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H. Sabe · SciRah

Researcher profile · Semantic Scholar

H. Sabe

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H. Sabe — researcher profile on SciRah

h-index: 51
Works: 172
Citations: 8,765

Most-cited papers

GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion
M. Morishige, S. Hashimoto, E. Ogawa, Y. Toda +13 more
2008Nature Cell Biology213 citations
Semantic Scholar
Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities
Yasuhito Onodera, S. Hashimoto, A. Hashimoto, M. Morishige +9 more
2005EMBO Journal177 citations Open access
Semantic Scholar
ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
S. Hashimoto, Shotaro Furukawa, A. Hashimoto, Akio Tsutaho +15 more
2019Proceedings of the National Academy of Sciences of the United States of America130 citations Open access
Semantic Scholar
The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis†
H. Sabe, S. Hashimoto, M. Morishige, E. Ogawa +5 more
2009Traffic : the International Journal of Intracellular Transport115 citations Open access
Semantic Scholar
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.
S. Hashimoto, M. Hirose, A. Hashimoto, M. Morishige +13 more
2006Proceedings of the National Academy of Sciences of the United States of America110 citations
Semantic Scholar
Rab5c promotes AMAP1–PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
Yasuhito Onodera, Jin-Min Nam, A. Hashimoto, J. Norman +3 more
2012Journal of Cell Biology106 citations Open access
Semantic Scholar
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
S. Hashimoto, S. Mikami, H. Sugino, Ayumu Yoshikawa +8 more
2016Nature Communications101 citations Open access
Semantic Scholar
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial–mesenchymal transition
M. Hirano, S. Hashimoto, S. Yonemura, H. Sabe +1 more
2008Journal of Cell Biology90 citations Open access
Semantic Scholar
Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2
Y. Mazaki, S. Hashimoto, T. Tsujimura, M. Morishige +7 more
2006Nature Immunology86 citations
Semantic Scholar
EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.
K. Miura, Jin-Min Nam, C. Kojima, N. Mochizuki +1 more
2009Molecular Biology of the Cell77 citations Open access
Semantic Scholar
ArfGAP family proteins in cell adhesion, migration and tumor invasion.
H. Sabe, Yasuhito Onodera, Y. Mazaki, S. Hashimoto
2006Current Opinion in Cell Biology74 citations
Semantic Scholar
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
Yasuhito Onodera, Jin-Min Nam, Mei Horikawa, H. Shirato +1 more
2018Nature Communications73 citations Open access
Semantic Scholar
CIN85, a Cbl‐interacting protein, is a component of AMAP1‐mediated breast cancer invasion machinery
Jin-Min Nam, Yasuhito Onodera, Y. Mazaki, H. Miyoshi +2 more
2007EMBO Journal73 citations Open access
Semantic Scholar
Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling.
H. Sabe
2011Journal of Biochemistry (Tokyo)67 citations Open access
Semantic Scholar
Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis.
Masaki Mori, H. Nakagami, Nobutaka Koibuchi, K. Miura +7 more
2009Molecular Biology of the Cell67 citations Open access
Semantic Scholar
GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis
A. Hashimoto, S. Hashimoto, Ryo Ando, K. Noda +9 more
2011PLoS ONE64 citations Open access
Semantic Scholar
Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure
S. Takada, S. Maekawa, T. Furihata, N. Kakutani +13 more
2021Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance
A. Hashimoto, Tsukasa Oikawa, S. Hashimoto, H. Sugino +9 more
2016Journal of Cell Biology58 citations Open access
Semantic Scholar
Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase
K. Miura, Yuki Wakayama, M. Tanino, Y. Orba +5 more
2013Oncogene52 citations Open access
Semantic Scholar
Grp1 plays a key role in linking insulin signaling to glut4 recycling
Jian Li, Andrew W. Malaby, M. Famulok, H. Sabe +2 more
2012Developmental Cell51 citations Open access
Semantic Scholar
Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1.
Shunsuke Kon, K. Tanabe, Toshio Watanabe, H. Sabe +1 more
2008Experimental Cell Research50 citations
Semantic Scholar
Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure
S. Maekawa, S. Takada, Hideo Nambu, T. Furihata +6 more
2019Cell Communication and Signaling48 citations Open access
Semantic Scholar
Intracellular trafficking of integrins in cancer cells.
Yasuhito Onodera, Jin-Min Nam, H. Sabe
2013Pharmacology and Therapeutics43 citations
Semantic Scholar
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production
Y. Mazaki, Y. Nishimura, H. Sabe
2012Molecular Biology of the Cell42 citations Open access
Semantic Scholar
Engagement of Overexpressed Her2 with GEP100 Induces Autonomous Invasive Activities and Provides a Biomarker for Metastases of Lung Adenocarcinoma
T. Menju, S. Hashimoto, A. Hashimoto, Yutaro Otsuka +6 more
2011PLoS ONE42 citations Open access
Semantic Scholar
β1-integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer
Jin-Min Nam, K. M. Ahmed, S. Costes, Hui Zhang +8 more
2013Breast Cancer Research41 citations Open access
Semantic Scholar
High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients
Hiroki Sato, K. Hatanaka, Y. Hatanaka, H. Hatakeyama +4 more
2014Cell Communication and Signaling39 citations Open access
Semantic Scholar
Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-activated Protein Kinase-α - Proliferator-Activated Receptor-r Coactivator-1α Signaling in Skeletal Muscle of Mice With Heart Failure.
J. Matsumoto, S. Takada, T. Furihata, Hideo Nambu +10 more
2020Circulation: Heart Failure35 citations Open access
Semantic Scholar
Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets
S. Takada, H. Sabe, S. Kinugawa
2020Frontiers in Cardiovascular Medicine34 citations Open access
Semantic Scholar
Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model
Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, S. Hashimoto +4 more
2018Cell Communication and Signaling32 citations Open access
Semantic Scholar
EphrinA1-EphA2 Signal Induces Compaction and Polarization of Madin-Darby Canine Kidney Cells by Inactivating Ezrin through Negative Regulation of RhoA
Yuki Wakayama, K. Miura, H. Sabe, N. Mochizuki
2011Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
T. Furihata, S. Takada, N. Kakutani, S. Maekawa +15 more
2021Communications Biology31 citations Open access
Semantic Scholar
Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure.
J. Matsumoto, S. Takada, S. Kinugawa, T. Furihata +15 more
2018Circulation31 citations Open access
Semantic Scholar
Fbx8 makes Arf6 refractory to function via ubiquitination.
H. Yano, Itaru Kobayashi, Yasuhito Onodera, F. Luton +6 more
2007Molecular Biology of the Cell31 citations Open access
Semantic Scholar
Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance.
Hideo Nambu, S. Takada, S. Maekawa, J. Matsumoto +19 more
2020Cardiovascular Research30 citations
Semantic Scholar
The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial–mesenchymal transition
Y. Komiya, Yasuhito Onodera, Miho Kuroiwa, Suguru Nomimura +7 more
2016Oncogenesis29 citations Open access
Semantic Scholar
Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer
A. Hashimoto, Haruka Handa, S. Hata, Akio Tsutaho +4 more
2021Cell communication and signaling : CCS27 citations Open access
Semantic Scholar
High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer
Akio Tsutaho, A. Hashimoto, S. Hashimoto, S. Hata +3 more
2020Cell Communication and Signaling25 citations Open access
Semantic Scholar
Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection
S. Nishikawa, T. Menju, Koji Takahashi, R. Miyata +6 more
2019Cancer Management and Research25 citations Open access
Semantic Scholar
Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.
N. Tanaka, T. Kosaka, Y. Miyazaki, S. Mikami +11 more
2016JCI Insight25 citations Open access
Semantic Scholar
Co-Overexpression of GEP100 and AMAP1 Proteins Correlates with Rapid Local Recurrence after Breast Conservative Therapy
R. Kinoshita, Jin-Min Nam, Y. Ito, K. Hatanaka +12 more
2013PLoS ONE25 citations Open access
Semantic Scholar
KRAS, MYC, and ARF6: inseparable relationships cooperatively promote cancer malignancy and immune evasion
H. Sabe
2023Cell Communication and Signaling23 citations Open access
Semantic Scholar
Treatments for skeletal muscle abnormalities in heart failure: sodium-glucose transporter 2 and ketone bodies.
S. Takada, H. Sabe, S. Kinugawa
2021American Journal of Physiology. Heart and Circulatory Physiology23 citations
Semantic Scholar
Assays and properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 function.
S. Hashimoto, A. Hashimoto, A. Yamada, Yasuhito Onodera +1 more
2005Methods in Enzymology22 citations
Semantic Scholar
Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Gyanu Parajuli, Murat Tekguc, J. Wing, A. Hashimoto +15 more
2021Cancer immunology research19 citations Open access
Semantic Scholar
Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy.
T. Tenma, Hirofumi Mitsuyama, Masaya Watanabe, N. Kakutani +8 more
2018American Journal of Physiology. Heart and Circulatory Physiology19 citations Open access
Semantic Scholar
p53-Dependent and -Independent Epithelial Integrity: Beyond miRNAs and Metabolic Fluctuations
Tsukasa Oikawa, Yutaro Otsuka, H. Sabe
2018Cancers19 citations Open access
Semantic Scholar
High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue
Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera +8 more
2016Cell Communication and Signaling17 citations Open access
Semantic Scholar
Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity
Tsukasa Oikawa, Yutaro Otsuka, Yasuhito Onodera, Mei Horikawa +4 more
2018Scientific Reports16 citations Open access
Semantic Scholar
The EGFR-GEP100-Arf6 pathway in breast cancer
H. Sabe, S. Hashimoto, M. Morishige, A. Hashimoto +1 more
2008Cell Adhesion & Migration16 citations Open access
Semantic Scholar

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S. Hashimoto×23
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A. Hashimoto×20
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Yasuhito Onodera×17
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Haruka Handa×12
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Jin-Min Nam — researcher profile on SciRah

Yutaro Otsuka×11

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S. Takada — researcher profile on SciRah

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S. Kinugawa — researcher profile on SciRah

M. Morishige×7

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M. Morishige — researcher profile on SciRah

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E. Ogawa — researcher profile on SciRah

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Y. Mazaki — researcher profile on SciRah

Tsukasa Oikawa×7

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