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K. Barnham · SciRah

Researcher profile · Semantic Scholar

K. Barnham

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K. Barnham — researcher profile on SciRah

h-index: 76
Works: 349
Citations: 24K

Most-cited papers

Biological metals and metal-targeting compounds in major neurodegenerative diseases.
K. Barnham, A. Bush
2014Chemical Society Reviews390 citations Open access
Semantic Scholar
A rigorous method to enrich for exosomes from brain tissue
L. Vella, Benjamin J Scicluna, Lesley Cheng, Emma Bawden +6 more
2017Journal of Extracellular Vesicles280 citations Open access
Semantic Scholar
Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease
H. Su, Y. Rustam, C. Masters, E. Makalic +5 more
2020bioRxiv171 citations Open access
Semantic Scholar
Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
A. Rembach, N. G. Faux, Andrew D. Watt, K. Pertile +22 more
2014Alzheimer's & Dementia148 citations
Semantic Scholar
Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
B. Roberts, N. Lim, E. McAllum, P. Donnelly +25 more
2014Journal of Neuroscience139 citations Open access
Semantic Scholar
CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease
A. Southon, Kathryn Szostak, Karla Acevedo, Krista A. Dent +7 more
2020British Journal of Pharmacology132 citations Open access
Semantic Scholar
A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding.
M. Mital, N. Wezynfeld, T. Frączyk, M. Wiloch +7 more
2015Angewandte Chemie107 citations
Semantic Scholar
Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples
Andrew D. Watt, Keyla Perez, A. Rembach, Nicki A. Sherrat +9 more
2013Acta Neuropathologica101 citations Open access
Semantic Scholar
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
D. Finkelstein, J. L. Billings, P. Adlard, S. Ayton +19 more
2017Acta Neuropathologica Communications93 citations Open access
Semantic Scholar
Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis
E. McAllum, N. Lim, J. L. Hickey, Brett M. Paterson +6 more
2013Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration93 citations
Semantic Scholar
Small RNA fingerprinting of Alzheimer’s disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles
Lesley Cheng, L. Vella, K. Barnham, C. Mclean +2 more
2020Journal of Extracellular Vesicles90 citations Open access
Semantic Scholar
Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry.
S. Mukherjee, E. Kapp, Amber Lothian, Anne M. Roberts +10 more
2017Analytical Chemistry72 citations Open access
Semantic Scholar
A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study
V. Villemagne, C. Rowe, K. Barnham, R. Cherny +11 more
2017Alzheimer's & Dementia66 citations Open access
Semantic Scholar
Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease.
V. Kenche, L. Hung, Keyla Perez, Irene Volitakes +11 more
2013Angewandte Chemie64 citations
Semantic Scholar
Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?
Andrew D. Watt, G. Crespi, Russell A. Down, D. Ascher +7 more
2014Acta Neuropathologica62 citations Open access
Semantic Scholar
Parkinsonism as a Third Wave of the COVID-19 Pandemic?
L. Beauchamp, D. Finkelstein, A. Bush, A. Evans +1 more
2020Journal of Parkinson's Disease60 citations Open access
Semantic Scholar
Synthesis of 2-pyridyl-benzimidazole iridium(III), ruthenium(II), and platinum(II) complexes. study of the activity as inhibitors of amyloid-β aggregation and neurotoxicity evaluation.
G. Yellol, Jyoti G Yellol, V. Kenche, Xiangyang Liu +4 more
2015Inorganic Chemistry59 citations
Semantic Scholar
Oral Treatment with Cu [ superscript II ] ( atsm ) Increases Mutant SOD 1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
N. Lim, E. McAllum, P. Donnelly, D. Hare +24 more
201457 citations
Semantic Scholar
Stabilization of Nontoxic Aβ-Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease
T. Ryan, B. Roberts, Gawain McColl, D. Hare +12 more
2015Journal of Neuroscience56 citations Open access
Semantic Scholar
Mixed ligand Cu2+ complexes of a model therapeutic with Alzheimer's amyloid-β peptide and monoamine neurotransmitters.
V. Kenche, I. Zawisza, C. Masters, W. Bal +2 more
2013Inorganic Chemistry56 citations
Semantic Scholar
Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease
S. Mukherjee, Keyla Perez, Larissa C. Lago, Stephan Klatt +5 more
2021Brain Communications43 citations Open access
Semantic Scholar
Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide.
V. Streltsov, V. Epa, S. James, Quentin I. Churches +3 more
2013Chemical Communications39 citations Open access
Semantic Scholar
Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression
Xin Huang, Chris J. Fowler, Yihan Li, Qiao-Xin Li +18 more
2024Nature Communications34 citations Open access
Semantic Scholar
Restoration of intestinal function in an MPTP model of Parkinson’s Disease
L. Ellett, Lin W. Hung, R. Munckton, N. A. Sherratt +7 more
2016Scientific Reports34 citations Open access
Semantic Scholar
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort
S. Pedrini, V. Gupta, E. Hone, J. Doecke +108 more
2017Scientific Reports31 citations Open access
Semantic Scholar
Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study.
C. Curtain, N. Kirby, H. Mertens, K. Barnham +6 more
2015Molecular Biosystems30 citations Open access
Semantic Scholar
Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux.
Karla Acevedo, David J. Hayne, Lachlan E. McInnes, Asif Noor +8 more
2018Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Using 18F-AV-133 VMAT2 PET Imaging to Monitor Progressive Nigrostriatal Degeneration in Parkinson Disease
L. Beauchamp, V. Doré, V. Villemagne, San-San Xu +3 more
2023Neurology24 citations Open access
Semantic Scholar
Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups.
Brett M. Paterson, C. Cullinane, P. Crouch, A. White +6 more
2019Inorganic Chemistry24 citations Open access
Semantic Scholar
Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII(atsm)
Lesley Cheng, Camelia Quek, Lin W. Hung, Robyn A. Sharples +3 more
2016Scientific Reports23 citations Open access
Semantic Scholar
Ablation of tau causes an olfactory deficit in a murine model of Parkinson’s disease
L. Beauchamp, Jacky Chan, L. Hung, B. Padman +8 more
2018Acta Neuropathologica Communications21 citations Open access
Semantic Scholar
Neurological Dysfunction in Early Maturity of a Model for Niemann–Pick C1 Carrier Status
Ya-Hui Hung, M. Walterfang, L. Churilov, L. Bray +6 more
2016Neurotherapeutics21 citations Open access
Semantic Scholar
Small angle X-ray scattering analysis of Cu(2+)-induced oligomers of the Alzheimer's amyloid β peptide.
T. Ryan, N. Kirby, H. Mertens, B. Roberts +5 more
2015Metallomics21 citations Open access
Semantic Scholar
Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies.
S. McKenzie-Nickson, Jacky Chan, Keyla Perez, L. Hung +10 more
2018ACS Chemical Neuroscience20 citations Open access
Semantic Scholar
PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning.
T. Johanssen, Nuttawat Suphantarida, P. Donnelly, Xiang M. Liu +3 more
2015Neurobiology of Disease19 citations Open access
Semantic Scholar
Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism
L. Beauchamp, V. Villemagne, D. Finkelstein, V. Doré +3 more
2020Scientific Reports18 citations Open access
Semantic Scholar
Targeting metals rescues the phenotype in an animal model of tauopathy.
Amelia Sedjahtera, Lydia Gunawan, L. Bray, L. Hung +11 more
2018Metallomics18 citations
Semantic Scholar
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function.
S. L. Leong, Tessa R. Young, K. Barnham, A. Wedd +3 more
2014Metallomics18 citations Open access
Semantic Scholar
Peripheral α-Defensins 1 and 2 are Elevated in Alzheimer's Disease
Andrew D. Watt, Keyla Perez, Ching-Seng Ang, P. O'Donnell +9 more
2015Journal of Alzheimer's Disease17 citations Open access
Semantic Scholar
Rhenium and technetium complexes that bind to amyloid-β plaques.
David J. Hayne, Andrea J. North, M. Fodero-Tavoletti, Jonathan M. White +9 more
2015Dalton Transactions16 citations Open access
Semantic Scholar
Orexin 2 receptor antagonism sex‐dependently improves sleep/wakefulness and cognitive performance in tau transgenic mice
R. Keenan, H. Daykin, Jeremy A Metha, L. Cornthwaite-Duncan +10 more
2023British Journal of Pharmacology15 citations Open access
Semantic Scholar
S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau
L. Beauchamp, Xiang M. Liu, Amelia Sedjahtera, Mirjana Bogeski +4 more
2020Journal of Alzheimer's Disease15 citations
Semantic Scholar
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy
D. Finkelstein, Jay J. Shukla, R. Cherny, J. L. Billings +4 more
2021Journal of Parkinson's Disease14 citations Open access
Semantic Scholar
Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels
J. Duce, S. Ayton, Alyson A. Miller, Andrew Tsatsanis +9 more
2013Molecular Psychiatry14 citations
Semantic Scholar
Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles
H. Su, C. Masters, A. Bush, K. Barnham +2 more
2023Proteomics13 citations Open access
Semantic Scholar
ATH434 Rescues Pre-motor Hyposmia in a Mouse Model of Parkinsonism
L. Beauchamp, Xiang M. Liu, L. Vella, P. Adlard +3 more
2022Neurotherapeutics13 citations Open access
Semantic Scholar
The N-Terminal Residues 43 to 60 Form the Interface for Dopamine Mediated α-Synuclein Dimerisation
S. L. Leong, M. G. Hinds, Andrea R. Connor, David P. Smith +4 more
2015PLoS ONE13 citations Open access
Semantic Scholar
Synthesis of Oxorhenium(V) and Oxotechnetium(V) Complexes That Bind to Amyloid-β Plaques.
David J. Hayne, Jonathan M. White, C. Mclean, V. Villemagne +2 more
2016Inorganic Chemistry12 citations Open access
Semantic Scholar
Small extracellular vesicles contain metals and transfer metal intercellularly
Adityas Purnianto, C. Mawal, Mita M. Kulkarni, H. Su +7 more
2024Journal of Extracellular Biology11 citations Open access
Semantic Scholar
The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours
R. Keenan, Jacky Chan, P. Donnelly, K. Barnham +1 more
2018Neurobiology of Stress11 citations Open access
Semantic Scholar

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