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R. Inoue · SciRah

Researcher profile · Semantic Scholar

R. Inoue

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R. Inoue — researcher profile on SciRah

h-index: 36
Works: 185
Citations: 6,378

Most-cited papers

Mechanosensitive TRP channels in cardiovascular pathophysiology.
R. Inoue, Zhong Jian, Y. Kawarabayashi
2009Pharmacology and Therapeutics195 citations
Semantic Scholar
Synergistic Activation of Vascular TRPC6 Channel by Receptor and Mechanical Stimulation via Phospholipase C/Diacylglycerol and Phospholipase A2/&ohgr;-Hydroxylase/ 20-HETE Pathways
R. Inoue, L. J. Jensen, Zhong Jian, Juan Shi +9 more
2009Circulation Research159 citations Open access
Semantic Scholar
Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
Hideyuki Kinoshita, K. Kuwahara, M. Nishida, Zhong Jian +14 more
2010Circulation Research155 citations Open access
Semantic Scholar
Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction
Michio Nakaya, K. Watari, Mitsuru Tajima, Takeo Nakaya +17 more
2017Journal of Clinical Investigation118 citations Open access
Semantic Scholar
Phosphorylation of TRPC6 Channels at Thr69 Is Required for Anti-hypertrophic Effects of Phosphodiesterase 5 Inhibition*
M. Nishida, Kenta Watanabe, Y. Sato, Michio Nakaya +4 more
2010Journal of Biological Chemistry101 citations Open access
Semantic Scholar
Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+ Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia*
Y. Mizoguchi, T. Kato, Y. Seki, Masahiro Ohgidani +8 more
2014Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells
T. Numaga, M. Nishida, Shigeki Kiyonaka, K. Kato +7 more
2010Journal of Cell Science73 citations Open access
Semantic Scholar
TRP channels in cardiac and intestinal fibrosis.
R. Inoue, L. Kurahara, K. Hiraishi
2019Seminars in Cell and Developmental Biology71 citations
Semantic Scholar
PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels
Kyohei Itsuki, Yuko Imai, Hideharu Hase, Y. Okamura +2 more
2014The Journal of General Physiology71 citations Open access
Semantic Scholar
SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation.
S. Komatsu, T. Nomiyama, T. Numata, Takako Kawanami +10 more
2019Endocrine journal67 citations Open access
Semantic Scholar
Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry.
Kei Yamaura, Shigeki Kiyonaka, T. Numata, R. Inoue +1 more
2016Nature Chemical Biology62 citations
Semantic Scholar
A self‐limiting regulation of vasoconstrictor‐activated TRPC3/C6/C7 channels coupled to PI(4,5)P2‐diacylglycerol signalling
Yuko Imai, Kyohei Itsuki, Y. Okamura, R. Inoue +1 more
2012Journal of Physiology61 citations Open access
Semantic Scholar
Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner
Yuki Nakamura, Xiu-yu Shi, T. Numata, Y. Mori +4 more
2013PLoS ONE59 citations Open access
Semantic Scholar
Cilostazol Suppresses Angiotensin II–Induced Vasoconstriction via Protein Kinase A–Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel
K. Nishioka, M. Nishida, M. Ariyoshi, Zhong Jian +9 more
2011Arteriosclerosis, Thrombosis and Vascular Biology53 citations Open access
Semantic Scholar
Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease
L. Kurahara, K. Hiraishi, Yao-Peng Hu, K. Koga +8 more
2017Cellular and Molecular Gastroenterology and Hepatology50 citations Open access
Semantic Scholar
Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel
Kaori Sato-Numata, T. Numata, R. Inoue, Yasunobu Okada
2016Pflügers Archiv: European Journal of Physiology37 citations
Semantic Scholar
Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin‐dependent kinase II
Juan Shi, N. Geshi, Shinichi Takahashi, Shigeki Kiyonaka +5 more
2013Journal of Physiology35 citations Open access
Semantic Scholar
Critical role of TRPC1-mediated Ca²⁺ entry in decidualization of human endometrial stromal cells.
Y. Kawarabayashi, Hai Lin, A. Honda, Shinji Horiuchi +3 more
2012Molecular Endocrinology35 citations Open access
Semantic Scholar
BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles
B. O. Hald, J. B. Jacobsen, T. Braunstein, R. Inoue +4 more
2011Pflügers Archiv: European Journal of Physiology33 citations
Semantic Scholar
Dynamics of receptor-operated Ca2+ currents through TRPC channels controlled via the PI(4,5)P2-PLC signaling pathway
Masayuki X. Mori, Kyohei Itsuki, Hideharu Hase, Seishiro Sawamura +3 more
2015Frontiers in Pharmacology32 citations Open access
Semantic Scholar
Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel
K. Hiraishi, L. Kurahara, M. Sumiyoshi, Yao-Peng Hu +7 more
2018World Journal of Gastroenterology31 citations Open access
Semantic Scholar
Intestinal Myofibroblast TRPC6 Channel May Contribute to Stenotic Fibrosis in Crohn's Disease
L. Kurahara, M. Sumiyoshi, K. Aoyagi, K. Hiraishi +4 more
2015Inflammatory Bowel Diseases31 citations
Semantic Scholar
Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes.
Onur K. Polat, M. Uno, Terukazu Maruyama, Ha Nam Tran +14 more
2019Journal of the American Society of Nephrology30 citations Open access
Semantic Scholar
Counteracting effect of TRPC1-associated Ca2+ influx on TNF-α-induced COX-2-dependent prostaglandin E2 production in human colonic myofibroblasts.
Hai Lin, Y. Kawarabayashi, Yuko Imai, A. Honda +1 more
2011American Journal of Physiology - Gastrointestinal and Liver Physiology29 citations
Semantic Scholar
17β-Estradiol-induced enhancement of estrogen receptor biosynthesis via MAPK pathway in mouse skeletal muscle myoblasts
Junna Hatae, Noboru Takami, Hai Lin, A. Honda +1 more
2009Journal of Physiological Sciences28 citations Open access
Semantic Scholar
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds
Seishiro Sawamura, M. Hatano, Yoshinori Takada, K. Hino +14 more
2016Molecular Pharmacology25 citations Open access
Semantic Scholar
Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates
Yuta Takano, T. Numata, Kazuto Fujishima, Kazuaki Miyake +8 more
2016Chemical Science24 citations Open access
Semantic Scholar
“TRP inflammation” relationship in cardiovascular system
T. Numata, Kiriko Takahashi, R. Inoue
2015Seminars in Immunopathology24 citations Open access
Semantic Scholar
Voltage-sensing phosphatase reveals temporal regulation of TRPC3/C6/C7 channels by membrane phosphoinositides
Kyohei Itsuki, Yuko Imai, Y. Okamura, K. Abe +2 more
2012Channels23 citations Open access
Semantic Scholar
Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches
Yao-Peng Hu, Y. Duan, A. Takeuchi, Lin Hai-Kurahara +10 more
2017Cardiovascular Research22 citations
Semantic Scholar
Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells.
Shigeki Kiyonaka, Ryou Kubota, Yu Michibata, M. Sakakura +5 more
2016Nature Chemistry22 citations
Semantic Scholar
TRPM7‐mediated spontaneous Ca2+ entry regulates the proliferation and differentiation of human leukemia cell line K562
Kiriko Takahashi, C. Umebayashi, T. Numata, A. Honda +4 more
2018Physiological Reports20 citations Open access
Semantic Scholar
TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells
J. Ichikawa, R. Inoue
2014British Journal of Pharmacology20 citations Open access
Semantic Scholar
Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On Probe
S. Sakamoto, Kei Yamaura, T. Numata, F. Harada +4 more
2019ACS Central Science19 citations Open access
Semantic Scholar
Quantitative measurement of Ca(2+)-dependent calmodulin-target binding by Fura-2 and CFP and YFP FRET imaging in living cells.
Masayuki X. Mori, Yuko Imai, Kyohei Itsuki, R. Inoue
2011Biochemistry19 citations
Semantic Scholar
Distinct contributions of LRRC8A and its paralogs to the VSOR anion channel from those of the ASOR anion channel
Kaori Sato-Numata, T. Numata, R. Inoue, R. Sabirov +1 more
2016Channels17 citations Open access
Semantic Scholar
Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
L. Kurahara, K. Hiraishi, A. Yamamura, Ying Zhang +14 more
2020Journal of Molecular and Cellular Cardiology16 citations Open access
Semantic Scholar
Mechano-sensitivity of mitochondrial function in mouse cardiac myocytes.
G. Iribe, Keiko Kaihara, Y. Yamaguchi, Michio Nakaya +2 more
2017Progress in Biophysics and Molecular Biology15 citations
Semantic Scholar
The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis
Yao-Peng Hu, Jiehui Cang, K. Hiraishi, T. Fujita +1 more
2023International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells.
Shohei Yoshimoto, M. Matsuda, Kenichi Kato, E. Jimi +8 more
2021European Journal of Pharmacology13 citations
Semantic Scholar
Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl−/water secretion that involves cAMP-dependent activation of CFTR
T. Numata, Kaori Sato-Numata, Y. Okada, R. Inoue
2018Journal of Natural Medicines12 citations Open access
Semantic Scholar
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension
K. Hiraishi, L. Kurahara, Jian-Lin Feng, A. Yamamura +15 more
2021Translational Research: The Journal of Laboratory and Clinical Medicine11 citations Open access
Semantic Scholar
Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation
Yao-Peng Hu, Daniela Ross Kaschitza, Maria C. Essers, Prakash Arullampalam +3 more
2021Pflügers Archiv: European Journal of Physiology11 citations
Semantic Scholar
Strategy to Attain Remarkably High Photoinduced Charge-Separation Yield of Donor-Acceptor Linked Molecules in Biological Environment via Modulating Their Cationic Moieties
Ning Cai, Yuta Takano, T. Numata, R. Inoue +3 more
201711 citations
Semantic Scholar
Regulation of cardiovascular TRP channel functions along the NO–cGMP–PKG axis
R. Inoue, Juan Shi, Jian Zhong, Yuko Imai
2010Expert Review of Clinical Pharmacology9 citations
Semantic Scholar
An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP2 Interaction
Yao-Peng Hu, Qin Li, L. Kurahara, Shioi Narumi +4 more
2021Cells8 citations Open access
Semantic Scholar
Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing
T. Numata, K. Tsumoto, Kazunori Yamada, Tatsuki Kurokawa +6 more
2017Scientific Reports8 citations Open access
Semantic Scholar
Significant contribution of TRPC6 channel-mediated Ca2+ influx to the pathogenesis of Crohn's disease fibrotic stenosis
L. Kurahara, K. Hiraishi, M. Sumiyoshi, Mayumi Doi +4 more
2016Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi8 citations Open access
Semantic Scholar
Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block
Yao-Peng Hu, Qin Li, Yang-Hua Shen, T. Fujita +2 more
2021International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
New experimental trends for phosphoinositides research on ion transporter/channel regulation.
Masayuki X. Mori, R. Inoue
2014Journal of Pharmacological Sciences7 citations Open access
Semantic Scholar

Frequent co-authors

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T. Numata×14
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T. Numata — researcher profile on SciRah
Yao-Peng Hu×12
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Yao-Peng Hu — researcher profile on SciRah
Y. Mori×11
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Y. Mori — researcher profile on SciRah
Masayuki X. Mori×10
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Masayuki X. Mori — researcher profile on SciRah

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K. Hiraishi — researcher profile on SciRah

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L. Kurahara — researcher profile on SciRah

Shigeki Kiyonaka×7

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Shigeki Kiyonaka — researcher profile on SciRah

Kyohei Itsuki×6

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Kyohei Itsuki — researcher profile on SciRah

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Yuko Imai — researcher profile on SciRah

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J. Ichikawa — researcher profile on SciRah

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M. Nishida — researcher profile on SciRah

Michio Nakaya×5

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Michio Nakaya — researcher profile on SciRah