Pathogenesis and Potential Therapeutics
Wen-Cheng Zhou, Jiao Qu, Sheng Xie, Yang Sun +1 more
2021Oxidative Medicine and Cellular Longevity76 citations Open access
Semantic Scholar
A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis
Jie Zheng, Lu Yao, Yijing Zhou, Xiaoqun Gu +4 more
2021Cell Death and Disease76 citations Open access
Semantic Scholar
Re-Du-Ning injection ameliorates LPS-induced lung injury through inhibiting neutrophil extracellular traps formation
Chenxi Yang, Chenglin Song, Yitong Liu, Jiao Qu +6 more
2021Phytomedicine73 citations Open access
Semantic Scholar
An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression.
Qiong Luo, Yijun Liu, Ke Shi, Xuecheng Shen +8 more
2023Immunity68 citations Open access
Semantic Scholar
Combination of Fruquintinib and Anti–PD-1 for the Treatment of Colorectal Cancer
Yuan-Yuan Wang, B. Wei, Jianhua Gao, Xiaomin Cai +7 more
2020Journal of Immunology68 citations Open access
Semantic Scholar
DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis
Yuan-Yuan Wang, B. Wei, Dan-Ping Wang, Jing-Jing Wu +7 more
2021Acta Pharmaceutica Sinica B66 citations Open access
Semantic Scholar
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis
Yu-Yu Zhu, Zhigui Wu, Wei Yan, Fenli Shao +9 more
2021EMBO Molecular Medicine62 citations Open access
Semantic Scholar
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer
Xiao-Fan Sun, Li-Sha Zhou, Yi Wang, Guoliang Deng +9 more
2023Journal of Pharmaceutical Analysis61 citations Open access
Semantic Scholar
A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys
Jiao Qu, Fa Yang, T. Zhu, Ying-Shuo Wang +10 more
2022Nature Communications61 citations Open access
Semantic Scholar
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics
Jian Gao, Zhigui Wu, Mingxia Zhao, Rui Zhang +9 more
2021Acta Pharmaceutica Sinica B59 citations Open access
Semantic Scholar
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway
Li Lu, Hailin Wang, Xuan Liu, Liping Tan +6 more
2021Journal of Neuroinflammation50 citations Open access
Semantic Scholar
Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice
Wen Liu, Wen-Jie Guo, Yong-Cheng Zhu, Shuang Peng +9 more
2018Journal of Immunology50 citations Open access
Semantic Scholar
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
D. Klionsky, K. Abdelmohsen, A. Abe, J. Abedin +496 more
201650 citations Open access
Semantic Scholar
(+)‐Borneol improves the efficacy of edaravone against DSS‐induced colitis by promoting M2 macrophages polarization via JAK2‐STAT3 signaling pathway
Xiong Zhang, Fang Xu, Li Liu, Lili Feng +5 more
2017International Immunopharmacology48 citations
Semantic Scholar
Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression.
Xiaomin Cai, B. Wei, Le-Le Li, Xiao-Feng Chen +7 more
2020International Immunopharmacology47 citations Open access
Semantic Scholar
Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.
Wen Liu, Ting Fan, Manru Li, Guohui Zhang +11 more
2020International Immunopharmacology45 citations
Semantic Scholar
Tyrosine phosphatase SHP2 exacerbates psoriasis‐like skin inflammation in mice via ERK5‐dependent NETosis
Yan Ding, Zi-Jun Ouyang, Chenyang Zhang, Yu-Yu Zhu +4 more
2022MedComm44 citations Open access
Semantic Scholar
Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
Fenli Shao, Qianqian Liu, Yu-Yu Zhu, Zhi-Dan Fan +8 more
2021Nature Communications44 citations Open access
Semantic Scholar
Andrographolide sulfonate improves Alzheimer-associated phenotypes and mitochondrial dysfunction in APP/PS1 transgenic mice.
Ji Geng, Wen Liu, Yu-Yun Xiong, Hongqun Ding +8 more
2018Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie44 citations
Semantic Scholar
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Minyi Zhang, Tao Zhang, Chenglin Song, Jiao Qu +7 more
2021Journal of Ethnopharmacology42 citations
Semantic Scholar
Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway.
Ge Xu, Lili Feng, Pingping Song, Fang Xu +9 more
2016International Immunopharmacology42 citations
Semantic Scholar
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective
Jiao Qu, Qianqian Liu, Guoquan You, Ling Ye +5 more
2021Medicinal research reviews (Print)39 citations
Semantic Scholar
Comparative genome mining and heterologous expression of an orphan NRPS gene cluster direct the production of ashimides
Jing Shi, Ying-Jie Zeng, Bo Zhang, Fenli Shao +6 more
2019Chemical Science39 citations Open access
Semantic Scholar
Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis.
Chenglin Song, Chenxi Yang, Siwei Meng, Manru Li +6 more
2021Journal of Ethnopharmacology37 citations
Semantic Scholar
NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion
Guang-yun Wang, Tiezheng Wang, Yang Hu, Jie-Man Wang +7 more
2020Cell Death and Disease35 citations Open access
Semantic Scholar
Triggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1
Minmin Fan, Jingwei Chen, Jian Gao, Wenwen Xue +11 more
2020Cell Death and Disease35 citations Open access
Semantic Scholar
Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete.
Shi-Ying Ma, Yong-Sheng Xiao, Bo Zhang, Fenli Shao +7 more
2017Organic Letters35 citations
Semantic Scholar
CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction
Ting-Ting Li, Jie Pan, Hong-Qi Chen, Yongliang Fang +1 more
2022Acta Pharmaceutica Sinica B34 citations Open access
Semantic Scholar
SH2 Domain–Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade
Qianqian Liu, Lin-Hui Zhai, Ming-Rui Han, D. Shi +11 more
2021Arthritis & Rheumatology34 citations
Semantic Scholar
Pterostilbene alleviates fructose‐induced renal fibrosis by suppressing TGF‐&bgr;1/TGF‐&bgr; type I receptor/Smads signaling in proximal tubular epithelial cells
Ting-Ting Gu, Tian-Yu Chen, Yan-zi Yang, Xiaojuan Zhao +4 more
2019European Journal of Pharmacology34 citations
Semantic Scholar
SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice
Wen Liu, Meijing Wang, Lihong Shen, Yu-Yu Zhu +6 more
2021Signal Transduction and Targeted Therapy33 citations Open access
Semantic Scholar
Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.
Yanpin Gu, Yong-Cheng Zhu, Guoliang Deng, Songjun Liu +2 more
2021International Immunopharmacology31 citations
Semantic Scholar
Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells
Jian Gao, Minmin Fan, Gang Xiang, Ju-Juan Wang +10 more
2017Cell Death and Disease31 citations Open access
Semantic Scholar
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice
Wen Liu, Wen-Jie Guo, Lihong Shen, Zhen Chen +7 more
2016OncoTarget31 citations Open access
Semantic Scholar
Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model
Rong-Liang Wang, Jia-Wei Li, Xing-Quan Xu, Jia Xu +9 more
2021Journal of Orthopaedic Translation28 citations Open access
Semantic Scholar

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