W. Gerthoffer

Most-cited papers

Universal physical responses to stretch in the living cell
X. Trepat, Lin-Hong Deng, S. An, D. Navajas +4 more
2007Nature719 citations Open access
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Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.
S. An, T.-R. Bai, J. Bates, J. Black +49 more
2007European Respiratory Journal406 citations Open access
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Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle.
R. Gosens, G. Stelmack, G. Dueck, K. McNeill +6 more
2006American Journal of Physiology - Lung cellular and Molecular Physiology198 citations
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MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype.
A. R. Kuhn, K. Schlauch, Ronna Lao, A. Halayko +2 more
2010American Journal of Respiratory Cell and Molecular Biology157 citations Open access
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Myocardin Is Sufficient for a Smooth Muscle–Like Contractile Phenotype
Xiao-Chun Long, R. Bell, W. Gerthoffer, B. Zlokovic +1 more
2008Arteriosclerosis, Thrombosis and Vascular Biology122 citations Open access
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MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle.
B. S. Comer, B. Camoretti-Mercado, P. Kogut, A. Halayko +2 more
2014American Journal of Physiology - Lung cellular and Molecular Physiology117 citations Open access
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Small heat shock proteins in smooth muscle.
S. Salinthone, M. Tyagi, W. Gerthoffer
2008Pharmacology and Therapeutics117 citations Open access
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Migration of airway smooth muscle cells.
W. Gerthoffer
2008Proceedings of the American Thoracic Society111 citations Open access
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Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension
J. McLendon, S. Joshi, J. Sparks, Majed M. Matar +5 more
2015Journal of Controlled Release108 citations Open access
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Signal-transduction pathways that regulate visceral smooth muscle function. III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles.
W. Gerthoffer
2005American Journal of Physiology - Gastrointestinal and Liver Physiology89 citations
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Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance.
R. Panettieri, M. Kotlikoff, W. Gerthoffer, M. Hershenson +3 more
2008American Journal of Respiratory and Critical Care Medicine87 citations Open access
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Epigenetic targets for novel therapies of lung diseases
B. S. Comer, Mariam A. Ba, C. Singer, W. Gerthoffer
2014Pharmacology and Therapeutics81 citations Open access
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Mechanisms of vascular smooth muscle cell migration.
W. Gerthoffer
2007Circulation Research76 citations Open access
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Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation.
R. Gosens, G. Dueck, E. Rector, R. Nunes +5 more
2007American Journal of Physiology - Lung cellular and Molecular Physiology76 citations
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Endogenous laminin is required for human airway smooth muscle cell maturation
Thai Tran, K. McNeill, W. Gerthoffer, H. Unruh +1 more
2006Respiratory Research75 citations Open access
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Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription
Kyuho Jeong, Jung-Hyun Kim, James M. Murphy, Hyeonsoo Park +12 more
2019Circulation Research70 citations Open access
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MicroRNA‐145 Antagonism Reverses TGF‐&bgr; Inhibition of F508del CFTR Correction in Airway Epithelia
F. L. Lutful Kabir, N. Ambalavanan, Gangshuo Liu, Peng Li +8 more
2017American Journal of Respiratory and Critical Care Medicine64 citations Open access
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Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats.
K. Abe, M. Toba, Abdallah Alzoubi, K. Koubský +7 more
2011American Journal of Respiratory Cell and Molecular Biology63 citations Open access
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Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in mice.
Minjae Kim, Sang Won Park, Mihwa Kim, Sean W. C. Chen +3 more
2010AJP - Renal Physiology61 citations Open access
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Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle.
R. Gosens, G. Stelmack, G. Dueck, M. Mutawe +9 more
2007American Journal of Physiology - Lung cellular and Molecular Physiology59 citations
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Identification of capsaicin-sensitive rectal mechanoreceptors activated by rectal distension in mice.
Nick J. Spencer, A. Kerrin, C. Singer, Grant W. Hennig +2 more
2008Neuroscience57 citations Open access
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Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes.
Thai Tran, Karen Ens-Blackie, E. Rector, G. Stelmack +5 more
2007American Journal of Respiratory Cell and Molecular Biology57 citations Open access
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Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation.
G. Gallos, P. Yim, Sucie Chang, Yi Zhang +4 more
2012American Journal of Physiology - Lung cellular and Molecular Physiology56 citations Open access
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Activation of Glucose-6-phosphate Dehydrogenase Promotes Acute Hypoxic Pulmonary Artery Contraction*
Rakhee S. Gupte, Dhawjbahadur K Rawat, Sukrutha Chettimada, Donna L. Cioffi +4 more
2010Journal of Biological Chemistry53 citations Open access
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Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells
Deanna L Milton, Amy N. Schneck, D. Ziech, Mariam A. Ba +5 more
2011Proceedings of the National Academy of Sciences of the United States of America52 citations Open access
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Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells.
B. S. Comer, B. Camoretti-Mercado, P. Kogut, A. Halayko +2 more
2015American Journal of Respiratory Cell and Molecular Biology50 citations Open access
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Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells
R. Gosens, G. Stelmack, S. Bos, G. Dueck +7 more
2011Journal of Cellular and Molecular Medicine49 citations Open access
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Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma?
Tera L. Lavoie, M. Dowell, O. Lakser, W. Gerthoffer +4 more
2009Proceedings of the American Thoracic Society48 citations Open access
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Emerging targets for novel therapy of asthma
W. Gerthoffer, J. Solway, B. Camoretti-Mercado
2013Current opinion in pharmacology (Print)47 citations Open access
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Loss of the &agr;7 Integrin Promotes Extracellular Signal-Regulated Kinase Activation and Altered Vascular Remodeling
J. Welser, N. Lange, C. Singer, Margaret Elorza +4 more
2007Circulation Research47 citations
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MicroRNAs-control of essential genes: Implications for pulmonary vascular disease
S. Joshi, J. McLendon, B. S. Comer, W. Gerthoffer
2011Pulmonary Circulation46 citations Open access
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The interaction and cellular localization of HSP27 and ERbeta are modulated by 17beta-estradiol and HSP27 phosphorylation.
Ashraf Al-Madhoun, Yong-Xiang Chen, L. Haidari, Katey J. Rayner +3 more
2007Molecular and Cellular Endocrinology46 citations
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Expression of functional leukotriene B4 receptors on human airway smooth muscle cells
Satoko Watanabe, A. Yamasaki, Kiyoshi Hashimoto, Y. Shigeoka +12 more
2009Journal of Allergy and Clinical Immunology45 citations Open access
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Overexpression of human Hsp27 inhibits serum-induced proliferation in airway smooth muscle myocytes and confers resistance to hydrogen peroxide cytotoxicity.
S. Salinthone, Mariam A. Ba, L. Hanson, Jody L. Martin +2 more
2007American Journal of Physiology - Lung cellular and Molecular Physiology41 citations
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Novel Role for STAT-5B in the Regulation of Hsp27–FGF-2 Axis Facilitating Thrombin-Induced Vascular Smooth Muscle Cell Growth and Motility
Hui-fang Cao, Nagadhara Dronadula, F. Rizvi, Quan-Yi Li +3 more
2006Circulation Research41 citations
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Proinflammatory and Th2 Cytokines Regulate the High Affinity IgE Receptor (FcεRI) and IgE-Dependant Activation of Human Airway Smooth Muscle Cells
Naresh S. Redhu, A. Saleh, Lianyu Shan, W. Gerthoffer +4 more
2009PLoS ONE40 citations Open access
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A ROLE FOR GAB1/SHP2 IN THROMBIN ACTIVATION OF PAK1: GENE TRANSFER OF KINASE-DEAD PAK1 INHIBITS INJURY-INDUCED RESTENOSIS
Dong Wang, B. Paria, Qiuhua Zhang, M. Karpurapu +4 more
2009Circulation Research40 citations Open access
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Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase Cδ in vascular smooth muscle cells
Elethia A. Woolfolk, S. Eguchi, H. Ohtsu, H. Nakashima +3 more
200536 citations
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p42/p44 MAP kinase activation is localized to caveolae-free membrane domains in airway smooth muscle.
R. Gosens, G. Dueck, W. Gerthoffer, H. Unruh +3 more
2007American Journal of Physiology - Lung cellular and Molecular Physiology35 citations
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MicroRNA Regulation of Smooth Muscle Phenotype
S. Joshi, B. S. Comer, J. McLendon, W. Gerthoffer
2012Molecular and Cellular Pharmacology31 citations
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Laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity
Thai Tran, C. Teoh, J. Tam, Y. Qiao +10 more
2013The FASEB Journal30 citations Open access
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IASH: PAK1 participates in vascular remodeling in vitro and in vivo
Akinari Hinoki, Keita Kimura, Sadaharu Higuchi, K. Eguchi +7 more
2009HYPERTENSION29 citations Open access
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Functional expression of IgG-Fc receptors in human airway smooth muscle cells.
Yuxiu C Xia, M. Schuliga, M. Shepherd, M. Powell +7 more
2011American Journal of Respiratory Cell and Molecular Biology25 citations Open access
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Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection.
E. Islamovic, A. Duncan, D. Bers, W. Gerthoffer +1 more
2007Journal of Molecular and Cellular Cardiology25 citations
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IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system: involvement of COX-2 and iNOS induction in muscularis resident macrophages.
Takashi Ohama, M. Hori, E. Momotani, Margaret Elorza +2 more
2007American Journal of Physiology - Gastrointestinal and Liver Physiology25 citations
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Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma
S. Ramelli, B. S. Comer, J. McLendon, L. L. Sandy +6 more
2020Molecular Therapy: Nucleic Acids23 citations Open access
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MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle
M. Dowell, Tera L. Lavoie, O. Lakser, N. Dulin +5 more
2010European Respiratory Journal21 citations Open access
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Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK
C. Singer, B. Lontay, H. Unruh, A. Halayko +1 more
2011Cell Communication and Signaling19 citations Open access
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HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation
Yong-Xiang Chen, C. Shi, Jingti Deng, C. Diao +16 more
2021Arteriosclerosis, Thrombosis and Vascular Biology17 citations Open access
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MicroRNA-146 a and microRNA-146 b expression and anti-inflammatory function in human airway smooth muscle
B. S. Comer, B. Camoretti-Mercado, P. Kogut, A. Halayko +2 more
201417 citations
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