Poulomi Acharya

Most-cited papers

1. Kinetic Identification of Membrane Transporters That Assist P-glycoprotein-Mediated Transport of Digoxin and Loperamide through a Confluent Monolayer of MDCKII-hMDR1 Cells

   Poulomi Acharya, Michael P. O'Connor, J. Polli, A. Ayrton +2 more

   2008Drug Metabolism And Disposition63 citations

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2. Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1

   Yongqiang Wang, S. Guan, Poulomi Acharya, D. Koop +4 more

   2011Journal of Biological Chemistry50 citations Open access

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3. A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation*

   Yongqiang Wang, M. Liao, N. Hoe, Poulomi Acharya +3 more

   2009Journal of Biological Chemistry50 citations Open access

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4. Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases

   Sungmi Kim, Poulomi Acharya, J. Engel, M. Correia

   2010Journal of Biological Chemistry38 citations Open access

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5. The ABCs of finding a good antibody: How to find a good antibody, validate it, and publish meaningful data

   Poulomi Acharya, Anna Quinlan, V. Neumeister

   2017F1000Research36 citations Open access

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6. Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2α (eIF2α)-Kinase (PERK) and General Control Nonderepressible-2 eIF2α Kinase

   Poulomi Acharya, J. Engel, M. Correia

   2009Molecular Pharmacology32 citations Open access

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7. P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.

   Poulomi Acharya, T. Tran, J. Polli, A. Ayrton +2 more

   2006Biochemistry32 citations

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8. Hepatic Heme-Regulated Inhibitor (HRI) Eukaryotic Initiation Factor 2α Kinase: A Protagonist of Heme-Mediated Translational Control of CYP2B Enzymes and a Modulator of Basal Endoplasmic Reticulum Stress Tone

   Poulomi Acharya, Jane-Jane Chen, M. Correia

   2010Molecular Pharmacology31 citations Open access

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9. Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination

   Yongqiang Wang, S. Guan, Poulomi Acharya, Yi Liu +5 more

   2011Molecular & Cellular Proteomics27 citations Open access

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10. If the KI Is Defined by the Free Energy of Binding to P-Glycoprotein, Which Kinetic Parameters Define the IC50 for the Madin-Darby Canine Kidney II Cell Line Overexpressing Human Multidrug Resistance 1 Confluent Cell Monolayer?

    A. Lumen, Poulomi Acharya, J. Polli, A. Ayrton +2 more

    2010Drug Metabolism And Disposition27 citations

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11. Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation

    Poulomi Acharya, M. Liao, J. Engel, M. Correia

    2010Journal of Biological Chemistry24 citations Open access

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12. Fitting the Elementary Rate Constants of the P-gp Transporter Network in the hMDR1-MDCK Confluent Cell Monolayer Using a Particle Swarm Algorithm

    Deep Agnani, Poulomi Acharya, Esteban Martinez, T. Tran +4 more

    2011PLoS ONE17 citations Open access

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13. THE UBIQUITIN-DEPENDENT PROTEASOMAL DEGRADATION ( UPD ) OF HUMAN LIVER CYTOCHROME P 450 2 E 1 : IDENTIFICATION OF SITES TARGETED FOR PHOSPHORYLATION AND UBIQUITINATION

    Yongqiang Wang, S. Guan, Poulomi Acharya, D. Koop +4 more

    201014 citations

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14. Mass Action Kinetic Analysis of Multidrug Resistance Transporters Expressed in Confluent Cell Monolayers

    A. Lumen, D. Silverman, Esteban Martinez, Z. Ahmed +3 more

    20111 citations

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15. define the IC50 for the MDCKII-hMDR1 confluent cell monolayer?

    A. Lumen, Poulomi Acharya, J. Polli, A. Ayrton +2 more

    20091 citations

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16. How to Validate Your Antibodies

    Poulomi Acharya

    20180 citations

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17. Role of p97 AAA ATPase in the autophagic‐lysosomal degradation of hepatic CYP2B1

    Poulomi Acharya, M. Correia

    20120 citations

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18. Dissecting the roles of p97 AAA ATPase and the 26S proteasome in endoplasmic reticulum (ER)‐extraction of CYP3A during degradation

    Poulomi Acharya, M. Correia

    20110 citations

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19. CYP3A4 Ser478‐phosphorylation by protein kinase (PK) A enhances its ubiquitination by UBC7/gp78 and thus its proteasomal degradation

    Yongqiang Wang, S. Guan, Poulomi Acharya, A. Burlingame +1 more

    20100 citations

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20. Regulation of hepatic CYP2B enzymes: Translational control via the heme‐regulated inhibitor (HRI)

    Poulomi Acharya, M. Correia

    20100 citations

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21. Hepatic CYP3A protein suppression by proteasomal inhibitors is due to induction of ER‐stress, activation of the eIF2‐alpha kinase PERK leading to translational arrest

    Poulomi Acharya, M. Correia

    20090 citations

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22. Translational control by hepatic eIF2‐alpha kinases: Constitutive activation/autophosphorylation of heme regulated inhibitor (HRI) in wild type (wt) mice and compensation by PERK in HRI‐knockout mice

    Poulomi Acharya, M. Correia

    20090 citations

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23. For P‐glycoprotein mediated transport through a confluent cell monolayer, the IC50 of a P‐gp substrate depends inversely upon the passive permeability coefficient of the probe substrate

    Poulomi Acharya, J. Bentz

    20070 citations

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