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Leila J. Williams · SciRah

Researcher profile · Semantic Scholar

Leila J. Williams

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Leila J. Williams — researcher profile on SciRah

h-index: 13
Works: 32
Citations: 2,763

Most-cited papers

Loss of PTEN promotes resistance to T cell-mediated immunotherapy
Weiyi Peng, Jie-Qing Chen, Chengwen Liu, Shruti Malu +40 more
2015Cancer Discovery1,377 citations Open access
Semantic Scholar
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T cell Therapy
T. Cascone, Jodi A. McKenzie, Rina M Mbofung, Simone Punt +33 more
2018Cell Metabolism560 citations Open access
Semantic Scholar
RNA editing derived epitopes function as cancer antigens to elicit immune responses
Min-Ying Zhang, J. Fritsche, J. Roszik, Leila J. Williams +21 more
2018Nature Communications146 citations Open access
Semantic Scholar
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
Rina M Mbofung, Jodi A. McKenzie, Shruti Malu, Min Zhang +24 more
2017Nature Communications140 citations Open access
Semantic Scholar
The glutaminase inhibitor CB-839 (Telaglenastat) enhances the anti-melanoma activity of T cell mediated immunotherapies.
Sruthy Varghese, Snigdha Pramanik, Leila J. Williams, Hannah R Hodges +12 more
2020Molecular Cancer Therapeutics136 citations Open access
Semantic Scholar
The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression
Lu Huang, Shruti Malu, Jodi A. McKenzie, M. Andrews +22 more
2018Clinical Cancer Research88 citations Open access
Semantic Scholar
The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy
Jodi A. McKenzie, Rina M Mbofung, Shruti Malu, Min Zhang +24 more
2017Journal of the National Cancer Institute86 citations Open access
Semantic Scholar
Anti-OX40 antibody directly enhances the function of tumor-reactive CD8+ T cells and synergizes with PI3Kβ inhibition in PTEN loss melanoma
Weiyi Peng, Leila J. Williams, Chunyu Xu, Brenda D. Melendez +16 more
2019Clinical Cancer Research44 citations Open access
Semantic Scholar
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators
Jiakai Hou, Yunfei Wang, Leilei Shi, Yuan Chen +17 more
2021Journal for ImmunoTherapy of Cancer41 citations Open access
Semantic Scholar
Abstract 1719: Superior efficacy of neoadjuvant compared to adjuvant immune checkpoint blockade in non-small cell lung cancer
T. Cascone, Haifa Hamdi, Fahao Zhang, A. Poteete +11 more
2018Immunology37 citations
Semantic Scholar
LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade
A. Hickman, J. Koetsier, T. Kurtanich, Michael C. Nielsen +26 more
2022Journal of Clinical Investigation33 citations Open access
Semantic Scholar
Inhibiting Type I arginine methyltransferase activity promotes T cell-mediated antitumor immune responses
A. Fedoriw, Leilei Shi, S. O'Brien, Kimberly N. Smitheman +16 more
2022Cancer immunology research29 citations Open access
Semantic Scholar
Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity
Simone Punt, Shruti Malu, Jodi A. McKenzie, S. Z. Manrique +25 more
2020Cancer Immunology and Immunotherapy28 citations Open access
Semantic Scholar
Abstract 4363: Loss of PTEN promotes resistance to T cell-mediated immunotherapy
Weiyi Peng, Jie-Qing Chen, Chengwen Liu, Shruti Malu +40 more
20169 citations
Semantic Scholar
204 KSQ-004: Unbiased pair-wise discovery of SOCS1 and Regnase-1 as the top CRISPR/Cas9 dual-edit combination enhancing in vivo TIL potency against solid tumors
Karrie K. Wong, C. Wrocklage, Sharon Lin, Isabelle Le Mercier +11 more
2021Journal for ImmunoTherapy of Cancer5 citations Open access
Semantic Scholar
186 Development of KSQ-001, an engineered TIL (eTIL) therapy for solid tumors through CRISPR/Cas9-mediated editing of SOCS1
Karrie K. Wong, Sharon Lin, C. Wrocklage, Katri Sofjan +14 more
2021Journal for ImmunoTherapy of Cancer2 citations Open access
Semantic Scholar
Abstract PR06: The glutaminase inhibitor CB-839 potentiates antimelanoma activity of standard-of-care targeted therapies and immunotherapies
Sruthy Varghese, Snigdha Pramanik, Rishika Prasad, Hannah R Hodges +4 more
2020Cancer Research2 citations
Semantic Scholar
Abstract 4938: OX40 agonist antibody-based combination therapy with PI3Kβ selective inhibitor enhances T cell immunity
Weiyi Peng, Chunyu Xu, Brenda D. Melendez, H. Jackson +9 more
2018Immunology1 citations
Semantic Scholar
Abstract B105: HSP90 inhibitor, ganetespib, enhances responses to cancer immunotherapy through increased expression of interferon response genes
Rina M Mbofung, Jodi A. McKenzie, Shruti Malu, Chengwen Liu +10 more
20161 citations
Semantic Scholar
554 The panorama of tumor intrinsic immune regulators exhibited by genome-wide CRPISR immune screen integrated with comprehensive clinical dataset analysis
Jiakai Hou, Yunfei Wang, Leilei Shi, Yuan Chen +17 more
2021Journal for ImmunoTherapy of Cancer0 citations Open access
Semantic Scholar
Abstract 1575: The landscape of tumor intrinsic immune regulators revealed by genome-wide CRISPR immune screen integrated with comprehensive clinical data analysis
Jiakai Hou, Yunfei Wang, Leilei Shi, Yuan Chen +17 more
2021Immunology0 citations
Semantic Scholar
624 Targeting Type I arginine methyltransferases promotes T cell mediated antitumor immune responses
Leilei Shi, A. Fedoriw, S. O'Brien, Kimberly N. Smitheman +16 more
2021Journal for ImmunoTherapy of Cancer0 citations Open access
Semantic Scholar
Abstract 2372: Tumoral p53 mutations differentially mediate poor T-cell infiltration and autologous T-cell killing in preclinical models
Deborah A. Silverman, Emily L Ashkin, B. Whitfield, Simone Punt +9 more
2019Immunology0 citations
Semantic Scholar
Abstract 3279: All-trans-retinoic acid (ATRA) markedly augments anti-tumor immunity
Lu Huang, Zi-bo Chen, Leila J. Williams, Yulong Chen +7 more
2019Clinical research0 citations
Semantic Scholar
Abstract 3956: A novel compound screen for enhancing T-cell based immunotherapy identifies aurora kinases as a targetable mechanism for tumor immune escape in pancreatic ductal adenocarcinoma preclinical models
Emily L Ashkin, Deborah A. Silverman, Simone Punt, S. Z. Manrique +3 more
2019Immunology0 citations
Semantic Scholar
The metabolic basis of resistance to Adoptive T Cell Therapy (ACT) in patients with solid tumors
Weiyi Peng, T. Cascone, Jodi A. McKenzie, Rina M Mbofung +28 more
2018Journal of Immunology0 citations
Semantic Scholar
Abstract 4360: Inhibition of HSP90 enhances T cell-mediated antitumor immune responses through expression of interferon-alpha response Genes
Rina M Mbofung, Jodi A. McKenzie, Shruti Malu, Chengwen Liu +16 more
20160 citations
Semantic Scholar
Abstract 1441: Systems-level interrogation of resistance mechanisms to immunotherapy through pooled shRNA screens
Zhe Wang, Shruti Malu, Weiyi Peng, Jodi A. McKenzie +5 more
20160 citations
Semantic Scholar
Abstract 4010: Identification of novel targeted and immunotherapy combinations by a high throughput assay of T cell-mediated cytotoxicity
Leila J. Williams, Shruti Malu, Jodi A. McKenzie, Rina M Mbofung +3 more
20160 citations
Semantic Scholar
Abstract B110: Topoisomerase I inhibitors enhance efficacy of immunotherapy through a p53 regulatory pathway
Jodi A. McKenzie, Rina M Mbofung, Shruti Malu, R. Amaria +9 more
20160 citations
Semantic Scholar
Abstract B118: Using a high throughput T-cell cytotoxicity assay to develop combination strategies for immunotherapy
Leila J. Williams, Shruti Malu, Jodi A. McKenzie, Rina M Mbofung +2 more
20160 citations
Semantic Scholar
Abstract IA19: Rational combinations of targeted and immunotherapies
Weiyi Peng, Rina M Mbofung, Leila J. Williams, P. Hwu
20160 citations
Semantic Scholar

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