H. Kumamoto

Most-cited papers

1. Radical-mediated stannylation of vinyl sulfones: access to novel 4′-modified neplanocin A analogues

   H. Kumamoto, Kazuki Deguchi, T. Wagata, Yuu Furuya +3 more

   200944 citations

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2. Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine In Vitro

   T. Nitanda, Xin Wang, H. Kumamoto, K. Haraguchi +3 more

   2005Antimicrobial Agents and Chemotherapy41 citations Open access

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3. Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis

   H. Kumamoto, D. Topalis, Julie Broggi, Ugo Pradère +9 more

   200838 citations

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4. A New Entry to 2-Substituted Purine Nucleosides Based on Lithiation-Mediated Stannyl Transfer of 6-Chloropurine Nucleosides

   Keisuke Kato, H. Hayakawa, Hiromichi Tanaka, H. Kumamoto +3 more

   199737 citations

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5. Click Azide‐Alkyne Cycloaddition for the Synthesis of D‐(–)‐1,4‐Disubstituted Triazolo‐Carbanucleosides

   Julie Broggi, H. Kumamoto, Sabine Berteina‐Raboin, S. Nolan +1 more

   200928 citations

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6. Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV

   Nobuyo Higashi-Kuwata, Sanae Hayashi, H. Kumamoto, Hiromi Ogata-Aoki +13 more

   2020Journal of Hepatology27 citations Open access

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7. Pyrolysis of UR-144, a synthetic cannabinoid, augments an affinity to human CB1 receptor and cannabimimetic effects in mice.

   Asuka Kaizaki-Mitsumoto, Kyoko Hataoka, M. Funada, Y. Odanaka +2 more

   2017Journal of Toxicological Sciences27 citations Open access

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8. Synthesis and anti-human immunodeficiency virus activity of 4'-branched (+/-)-4'-thiostavudines.

   H. Kumamoto, Takahito Nakai, K. Haraguchi, K. Nakamura +3 more

   2006Journal of Medicinal Chemistry26 citations

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9. Development of radioiodinated nucleoside analogs for imaging tissue proliferation: comparisons of six 5-iodonucleosides.

   J. Toyohara, Akio Hayashi, Mikiko Sato, A. Gogami +6 more

   2003Nuclear Medicine and Biology22 citations

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10. Sulfur extrusion with tin radical: synthesis of 4',5'-didehydro-5'-deoxy-5'-(tributylstannyl)adenosine, an intermediate for potential inhibitors against S-adenosyl homocysteine hydrolase.

    H. Kumamoto, Sayoko Onuma, Hiromichi Tanaka

    2004Journal of Organic Chemistry19 citations

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11. A versatile intermediate for the synthesis of 3′-substituted 2′,3′-didehydro-2′,3′-dideoxyadenosine (d4A): preparation of 3′-C-stannyl-d4A via radical-mediated desulfonylative stannylation

    Sayoko Onuma, H. Kumamoto, Misono Kawato, Hiromichi Tanaka

    200218 citations

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12. First Evident Generation of Purin-2-yllithium: Lithiation of an 8-Silyl-Protected 6-Chloropurine Riboside as a Key Step for the Synthesis of 2-Carbon-Substituted Adenosines†

    H. Kumamoto, Hiromichi Tanaka, Ryota Tsukioka, Yumiko Ishida +5 more

    199917 citations

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13. Pointer 4'-Ethynylstavudine (4'-Ed4T) Has Potent Anti-HIV-1 Activity with Reduced Toxicity and Shows a Unique Activity Profile against Drug-Resistant Mutants

    Hiromichi Tanaka, K. Haraguchi, H. Kumamoto, M. Baba +1 more

    2005Antiviral Chemistry & Chemotherapy16 citations Open access

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14. Synthesis of (±)-4′-Ethynyl and 4′-Cyano Carbocyclic Analogues of Stavudine (d4T)

    H. Kumamoto, K. Haraguchi, Hiromichi Tanaka, Keisuke Kato +4 more

    2005Nucleosides, Nucleotides & Nucleic Acids16 citations

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15. Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market

    Asuka Kaizaki-Mitsumoto, Naoki Noguchi, Saki Yamaguchi, Y. Odanaka +6 more

    2015Forensic Toxicology15 citations

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16. Lithiation-mediated CC silyl and stannyl migrations observed in 6-chloro-9-(β-d-ribofuranosyl)purine

    Keisuke Kato, H. Hayakawa, Hiromichi Tanaka, H. Kumamoto +1 more

    199515 citations

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17. Nucleotide binding to human UMP‐CMP kinase using fluorescent derivatives − a screening based on affinity for the UMP‐CMP binding site

    D. Topalis, H. Kumamoto, Maria-Fernanda Amaya Velasco, Laurence Dugué +7 more

    2007The FEBS Journal14 citations Open access

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18. From the Chemistry of Epoxy-Sugar Nucleosides to the Discovery of Anti-HIV Agent 4′-ethynylstavudine-Festinavir

    K. Haraguchi, Shingo Takeda, Yutaka Kubota, H. Kumamoto +5 more

    2013Current pharmaceutical design13 citations Open access

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19. Simple entry to 3'-substituted analogues of anti-HIV agent stavudine based on an anionic O --> C stannyl migration.

    H. Kumamoto, Hiromichi Tanaka

    2002Journal of Organic Chemistry13 citations

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20. Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers

    H. Kumamoto, Misato Fukano, T. Nakano, Keito Iwagami +10 more

    2016Journal of Organic Chemistry12 citations Open access

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21. Lithiation at the 6-position of uridine with lithium hexamethyldisilazide: crucial role of temporary silylation.

    Y. Yoshimura, H. Kumamoto, A. Baba, Shingo Takeda +1 more

    2004Organic Letters12 citations

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22. Nucleophilic addition of benzenethiol to 1',2'-unsaturated nucleosides: 1'-C-phenylthio-2'-deoxynucleosides as anomeric radical precursors.

    H. Kumamoto, M. Murasaki, K. Haraguchi, Aki Anamura +1 more

    2002Journal of Organic Chemistry12 citations

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23. Synthesis of 2-Alkynylcordycepins and Evaluation of Their Vasodilating Activity

    H. Kumamoto, H. Hayakawa, Hiromichi Tanaka, Satoru Shindoh +5 more

    199812 citations

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24. Synthesis of the 5′‐Fluoro‐2′β‐methyl Analogues of Neplanocin

    H. Kumamoto, Marina Kobayashi, Nobuyuki Kato, J. Balzarini +1 more

    201111 citations Open access

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25. Cross‐Metathesis in the Synthesis of Bioactive Phosphonates

    L. Agrofoglio, H. Kumamoto, Vincent Roy

    200811 citations

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26. Synthesis of (±)-9-[c-4, t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine (BCA) derivatives branched at the 4′-position based on intramolecular SH2′ cyclization

    H. Kumamoto, N. Takahashi, Tomomi Shimamura, Hiromichi Tanaka +6 more

    200810 citations

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27. An Intramolecular Anionic Migration of a Stannyl Group from the 6-Position of 1-(2-Deoxy-d-erythro-pent-1-enofuranosyl)uracil to the 2′-Position: Synthesis of 2′-Substituted 1′,2′-Unsaturated Uridines

    H. Kumamoto, Satoru Shindoh, Hiromichi Tanaka, Yoshiharu Itoh +6 more

    200010 citations

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28. Synthesis of 4′-substituted 2′-deoxy-4′-thiocytidines and its evaluation for antineoplastic and antiviral activities

    K. Haraguchi, H. Kumamoto, Kiju Konno, Hideki Yagi +5 more

    2019Tetrahedron9 citations

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29. Synthesis of (±)-4′-ethynyl-5′,5′-difluoro-2′,3′-dehydro-3′-deoxy- carbocyclic thymidine: a difluoromethylidene analogue of promising anti-HIV agent Ed4T

    H. Kumamoto, K. Haraguchi, M. Ida, K. Nakamura +5 more

    20099 citations

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30. 5-Exo versus 6-endo cyclization of nucleoside 2-sila-5-hexenyl radicals: reaction of 6-(bromomethyl)dimethylsilyl 1',2'-unsaturated uridines.

    J. Ogamino, H. Mizunuma, H. Kumamoto, Shingo Takeda +4 more

    2005Journal of Organic Chemistry9 citations

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31. Radical-mediated furanose ring reconstruction from 2′,3′-seco-uridine

    H. Kumamoto, J. Ogamino, Hiromichi Tanaka, Hisaki Suzuki +4 more

    20019 citations

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32. A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity

    H. Kumamoto, Misato Fukano, Shuhei Imoto, S. Kohgo +6 more

    2017Nucleosides, Nucleotides & Nucleic Acids7 citations Open access

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33. Synthesis, Anti-HBV, and Anti-HIV Activities of 3'-Halogenated Bis(hydroxymethyl)-cyclopentenyladenines.

    H. Kumamoto, Shuhei Imoto, Masayuki Amano, Nobuyo Kuwata-Higashi +6 more

    2018ACS Medicinal Chemistry Letters6 citations Open access

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34. Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside.

    H. Kumamoto, Sachiko Kawahigashi, Hiromichi Wakabayashi, T. Nakano +8 more

    2012Chemical Communications6 citations Open access

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35. Stannyl migration from the base to the sugar portion of 1′,2′-unsaturated uridine: the first example of substitution at the 2′-position

    H. Kumamoto, Satoru Shindoh, Hiromichi Tanaka, Eisen Gen +3 more

    19986 citations

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36. A New Entry to 2‐Substituted Purine Nucleosides Based on Lithiation‐Mediated Stannyl Transfer of 6‐Chloropurine Nucleosides.

    Keisuke Kato, H. Hayakawa, Hiromichi Tanaka, H. Kumamoto +3 more

    19985 citations

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37. DESIGN, SYNTHESIS, AND EVALUATION OF ANTI-HBV ACTIVITY OF HYBRID MOLECULES OF ENTECAVIR AND ADEFOVIR: EXOMETHYLENE ACYCLOGUANINE NUCLEOSIDES AND THEIR MONOPHOSPHATE DERIVATIVES

    Shuhei Imoto, S. Kohgo, Ryoh Tokuda, H. Kumamoto +5 more

    2015Nucleosides, Nucleotides & Nucleic Acids3 citations Open access

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38. Preparation of Carbocyclic C‐Nucleosides from α‐Chlorooxime Precursor

    Ugo Pradère, H. Kumamoto, Vincent Roy, L. Agrofoglio

    20103 citations

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39. SULFOXIDE-METAL EXCHANGE FOR THE SYNTHESIS OF THE 2′-TRIBUTYLSTANNYL DERIVATIVE OF 2′,3′-DIDEHYDRO-2′,3′-DIDEOXYURIDINE (d4U): A GENERAL ENTRY TO 2′-CARBON-SUBSTITUTED ANALOGUES OF d4U

    H. Kumamoto, Sayoko Onuma, Kumiko Tsuchiya, Yuko Egusa +2 more

    2002Nucleosides, Nucleotides & Nucleic Acids3 citations

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40. New Aspects in the Lithiation Chemistry of Nucleosides : Anionic Migration of Silyl and Stannyl Groups

    H. Kumamoto, Hiromichi Tanaka

    20023 citations Open access

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41. 4-Thiofuranoid Glycal: Versatile Glycosyl Donor for the Selective Synthesis of -anomer of 4'-thionucleoside and its biological activities.

    K. Haraguchi, H. Kumamoto, Hiromichi Tanaka

    2021Current Medicinal Chemistry2 citations

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42. Synthesis and evaluation of the anti-hepatitis B virus activity of 4′-Azido-thymidine analogs and 4′-Azido-2′-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent

    Kengo Onitsuka, Ryoh Tokuda, Nobuyo Kuwata-Higashi, H. Kumamoto +7 more

    2019Nucleosides, Nucleotides & Nucleic Acids2 citations Open access

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43. Frontiers in Clinical Drug Research- HIV

    Atta-ur-Rahman, Benjamin L. Miller, E. Paintsil, H. Kumamoto +20 more

    20152 citations Open access

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44. Next Generation Anti-HIV Agent 4’-Ethynylstavudine: From the Bench to the Clinic

    K. Haraguchi, Shingo Takeda, Yutaka Kubota, H. Kumamoto +6 more

    20152 citations

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45. Synthesis Of Novel 4′-Modified Neplanocin A Analogues And Their Inhibitory Activity Against S-Adenosyl-L-l-Homocysteine Hydrolase

    H. Kumamoto, Kazuki Deguchi, N. Takahashi, Hiromichi Tanaka +1 more

    2007Nucleosides, Nucleotides & Nucleic Acids2 citations

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46. Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

    Vincent Roy, H. Kumamoto, Sabine Berteina‐Raboin, S. Nolan +7 more

    2007Nucleosides, Nucleotides & Nucleic Acids2 citations

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47. Looking for New Pyrimidine Acyclic Nucleotide Analogues Designed for Phosphorylation by Human Ump-Cmp Kinase

    D. Topalis, H. Kumamoto, J. A. C. Alexandre, Laurence Dugué +4 more

    2007Nucleosides, Nucleotides & Nucleic Acids2 citations

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48. 3'-Carbon-Substituted Pyrimidine Nucleosides Having a 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy Structure: Synthesis and Antiviral Evaluation

    H. Kumamoto, Sayoko Onuma, Hiromichi Tanaka, G. Dutschman +1 more

    2006Antiviral Chemistry & Chemotherapy2 citations Open access

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49. Synthesis of carbocyclic analogues of 4'-ethynyl- and 4'-cyano-d4T.

    H. Kumamoto, Keisuke Kato, K. Haraguchi, Hiromichi Tanaka +4 more

    2004Nucleic Acids Symposium Series2 citations Open access

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50. Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent

    H. Kumamoto, Nobuyo Higashi-Kuwata, Sanae Hayashi, D. Das +10 more

    2023RSC Advances1 citations Open access

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