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A. Shekhar · SciRah

Researcher profile · Semantic Scholar

A. Shekhar

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A. Shekhar — researcher profile on SciRah

h-index: 77
Works: 294
Citations: 15K

Most-cited papers

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach
Alexander B. Niculescu, D. Levey, Peter L. Phalen, H. Le-Niculescu +25 more
2015Molecular Psychiatry164 citations Open access
Semantic Scholar
Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase
A. Molosh, P. Johnson, J. P. Spence, David H. Arendt +12 more
2014Nature Neuroscience129 citations Open access
Semantic Scholar
Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment
D. Levey, E. M. Niculescu, H. Le-Niculescu, H. Dainton +17 more
2016Molecular Psychiatry97 citations Open access
Semantic Scholar
A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects
P. Bonaventure, S. Yun, P. Johnson, A. Shekhar +10 more
2015Journal of Pharmacology and Experimental Therapeutics88 citations Open access
Semantic Scholar
Genetic risk prediction and neurobiological understanding of alcoholism
D. Levey, H. Le-Niculescu, J. Frank, M. Ayalew +19 more
2014Translational Psychiatry88 citations Open access
Semantic Scholar
Precision medicine for suicidality: from universality to subtypes and personalization
Alexander B. Niculescu, H. Le-Niculescu, D. Levey, Peter L. Phalen +16 more
2017Molecular Psychiatry86 citations Open access
Semantic Scholar
Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
H. Le-Niculescu, K. Roseberry, S. Gill, D. Levey +9 more
2021Molecular Psychiatry84 citations Open access
Semantic Scholar
Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs
A. Niculescu, H. Le-Niculescu, K. Roseberry, Sophia Wang +11 more
2019Molecular Psychiatry70 citations Open access
Semantic Scholar
The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic
E. Paul, P. Johnson, A. Shekhar, C. Lowry
2014Neuroscience and Biobehavioral Reviews70 citations Open access
Semantic Scholar
OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2-INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES
P. Johnson, Lauren M. Federici, S. Fitz, J. Renger +4 more
2015Depression and Anxiety64 citations Open access
Semantic Scholar
ETIOLOGY, TRIGGERS AND NEUROCHEMICAL CIRCUITS ASSOCIATED WITH UNEXPECTED, EXPECTED, AND LABORATORY-INDUCED PANIC ATTACKS
P. Johnson, Lauren M. Federici, A. Shekhar
2014Neuroscience and Biobehavioral Reviews59 citations Open access
Semantic Scholar
Antidepressant use in the elderly is associated with an increased risk of dementia
Chenkun Wang, Su-Juan Gao, H. Hendrie, J. Kesterson +3 more
2016Alzheimer Disease and Associated Disorders57 citations Open access
Semantic Scholar
The First Implementation of the NIMH FAST-FAIL Approach to Psychiatric Drug Development
A. Krystal, D. Pizzagalli, S. Mathew, G. Sanacora +14 more
2018Nature reviews. Drug discovery56 citations Open access
Semantic Scholar
Electroacupuncture promotes CNS-dependent release of mesenchymal stem cells
Tatiana E. Salazar, M. R. Richardson, Eleni Beli, M. Ripsch +40 more
2017Stem Cells53 citations Open access
Semantic Scholar
Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning
P. Johnson, A. Molosh, S. Fitz, David H. Arendt +7 more
2015Pharmacology, Biochemistry and Behavior52 citations Open access
Semantic Scholar
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans
G. Salvadore, P. Bonaventure, A. Shekhar, P. Johnson +16 more
2020Translational Psychiatry43 citations Open access
Semantic Scholar
Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear
E. Dustrude, I. Caliman, C. Bernabe, S. Fitz +6 more
2018Frontiers in Neuroscience43 citations Open access
Semantic Scholar
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
P. Bonaventure, C. Dugovic, B. Shireman, Cathy Préville +9 more
2017Frontiers in Pharmacology41 citations Open access
Semantic Scholar
Evaluation of Low versus High Volume per Minute Displacement CO2 Methods of Euthanasia in the Induction and Duration of Panic-Associated Behavior and Physiology
D. Hickman, S. Fitz, C. Bernabe, I. Caliman +4 more
2016Animals41 citations Open access
Semantic Scholar
The Role of the Medial Prefrontal Cortex in Regulating Social Familiarity-Induced Anxiolysis
Elizabeth A. Lungwitz, G. Stuber, P. Johnson, A. Dietrich +4 more
2014Neuropsychopharmacology40 citations Open access
Semantic Scholar
Disrupting nNOS-PSD95 Interaction Improves Neurological and Cognitive Recoveries after Traumatic Brain Injury.
Wen-Rui Qu, Nai-Kui Liu, Xiangbing Wu, Ying Wang +6 more
2020Cerebral Cortex34 citations Open access
Semantic Scholar
PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD
Liangping Li, E. Dustrude, Melissa M. Haulcomb, A. R. Abreu +6 more
2018Translational Psychiatry32 citations Open access
Semantic Scholar
Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
K. Roseberry, H. Le-Niculescu, D. Levey, R. Bhagar +9 more
2023Molecular Psychiatry31 citations Open access
Semantic Scholar
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
A. Bellail, H. Jin, Ho Y. Lo, S. Jung +15 more
2021Science Translational Medicine31 citations Open access
Semantic Scholar
The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents
Yu Xu, Lucas N. Cantwell, A. Molosh, L. Plant +10 more
2020Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels
P. Johnson, A. Molosh, Lauren M. Federici, C. Bernabe +5 more
2019Translational Psychiatry24 citations Open access
Semantic Scholar
Overview of genetic models of autism spectrum disorders.
Jheel Patel, J. Lukkes, A. Shekhar
2018Progress in Brain Research21 citations
Semantic Scholar
Hypothalamic orexin’s role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model
Lauren M. Federici, I. Caliman, A. Molosh, S. Fitz +5 more
2015Psychoneuroendocrinology21 citations Open access
Semantic Scholar
The Rewarding and Anxiolytic Properties of Ethanol within the Central Nucleus of the Amygdala: Mediated by Genetic Background and Nociceptin
Christopher P. Knight, S. R. Hauser, R. A. Waeiss, A. Molosh +6 more
2020Journal of Pharmacology and Experimental Therapeutics19 citations Open access
Semantic Scholar
Crh receptor priming in the bed nucleus of the stria terminalis induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety
Nina C. Donner, S. Mani, S. Fitz, Drake M. Kienzle +2 more
2019Progress in Neuro-psychopharmacology and Biological Psychiatry19 citations Open access
Semantic Scholar
Alcohol-preferring rats show decreased corticotropin-releasing hormone 2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats
Wei-Dong Yong, J. P. Spence, R. Eskay, S. Fitz +8 more
2014Alcoholism: Clinical and Experimental Research19 citations Open access
Semantic Scholar
Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics
M. Hill, S. Gill, H. Le-Niculescu, O. MacKie +8 more
2024Molecular Psychiatry18 citations
Semantic Scholar
Role of medial hypothalamic orexin system in panic, phobia and hypertension.
A. R. Abreu, A. Molosh, P. Johnson, A. Shekhar
2020Brain Research18 citations Open access
Semantic Scholar
The social symbiome framework: Linking genes-to-global cultures in public health using network science
B. Pescosolido, S. Ólafsdóttir, O. Sporns, B. Perry +8 more
201618 citations
Semantic Scholar
Panic results in unique molecular and network changes in the amygdala that facilitate fear responses.
A. Molosh, E. T. Dustrude, J. Lukkes, S. Fitz +9 more
2018Molecular Psychiatry16 citations Open access
Semantic Scholar
Neurofibromatosis type 1 as a model system to study molecular mechanisms of autism spectrum disorder symptoms.
A. Molosh, A. Shekhar
2018Progress in Brain Research16 citations
Semantic Scholar
Event-related potentials reflect impaired temporal interval learning following haloperidol administration
Sarah E. Forster, P. Zirnheld, A. Shekhar, S. Steinhauer +2 more
2017Psychopharmacology16 citations
Semantic Scholar
Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma
A. Lakhter, James Hamilton, P. Dagher, Suresh Mukkamala +8 more
2014OncoTarget16 citations Open access
Semantic Scholar
A controlled trial of quetiapine XR coadministration treatment of SSRI-resistant panic disorder
A. Goddard, Waqar Mahmud, C. Medlock, Y. Shin +1 more
2015Annals of General Psychiatry15 citations Open access
Semantic Scholar
Next-generation precision medicine for pain
R. Bhagar, H. Le-Niculescu, S. Corey, A. S. Gettelfinger +9 more
2025Molecular Psychiatry13 citations Open access
Semantic Scholar
Stress, Panic, and Central Serotonergic Inhibition
James E. Hassell, Paula S. M. Yamashita, P. Johnson, H. Zangrossi +2 more
201713 citations
Semantic Scholar
Anxiogenic CO2 Stimulus Elicits Exacerbated Hot Flash-like Responses in a Rat Menopause Model and Hot Flashes in Menopausal Women
Lauren M. Federici, S. Roth, Connie Krier, S. Fitz +4 more
2016Menopause13 citations Open access
Semantic Scholar
Angiotensin type 1 receptor antagonists-a novel approach to augmenting posttraumatic stress disorder and phobia therapies?
A. Shekhar
2014Biological Psychiatry13 citations
Semantic Scholar
Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury
Young Lee, P. Mehrotra, D. Basile, M. Ullah +6 more
2020Journal of Pharmacology and Experimental Therapeutics12 citations Open access
Semantic Scholar
Next-generation precision medicine for suicidality prevention
R. Bhagar, S. Gill, H. Le-Niculescu, C. Yin +15 more
2024Translational Psychiatry11 citations
Semantic Scholar
Psychosocial impairment following mild blast-induced traumatic brain injury in rats
N. Race, Katharine D. Andrews, Elizabeth A. Lungwitz, Sasha M. Vega Alvarez +10 more
2021Behavioural Brain Research11 citations Open access
Semantic Scholar
Using loss and gain of function approaches to target amygdala-projecting serotonergic neurons in the dorsal raphe nucleus that enhance anxiety-related and conditioned fear behaviors
C. Bernabe, I. Caliman, W. Truitt, A. Molosh +4 more
2020Journal of Psychopharmacology11 citations Open access
Semantic Scholar
Role of Kappa Opioid Receptors in Symptoms of Schizophrenia: What Is the Neurobiology?
A. Shekhar
2019Biological Psychiatry11 citations Open access
Semantic Scholar
Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model
J. Lukkes, H. P. Drozd, S. Fitz, A. Molosh +2 more
2020Journal of Neurodevelopmental Disorders9 citations Open access
Semantic Scholar
Review of Marijuana Use in the Adolescent Population and Implications of its Legalization in the United States
M. McCormick, A. Shekhar
20149 citations
Semantic Scholar

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P. Johnson×20
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S. Fitz×16
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A. Molosh×13
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H. Le-Niculescu×10
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Lauren M. Federici×8

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D. Levey — researcher profile on SciRah

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C. Lowry — researcher profile on SciRah