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Zhi-Heng He · SciRah

Researcher profile · Semantic Scholar

Zhi-Heng He

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Zhi-Heng He — researcher profile on SciRah

h-index: 30
Works: 88
Citations: 4,077

Most-cited papers

Progranulin is a mediator of the wound response
Zhi-Heng He, C. H. Ong, J. Halper, A. Bateman
2003Nature Medicine495 citations
Semantic Scholar
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis
Zhi-Heng He, A. Bateman
2003Journal of molecular medicine487 citations
Semantic Scholar
Hyperglycemia Promotes Oxidative Stress through Inhibition of Thioredoxin Function by Thioredoxin-interacting Protein*
P. C. Schulze, J. Yoshioka, Tomosaburo Takahashi, Zhi-Heng He +2 more
2004Journal of Biological Chemistry385 citations Open access
Semantic Scholar
Microvascular complications of diabetes.
Zhi-Heng He, G. King
2004Endocrinology and metabolism clinics of North America (Print)202 citations
Semantic Scholar
Biological activities and signaling pathways of the granulin/epithelin precursor.
T. Zanocco-Marani, A. Bateman, G. Romano, B. Valentinis +2 more
1999Cancer Research200 citations
Semantic Scholar
A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKɛ
Deguang Liang, Yuan Gao, Xianzhi Lin, Zhi-Heng He +3 more
2011Cell Research182 citations Open access
Semantic Scholar
Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival.
Zhi-Heng He, A. Ismail, L. Kriazhev, G. Sadvakassova +1 more
2002Cancer Research163 citations
Semantic Scholar
Progranulin (acrogranin/PC cell‐derived growth factor/granulin‐epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development
R. Daniel, E. Daniels, Zhi-Heng He, A. Bateman
2003Developmental Dynamics160 citations
Semantic Scholar
miR-K12-7-5p Encoded by Kaposi's Sarcoma-Associated Herpesvirus Stabilizes the Latent State by Targeting Viral ORF50/RTA
Xianzhi Lin, Deguang Liang, Zhi-Heng He, Q. Deng +2 more
2011PLoS ONE141 citations Open access
Semantic Scholar
A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKK ε
Deguang Liang, Yuan Gao, Xianzhi Lin, Zhi-Heng He +3 more
2011129 citations
Semantic Scholar
Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis*
Zhen Y. Jiang, Zhi-Heng He, Benjamin L. King, T. Kuroki +7 more
2003Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia
Zhi-Heng He, Darren M. Opland, Kerrie J. Way, K. Ueki +8 more
2006Arteriosclerosis, Thrombosis and Vascular Biology90 citations Open access
Semantic Scholar
Molecular targets of diabetic cardiovascular complications.
F. K. Ahmad, Zhi-Heng He, G. King
2005Current Drug Targets80 citations
Semantic Scholar
Differential Regulation of Angiotensin II-induced Expression of Connective Tissue Growth Factor by Protein Kinase C Isoforms in the Myocardium*
Zhi-Heng He, Kerrie J. Way, E. Arikawa, E. Chou +8 more
2005Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Selective Regulation of Heme Oxygenase-1 Expression and Function by Insulin through IRS1/Phosphoinositide 3-Kinase/Akt-2 Pathway*
Pedro M. Geraldes, K. Yagi, Y. Ohshiro, Zhi-Heng He +6 more
2008Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Residual β cell function and monogenic variants in long-duration type 1 diabetes patients.
M. Yu, H. Keenan, Hetal S. Shah, S. G. Frodsham +8 more
2019Journal of Clinical Investigation62 citations Open access
Semantic Scholar
Effects of Insulin Replacements, Inhibitors of Angiotensin, and PKCβ's Actions to Normalize Cardiac Gene Expression and Fuel Metabolism in Diabetic Rats
E. Arikawa, Ronald C. W. Ma, K. Isshiki, I. Luptak +9 more
2007Diabetes60 citations
Semantic Scholar
Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications
Yizhen Xu, Zhi-Heng He, G. King
2005Current Diabetes Reports59 citations
Semantic Scholar
Regulation of progranulin expression in myeloid cells.
C. H. Ong, Zhi-Heng He, L. Kriazhev, Xiaochuan Shan +2 more
2006American Journal of Physiology. Regulatory Integrative and Comparative Physiology51 citations
Semantic Scholar
Two amino acid mutation disrupts RORγt function in Th17 differentiation but not thymocyte development
Zhi-Heng He, Jian Ma, Ruiqing Wang, Jing Zhang +5 more
2017Nature Immunology49 citations Open access
Semantic Scholar
Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1.
Xing Wang, Zhi-Heng He, Tian Xia, Xiaofan Li +4 more
2014Cancer Research49 citations Open access
Semantic Scholar
The N-glycome regulates the endothelial-to-hematopoietic transition
Dionna M. Kasper, Jared Hintzen, Yinyuan Wu, Joey J. Ghersi +13 more
2019Science39 citations Open access
Semantic Scholar
Modulating Notch Signaling to Enhance Neovascularization and Reperfusion in Diabetic Mice
Lan Cao, P. Arany, Jaeyun Kim, José Rivera-Feliciano +5 more
2010Biomaterials39 citations Open access
Semantic Scholar
Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus
Quanyuan Wan, Leah Tavakoli, Ting-Yu Wang, Andrew J Tucker +7 more
2024Nature Communications38 citations Open access
Semantic Scholar
Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
Zhi-Heng He, Jing Zhang, Zhaofeng Huang, Q. Du +4 more
2018Nature Communications38 citations Open access
Semantic Scholar
Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Co-activator Recruitment
Zhi-Heng He, Fei Wang, Jian Ma, S. Sen +4 more
2016Journal of Immunology38 citations Open access
Semantic Scholar
Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases.
Zhi-Heng He, G. King
2004Circulation38 citations Open access
Semantic Scholar
Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Debra L. Rigor, Natalya D. Bodyak, Soochan Bae, Jun-Hyuk Choi +8 more
2009American Journal of Physiology. Heart and Circulatory Physiology32 citations Open access
Semantic Scholar
Murine Gammaherpesvirus 68 Evades Host Cytokine Production via Replication Transactivator-Induced RelA Degradation
Xiao-Nan Dong, Zhi-Heng He, D. Durakoglugil, L. Arneson +2 more
2011Journal of Virology31 citations Open access
Semantic Scholar
SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner
S. Sen, Fei Wang, Jing Zhang, Zhi-Heng He +4 more
2017Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis
Deguang Liang, Hao Hu, Shasha Li, Jiazhen Dong +7 more
2014PLoS Pathogens29 citations Open access
Semantic Scholar
Inhibition of KSHV infected primary effusion lymphomas in NOD/SCID mice by γ-secretase inhibitor
Ke Lan, Masanao Murakami, B. Bajaj, Rajeev Kaul +4 more
2009Cancer Biology & Therapy29 citations Open access
Semantic Scholar
Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
Gang Xue, Xin Li, Muhammad Kalim, Jing Fang +9 more
2024Cancer Cell28 citations Open access
Semantic Scholar
Critical role of PRMT1 in Th17 differentiation by regulating the reciprocal recruitments of STAT3 and STAT5
S. Sen, Zhi-Heng He, Shubhamoy Ghosh, Kenneth J. Dery +3 more
2018Journal of Immunology28 citations Open access
Semantic Scholar
Fine-Tuning of the Kaposi’s Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway
Shasha Li, Hao Hu, Zhi-Heng He, Deguang Liang +2 more
2016PLoS Pathogens27 citations Open access
Semantic Scholar
Regulation of Th17 differentiation by IKKα-dependent and -independent phosphorylation of RORγt
Zhi-Heng He, Fei Wang, Jing Zhang, S. Sen +4 more
2017Journal of Immunology26 citations Open access
Semantic Scholar
Cellular Corepressor TLE2 Inhibits Replication-and-Transcription- Activator-Mediated Transactivation and Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
Zhi-Heng He, Yun-Hua Liu, Deguang Liang, Zhuo Wang +2 more
2009Journal of Virology24 citations Open access
Semantic Scholar
Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells
K. Isshiki, Zhi-Heng He, Yasuhiro Maeno, Ronald C. W. Ma +6 more
2008Kidney International23 citations Open access
Semantic Scholar
Distinct inflammatory Th17 subsets emerge in autoimmunity and infection
Ronald J. Bouch, Jing Zhang, Brandi C. Miller, Caroline J Robbins +10 more
2023Journal of Experimental Medicine22 citations Open access
Semantic Scholar
TCF-1 inhibits IL-17 gene expression to restrain Th17 immunity in a stage specific manner
Jing Zhang, Zhi-Heng He, S. Sen, Fei Wang +2 more
2018Journal of Immunology20 citations Open access
Semantic Scholar
Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-Jκ and Are Responsible for LANA-Mediated RTA Repression
Yi Jin, Zhi-Heng He, Deguang Liang, Quanzhi Zhang +4 more
2012Journal of Virology20 citations Open access
Semantic Scholar
Decoding the mosaic of inflammatory bowel disease: Illuminating insights with single-cell RNA technology
Liang Liu, Benjamin Davidorf, Pei-Xiang Dong, Alice Peng +2 more
2024Computational and Structural Biotechnology Journal18 citations Open access
Semantic Scholar
SRC3 is a co-factor for RORγt in Th17 differentiation but not thymocyte development
Zhi-Heng He, Jing Zhang, Q. Du, Jian-Ming Xu +2 more
2018Journal of Immunology18 citations Open access
Semantic Scholar
Cardiovascular Disease Protection in Long-Duration Type 1 Diabetes and Sex Differences
Zhi-Heng He, S. D’eon, Liane J. Tinsley, Shane Fitzgerald +7 more
2015Diabetes Care18 citations Open access
Semantic Scholar
NF-κB Activation Coordinated by IKKβ and IKKε Enables Latent Infection of Kaposi's Sarcoma-Associated Herpesvirus
Zhi-Heng He, Jun Zhao, Jun-Jie Zhang, Jae U. Jung +1 more
2013Journal of Virology18 citations Open access
Semantic Scholar
Vascular Endothelial Growth Factor–Induced Neovascularization Rescues Cardiac Function But Not Adverse Remodeling at Advanced Ischemic Heart Disease
Oren Gordon, D. Gilon, Zhi-Heng He, Dalit May +3 more
2012Arteriosclerosis, Thrombosis and Vascular Biology15 citations Open access
Semantic Scholar
Decoupling the role of RORγt in the differentiation and effector function of TH17 cells
Xiancai Zhong, Hong-Min Wu, Wen-Can Zhang, Y. Gwack +5 more
2022Science Advances13 citations Open access
Semantic Scholar
Pathogenesis of Diabetic Microvascular Complications
Zhi-Heng He, C. Rask-Madsen, G. King
200413 citations
Semantic Scholar
USP19 suppresses Th17-driven pathogenesis in autoimmunity
Jing Zhang, Ronald J. Bouch, M. Blekhman, Zhi-Heng He
2021Journal of Immunology12 citations Open access
Semantic Scholar
Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients?
Zhi-Heng He, G. King
2005Diabetes Care10 citations
Semantic Scholar

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