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J. K. Horton · SciRah

Researcher profile · Semantic Scholar

J. K. Horton

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J. K. Horton — researcher profile on SciRah

h-index: 37
Works: 89
Citations: 5,142

Most-cited papers

Requirement of mammalian DNA polymerase-β in base-excision repair
R. Sobol, J. K. Horton, Ralf Kühn, H. Gu +4 more
1996Nature649 citations
Semantic Scholar
The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity
R. Sobol, R. Prasad, Andrea Evenski, Audrey Baker +3 more
2000Nature357 citations
Semantic Scholar
Requirement of mammalian DNA polymerase-beta in base-excision repair.
R. Sobol, J. K. Horton, Ralf Kühn, H. Gu +4 more
1996Nature252 citations
Semantic Scholar
XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks
J. K. Horton, M. Watson, Donna F. Stefanick, Daniel T. Shaughnessy +2 more
2008Cell Research219 citations Open access
Semantic Scholar
Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses*
R. Sobol, M. Kartalou, Karen H. Almeida, Donna F Joyce +5 more
2003Journal of Biological Chemistry191 citations Open access
Semantic Scholar
Photoaffinity Labeling of Mouse Fibroblast Enzymes by a Base Excision Repair Intermediate
O. Lavrik, R. Prasad, R. Sobol, J. K. Horton +2 more
2001Journal of Biological Chemistry181 citations Open access
Semantic Scholar
Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism
W. A. Beard, J. K. Horton, R. Prasad, S. Wilson
2019Annual Review of Biochemistry176 citations Open access
Semantic Scholar
HMGB1 is a cofactor in mammalian base excision repair.
R. Prasad, Yuan Liu, L. Deterding, V. Poltoratsky +10 more
2007Molecules and Cells159 citations Open access
Semantic Scholar
Protection against Methylation-induced Cytotoxicity by DNA Polymerase β-Dependent Long Patch Base Excision Repair*
J. K. Horton, R. Prasad, E. Hou, S. Wilson
2000Journal of Biological Chemistry156 citations Open access
Semantic Scholar
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells.
Masayuki Nakagawa, E. Schneider, K. H. Dixon, J. K. Horton +3 more
1992Cancer Research152 citations
Semantic Scholar
Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion*
Yuan Liu, R. Prasad, W. A. Beard, E. Hou +3 more
2009Journal of Biological Chemistry122 citations Open access
Semantic Scholar
Direct Interaction between Mammalian DNA Polymerase β and Proliferating Cell Nuclear Antigen*
P. Kedar, Soon-jong Kim, A. Robertson, E. Hou +3 more
2002Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress
R. Sobol, D. E. Watson, Jun Nakamura, F. Yakes +8 more
2002Proceedings of the National Academy of Sciences of the United States of America95 citations Open access
Semantic Scholar
Identification of Small Molecule Synthetic Inhibitors of DNA Polymerase β by NMR Chemical Shift Mapping*
Hong-Yu Hu, J. K. Horton, M. Gryk, R. Prasad +5 more
2004Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions.
J. K. Horton, Donna F Joyce-Gray, B. Pachkowski, J. Swenberg +1 more
2003DNA Repair88 citations
Semantic Scholar
Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage.
J. K. Horton, Audrey Baker, B. V. Vande Berg, R. Sobol +1 more
2002DNA Repair87 citations
Semantic Scholar
Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair
R. Prasad, J. K. Horton, Paul Chastain, Natalie R. Gassman +3 more
2014Nucleic Acids Research83 citations Open access
Semantic Scholar
Base excision repair defects invoke hypersensitivity to PARP inhibition
J. K. Horton, Donna F. Stefanick, R. Prasad, Natalie R. Gassman +2 more
2014Molecular Cancer Research82 citations Open access
Semantic Scholar
DNA Damage and Cellular Stress Responses Increased PARP-1 Association with DNA in Alkylation Damaged , PARP-Inhibited Mouse Fibroblasts
P. Kedar, Donna F. Stefanick, J. K. Horton, S. Wilson
201274 citations
Semantic Scholar
DNA Polymerase (cid:1) Protects Mouse Fibroblasts against Oxidative DNA Damage and Is Recruited to Sites of DNA Damage/Repair*
Elena K. Braithwaite, P. Kedar, Lan Li, Y. Y. Polosina +7 more
200572 citations
Semantic Scholar
Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.
J. K. Horton, S. Wilson
2007DNA Repair70 citations Open access
Semantic Scholar
Poly(ADP-ribose) Polymerase Activity Prevents Signaling Pathways for Cell Cycle Arrest after DNA Methylating Agent Exposure*
J. K. Horton, Donna F. Stefanick, Jana M Naron, P. Kedar +1 more
2005Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
M. Çağlayan, J. K. Horton, Da-Peng Dai, Donna F. Stefanick +1 more
2017Nature Communications66 citations Open access
Semantic Scholar
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.
Elena K. Braithwaite, P. Kedar, Li Lan, Y. Y. Polosina +7 more
2005Journal of Biological Chemistry61 citations
Semantic Scholar
Bisphenol A Promotes Cell Survival Following Oxidative DNA Damage in Mouse Fibroblasts
Natalie R. Gassman, E. Coskun, Donna F. Stefanick, J. K. Horton +3 more
2015PLoS ONE59 citations Open access
Semantic Scholar
DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria
R. Prasad, M. Çağlayan, Da-Peng Dai, C. Nadalutti +10 more
2017DNA Repair57 citations Open access
Semantic Scholar
DNA polymerase β-dependent long patch base excision repair in living cells
K. Asagoshi, Yuan Liu, A. Masaoka, Li Lan +9 more
2009DNA Repair57 citations Open access
Semantic Scholar
Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks
M. Heacock, Donna F. Stefanick, J. K. Horton, S. Wilson
2010DNA Repair55 citations Open access
Semantic Scholar
DNA polymerase beta and mammalian base excision repair.
S. Wilson, R. Sobol, W. A. Beard, J. K. Horton +2 more
2000Cold Spring Harbor Symposia on Quantitative Biology53 citations
Semantic Scholar
Predicting Enhanced Cell Killing through PARP Inhibition
J. K. Horton, S. Wilson
2012Molecular Cancer Research52 citations Open access
Semantic Scholar
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.
P. Kedar, Soon-jong Kim, A. Robertson, E. Hou +3 more
2002Journal of Biological Chemistry52 citations
Semantic Scholar
Repair pathway for PARP-1 DNA-protein crosslinks
R. Prasad, J. K. Horton, Da-Peng Dai, S. Wilson
2018DNA Repair44 citations Open access
Semantic Scholar
BASE EXCISION REPAIR AND DESIGN OF SMALL MOLECULE INHIBITORS OF HUMAN DNA POLYMERASE β
S. Wilson, W. A. Beard, D. D. Shock, V. Batra +11 more
2010Cellular and Molecular Life Sciences43 citations Open access
Semantic Scholar
DNA polymerase β and PARP activities in base excision repair in living cells
A. Masaoka, J. K. Horton, W. A. Beard, S. Wilson
2009DNA Repair42 citations Open access
Semantic Scholar
Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition
P. Kedar, Donna F. Stefanick, J. K. Horton, S. Wilson
2008DNA Repair42 citations Open access
Semantic Scholar
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses
J. K. Horton, Donna F. Stefanick, Natalie R. Gassman, Jason G. Williams +8 more
2013DNA Repair40 citations Open access
Semantic Scholar
Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity
J. K. Horton, S. Wilson
2013Frontiers in Oncology38 citations Open access
Semantic Scholar
HMGN1 Protein Regulates Poly(ADP-ribose) Polymerase-1 (PARP-1) Self-PARylation in Mouse Fibroblasts*
A. Masaoka, Natalie R. Gassman, P. Kedar, R. Prasad +4 more
2012Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts
C. Nadalutti, Donna F. Stefanick, Ming-Lang Zhao, J. K. Horton +4 more
2020Scientific Reports35 citations Open access
Semantic Scholar
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines.
V. Poltoratsky, R. Prasad, J. K. Horton, S. Wilson
2007DNA Repair35 citations Open access
Semantic Scholar
Glutathione biosynthesis from sulfur-containing amino acids in enriched populations of Clara and type II cells and macrophages freshly isolated from rabbit lung.
J. K. Horton, M. Meredith, J. R. Bend
1987Journal of Pharmacology and Experimental Therapeutics35 citations
Semantic Scholar
A new light on the photo‐decomposition of the antitumour drug DTIC
J. K. Horton, Malcolm F. G. Stevens
1981The Journal of pharmacy and pharmacology35 citations
Semantic Scholar
Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.
J. K. Horton, Donna F. Stefanick, S. Wilson
2005DNA Repair34 citations
Semantic Scholar
Complementation of aprataxin deficiency by base excision repair enzymes
M. Çağlayan, J. K. Horton, R. Prasad, S. Wilson
2015Nucleic Acids Research33 citations Open access
Semantic Scholar
Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase
Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay +10 more
2020Cells30 citations Open access
Semantic Scholar
Paraquat uptake into freshly isolated rabbit lung epithelial cells and its reduction to the paraquat radical under anaerobic conditions.
J. K. Horton, R. Brigelius, R. Mason, J. R. Bend
1986Molecular Pharmacology30 citations
Semantic Scholar
Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro- and anti-apoptotic proteins
G. Roy, J. K. Horton, R. Roy, T. Denning +2 more
2000Oncogene29 citations
Semantic Scholar
Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard.
J. K. Horton, Peter J. Houghton, J. A. Houghton
1987Cancer Research29 citations
Semantic Scholar
ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.
J. K. Horton, Donna F. Stefanick, P. Kedar, S. Wilson
2007DNA Repair28 citations Open access
Semantic Scholar
Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts
Natalie R. Gassman, Donna F. Stefanick, P. Kedar, J. K. Horton +1 more
2012PLoS ONE27 citations Open access
Semantic Scholar

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S. Wilson×43
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S. Wilson — researcher profile on SciRah
R. Prasad×23
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R. Prasad — researcher profile on SciRah
Donna F. Stefanick×15
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Donna F. Stefanick — researcher profile on SciRah
P. Kedar×14
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E. Hou — researcher profile on SciRah

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R. Sobol — researcher profile on SciRah

Natalie R. Gassman×7

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K. Asagoshi — researcher profile on SciRah

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W. A. Beard — researcher profile on SciRah

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Yuan Liu — researcher profile on SciRah

V. Poltoratsky×4

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