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J. Durkin · SciRah

Researcher profile · Semantic Scholar

J. Durkin

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J. Durkin — researcher profile on SciRah

h-index: 30
Works: 71
Citations: 3,952

Most-cited papers

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.
M. Bertrand, S. Milutinovic, K. Dickson, W. Ho +6 more
2008Molecules and Cells1,135 citations Open access
Semantic Scholar
Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.
Yanping Hu, G. Cherton-Horvat, V. Dragowska, S. Baird +4 more
2003Clinical Cancer Research230 citations
Semantic Scholar
Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics
D. Mcmanus, Charles A. Lefebvre, G. Cherton-Horvat, M. St-Jean +5 more
2004Oncogene183 citations
Semantic Scholar
AMPA receptor-mediated regulation of a Gi-protein in cortical neurons
Yi-Zheng Wang, D. Small, D. Stanimirovic, P. Morley +1 more
1997Nature160 citations
Semantic Scholar
Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier
A. Muruganandam, L. M. Herx, R. Monette, J. Durkin +1 more
1997The FASEB Journal140 citations
Semantic Scholar
Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis
E. LaCasse, G. Cherton-Horvat, K. Hewitt, Lori Jerome +9 more
2006Clinical Cancer Research131 citations
Semantic Scholar
Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase
Ray H. Rixon, J. Whitfield, L. Gagnon, R. Isaacs +7 more
1994Journal of Bone and Mineral Research128 citations
Semantic Scholar
Increase in surface expression of ICAM-1, VCAM-1 and E-selectin in human cerebromicrovascular endothelial cells subjected to ischemia-like insults.
Danica Stanimirovic, J. Wong, Anthony Shapiro, J. Durkin
1997Acta neurochirurgica. Supplement127 citations
Semantic Scholar
Further definition of the protein kinase C activation domain of the parathyroid hormone
H. Jouishomme, J. F. Whitfield, L. Gagnon, S. Maclean +6 more
1994Journal of Bone and Mineral Research121 citations
Semantic Scholar
The induction of ICAM-1 in human cerebromicrovascular endothelial cells (HCEC) by ischemia-like conditions promotes enhanced neutrophil/HCEC adhesion.
D. Stanimirovic, Anthony Shapiro, J. Wong, J. Hutchison +1 more
1997Journal of Neuroimmunology109 citations
Semantic Scholar
Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer.
E. Dean, D. Jodrell, K. Connolly, S. Danson +12 more
2009Journal of Clinical Oncology96 citations
Semantic Scholar
Evaluation of glutathione‐sensitive fluorescent dyes in cortical culture
Joseph S. Tauskela, K. Hewitt, L. Kang, T. Comas +5 more
2000Glia94 citations
Semantic Scholar
Transient NMDA Receptor Inactivation Provides Long-Term Protection to Cultured Cortical Neurons from a Variety of Death Signals
R. Tremblay, B. Chakravarthy, K. Hewitt, J. Tauskela +3 more
2000Journal of Neuroscience93 citations Open access
Semantic Scholar
Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP
Jeffrey Cummings, T. H. Ward, Eric C. LaCasse, Charles A. Lefebvre +4 more
2005British Journal of Cancer89 citations Open access
Semantic Scholar
Evidence that Functional Glutamate Receptors are not Expressed on Rat or Human Cerebromicrovascular Endothelial Cells
P. Morley, D. Small, C. L. Murray, G. Mealing +3 more
1998Journal of Cerebral Blood Flow and Metabolism89 citations Open access
Semantic Scholar
Role of stimulation of arachidonic acid release in the proliferative response of 3T3 mouse fibroblasts to platelet‐derived growth factor
W. Shier, J. Durkin
1982Journal of Cellular Physiology77 citations
Semantic Scholar
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but Not N-Methyl-D-aspartate, Activates Mitogen-activated Protein Kinase through G-protein βγ Subunits in Rat Cortical Neurons (*)
Yi-Zheng Wang, J. Durkin
1995Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640
E. LaCasse, Ekambar R. Kandimalla, P. Winocour, T. Sullivan +3 more
2005Annals of the New York Academy of Sciences69 citations
Semantic Scholar
The role of intracellular calcium and protein kinase C in endothelin‐stimulated proliferation of rat type I astrocytes
D. Stanimirovic, Rita Ball, G. Mealing, P. Morley +1 more
1995Glia68 citations
Semantic Scholar
Downregulation of XIAP expression in ovarian cancer cells induces cell death in vitro and in vivo
T. Shaw, E. LaCasse, J. Durkin, B. Vanderhyden
2008International Journal of Cancer59 citations
Semantic Scholar
Angiotensin II‐induced fluid phase endocytosis in human cerebromicrovascular endothelial cells is regulated by the inositol‐phosphate signaling pathway
D. Stanimirovic, P. Morley, Rita Ball, E. Hamel +2 more
1996Journal of Cellular Physiology58 citations
Semantic Scholar
CYTOPROTECTIVE EFFECTS OF IAPS REVEALED BY A SMALL MOLECULE ANTAGONIST
S. Galban, C. Hwang, J. Rumble, K. Oetjen +7 more
2009Biochemical Journal52 citations Open access
Semantic Scholar
Protein kinase C‐activating domains of parathyroid hormone‐related protein
L. Gagnon, H. Jouishomme, J. Whitfield, J. Durkin +5 more
1993Journal of Bone and Mineral Research52 citations
Semantic Scholar
AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.
Amir H. Salehi, S. Morris, W. Ho, K. Dickson +5 more
2006Chemistry and Biology51 citations Open access
Semantic Scholar
Stimulation of glutamate uptake and Na, K‐ATPase activity in rat astrocytes exposed to ischemia‐like insults
D. Stanimirovic, Rita Ball, J. Durkin
1997Glia51 citations
Semantic Scholar
Investigations into the cross-reactivity of rabbit antibodies raised against nonhomologous pairs of synthetic peptides derived from HIV-1 gp120 proteins.
V. Krsmanovic, J. Biquard, M. Sikorska-Walker, Irena Cosic +6 more
2009Journal of Peptide Research41 citations
Semantic Scholar
Clavulanic acid inhibition of beta-lactamase I from Bacillus cereus 569/H.
J. Durkin, Thammiah Viswanatha
1978Journal of antibiotics (Tokyo. 1968)38 citations Open access
Semantic Scholar
Staphylococcal delta toxin stimulates endogenous phospholipase A2 activity and prostaglandin synthesis in fibroblasts.
J. Durkin, W. Shier
1981Biochimica et Biophysica Acta32 citations
Semantic Scholar
Oncomodulin--a widely distributed, tumour-specific, calcium-binding protein.
J. Macmanus, J. Whitfield, A. Boynton, J. Durkin +1 more
1982Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine31 citations
Semantic Scholar
Characterization of G1 transit induced by the mitogenic-oncogenic viral Ki-ras gene product
J. Durkin, J. Whitfield
1986Molecular and Cellular Biology30 citations Open access
Semantic Scholar
X-linked Inhibitor of Apoptosis Regulates T Cell Effector Function1
S. Zehntner, L. Bourbonnière, C. Moore, S. Morris +8 more
2007Journal of Immunology24 citations Open access
Semantic Scholar
Phospholipase A2 electrophoretic variants in reptile venoms.
J. Durkin, G. Pickwell, J. Trotter, W. Shier
1981Toxicon23 citations
Semantic Scholar
The viral Ki-ras gene must be expressed in the G2 phase if ts Kirsten sarcoma virus-infected NRK cells are to proliferate in serum-free medium
J. Durkin, J. Whitfield
1987Molecular and Cellular Biology20 citations Open access
Semantic Scholar
Evidence for the role of protein kinase C in astrocyte-induced proliferation of rat cerebromicrovascular endothelial cells.
D. Stanimirovic, Rita Ball, J. Durkin
1995Neuroscience Letters19 citations
Semantic Scholar
Free radical-induced endothelial membrane dysfunction at the site of blood-brain barrier: Relationship between lipid peroxidation, Na,K-ATPase activity, and51Cr release
D. Stanimirovic, J. Wong, Rita Ball, J. Durkin
1995Neurochemical Research18 citations
Semantic Scholar
Evidence that the Modulation of Membrane‐Associated Protein Kinase C Activity by an Endogenous Inhibitor Plays a Role in N1E‐115 Murine Neuroblastoma Cell Differentiation
B. Chakravarthy, J. Wong, J. Durkin
1995Journal of Neurochemistry16 citations
Semantic Scholar
MEDIATION BY CALCICALMODULIN AND CYCLIC AMP OF TUMOR PROMOTER-INDUCED DNA SYNTHESIS IN CALCIUM-DEPRIVED RAT LIVER CELLS
A. Boynton, L. Kleine, J. Durkin, J. Whitfield +1 more
198213 citations
Semantic Scholar
Calcium, cyclic AMP and protein kinase C — partners in mitogenesis
J. Whitfield, J. Durkin, D. J. Franks, L. Kleine +4 more
2004Cancer Metastasis Review12 citations
Semantic Scholar
Changes in the polypeptide profiles during photoinduction of Xanthium strumarium
T. Kannangara, J. Durkin, J. Apsimon, F. Wightman
199010 citations
Semantic Scholar
Glutamate uptake and Na,K-ATPase activity in rat astrocyte cultures exposed to ischemia.
Danica Stanimirovic, Rita Ball, J. Durkin
1997Acta neurochirurgica. Supplement8 citations
Semantic Scholar
Characterization of the mitogenic signal from an oncogene ras protein.
J. Durkin, J. Whitfield
1989Anticancer Research8 citations
Semantic Scholar
N-(2-Furyl) acryloyl penicillin: a novel compound for the spectrophotometric assay of beta-lactamase I.
J. Durkin, G. Dmitrienko, T. Viswanatha
1977Journal of antibiotics (Tokyo. 1968)8 citations Open access
Semantic Scholar
A phase I trial of AEG35156 (XIAP antisense) administered as a continuous intravenous infusion in patients with advanced tumors.
M. Ranson, C. Dive, T. Ward, J. Cummings +6 more
2006Journal of Clinical Oncology7 citations
Semantic Scholar
Protein kinase C in IL- 2 signal transduction
Yin Lu, J. Durkin
1997Immunologic research7 citations
Semantic Scholar
The cytotoxicity of Pseudomonas exotoxin A, inactivated by modification of the cell-binding domain I, is restored when conjugated to an erythroid cell-specific targeting agent.
S. Bourdenet, R. Doyonnas, M. Vacheron, Micheline Guinand +7 more
1990Cancer Letters7 citations
Semantic Scholar
Autocrine differentiation-inhibiting factor (ADIF) from chicken erythroleukemia cells acts on human and mouse early BFU-E erythroid progenitors.
V. Krsmanović, N. Morardet, J. Biquard, G. Mouchirout +7 more
1988Biochemical and Biophysical Research Communications - BBRC7 citations
Semantic Scholar
Reversibility of the ampicillin-and nitrite-induced inactivation of beta-lactamase I.
J. Durkin, G. Dmitrienko, T. Viswanatha
1977Canadian Journal of Biochemistry7 citations
Semantic Scholar
The selective induction of a small number of proteins during G1 transit results from the mitogenic action of pp60v‐src in tsASV‐infected rat cells
J. Durkin, J. Whitfield
1985Journal of Cellular Physiology6 citations
Semantic Scholar
AEG35156, a XIAP antisense oligonucleotide, suppresses XIAP levels in targeted tissues isolated from pre-clinical models and from patients
E. LaCasse, S. Morris, T. Ward, J. Cumings +10 more
20065 citations
Semantic Scholar
Transforming NRK cells with avian sarcoma virus reduces the extracellular Ca2+ requirement without affecting the calcicalmodulin requirement for the G1/S transition.
J. Durkin, J. Whitfield
1985Experimental Cell Research5 citations
Semantic Scholar

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D. Stanimirovic×8
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P. Morley — researcher profile on SciRah

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B. Chakravarthy×5

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