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L. Tilley · SciRah

Researcher profile · Semantic Scholar

L. Tilley

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L. Tilley — researcher profile on SciRah

h-index: 68
Works: 231
Citations: 13K

Most-cited papers

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion
N. Klonis, M. Crespo-Ortiz, Iveta Bottová, N. Abubakar +3 more
2011Proceedings of the National Academy of Sciences of the United States of America352 citations Open access
Semantic Scholar
Artemisinin action and resistance in Plasmodium falciparum
L. Tilley, J. Straimer, Nina F. Gnädig, Stuart A. Ralph +1 more
2016Trends in Parasitology309 citations Open access
Semantic Scholar
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
Jessica L. Bridgford, S. Xie, Simon A. Cobbold, C. Pasaje +8 more
2018Nature Communications261 citations Open access
Semantic Scholar
Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum
J. MacRae, Matthew W. A. Dixon, M. Dearnley, H. H. Chua +5 more
2013BMC Biology257 citations Open access
Semantic Scholar
Structure and function based design of Plasmodium-selective proteasome inhibitors
Hao Li, A. O'Donoghue, W. van der Linden, S. Xie +6 more
2016Nature224 citations Open access
Semantic Scholar
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
N. Klonis, S. Xie, J. McCaw, M. Crespo-Ortiz +3 more
2013Proceedings of the National Academy of Sciences of the United States of America206 citations Open access
Semantic Scholar
A thiol probe for measuring unfolded protein load and proteostasis in cells
Moore Z. Chen, Nagaraj S. Moily, Jessica L. Bridgford, Rebecca J. Wood +10 more
2017Nature Communications168 citations Open access
Semantic Scholar
Plasmodium species: master renovators of their host cells
T. D. de Koning-Ward, Matthew W. A. Dixon, L. Tilley, P. Gilson
2016Nature Reviews Microbiology155 citations Open access
Semantic Scholar
Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum
E. Hanssen, C. Knoechel, M. Dearnley, Matthew W. A. Dixon +3 more
2011Journal of Structural Biology152 citations Open access
Semantic Scholar
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance.
Tuo Yang, L. M. Yeoh, Madel V. Tutor, Matthew W. A. Dixon +9 more
2019Cell Reports151 citations Open access
Semantic Scholar
The Plasmodium falciparum-infected red blood cell.
L. Tilley, Matthew W. A. Dixon, K. Kirk
2011International Journal of Biochemistry and Cell Biology146 citations
Semantic Scholar
Tip-enhanced Raman scattering (TERS) from hemozoin crystals within a sectioned erythrocyte.
B. Wood, E. Bailo, Mehdi Asghari Khiavi, L. Tilley +4 more
2011Nano letters (Print)138 citations
Semantic Scholar
Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes
M. Dearnley, Jeffrey A. Yeoman, E. Hanssen, Shannon Kenny +4 more
2012Journal of Cell Science137 citations Open access
Semantic Scholar
Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins.
N. Klonis, D. Creek, L. Tilley
2013Current Opinion in Microbiology130 citations
Semantic Scholar
Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite
Yao Zhang, Changjin Huang, Sangtae Kim, Mahdi Golkaram +5 more
2015Proceedings of the National Academy of Sciences of the United States of America115 citations Open access
Semantic Scholar
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
S. Xie, C. Dogovski, E. Hanssen, F. Chiu +8 more
2016Journal of Cell Science110 citations Open access
Semantic Scholar
The Apical Complex Provides a Regulated Gateway for Secretion of Invasion Factors in Toxoplasma
Nicholas J. Katris, G. V. van Dooren, P. McMillan, E. Hanssen +2 more
2014PLoS Pathogens108 citations Open access
Semantic Scholar
A new Python library to analyse skeleton images confirms malaria parasite remodelling of the red blood cell membrane skeleton
Juan Nunez-Iglesias, A. Blanch, O. Looker, Matthew W. A. Dixon +1 more
2018PeerJ100 citations Open access
Semantic Scholar
K13, the Cytostome, and Artemisinin Resistance.
S. Xie, Stuart A. Ralph, L. Tilley
2020Trends in Parasitology88 citations Open access
Semantic Scholar
Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development
Molly Parkyn Schneider, Bo-Yin Liu, Philipp Glock, A. Suttie +9 more
2017PLoS Pathogens82 citations Open access
Semantic Scholar
Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
Kit Kennedy, Simon A. Cobbold, E. Hanssen, Jakob Birnbaum +7 more
2019PLoS Biology81 citations Open access
Semantic Scholar
Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum
Paul J. McMillan, C. Millet, Steven Batinovic, Mauro Maiorca +8 more
2013Cellular Microbiology79 citations Open access
Semantic Scholar
Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages
M. Dearnley, T. Chu, Yao Zhang, O. Looker +10 more
2016Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
Semantic Scholar
Detection and Quantification of Early-Stage Malaria Parasites in Laboratory Infected Erythrocytes by Attenuated Total Reflectance Infrared Spectroscopy and Multivariate Analysis
Aazam Khoshmanesh, Matthew W. A. Dixon, Shannon Kenny, L. Tilley +2 more
2014Analytical Chemistry75 citations Open access
Semantic Scholar
An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
Steven Batinovic, Emma McHugh, Scott A. Chisholm, Kathryn M. Matthews +8 more
2017Nature Communications70 citations Open access
Semantic Scholar
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
S. Xie, D. Gillett, Natalie J. Spillman, C. Tsu +17 more
2018Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
A 95 kDa protein of Plasmodium vivax and P. cynomolgi visualized by 3-D tomography in the caveola-vesicle complexes (Schüffner’s dots) of infected erythrocytes is a member of the PHIST family
S. Akinyi, E. Hanssen, E. Meyer, Jianlin Jiang +6 more
2012Molecular Microbiology66 citations Open access
Semantic Scholar
Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150
Brendan Elsworth, P. Sanders, T. Nebl, Steven Batinovic +8 more
2016Cellular Microbiology65 citations Open access
Semantic Scholar
Organization and function of an actin cytoskeleton in Plasmodium falciparum gametocytes
Marion Hliscs, C. Millet, Matthew W. A. Dixon, I. Sidén-Kiamos +2 more
2015Cellular Microbiology65 citations
Semantic Scholar
Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?
Matthew W. A. Dixon, M. Dearnley, E. Hanssen, T. Gilberger +1 more
2012Trends in Parasitology64 citations
Semantic Scholar
Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks the gametocyte ring stage
M. Tibúrcio, Matthew W. A. Dixon, O. Looker, S. Younis +2 more
2015Malaria Journal61 citations Open access
Semantic Scholar
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.
Silvia C Teguh, N. Klonis, Sandra Duffy, L. Lucantoni +4 more
2013Journal of Medicinal Chemistry61 citations
Semantic Scholar
Tracking Glideosome-Associated Protein 50 Reveals the Development and Organization of the Inner Membrane Complex of Plasmodium falciparum
Jeffrey A. Yeoman, E. Hanssen, A. Maier, N. Klonis +6 more
2011Eukaryotic Cell60 citations Open access
Semantic Scholar
Bio-sensing with butterfly wings: naturally occurring nano-structures for SERS-based malaria parasite detection.
N. Garrett, Ryo Sekine, Matthew W. A. Dixon, L. Tilley +2 more
2015Physical Chemistry, Chemical Physics - PCCP57 citations
Semantic Scholar
The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites
Sarah C. Charnaud, Matthew W. A. Dixon, Catherine Q. Nie, Lia Chappell +12 more
2017PLoS ONE52 citations Open access
Semantic Scholar
Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains
Tuo Yang, S. Xie, Peng-Xing Cao, Carlo Giannangelo +5 more
2016Antimicrobial Agents and Chemotherapy52 citations Open access
Semantic Scholar
Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodium falciparum virulence complex
Matthew W. A. Dixon, Shannon Kenny, Paul J. McMillan, E. Hanssen +3 more
2011Molecular Microbiology47 citations Open access
Semantic Scholar
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
S. Xie, R. D. Metcalfe, E. Hanssen, Tuo Yang +11 more
2019Nature Microbiology45 citations
Semantic Scholar
The proteasome as a target for protozoan parasites
S. Xie, L. Dick, A. Gould, S. Brand +1 more
2019Expert opinion on therapeutic targets42 citations Open access
Semantic Scholar
Whole-cell phase contrast imaging at the nanoscale using Fresnel Coherent Diffractive Imaging Tomography
Michael W. M. Jones, G. V. van Riessen, B. Abbey, C. T. Putkunz +10 more
2013Scientific Reports42 citations Open access
Semantic Scholar
Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P. falciparum and P. berghei Unmasks a Role in Parasite Virulence
Scott A. Chisholm, Emma McHugh, R. Lundie, Matthew W. A. Dixon +5 more
2016PLoS ONE37 citations Open access
Semantic Scholar
Spatial organization of protein export in malaria parasite blood stages
Sarah C. Charnaud, Thorey K. Jonsdottir, P. Sanders, H. Bullen +10 more
2018Traffic : the International Journal of Intracellular Transport34 citations Open access
Semantic Scholar
Diagnosing malaria infected cells at the single cell level using focal plane array Fourier transform infrared imaging spectroscopy.
B. Wood, K. Bambery, Matthew W. A. Dixon, L. Tilley +3 more
2014In Analysis33 citations Open access
Semantic Scholar
Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection
Ryan Farid, Matthew W. A. Dixon, L. Tilley, J. McCarthy
2017Journal of Infectious Diseases32 citations Open access
Semantic Scholar
Surface area‐to‐volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels
Arman Namvar, A. Blanch, Matthew W. A. Dixon, Olivia M. S. Carmo +9 more
2020Cellular Microbiology31 citations Open access
Semantic Scholar
Red Blood Cells Polarize Green Laser Light Revealing Hemoglobin's Enhanced Non-Fundamental Raman Modes
K. M. Marzec, D. Pérez-Guaita, M. de Veij, D. McNaughton +4 more
2014ChemPhysChem31 citations Open access
Semantic Scholar
A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking
Emma McHugh, Steven Batinovic, E. Hanssen, Paul J. McMillan +7 more
2015Molecular Microbiology30 citations Open access
Semantic Scholar
An atypical cyclin-dependent kinase controls Plasmodium falciparum proliferation rate
Dominique Dorin-Semblat, T. G. Carvalho, M. Nivez, Jean Halbert +11 more
201329 citations
Semantic Scholar
The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly
O. Looker, A. Blanch, Bo-Yin Liu, Juan Nunez-Iglesias +3 more
2019PLoS Pathogens28 citations Open access
Semantic Scholar
Multimodal analysis of Plasmodium knowlesi‐infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects
Bo-Yin Liu, A. Blanch, Arman Namvar, Olivia M. S. Carmo +6 more
2019Cellular Microbiology27 citations Open access
Semantic Scholar

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