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H. Ishihara · SciRah

Researcher profile · Semantic Scholar

H. Ishihara

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H. Ishihara — researcher profile on SciRah

h-index: 51
Works: 156
Citations: 8,719

Most-cited papers

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
Sonya G. Fonseca, Shinsuke Ishigaki, C. M. Oslowski, Si-Min Lu +7 more
2010Journal of Clinical Investigation408 citations Open access
Semantic Scholar
Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion.
H. Ishihara, S. Takeda, Akira Tamura, Rui Takahashi +8 more
2004Human Molecular Genetics286 citations
Semantic Scholar
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.
Takahiro Yamada, H. Ishihara, Akira Tamura, Rui Takahashi +9 more
2006Human Molecular Genetics271 citations
Semantic Scholar
Regulation of Pancreatic β Cell Mass by Neuronal Signals from the Liver
Junta Imai, H. Katagiri, Tetsuya Yamada, Y. Ishigaki +12 more
2008Science244 citations Open access
Semantic Scholar
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress.
Suguru Yamaguchi, H. Ishihara, Takahiro Yamada, Akira Tamura +11 more
2008Cell Metabolism205 citations Open access
Semantic Scholar
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.
H. Ishihara, P. Maechler, A. Gjinovci, P. Herrera +1 more
2003Nature Cell Biology203 citations
Semantic Scholar
Activation of Type I Phosphatidylinositol 4-Phosphate 5-Kinase Isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42*
P. A. Oude Weernink, Konstantinos Meletiadis, Silvia Hommeltenberg, M. Hinz +3 more
2004Journal of Biological Chemistry194 citations Open access
Semantic Scholar
WFS1 protein modulates the free Ca2+ concentration in the endoplasmic reticulum
Daisuke Takei, H. Ishihara, Suguru Yamaguchi, Takahiro Yamada +4 more
2006FEBS Letters189 citations
Semantic Scholar
Impact of Plasma Oxidized Low-Density Lipoprotein Removal on Atherosclerosis
Y. Ishigaki, H. Katagiri, Jun-Hong Gao, Tetsuya Yamada +12 more
2008Circulation178 citations
Semantic Scholar
Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.
M. Usui, Suguru Yamaguchi, Yasuhiro Tanji, Ryu Tominaga +6 more
2012Metabolism: Clinical and Experimental136 citations
Semantic Scholar
Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation.
Tetsuya Yamada, H. Katagiri, Y. Ishigaki, T. Ogihara +10 more
2006Cell Metabolism129 citations Open access
Semantic Scholar
Bone marrow (BM) transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization.
Yutaka Hasegawa, T. Ogihara, Tetsuya Yamada, Y. Ishigaki +9 more
2007Endocrinology121 citations Open access
Semantic Scholar
Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells
Toshinobu Suzuki, Junta Imai, Tetsuya Yamada, Y. Ishigaki +6 more
2011Diabetes104 citations Open access
Semantic Scholar
Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets
S. Carobbio, H. Ishihara, S. Fernández-Pascual, C. Bartley +2 more
2004Diabetologia103 citations Open access
Semantic Scholar
Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice
Junta Imai, H. Katagiri, Tetsuya Yamada, Y. Ishigaki +7 more
2006Obesity98 citations Open access
Semantic Scholar
Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.
Sohei Tsukita, Tetsuya Yamada, Kenji Uno, Kei Takahashi +8 more
2012Cell Metabolism84 citations Open access
Semantic Scholar
Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.
Y. Ishigaki, H. Katagiri, Tetsuya Yamada, T. Ogihara +9 more
2005Diabetes78 citations
Semantic Scholar
Oligonucleotide Microarray Analysis Reveals PDX1 as an Essential Regulator of Mitochondrial Metabolism in Rat Islets*
B. R. Gauthier, Thierry Brun, E. Sarret, H. Ishihara +3 more
2004Journal of Biological Chemistry78 citations Open access
Semantic Scholar
The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines
Toshihide Kimura, Yukiko K. Kaneko, S. Yamada, H. Ishihara +3 more
2008Journal of Cell Science75 citations
Semantic Scholar
Constitutively active PDX1 induced efficient insulin production in adult murine liver.
Junta Imai, H. Katagiri, Tetsuya Yamada, Y. Ishigaki +9 more
2005Biochemical and Biophysical Research Communications - BBRC75 citations Open access
Semantic Scholar
Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses
Jun-Hong Gao, Y. Ishigaki, Tetsuya Yamada, K. Kondo +10 more
2011Circulation61 citations Open access
Semantic Scholar
Secondary sulfonylurea failure: comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.
J. Satoh, Kazuma Takahashi, Y. Takizawa, H. Ishihara +6 more
2005Diabetes Research and Clinical Practice56 citations
Semantic Scholar
DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
T. Shinjo, Yusuke Nakatsu, M. Iwashita, T. Sano +9 more
2015American Journal of Physiology. Endocrinology and Metabolism55 citations Open access
Semantic Scholar
Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder.
T. Kato, M. Ishiwata, Kazuyuki Yamada, Takaoki Kasahara +5 more
2008Neurosciences research55 citations
Semantic Scholar
Efficacy and safety of ipragliflozin as add‐on therapy to insulin in Japanese patients with type 2 diabetes mellitus (IOLITE): a multi‐centre, randomized, placebo‐controlled, double‐blind study
H. Ishihara, S. Yamaguchi, Ikko Nakao, Akira Okitsu +1 more
2016Diabetes, obesity and metabolism48 citations Open access
Semantic Scholar
Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes.
T. Nagai, Mariko Tanaka-Ishikawa, R. Aikawa, H. Ishihara +4 more
2003Biochemical and Biophysical Research Communications - BBRC47 citations
Semantic Scholar
Endoplasmic reticulum stress and N-glycosylation modulate expression of WFS1 protein.
Suguru Yamaguchi, H. Ishihara, Akira Tamura, Takahiro Yamada +4 more
2004Biochemical and Biophysical Research Communications - BBRC45 citations
Semantic Scholar
The conserved carboxyl terminus of human parainfluenza virus type 2 V protein plays an important role in virus growth.
M. Nishio, M. Tsurudome, H. Ishihara, Morihiro Ito +1 more
2007Virology28 citations Open access
Semantic Scholar
Carotid arterial elasticity is a sensitive atherosclerosis value reflecting visceral fat accumulation in obese subjects.
A. Tokita, Y. Ishigaki, Hisashi Okimoto, H. Hasegawa +7 more
2009Atherosclerosis24 citations
Semantic Scholar
Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.
Yusuke Nakatsu, Y. Matsunaga, Takeshi Yamamotoya, K. Ueda +21 more
2019Cell Reports23 citations Open access
Semantic Scholar
The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion
Yusuke Nakatsu, Keiichi Mori, Y. Matsunaga, Takeshi Yamamotoya +10 more
2017Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity
Takeshi Yamamotoya, Yusuke Nakatsu, A. Kushiyama, Y. Matsunaga +9 more
2017Scientific Reports20 citations Open access
Semantic Scholar
Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes
Yoshihiro Tomofuji, Ken Suzuki, T. Kishikawa, N. Shojima +34 more
2023Communications Medicine19 citations Open access
Semantic Scholar
Hepatic Nuclear Factor 1α (HNF1α) Dysfunction Down-regulates X-box-binding Protein 1 (XBP1) and Sensitizes β-Cells to Endoplasmic Reticulum Stress*
C. Kirkpatrick, A. Wiederkehr, M. Baquié, Dmitry Akhmedov +6 more
2011Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Comparison of tofogliflozin versus glimepiride as the third oral agent added to metformin plus a dipeptidyl peptidase‐4 inhibitor in Japanese patients with type 2 diabetes: A randomized, 24‐week, open‐label, controlled trial (STOP‐OB)
Toru Kitazawa, H. Seino, H. Ohashi, Takeshi Inazawa +7 more
2020Diabetes, obesity and metabolism16 citations Open access
Semantic Scholar
Is zinc an intra-islet regulator of glucagon secretion?
H. Ishihara, C. Wollheim
2016Diabetology International16 citations Open access
Semantic Scholar
Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors.
Rui Takahashi, H. Ishihara, Kazuma Takahashi, Akira Tamura +4 more
2007Journal of Molecular Endocrinology16 citations Open access
Semantic Scholar
Seasonal variation in hydration status among community‐dwelling elderly in Japan
Sho Tanaka, M. Fujishiro, Kentaro Watanabe, K. Imatake +4 more
2020Geriatrics & Gerontology International15 citations
Semantic Scholar
Ipragliflozin Add-on Therapy to a GLP-1 Receptor Agonist in Japanese Patients with Type 2 Diabetes (AGATE): A 52-Week Open-Label Study
H. Ishihara, S. Yamaguchi, Ikko Nakao, T. Sakatani
2018Diabetes Therapy15 citations Open access
Semantic Scholar
Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control via different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes.
Y. Otsuka, Suguru Yamaguchi, Asami Furukawa, Minami Kosuda +2 more
2015Endocrine journal15 citations Open access
Semantic Scholar
The JNK pathway modulates expression and phosphorylation of 4E‐BP1 in MIN6 pancreatic β‐cells under oxidative stress conditions
Ryu Tominaga, Suguru Yamaguchi, C. Satake, M. Usui +5 more
2010Cell Biochemistry and Function15 citations
Semantic Scholar
Cell type-specific activation of metabolism reveals that β-cell secretion suppresses glucagon release from α-cells in rat pancreatic islets
Rui Takahashi, H. Ishihara, Akira Tamura, Suguru Yamaguchi +5 more
200615 citations
Semantic Scholar
Metabolism-secretion coupling in glucose-stimulated insulin secretion
H. Ishihara
2022Diabetology International14 citations Open access
Semantic Scholar
Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus
Hitoki Saito, Momoko Ebashi, Masaru Kushimoto, Jin Ikeda +7 more
2018Therapeutics and Clinical Risk Management13 citations Open access
Semantic Scholar
Vitamin D receptor activation induces peptide YY transcription in pancreatic islets.
Mihwa Choi, Jun Ozeki, M. Hashizume, S. Kato +2 more
2012Endocrinology12 citations
Semantic Scholar
A rare case of fulminant type 1 diabetes mellitus accompanied by both acute pancreatitis and myocarditis - case report
Fujiko Egashira, Midori Kawashima, Ai Morikawa, Minami Kosuda +2 more
2020BMC Endocrine Disorders11 citations Open access
Semantic Scholar
High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice
T. Shinjo, Yusuke Nakatsu, M. Iwashita, T. Sano +6 more
2015Diabetology & Metabolic Syndrome11 citations Open access
Semantic Scholar
Effects of GLP-1RA and SGLT2i, Alone or in Combination, on Mouse Models of Type 2 Diabetes Representing Different Disease Stages
Masao Koike, Hitoki Saito, Genta Kohno, Masahiro Takubo +2 more
2021International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Hemichorea after hypoglycemic episodes with negative MRI findings in an elderly woman with poorly controlled type 2 diabetes mellitus: a case report
Eriko Matsushima, H. Shiota, Kentaro Watanabe, Y. Otsuka +5 more
2019BMC Neurology10 citations Open access
Semantic Scholar
Acute esophageal necrosis after cellulitis in an obese patient with diabetes mellitus
Sho Tanaka, M. Fujishiro, Ryoji Ichijima, Genta Kohno +2 more
2019Journal of Diabetes Investigation10 citations Open access
Semantic Scholar

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