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I. Ott · SciRah

Researcher profile · Semantic Scholar

I. Ott

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I. Ott — researcher profile on SciRah

h-index: 54
Works: 195
Citations: 12K

Most-cited papers

DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy.
C. Mari, Vanessa Pierroz, Riccardo Rubbiani, M. Patra +8 more
2014Chemistry159 citations Open access
Semantic Scholar
Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.
C. Schmidt, Bianka Karge, Rainer Misgeld, A. Prokop +3 more
2017Chemistry138 citations
Semantic Scholar
A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells
Xinlai Cheng, Palvo Holenya, Suzan Can, H. Alborzinia +3 more
2014Molecular Cancer116 citations Open access
Semantic Scholar
Insights on the mechanism of thioredoxin reductase inhibition by gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation.
A. Pratesi, C. Gabbiani, E. Michelucci, M. Ginanneschi +4 more
2014Journal of Inorganic Biochemistry83 citations Open access
Semantic Scholar
A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs.
C. Schmidt, Lucia Albrecht, Shantheya Balasupramaniam, Rainer Misgeld +6 more
2019Metallomics74 citations
Semantic Scholar
Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs.
J. Muenzner, B. Biersack, A. Albrecht, Tobias Rehm +11 more
2016Chemistry63 citations Open access
Semantic Scholar
Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike‐ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics**
Maria Gil-Moles, Uttara Basu, Rolf Büssing, Henrik Hoffmeister +3 more
2020Chemistry60 citations Open access
Semantic Scholar
Gold(I) N‐Heterocyclic Carbene Complexes with Naphthalimide Ligands as Combined Thioredoxin Reductase Inhibitors and DNA Intercalators
A. Meyer, Luciano Oehninger, Yvonne Geldmacher, H. Alborzinia +3 more
2014ChemMedChem60 citations
Semantic Scholar
Caffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities
Jing-Jing Zhang, C. Che, I. Ott
201558 citations
Semantic Scholar
Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity.
Julià Arcau, Vincent Andermark, E. Aguiló, Albert Gandioso +6 more
2014Dalton Transactions58 citations
Semantic Scholar
Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PLpro
Maria Gil-Moles, Sebastian Türck, Uttara Basu, Andrea Pettenuzzo +37 more
2021Chemistry56 citations Open access
Semantic Scholar
From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents.
Nelson Y. S. Lam, Dianna Truong, H. Burmeister, Maria V. Babak +12 more
2018Inorganic Chemistry56 citations
Semantic Scholar
Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.
Vincent Andermark, Katrin Göke, M. Kokoschka, Mohamed A. Abu El Maaty +10 more
2016Journal of Inorganic Biochemistry56 citations Open access
Semantic Scholar
Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes.
Dianna Truong, M. Sullivan, K. Tong, Tasha R. Steel +13 more
2020Inorganic Chemistry55 citations
Semantic Scholar
Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones
Paweł Hikisz, Łukasz Szczupak, A. Koceva-Chyła, Adam Guśpiel +5 more
2015Molecules55 citations Open access
Semantic Scholar
Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone: cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase.
G. L. Parrilha, K. O. Ferraz, Josane A. Lessa, K. N. de Oliveira +5 more
2014European journal of medicinal chemistry54 citations
Semantic Scholar
A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
Jing-Jing Zhang, Mohamed A. Abu el Maaty, Henrik Hoffmeister, C. Schmidt +4 more
2020Angewandte Chemie53 citations Open access
Semantic Scholar
Highly Electrophilic, Catalytically Active and Redox‐Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes
Stefan Vanicek, Maren Podewitz, J. Stubbe, D. Schulze +10 more
2018Chemistry53 citations Open access
Semantic Scholar
Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability.
C. Schmidt, Bianka Karge, Rainer Misgeld, A. Prokop +2 more
2017MedChemComm52 citations Open access
Semantic Scholar
A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.
Jing-Jing Zhang, J. Muenzner, Mohamed A. Abu El Maaty, Bianka Karge +3 more
2016Dalton Transactions49 citations Open access
Semantic Scholar
Gold(I) and Gold(III) N‐Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase
Rolf Büssing, Bianka Karge, P. Lippmann, P. Jones +2 more
2021ChemMedChem48 citations Open access
Semantic Scholar
Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.
Wojciech Streciwilk, A. Terenzi, Xinlai Cheng, L. Hager +6 more
2018European journal of medicinal chemistry48 citations
Semantic Scholar
Medicinal Chemistry of Gold Anticancer Metallodrugs.
A. Casini, R. W. Sun, I. Ott
2018Metal ions in life sciences48 citations
Semantic Scholar
Gold(I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents.
T. V. Serebryanskaya, A. Lyakhov, L. Ivashkevich, J. Schur +3 more
2015Dalton Transactions41 citations Open access
Semantic Scholar
Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling.
Luciano Oehninger, Sarah Spreckelmeyer, P. Holenya, S. Meier +6 more
2015Journal of Medicinal Chemistry41 citations
Semantic Scholar
Synthesis, DNA and BSA binding of Pd(II) and Pt(II) complexes featuring tetrazolylacetic acids and their esters
A. V. Protas, E. A. Popova, O. Mikolaichuk, Y. Porozov +5 more
201839 citations
Semantic Scholar
A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway
Y. Dabiri, A. Schmid, J. Theobald, Biljana Blagojević +4 more
2018International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
Cyclometalated Pt Complexes of CNC Pincer Ligands: Luminescence and Cytotoxic Evaluation
Simon Garbe, Maren Krause, Annika Klimpel, I. Neundorf +6 more
202038 citations
Semantic Scholar
Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?
C. Schmidt, Tomer Babu, Hana Kostrhunová, Annika Timm +5 more
2021Journal of Medicinal Chemistry37 citations
Semantic Scholar
An Erlotinib gold(I) conjugate for combating triple-negative breast cancer.
Enrique Ortega, A. Zamora, Uttara Basu, P. Lippmann +4 more
2020Journal of Inorganic Biochemistry37 citations
Semantic Scholar
p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells
Y. Dabiri, Mohamed A. Abu el Maaty, Hoi-Yin Chan, Jessica Wölker +3 more
2019Frontiers in Oncology35 citations Open access
Semantic Scholar
Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
Kely Navakoski de Oliveira, Vincent Andermark, Liliane A. Onambele, G. Dahl +2 more
2014European journal of medicinal chemistry35 citations
Semantic Scholar
Metal N-heterocyclic carbene complexes in medicinal chemistry
I. Ott
2020Medicinal chemistry34 citations
Semantic Scholar
Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo.
Esther Jortzik, M. Farhadi, Rezvan Ahmadi, Katalin Tóth +11 more
2014Biochimica et Biophysica Acta34 citations
Semantic Scholar
Metal NHC Complexes with Naphthalimide Ligands as DNA‐Interacting Antiproliferative Agents
Wojciech Streciwilk, A. Terenzi, Rainer Misgeld, C. Frias +4 more
2017ChemMedChem33 citations
Semantic Scholar
A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation
T. V. Serebryanskaya, A. Zolotarev, I. Ott
201532 citations Open access
Semantic Scholar
Multi-stimuli responsive block copolymers as a smart release platform for a polypyridyl ruthenium complex
Michael Appold, C. Mari, C. Lederle, J. Elbert +5 more
201731 citations Open access
Semantic Scholar
Oral Anticancer Heterobimetallic PtIV-AuI Complexes Show High In Vivo Activity and Low Toxicity.
Tomer Babu, Hiba Ghareeb, Uttara Basu, H. Schueffl +8 more
2023Angewandte Chemie30 citations Open access
Semantic Scholar
Study of the effect of the chromophore and nuclearity on the aggregation and potential biological activity of gold(I) alkynyl complexes
Raquel Gavara, E. Aguiló, J. Schur, J. Llorca +2 more
201630 citations Open access
Semantic Scholar
Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands
Wojciech Streciwilk, A. Terenzi, Federico Lo Nardo, Pascal Prochnow +3 more
2018European Journal of Inorganic Chemistry29 citations
Semantic Scholar
Synthesis and Biological Activity of Gold(I) N‐Heterocyclic Carbene Complexes with Long Aliphatic Side Chains
Julià Arcau, Vincent Andermark, M. Rodrigues, Ilaria Giannicchi +3 more
201429 citations Open access
Semantic Scholar
Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies.
Morwen R M Williams, B. Bertrand, D. Hughes, Z. A. E. Waller +5 more
2018Metallomics28 citations Open access
Semantic Scholar
Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes.
C. Cullinane, G. Deacon, Penny R. Drago, Anja P. Erven +8 more
2018Dalton Transactions28 citations Open access
Semantic Scholar
Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals.
B. Bertrand, A. Romanov, M. Brooks, Josh Davis +4 more
2017Dalton Transactions26 citations Open access
Semantic Scholar
Platinum Diolefin Complexes – Synthesis, Structures, and Cytotoxicity
Anna Lüning, M. Neugebauer, Verena Lingen, Alexander Krest +8 more
201526 citations
Semantic Scholar
Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype
Anne Walter, A. Chaikuad, R. Helmer, Nadège Loaëc +5 more
2018PLoS ONE25 citations Open access
Semantic Scholar
Metallocene-uracil conjugates: Synthesis and biological evaluation of novel mono-, di- and tri-nuclear systems
J. Skiba, K. Kowalski, A. Próchnicka, I. Ott +3 more
201525 citations
Semantic Scholar
Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity
Anja Busemann, Ingrid Flaspohler, Xue-Quan Zhou, C. Schmidt +5 more
2021JBIC Journal of Biological Inorganic Chemistry22 citations Open access
Semantic Scholar
Organoruthenium Complexes with Benzo-Fused Pyrithiones Overcome Platinum Resistance in Ovarian Cancer Cells
J. Kladnik, James P. C. Coverdale, Jakob Kljun, H. Burmeister +6 more
2021Cancers22 citations Open access
Semantic Scholar
Ferrocenyl derivatives of pterocarpene and coumestan: Synthesis, structure and anticancer activity studies
K. Kowalski, Łukasz Szczupak, Luciano Oehninger, I. Ott +3 more
201421 citations
Semantic Scholar

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Luciano Oehninger×7
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