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I. Lavrik · SciRah

Researcher profile · Semantic Scholar

I. Lavrik

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I. Lavrik — researcher profile on SciRah

h-index: 37
Works: 113
Citations: 6,271

Most-cited papers

Life and death in peripheral T cells
P. Krammer, R. Arnold, I. Lavrik
2007Nature reviews. Immunology672 citations
Semantic Scholar
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I. Vitale, F. Pietrocola, E. Guilbaud, S. Aaronson +224 more
2023Cell Death and Differentiation346 citations Open access
Semantic Scholar
c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis*
Alexander Golks, D. Brenner, C. Fritsch, P. Krammer +1 more
2005Journal of Biological Chemistry293 citations Open access
Semantic Scholar
Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining.
S. Pietkiewicz, Jörn H. Schmidt, I. Lavrik
2015JIM - Journal of Immunological Methods208 citations
Semantic Scholar
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model.
Kolja Schleich, U. Warnken, Nicolai Fricker, Selcen Oztürk +5 more
2012Molecules and Cells194 citations Open access
Semantic Scholar
The c-FLIP–NH2 terminus (p22-FLIP) induces NF-κB activation
Alexander Golks, D. Brenner, P. Krammer, I. Lavrik
2006Journal of Experimental Medicine186 citations Open access
Semantic Scholar
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL
Nicolai Fricker, Joël Beaudouin, Petra Richter, R. Eils +2 more
2010Journal of Cell Biology172 citations Open access
Semantic Scholar
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells
Leo Neumann, Carina Pforr, Joël Beaudouin, Alexander Pappa +4 more
2010Molecular Systems Biology164 citations Open access
Semantic Scholar
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
Yannick Boege, Mohsen Malehmir, M. E. Healy, K. Bettermann +49 more
2017Cancer Cell147 citations Open access
Semantic Scholar
Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation.
A. V. Zamaraev, G. Kopeina, E. Prokhorova, B. Zhivotovsky +1 more
2017Trends in Cell Biology128 citations
Semantic Scholar
Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions.
Selcen Oztürk, Kolja Schleich, I. Lavrik
2012Experimental Cell Research109 citations
Semantic Scholar
Role of the nucleus in apoptosis: signaling and execution
E. Prokhorova, A. V. Zamaraev, G. Kopeina, B. Zhivotovsky +1 more
2015Cellular and Molecular Life Sciences104 citations
Semantic Scholar
Systems biology of apoptosis signaling networks.
I. Lavrik
2010Current Opinion in Biotechnology99 citations
Semantic Scholar
The E. coli Effector Protein NleF Is a Caspase Inhibitor
S. Blasche, Mario Mörtl, H. Steuber, Gabriella Siszler +9 more
2013PLoS ONE98 citations Open access
Semantic Scholar
Cdk1/Cyclin B1 Controls Fas-Mediated Apoptosis by Regulating Caspase-8 Activity
Y. Matthess, M. Raab, M. Sanhaji, I. Lavrik +1 more
2010Molecular and Cellular Biology97 citations Open access
Semantic Scholar
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes
L. Möhle, N. Israël, K. Paarmann, M. Krohn +11 more
2016Acta Neuropathologica Communications92 citations Open access
Semantic Scholar
Apoptosis regulation by subcellular relocation of caspases
E. Prokhorova, G. Kopeina, I. Lavrik, B. Zhivotovsky
2018Scientific Reports78 citations Open access
Semantic Scholar
Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks.
N. Ivanisenko, K. Seyrek, L. K. Hillert-Richter, Corinna König +3 more
2021Trends in Cancer75 citations
Semantic Scholar
Analysis of CD95 Threshold Signaling
I. Lavrik, Alexander Golks, D. Riess, M. Bentele +2 more
2007Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation
Olga Shatnyeva, A. Kubarenko, Claudia E. M. Weber, Alexander Pappa +4 more
2011PLoS ONE69 citations Open access
Semantic Scholar
Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis.
I. Lavrik, Alexander Golks, Simone Baumann, P. Krammer
2006Blood69 citations Open access
Semantic Scholar
CD95 Stimulation Results in the Formation of a Novel Death Effector Domain Protein-containing Complex*
I. Lavrik, T. Mock, Alexander Golks, Julia C Hoffmann +2 more
2008Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways
K. Seyrek, Max Richter, I. Lavrik
2019Cell Death and Differentiation62 citations Open access
Semantic Scholar
Controlling Cell Death through Post-translational Modifications of DED Proteins.
K. Seyrek, N. Ivanisenko, Max Richter, L. Hillert +2 more
2020Trends in Cell Biology60 citations Open access
Semantic Scholar
Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way
G. Kopeina, E. Prokhorova, I. Lavrik, B. Zhivotovsky
2018Cell Proliferation59 citations Open access
Semantic Scholar
A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 Activation
Julia C Hoffmann, Alexander Pappa, P. Krammer, I. Lavrik
2009Molecular and Cellular Biology54 citations Open access
Semantic Scholar
Understanding apoptosis by systems biology approaches.
I. Lavrik, R. Eils, Nicolai Fricker, Carina Pforr +1 more
2009Molecular Biosystems53 citations
Semantic Scholar
Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death
M. C. Lim, G. Maubach, O. Sokolova, M. Feige +6 more
2017Cell Death and Differentiation52 citations Open access
Semantic Scholar
The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications
N. Ivanisenko, K. Seyrek, N. Kolchanov, V. Ivanisenko +1 more
2020Cell Death Discovery42 citations Open access
Semantic Scholar
Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks
O. Saik, P. Demenkov, T. V. Ivanisenko, E. Bragina +8 more
2018BMC Medical Genomics42 citations Open access
Semantic Scholar
Mathematical modeling of apoptosis
Kolja Schleich, I. Lavrik
2013Cell Communication and Signaling42 citations Open access
Semantic Scholar
Cell death controlling complexes and their potential therapeutic role
A. V. Zamaraev, G. Kopeina, B. Zhivotovsky, I. Lavrik
2015Cellular and Molecular Life Sciences40 citations Open access
Semantic Scholar
Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer
L. Hillert, N. Ivanisenko, Denise Busse, J. Espe +5 more
2020Cell Death and Differentiation38 citations Open access
Semantic Scholar
Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem
O. Saik, V. Nimaev, D. B. Usmonov, P. Demenkov +3 more
2019BMC Medical Genomics34 citations Open access
Semantic Scholar
Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly
L. Hillert, N. Ivanisenko, J. Espe, Corinna König +3 more
2019Oncogene32 citations
Semantic Scholar
Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients
Yuriy V. Shebzukhov, I. Lavrik, J. Karbach, S. Khlgatian +8 more
2008Cancer Immunology and Immunotherapy26 citations Open access
Semantic Scholar
Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network.
S. Pietkiewicz, R. Eils, P. Krammer, N. Giese +1 more
2015Experimental Cell Research25 citations
Semantic Scholar
Quantitative single cell analysis uncovers the life/death decision in CD95 network
Jörn H. Buchbinder, Dennis Pischel, K. Sundmacher, R. Flassig +1 more
2018PLoS Comput. Biol.24 citations Open access
Semantic Scholar
A20 Curtails Primary but Augments Secondary CD8+ T Cell Responses in Intracellular Bacterial Infection
S. Just, G. Nishanth, Jörn H. Buchbinder, Xu Wang +3 more
2016Scientific Reports24 citations Open access
Semantic Scholar
Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks
K. Seyrek, I. Lavrik
2019Apoptosis23 citations
Semantic Scholar
Caspase-2 is a negative regulator of necroptosis.
A. V. Zamaraev, G. Kopeina, Jörn H. Buchbinder, B. Zhivotovsky +1 more
2018International Journal of Biochemistry and Cell Biology23 citations
Semantic Scholar
The chains of death
Kolja Schleich, P. Krammer, I. Lavrik
2013Cell Cycle22 citations Open access
Semantic Scholar
YB-1 Mediates TNF-Induced Pro-Survival Signaling by Regulating NF-κB Activation
Aneri Shah, Carlos Plaza-Sirvent, S. Weinert, Jörn H. Buchbinder +4 more
2020Cancers20 citations Open access
Semantic Scholar
Targeting RIPK1 in AML cells carrying FLT3‐ITD
L. Hillert, Kira Bettermann-Bethge, S. C. Nimmagadda, T. Fischer +2 more
2019International Journal of Cancer19 citations Open access
Semantic Scholar
A guide to automated apoptosis detection: How to make sense of imaging flow cytometry data
Dennis Pischel, Jörn H. Buchbinder, K. Sundmacher, I. Lavrik +1 more
2018PLoS ONE19 citations Open access
Semantic Scholar
Regulation of death receptor-induced apoptosis induced via CD95/Fas and other death receptors
I. Lavrik
2011Molecular Biology19 citations
Semantic Scholar
Quantification of CD95-induced apoptosis and NF-κB activation at the single cell level.
Jörn H. Schmidt, S. Pietkiewicz, M. Naumann, I. Lavrik
2015JIM - Journal of Immunological Methods18 citations
Semantic Scholar
Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain
E. Petrovskiy, O. Saik, E. Tiys, I. Lavrik +2 more
2015BMC Genomics16 citations Open access
Semantic Scholar
Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors
Anastasia V. Bagamanshina, O. Troitskaya, A. Nushtaeva, A. Y. Yunusova +9 more
2019BioMed Research International15 citations Open access
Semantic Scholar
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?
K. Seyrek, Fabian Wohlfromm, J. Espe, I. Lavrik
2022Biochemical Journal14 citations
Semantic Scholar

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P. Krammer×14
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P. Krammer — researcher profile on SciRah
B. Zhivotovsky×7
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G. Kopeina×6
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K. Seyrek×6
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K. Seyrek — researcher profile on SciRah

Jörn H. Buchbinder

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V. Ivanisenko×6

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Alexander Golks×5

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Alexander Golks — researcher profile on SciRah

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R. Eils — researcher profile on SciRah

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L. Hillert — researcher profile on SciRah

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M. Naumann — researcher profile on SciRah

N. Ivanisenko×5

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N. Ivanisenko — researcher profile on SciRah

S. Pietkiewicz×4

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S. Pietkiewicz — researcher profile on SciRah