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L. Jordheim · SciRah

Researcher profile · Semantic Scholar

L. Jordheim

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L. Jordheim — researcher profile on SciRah

h-index: 30
Works: 146
Citations: 4,234

Most-cited papers

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
L. Jordheim, D. Durantel, F. Zoulim, C. Dumontet
2013Nature reviews. Drug discovery1,091 citations
Semantic Scholar
The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent
Chloé Grasselly, Morgane Denis, A. Bourguignon, Nolan Talhi +6 more
2018Frontiers in Immunology120 citations Open access
Semantic Scholar
Nano-encapsulation of Vitamin D3 Active Metabolites for Application in Chemotherapy: Formulation Study and in Vitro Evaluation
Eyad Almouazen, S. Bourgeois, L. Jordheim, H. Fessi +1 more
2013Pharmaceutical Research63 citations
Semantic Scholar
Hybrid core-shell particles for mRNA systemic delivery.
Valentina Andretto, M. Repellin, M. Pujol, Eyad Almouazen +13 more
2022Journal of Controlled Release44 citations Open access
Semantic Scholar
Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors.
Christian Schnaars, Geir Kildahl-Andersen, Anthony Prandina, Roya Popal +12 more
2018ACS Infectious Diseases41 citations
Semantic Scholar
Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells
S. Nicolas, M. Bolzinger, L. Jordheim, Y. Chevalier +2 more
2018International journal of pharmaceutics41 citations
Semantic Scholar
Fully validated assay for the quantification of endogenous nucleoside mono- and triphosphates using online extraction coupled with liquid chromatography–tandem mass spectrometry
C. Machon, L. Jordheim, J. Puy, I. Lefebvre +2 more
2014Analytical and Bioanalytical Chemistry37 citations
Semantic Scholar
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines
T. Bjånes, L. Jordheim, J. Schjøtt, Tina Kamčeva +6 more
2019Drug Metabolism And Disposition36 citations Open access
Semantic Scholar
IN VIVO SYNGENEIC TUMOR MODELS WITH ACQUIRED RESISTANCE TO ANTI-PD-1/PD-L1 THERAPIES.
Morgane Denis, Chloé Grasselly, Pierre-Antoine Choffour, A. Wierinckx +11 more
2022Cancer immunology research35 citations Open access
Semantic Scholar
Rationally designed hyaluronic acid-based nano-complexes for pentamidine delivery.
F. Carton, Y. Chevalier, L. Nicoletti, M. Tarnowska +6 more
2019International journal of pharmaceutics33 citations Open access
Semantic Scholar
CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates.
C. Dumontet, S. Peyrottes, Céline Rabeson, Emeline Cros-Perrial +3 more
2018European journal of medicinal chemistry29 citations Open access
Semantic Scholar
The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor.
F. Cividini, R. Pesi, L. Chaloin, S. Allegrini +5 more
2015Biochemical Pharmacology25 citations Open access
Semantic Scholar
Structure-activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies.
M. Meurillon, Z. Márton, Audrey Hospital, L. Jordheim +6 more
2014European journal of medicinal chemistry25 citations
Semantic Scholar
Therapeutic perspectives for cN-II in cancer.
L. Jordheim, L. Chaloin
2013Current Medicinal Chemistry25 citations
Semantic Scholar
Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface
R. Rahimova, Simon Fontanel, C. Lionne, L. Jordheim +2 more
2018PLoS Comput. Biol.24 citations Open access
Semantic Scholar
The druggability of intracellular nucleotide-degrading enzymes
C. Rampazzo, M. Tozzi, C. Dumontet, L. Jordheim
2016Cancer Chemotherapy and Pharmacology23 citations
Semantic Scholar
Determination of the enzymatic activity of cytosolic 5′-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models
L. Jordheim, J. Puy, Emeline Cros-Perrial, S. Peyrottes +3 more
2015Analytical and Bioanalytical Chemistry23 citations
Semantic Scholar
Characterization of T‐DM1‐resistant breast cancer cells
Juliette Sauveur, L. Conilh, S. Beaumel, K. Chettab +3 more
2020Pharmacology Research & Perspectives22 citations Open access
Semantic Scholar
Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.
F. Cividini, Emeline Cros-Perrial, R. Pesi, C. Machon +5 more
2015International Journal of Biochemistry and Cell Biology22 citations
Semantic Scholar
Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
Z. Márton, Rémi Guillon, Isabelle Krimm, Preeti +9 more
2015Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
Anthony Prandina, S. Radix, M. le Borgne, L. Jordheim +7 more
2019Tetrahedron18 citations Open access
Semantic Scholar
5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer
F. Toffalorio, M. Santarpia, D. Radice, C. A. Jaramillo +12 more
2018OncoTarget18 citations Open access
Semantic Scholar
Cytosolic 5’-Nucleotidase II Interacts with the Leucin Rich Repeat of NLR Family Member Ipaf
F. Cividini, M. Tozzi, A. Galli, R. Pesi +4 more
2015PLoS ONE18 citations Open access
Semantic Scholar
Cytosolic 5′-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation
R. Pesi, Edoardo Petrotto, L. Colombaioni, S. Allegrini +4 more
2018International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Expanding the clinical relevance of the 5′-nucleotidase cN-II/NT5C2
L. Jordheim
2018Purinergic Signalling Purinergic Signalling17 citations Open access
Semantic Scholar
The cytosolic 5′-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells
G. Bricard, Octavia Cadassou, L. Cassagnes, Emeline Cros-Perrial +6 more
2017OncoTarget17 citations Open access
Semantic Scholar
Neutrophils protect lymphoma cells against cytotoxic and targeted therapies through CD11b/ICAM-1 binding
Taghreed Hirz, E. Matera, K. Chettab, L. Jordheim +5 more
2017OncoTarget17 citations Open access
Semantic Scholar
Enhancing the activity of platinum-based drugs by improved inhibitors of ERCC1–XPF-mediated DNA repair
G. Ciniero, Ahmed H. Elmenoufy, Francesco Gentile, M. Weinfeld +6 more
2021Cancer Chemotherapy and Pharmacology16 citations Open access
Semantic Scholar
Therapeutic Enhancement of ER Stress by Insulin-Like Growth Factor I Sensitizes Myeloma Cells to Proteasomal Inhibitors
Ines Tagoug, L. Jordheim, Stéphanie Herveau, E. Matera +4 more
2013Clinical Cancer Research16 citations
Semantic Scholar
Regulation of tumor infiltrated innate immune cells by adenosine
Regina Strakhova, Octavia Cadassou, Emeline Cros-Perrial, L. Jordheim
2020Purinergic Signalling Purinergic Signalling15 citations Open access
Semantic Scholar
Synthesis of Substituted 5′‐Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73
Rayane Ghoteimi, Văn Tài Nguyễn, R. Rahimova, Félix Grosjean +6 more
2019ChemMedChem15 citations
Semantic Scholar
A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models
K. Chettab, C. Fitzsimmons, A. Novikov, Morgane Denis +14 more
2023Frontiers in Immunology14 citations Open access
Semantic Scholar
Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation
Octavia Cadassou, Muhammad-Zawwad Raza, C. Machon, Laura Gudefin +7 more
2020Cellular Oncology14 citations Open access
Semantic Scholar
Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma
L. Jordheim, V. Ribrag, H. Ghesquières, S. Pallardy +7 more
2015Haematologica14 citations Open access
Semantic Scholar
Cytosolic 5′-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator
R. Pesi, S. Allegrini, F. Balestri, M. Garcia-Gil +5 more
2021Cells13 citations Open access
Semantic Scholar
4-Substituted-1,2,3-triazolo nucleotide analogues as CD73 inhibitors, their synthesis, in vitro screening, kinetic and in silico studies.
Rayane Ghoteimi, A. Braka, C. Rodriguez, Emeline Cros-Perrial +7 more
2020Bioorganic chemistry (Print)13 citations Open access
Semantic Scholar
Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation
Tài Nguyễn Văn, Audrey Hospital, C. Lionne, L. Jordheim +4 more
2016Beilstein Journal of Organic Chemistry13 citations Open access
Semantic Scholar
Exploring and bypassing resistance to targeted therapies in colorectal cancer.
Solène Favier, Wei Xiong, Mounira Chalabi-Dchar, K. Chettab +9 more
2025Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie12 citations Open access
Semantic Scholar
Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies.
Abdelfattah Faouzi, A. Arnaud, Alexandre Bancet, Caroline Barette +10 more
2021European journal of medicinal chemistry12 citations Open access
Semantic Scholar
Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Rémi Guillon, R. Rahimova, Preeti, D. Egron +6 more
2019European journal of medicinal chemistry11 citations Open access
Semantic Scholar
Functions of the multi‐interacting protein KIDINS220/ARMS in cancer and other pathologies
Muhammad-Zawwad Raza, S. Allegrini, C. Dumontet, L. Jordheim
2018Genes, Chromosomes and Cancer11 citations Open access
Semantic Scholar
Recent updates on purine and pyrimidine metabolism in physiological and pathological settings
L. Jordheim, G. Peters
2020Nucleosides, Nucleotides & Nucleic Acids9 citations Open access
Semantic Scholar
Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC-MS/MS in human cancer cells.
J. Puy, L. Jordheim, Emeline Cros-Perrial, C. Dumontet +2 more
2017Journal of chromatography. B, Analytical technologies in the biomedical and life sciences9 citations
Semantic Scholar
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors.
Geir Kildahl-Andersen, Christian Schnaars, Anthony Prandina, S. Radix +9 more
2019MedChemComm8 citations Open access
Semantic Scholar
Stably transfected adherent cancer cell models with decreased expression of 5′-nucleotidase cN-II
G. Bricard, Emeline Cros-Perrial, C. Machon, C. Dumontet +1 more
2016Nucleosides, Nucleotides & Nucleic Acids8 citations
Semantic Scholar
Unexpected Growth-Promoting Effect of Oxaliplatin in Excision Repair Cross-Complementation Group 1 Transfected Human Colon Cancer Cells
L. Jordheim, K. Chettab, Emeline Cros-Perrial, E. Matera +1 more
2018Pharmacology7 citations
Semantic Scholar
Interactive Web Application as a Teaching Tool to Introduce Basics of Chromatography and the Plate Theory
L. Jordheim, A. Denuzière, C. Machon, Wael Zeinyeh
20216 citations Open access
Semantic Scholar
New insights in research on purine and pyrimidine metabolism
L. Jordheim, G. Peters
2021Nucleosides, Nucleotides & Nucleic Acids6 citations Open access
Semantic Scholar
CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
Muhammad-Zawwad Raza, Octavia Cadassou, C. Dumontet, Emeline Cros-Perrial +1 more
2021Biochimica et Biophysica Acta - General Subjects6 citations Open access
Semantic Scholar
PARP Inhibitors and Proteins Interacting with SLX4
L. Jordheim
2023Cancers5 citations Open access
Semantic Scholar

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C. Dumontet — researcher profile on SciRah
Emeline Cros-Perrial×15
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S. Peyrottes×10
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K. Chettab — researcher profile on SciRah

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M. Tozzi — researcher profile on SciRah

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C. Machon — researcher profile on SciRah

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R. Pesi — researcher profile on SciRah

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