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Nicholas E. Propson · SciRah

Researcher profile · Semantic Scholar

Nicholas E. Propson

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Nicholas E. Propson — researcher profile on SciRah

h-index: 22
Works: 29
Citations: 5,821

Most-cited papers

Chemically defined conditions for human iPS cell derivation and culture
Guokai Chen, Daniel R. Gulbranson, Z. Hou, Jennifer M. Bolin +11 more
2011Nature Methods1,427 citations Open access
Semantic Scholar
Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells
Wei Xie, M. Schultz, R. Lister, Z. Hou +38 more
2013Cell705 citations Open access
Semantic Scholar
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
Z. Hou, Yan Zhang, Nicholas E. Propson, Sara E. Howden +3 more
2013Proceedings of the National Academy of Sciences of the United States of America661 citations Open access
Semantic Scholar
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.
Ethan R. Roy, Bai-Ping Wang, Y. Wan, G. Chiu +12 more
2020Journal of Clinical Investigation465 citations Open access
Semantic Scholar
Complement C3aR inactivation attenuates tau pathology and reverses an immune network deregulated in tauopathy models and Alzheimer’s disease
Alexandra Litvinchuk, Y. Wan, D. Swartzlander, Fa-Ding Chen +6 more
2018Neuron456 citations Open access
Semantic Scholar
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity
Michael P. Schwartz, Z. Hou, Nicholas E. Propson, Jue Zhang +11 more
2015Proceedings of the National Academy of Sciences of the United States of America305 citations Open access
Semantic Scholar
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Bettina van Lengerich, Lihong Zhan, D. Xia, D. Chan +59 more
2023Nature Neuroscience256 citations Open access
Semantic Scholar
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
Ethan R. Roy, G. Chiu, Sanming Li, Nicholas E. Propson +5 more
2022Immunity208 citations Open access
Semantic Scholar
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease
D. Jennings, S. Huntwork-Rodriguez, Anastasia G. Henry, J. Sasaki +35 more
2022Science Translational Medicine204 citations
Semantic Scholar
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Henna Konttinen, Mauricio E. Castro Cabral-da-Silva, S. Ohtonen, S. Wojciechowski +26 more
2019Stem Cell Reports169 citations Open access
Semantic Scholar
Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading
Yin Xu, Nicholas E. Propson, S. Du, Wen Xiong +1 more
2021Proceedings of the National Academy of Sciences of the United States of America145 citations Open access
Semantic Scholar
Endothelial C3a receptor mediates vascular inflammation and BBB permeability during aging.
Nicholas E. Propson, Ethan R. Roy, A. Litvinchuk, J. Köhl +1 more
2020Journal of Clinical Investigation133 citations Open access
Semantic Scholar
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging
Nicholas E. Propson, Ethan R. Roy, Alexandra Litvinchuk, J. Köhl +1 more
2020124 citations
Semantic Scholar
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease
A. Ghosh, Michele M. Comerota, Debin Wan, Fa-Ding Chen +4 more
2020Science Translational Medicine118 citations Open access
Semantic Scholar
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
Jing L. Guo, Dylan Braun, Gabriel A. Fitzgerald, Yun-Ting Hsieh +38 more
2024Cell86 citations Open access
Semantic Scholar
Characterization and target identification of a DNA aptamer that labels pluripotent stem cells
Z. Hou, S. Meyer, Nicholas E. Propson, Jeff Nie +3 more
2015Cell Research77 citations Open access
Semantic Scholar
Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology
Manasee Gedam, Michele M. Comerota, Nicholas E. Propson, Tao Chen +3 more
2023Journal of Clinical Investigation60 citations Open access
Semantic Scholar
MPBind: a Meta-motif-based statistical framework and pipeline to Predict Binding potential of SELEX-derived aptamers
Peng Jiang, S. Meyer, Z. Hou, Nicholas E. Propson +3 more
2014Bioinform.58 citations Open access
Semantic Scholar
Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease.
D. Swartzlander, Nicholas E. Propson, Ethan R. Roy, T. Saito +3 more
2018JCI Insight52 citations Open access
Semantic Scholar
Complement in Neurologic Disease.
Nicholas E. Propson, Manasee Gedam, Hui Zheng
2020Annual Review of Pathology36 citations
Semantic Scholar
Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques
C. Barry, M. Schmitz, Nicholas E. Propson, Z. Hou +11 more
2017Experimental biology and medicine35 citations Open access
Semantic Scholar
Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation
Kyle Friend, Hunter Brooks, Nicholas E. Propson, J. Thomson +1 more
2015PLoS ONE28 citations Open access
Semantic Scholar
Reduction of neuronal activity mediated by blood-vessel regression in the adult brain
Xiao-Fei Gao, Xing-Jun Chen, Meng Ye, Jun-Liszt Li +45 more
2025Nature Communications14 citations Open access
Semantic Scholar
Reduction of neuronal activity mediated by blood-vessel regression in the brain
Xiao-Fei Gao, Jun-Liszt Li, Xingjun Chen, Ci Bo +37 more
2020bioRxiv8 citations Open access
Semantic Scholar
LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome
M. T. Maloney, Xiang Wang, R. Ghosh, Shan V. Andrews +22 more
2022bioRxiv7 citations Open access
Semantic Scholar
Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer’s disease is resolved by a soluble epoxide hydrolase inhibitor
A. Ghosh, Michele M. Comerota, Debin Wan, Fa-Ding Chen +4 more
2020bioRxiv5 citations Open access
Semantic Scholar
Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques
Ethan R. Roy, G. Chiu, Sanming Li, Nicholas E. Propson +2 more
2021bioRxiv0 citations
Semantic Scholar
Human trait of microglia: iPSC-derived microglia in modeling microglial functions.
Henna Konttinen, M. C. Cabral-da-Silva, S. Ohtonen, A. Shakirzyanova +21 more
20190 citations
Semantic Scholar
INCREASED C3 IN THE AGING BRAIN PROMOTES INFLAMMATORY TRANSITION IN ENDOTHELIAL CELLS
Nicholas E. Propson, Alexandra Litvinchuk, Ethan R. Roy, Bianca Contreras +2 more
2019Innovation in aging0 citations Open access
Semantic Scholar

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