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A. Kulkarni · SciRah

Researcher profile · Semantic Scholar

A. Kulkarni

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A. Kulkarni — researcher profile on SciRah

h-index: 17
Works: 58
Citations: 656

Most-cited papers

Pendant Polymer:Amino-β-Cyclodextrin:siRNA Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing
A. Kulkarni, Kyle Defrees, S. Hyun, David H. Thompson
2012Journal of the American Chemical Society100 citations Open access
Semantic Scholar
Biosynthesis of albomycin δ2 provides a template for assembling siderophore and aminoacyl-tRNA synthetase inhibitor conjugates
Yu Zeng, A. Kulkarni, Zhao-Yong Yang, Preeti B. Patil +4 more
2012ACS Chemical Biology64 citations Open access
Semantic Scholar
Synthesis of 2-Hydroxypropyl-β-cyclodextrin/Pluronic-Based Polyrotaxanes via Heterogeneous Reaction as Potential Niemann-Pick Type C Therapeutics
Yawo A. Mondjinou, Leslie A. McCauliff, A. Kulkarni, Lake N. Paul +6 more
2013Biomacromolecules49 citations Open access
Semantic Scholar
Cationic α-Cyclodextrin:Poly(ethylene glycol) Polyrotaxanes for siRNA Delivery
A. Kulkarni, Kyle Defrees, Ryan A Schuldt, S. Hyun +4 more
2013Molecular Pharmaceutics42 citations Open access
Semantic Scholar
Development of a Low Toxicity, Effective pDNA Vector Based on Non-covalent Assembly of Bioresponsive Amino-β-Cyclodextrin:Adamantane-Poly(vinyl alcohol)-Poly(ethylene glycol) Transfection Complexes
A. Kulkarni, W. Deng, S. Hyun, David H. Thompson
2012Bioconjugate chemistry39 citations Open access
Semantic Scholar
Gd3+-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-Hydroxypropyl-β-Cyclodextrin/Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent
Zhu-Xian Zhou, Yawo A. Mondjinou, S. Hyun, A. Kulkarni +2 more
2015ACS Applied Materials and Interfaces37 citations Open access
Semantic Scholar
Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion
K. Alpadi, A. Kulkarni, S. Namjoshi, Sankaranarayanan Srinivasan +8 more
2013Nature Communications36 citations Open access
Semantic Scholar
Synthesis, characterization, and evaluation of pluronic-based β-cyclodextrin polyrotaxanes for mobilization of accumulated cholesterol from Niemann-Pick type C fibroblasts.
Christopher J. Collins, Leslie A. McCauliff, S. Hyun, Zhaorui Zhang +6 more
2013Biochemistry31 citations Open access
Semantic Scholar
Multi-armed cationic cyclodextrin:poly(ethylene glycol) polyrotaxanes as efficient gene silencing vectors
A. Kulkarni, Kyle Defrees, Ryan A Schuldt, Alexander C. Vlahu +4 more
2013Integrative Biology25 citations Open access
Semantic Scholar
Mechanistic Insight into Receptor-mediated Delivery of Cationic-β-Cyclodextrin:Hyaluronic Acid-Adamantamethamidyl Host:Guest pDNA Nanoparticles to CD44+ Cells
Vivek D. Badwaik, Linjia Liu, D. Gunasekera, A. Kulkarni +1 more
2016Molecular Pharmaceutics23 citations Open access
Semantic Scholar
A dynamin homolog promotes the transition from hemifusion to content mixing in intracellular membrane fusion
A. Kulkarni, K. Alpadi, Tirupataiah Sirupangi, C. Peters
2014Traffic : the International Journal of Intracellular Transport23 citations Open access
Semantic Scholar
Microfluidic Assembly of Cationic-β-Cyclodextrin:Hyaluronic Acid-Adamantane Host:Guest pDNA Nanoparticles
A. Kulkarni, Ross VerHeul, Kyle Defrees, Christopher J. Collins +3 more
2013Biomaterials Science23 citations Open access
Semantic Scholar
Poly(ethylene glycol)-poly(vinyl alcohol)-adamantanate: synthesis and stimuli-responsive micelle properties
W. Deng, Jing Chen, A. Kulkarni, David H. Thompson
2012Soft Matter23 citations Open access
Semantic Scholar
A Branch Point of Streptomyces Sulfur Amino Acid Metabolism Controls the Production of Albomycin
A. Kulkarni, Yu Zeng, Wei Zhou, S. V. Van Lanen +2 more
2015Applied and Environmental Microbiology22 citations Open access
Semantic Scholar
Sequential Analysis of Trans-SNARE Formation in Intracellular Membrane Fusion
K. Alpadi, A. Kulkarni, V. Comte, M. Reinhardt +4 more
2012PLoS Biology21 citations Open access
Semantic Scholar
Effect of Pendant Group on pDNA Delivery by Cationic-β-Cyclodextrin:Alkyl-PVA-PEG Pendant Polymer Complexes
A. Kulkarni, Vivek D. Badwaik, Kyle Defrees, Ryan A Schuldt +5 more
2013Biomacromolecules20 citations Open access
Semantic Scholar
Effective Targeted Gene Delivery to Dendritic Cells via Synergetic Interaction of Mannosylated Lipid with DOPE and BCAT
Hee-kwon Kim, Huiling Wei, A. Kulkarni, R. Pogranichniy +1 more
2012Biomacromolecules20 citations Open access
Semantic Scholar
Artificial intelligence platform, RADR®, aids in the discovery of DNA damaging agent for the ultra-rare cancer Atypical Teratoid Rhabdoid Tumors
J. McDermott, D. Sturtevant, Umesh Kathad, Sudhir Varma +9 more
2022Frontiers in Drug Discovery10 citations Open access
Semantic Scholar
Efficient pDNA Delivery Using Cationic 2-Hydroxypropyl-β-Cyclodextrin Pluronic Based Polyrotaxanes
Vivek D. Badwaik, Yawo A. Mondjinou, A. Kulkarni, Linjia Liu +2 more
2015Macromolecular Bioscience9 citations Open access
Semantic Scholar
Preclinical efficacy of LP-184, a tumor site activated synthetic lethal therapeutic, in glioblastoma.
B. Lal, A. Kulkarni, J. McDermott, R. Rais +9 more
2023Clinical Cancer Research8 citations
Semantic Scholar
Photoassisted one-step aerosol fabrication of zwitterionic chitosan nanoparticles.
J. Byeon, A. Kulkarni, Hee-kwon Kim, David H. Thompson +1 more
2014Biomacromolecules5 citations
Semantic Scholar
© 2012 Landes Bioscience. Do not distribute. A tethering complex dimer catalyzes trans-SNARE complex formation in intracellular membrane fusion
A. Kulkarni, K. Alpadi, S. Namjoshi, C. Peters
20125 citations
Semantic Scholar
Conditional dependency of LP-184 on prostaglandin reductase 1 is synthetic lethal in pancreatic cancers with DNA damage repair deficiencies.
Diana Restifo, J. McDermott, D. Cvetkovic, Troy Dos Santos +12 more
2023Molecular Cancer Therapeutics4 citations
Semantic Scholar
A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications
Umesh Kathad, A. Kulkarni, J. McDermott, Jordan Wegner +6 more
2021BMC Bioinformatics4 citations Open access
Semantic Scholar
A Novel Inhibitor Of Topoisomerase I is Selectively Toxic For A Subset of Non-Small Cell Lung Cancer Cell Lines
Iryna Zubovych, A. Sethi, A. Kulkarni, V. Tagal +1 more
2015Molecular Cancer Therapeutics4 citations Open access
Semantic Scholar
LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair
Jian-Li Zhou, D. Sturtevant, C. Love, A. Kulkarni +5 more
2023OncoTarget2 citations Open access
Semantic Scholar
The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations
A. Kulkarni, J. McDermott, Umesh Kathad, R. Modali +3 more
2021OncoTarget2 citations Open access
Semantic Scholar
Development of a Potent DNA Damaging Agent LP-284 for Treatment of Mantle Cell Lymphoma
Jian-Li Zhou, A. Kulkarni, C. Love, Lanie Happ +5 more
2022Blood1 citations Open access
Semantic Scholar
Synthetic lethality of LP-184, a next generation acylfulvene, in ex vivo PDX models with homologous recombination defects.
A. Kulkarni, Diana Restifo, I. Astsaturov, Umesh Kathad +3 more
20211 citations
Semantic Scholar
Abstract 2090: Machine learning-derived gene signature predicts strong sensitivity of several solid tumors to the alkylating agent LP-184
Umesh Kathad, A. Kulkarni, Jean-Philippe Richard, T. Lehman +6 more
2020Clinical research1 citations
Semantic Scholar
Development and clinical validation of Lantern Pharma’s AI engine: Response algorithm for drug positioning and rescue (RADR).
Umesh Kathad, Yuvanesh Vedaraju, A. Kulkarni, G. Tobin +1 more
2019Journal of Clinical Oncology1 citations
Semantic Scholar
Characterization of Heat Transfer in Serpentine Passages using Thermochromic Liquid Crystals
A. Kulkarni
20181 citations
Semantic Scholar
Addendum: LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin’s lymphoma models and in cells deficient in DNA damage repair
Jian-Li Zhou, D. Sturtevant, C. Love, A. Kulkarni +5 more
2023OncoTarget0 citations Open access
Semantic Scholar
Abstract P4-01-06: LP-184, an acylfulvene class small molecule therapeutic, is synthetically lethal in HR deficient and PARP inhibitor resistant triple negative breast cancer
A. Kulkarni, Neha Biyani, Laura Brullé-Soumaré, S. Cairo +2 more
2023Cancer Research0 citations
Semantic Scholar
SYST-12 LP-184, A NOVEL ACYLFULVENE-DERIVED TUMOR SITE ACTIVATED SMALL MOLECULE INHIBITS ADULT AND PEDIATRIC CNS TUMOR CELL GROWTH
A. Kulkarni, B. Lal, J. Laterra, Eric Raabe +3 more
2023Neuro-Oncology Advances0 citations Open access
Semantic Scholar
Tumor sensitization to PARP inhibitors by DNA damaging synthetically lethal acylfulvenes.
A. Kulkarni, Jian-Li Zhou, K. Bhatia, Panna Sharma
2023Journal of Clinical Oncology0 citations Open access
Semantic Scholar
Abstract 6241: LP-184, an acylfulvene class small molecule therapeutic, is synthetically lethal in DNA damage repair deficient cancers
A. Kulkarni, Jian-Li Zhou, Neha Biyani, K. Bhatia +1 more
2023Cancer Research0 citations
Semantic Scholar
Glioblastoma response to blood-brain-barrier permeable, MGMT-agnostic therapeutic LP-184 and sensitization by nucleotide-excision repair deficiency.
J. McDermott, B. Lal, H. Lopez-Bertoni, A. Kulkarni +6 more
2022Journal of Clinical Oncology0 citations
Semantic Scholar
Abstract B033: LP-184, a tumor site activated small molecule therapeutic, is synthetically lethal in pancreatic cancers with DNA damage repair defects
A. Kulkarni, Diana Restifo, Troy Dos Santos, D. Cvetkovic +5 more
2022Cancer Research0 citations
Semantic Scholar
EXTH-47. PRECLINICAL EFFICACY OF LP-184, A TUMOR SITE ACTIVATED SYNTHETICALLY LETHAL THERAPEUTIC, IN GLIOBLASTOMA
B. Lal, A. Kulkarni, J. McDermott, H. Lopez-Bertoni +3 more
2022Neuro-Oncology0 citations Open access
Semantic Scholar
The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers
Jian-Li Zhou, Neha Biyani, Umesh Kathad, A. Kulkarni +2 more
2021Blood0 citations Open access
Semantic Scholar
Abstract 1249: LP184, a novel alkylating agent, is efficacious in prostate cancer models with DNA damage repair defects
A. Kulkarni, P. Banerjee, Umesh Kathad, K. Bhatia +1 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract PO-036: LP184, a novel alkylating agent, is highly effective in pancreatic cancers with DNA damage repair defects
Diana Restifo, A. Kulkarni, Caleb Schimke, J. McDermott +4 more
2021Other Topics0 citations
Semantic Scholar
Correlation of gene expression profile to identify tumors with extreme sensitivity to the alkylating agent LP184.
Umesh Kathad, A. Kulkarni, K. Bhatia, K. Barnhart +1 more
20200 citations
Semantic Scholar
LP-300 as a potential first-in-class combination agent with tyrosine kinase inhibitors (TKIs) in non-smoker lung adenocarcinoma.
A. Kulkarni, Aulma R. Parker, K. Jair, P. Petluru +7 more
20200 citations
Semantic Scholar
Abstract 4185: LP-184, a molecule with nanomolar potency, exhibits strong activity in lung cancers with KEAP1 and KRAS mutations
A. Kulkarni, Jean-Philippe Richard, Umesh Kathad, M. Seddon +3 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 672: Establishment of a drug-tumor interaction database using Lantern Pharma’s Response Algorithm for Drug Positioning and Rescue (RADRTM)
Umesh Kathad, Yuvanesh Vedaraju, A. Kulkarni, B. Henderson +3 more
2019Bioinformatics, Convergence Science, and Systems Biology0 citations
Semantic Scholar
Abstract 4014: Clinical validation of Lantern Pharma’s Response Algorithm for Drug Positioning and Rescue (RADRTM)
Yuvanesh Vedaraju, Umesh Kathad, A. Kulkarni, B. Henderson +3 more
2019Clinical research0 citations
Semantic Scholar
Abstract 4789: Predicting sensitivity to Lantern Pharma’s pipeline drug candidate LP-184 using the Response Algorithm for Drug Positioning and Rescue
A. Kulkarni, Umesh Kathad, Yuvanesh Vedaraju, B. Henderson +3 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Advances in Ex vivo Cell Screening Methodologies for Clinical Therapy Guidance to Leukemic Patients
A. Kulkarni
2018Developments in Clinical & Medical Pathology0 citations Open access
Semantic Scholar

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Panna Sharma×21
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Panna Sharma — researcher profile on SciRah
Umesh Kathad×20
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Umesh Kathad — researcher profile on SciRah
K. Bhatia×16
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K. Bhatia — researcher profile on SciRah
David H. Thompson×14
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David H. Thompson — researcher profile on SciRah

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Jian-Li Zhou×9

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Jian-Li Zhou — researcher profile on SciRah

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Neha Biyani — researcher profile on SciRah

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S. Hyun — researcher profile on SciRah

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K. Bhatia — researcher profile on SciRah

Kyle Defrees×5

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Kyle Defrees — researcher profile on SciRah

Ryan A Schuldt×4

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Ryan A Schuldt — researcher profile on SciRah

Ross VerHeul×4

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