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L. Winn · SciRah

Researcher profile · Semantic Scholar

L. Winn

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L. Winn — researcher profile on SciRah

h-index: 28
Works: 76
Citations: 2,307

Most-cited papers

Valproic Acid Increases Formation of Reactive Oxygen Species and Induces Apoptosis in Postimplantation Embryos: A Role for Oxidative Stress in Valproic Acid-Induced Neural Tube Defects
Emily W. Y. Tung, L. Winn
2011Molecular Pharmacology187 citations
Semantic Scholar
The effect of TiO(2) and Ag nanoparticles on reproduction and development of Drosophila melanogaster and CD-1 mice.
Nicola A. Philbrook, L. Winn, A. R. M. Nabiul Afrooz, Navid B. Saleh +1 more
2011Toxicology and Applied Pharmacology120 citations
Semantic Scholar
Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.
L. Winn, P. G. Wells
1997Free Radical Biology & Medicine115 citations
Semantic Scholar
Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress.
L. Winn
2003Toxicological Sciences110 citations
Semantic Scholar
Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity.
L. Winn, P. G. Wells
1999Free Radical Biology & Medicine108 citations
Semantic Scholar
Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity.
L. Winn, P. G. Wells
1995Molecular Pharmacology105 citations
Semantic Scholar
Investigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 mice.
Nicola A. Philbrook, V. K. Walker, A. R. M. Nabiul Afrooz, Navid B. Saleh +1 more
2011Reproductive Toxicology94 citations
Semantic Scholar
Valproic Acid Increases Conservative Homologous Recombination Frequency and Reactive Oxygen Species Formation: A Potential Mechanism for Valproic Acid-Induced Neural Tube Defects
Ericka N Defoort, P. Kim, L. Winn
2006Molecular Pharmacology85 citations
Semantic Scholar
Epigenetic modifications in valproic acid-induced teratogenesis.
Emily W. Y. Tung, L. Winn
2010Toxicology and Applied Pharmacology81 citations
Semantic Scholar
Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice.
Jennifer E. Dawson, Angela Raymond, L. Winn
2006Toxicology and Applied Pharmacology81 citations
Semantic Scholar
Pim-1 Phosphorylates the DNA Binding Domain of c-Myb
L. Winn, W. Lei, S. Ness
2003Cell Cycle77 citations Open access
Semantic Scholar
Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV‐infected patients: toxicological and pathological implications
S. Walmsley, L. Winn, Maureen L. Harrison, J. Uetrecht +1 more
1997AIDS (London)73 citations Open access
Semantic Scholar
Benzene-initiated oxidative stress: Effects on embryonic signaling pathways.
H. Badham, S. Renaud, J. Wan, L. Winn
2010Chemico-Biological Interactions69 citations
Semantic Scholar
In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen species.
H. Badham, L. Winn
2010Toxicological Sciences67 citations Open access
Semantic Scholar
Benzo[a]pyrene increases DNA double strand break repair in vitro and in vivo: a possible mechanism for benzo[a]pyrene-induced toxicity.
Emily W. Y. Tung, Nicola A. Philbrook, Christine L Belanger, Saad Ansari +1 more
2014Mutation Research. Genetic Toxicology and Environmental Mutagenesis65 citations
Semantic Scholar
In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species.
H. Badham, L. Winn
2010Toxicology and Applied Pharmacology48 citations
Semantic Scholar
In utero and acute exposure to benzene: investigation of DNA double-strand breaks and DNA recombination in mice.
Annette Lau, Christine L Belanger, L. Winn
2009Mutation research47 citations
Semantic Scholar
Killing two birds with one stone: Pregnancy is a sensitive window for endocrine effects on both the mother and the fetus.
Isabelle Plante, L. Winn, C. Vaillancourt, P. Grigorova +1 more
2021Environmental Research40 citations Open access
Semantic Scholar
DNA double-strand breaks and DNA recombination in benzene metabolite-induced genotoxicity.
Emily W. Y. Tung, Nicola A. Philbrook, K. Macdonald, L. Winn
2012Toxicological Sciences40 citations Open access
Semantic Scholar
Oxidative Stress-Induced Homologous Recombination As a Novel Mechanism for Phenytoin-Initiated Toxicity
L. Winn, P. Kim, J. Nickoloff
2003Journal of Pharmacology and Experimental Therapeutics38 citations
Semantic Scholar
Benzene and its effects on cell signaling pathways related to hematopoiesis and leukemia
Peter C W Lu, Sara Shahbaz, L. Winn
2020Journal of Applied Toxicology37 citations
Semantic Scholar
The role of c-MYB in benzene-initiated toxicity.
J. Wan, H. Badham, L. Winn
2005Chemico-Biological Interactions37 citations
Semantic Scholar
Transplacental benzene exposure increases tumor incidence in mouse offspring: possible role of fetal benzene metabolism.
H. Badham, D. LeBrun, A. Rutter, L. Winn
2010Carcinogenesis34 citations Open access
Semantic Scholar
In utero-initiated cancer: the role of reactive oxygen species.
J. Wan, L. Winn
2006Birth Defects Research Part C Embryo Today Reviews33 citations
Semantic Scholar
Benzene's metabolites alter c-MYB activity via reactive oxygen species in HD3 cells.
J. Wan, L. Winn
2007Toxicology and Applied Pharmacology32 citations
Semantic Scholar
Investigating the role of the aryl hydrocarbon receptor in benzene-initiated toxicity in vitro.
H. Badham, L. Winn
2007Toxicology32 citations
Semantic Scholar
NF-κB signaling is increased in HD3 cells following exposure to 1,4-benzoquinone: role of reactive oxygen species and p38-MAPK.
S. Stokes, L. Winn
2014Toxicological Sciences31 citations Open access
Semantic Scholar
Evidence for Ras-dependent signal transduction in phenytoin teratogenicity.
L. Winn, P. G. Wells
2002Toxicology and Applied Pharmacology30 citations
Semantic Scholar
In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 mice.
J. Wan, L. Winn
2008Toxicology and Applied Pharmacology23 citations
Semantic Scholar
Valproic acid-induced DNA damage increases embryonic p27(KIP1) and caspase-3 expression: a mechanism for valproic-acid induced neural tube defects.
Emily W. Y. Tung, L. Winn
2011Reproductive Toxicology22 citations
Semantic Scholar
Characterization of valproic acid-initiated homologous recombination.
K. Sha, L. Winn
2010Birth defects research. Part B. Developmental and reproductice toxicology22 citations Open access
Semantic Scholar
Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.
Nicola A. Philbrook, L. Winn
2014Reproductive Toxicology21 citations
Semantic Scholar
The effects of benzene and the metabolites phenol and catechol on c-Myb and Pim-1 signaling in HD3 cells.
J. Wan, L. Winn
2004Toxicology and Applied Pharmacology21 citations
Semantic Scholar
Are We Exposed to Halogenated Flame Retardants from both Primary and Secondary Sources?
Congqiao Yang, S. R. Jílková, L. Melymuk, S. Harris +4 more
202018 citations
Semantic Scholar
Persistence of risk factors associated with maternal cardiovascular disease following aberrant inflammation in rat pregnancy†
T. Ushida, S. Macdonald-Goodfellow, Allegra M. Quadri, M. Tse +6 more
2017Biology of Reproduction17 citations
Semantic Scholar
Reactive oxygen species, diabetes and toxicity in the placenta - a workshop report.
W. Foster, P. Myllynen, L. Winn, A. Ornoy +1 more
2008Placenta17 citations
Semantic Scholar
TCDD affects DNA double strand-break repair.
C. Y. Chan, P. Kim, L. Winn
2004Toxicological Sciences17 citations Open access
Semantic Scholar
Gestational triphenyl phosphate exposure in C57Bl/6 mice perturbs expression of insulin-like growth factor signaling genes in maternal and fetal liver.
Nicola A. Philbrook, Victoria E Restivo, Christine L Belanger, L. Winn
2018Birth Defects Research16 citations
Semantic Scholar
Investigating the effects of in utero benzene exposure on epigenetic modifications in maternal and fetal CD-1 mice.
Nicola A. Philbrook, L. Winn
2015Toxicology and Applied Pharmacology15 citations
Semantic Scholar
The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells.
Roopam Singh, L. Winn
2008Mutation research15 citations
Semantic Scholar
Characterizing the effects of in utero valproic acid exposure on murine fetoplacental development.
Sidra Shafique, L. Winn
2021Placenta12 citations
Semantic Scholar
Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells.
C. Lamparter, L. Winn
2016Toxicology and Applied Pharmacology12 citations
Semantic Scholar
Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example.
Helen J. Renaud, A. Rutter, L. Winn
2012Methods in molecular biology12 citations
Semantic Scholar
TCDD-induced homologous recombination: the role of the Ah receptor versus oxidative DNA damage.
C. Y. Chan, P. Kim, L. Winn
2004Mutation research12 citations
Semantic Scholar
DNA Damage and Perturbed Topoisomerase IIα as a Target of 1,4-Benzoquinone Toxicity in Murine Fetal Liver Cells.
Trent H Holmes, L. Winn
2019Toxicological Sciences11 citations
Semantic Scholar
Benzoquinone toxicity is not prevented by sulforaphane in CD‐1 mouse fetal liver cells
Nicola A. Philbrook, L. Winn
2016Journal of Applied Toxicology11 citations
Semantic Scholar
Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in the offspring and intrauterine growth restriction in the F2 generation
T. Ushida, T. Cotechini, N. Protopapas, Aline Atallah +11 more
2022Journal of Developmental Origins of Health and Disease10 citations Open access
Semantic Scholar
Gestational exposure to triphenyl phosphate induces epigenetic modifications in C57Bl/6 fetal liver
Sidra Shafique, Sydney H Wolpert, Nicola A. Philbrook, L. Winn
2022Birth Defects Research9 citations
Semantic Scholar
Gestational valproic acid exposure induces epigenetic modifications in murine decidua.
Sidra Shafique, L. Winn
2021Placenta8 citations
Semantic Scholar
Tissue-specific effects of valproic acid on DNA repair genes and apoptosis in postimplantation mouse embryos.
C. Lamparter, L. Winn
2014Toxicological Sciences8 citations Open access
Semantic Scholar

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H. Badham — researcher profile on SciRah
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J. Wan — researcher profile on SciRah
Nicola A. Philbrook×6
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Emily W. Y. Tung×5
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P. G. Wells — researcher profile on SciRah

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