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T. Otsuka · SciRah

Researcher profile · Semantic Scholar

T. Otsuka

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T. Otsuka — researcher profile on SciRah

h-index: 29
Works: 67
Citations: 3,620

Most-cited papers

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.
T. Yokota, T. Otsuka, T. Mosmann, J. Banchereau +5 more
1986Proceedings of the National Academy of Sciences of the United States of America483 citations Open access
Semantic Scholar
Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.
Frank X. Lee, T. Yokota, T. Otsuka, P. Meyerson +6 more
1986Proceedings of the National Academy of Sciences of the United States of America470 citations Open access
Semantic Scholar
Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.
Frank S. Lee, Takashi Yokota, T. Otsuka, L. Gemmell +4 more
1985Proceedings of the National Academy of Sciences of the United States of America234 citations Open access
Semantic Scholar
Structure of the chromosomal gene for granulocyte‐macrophage colony stimulating factor: comparison of the mouse and human genes.
S. Miyatake, T. Otsuka, T. Yokota, F. Lee +1 more
1985EMBO Journal204 citations Open access
Semantic Scholar
Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils.
H. Niiro, T. Otsuka, K. Izuhara, K. Yamaoka +7 more
1997Blood177 citations Open access
Semantic Scholar
Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population.
Saifuddin Ahmed, K. Ihara, S. Kanemitsu, H. Nakashima +4 more
2001Rheumatology162 citations
Semantic Scholar
Association between IL-4 genotype and IL-4 production in the Japanese population
H. Nakashima, K. Miyake, Y. Inoue, S. Shimizu +4 more
2002Genes and Immunity152 citations Open access
Semantic Scholar
Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis.
Chika Morita, T. Horiuchi, H. Tsukamoto, N. Hatta +7 more
2001Arthritis & Rheumatism131 citations Open access
Semantic Scholar
Leflunomide-induced interstitial lung disease: prevalence and risk factors in Japanese patients with rheumatoid arthritis.
T. Sawada, S. Inokuma, Takeo Sato, T. Otsuka +5 more
2009Rheumatology123 citations Open access
Semantic Scholar
A functional polymorphism in fas (CD95/APO-1) gene promoter associated with systemic lupus erythematosus.
S. Kanemitsu, K. Ihara, Ahmed Saifddin, T. Otsuka +4 more
2002Journal of Rheumatology123 citations
Semantic Scholar
Effects of recombinant human interleukin-3 on CD34-enriched normal hematopoietic progenitors and on myeloblastic leukemia cells.
S. Saeland, C. Caux, C. Favre, J. Aubry +6 more
1988Blood122 citations
Semantic Scholar
Influence of interleukin-12 receptor β1 polymorphisms on tuberculosis
M. Akahoshi, H. Nakashima, K. Miyake, Y. Inoue +5 more
2003Human Genetics113 citations
Semantic Scholar
Interleukin‐10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast‐like cells in rat bone marrow culture system
Li-Xin Xu, T. Kukita, A. Kukita, T. Otsuka +2 more
1995Journal of Cellular Physiology102 citations
Semantic Scholar
Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients (*)
K. Izuhara, T. Heike, T. Otsuka, Kunihiro Yamaoka +4 more
1996Journal of Biological Chemistry100 citations Open access
Semantic Scholar
Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.
T. Otsuka, A. Miyajima, N. Brown, K. Otsu +6 more
1988Journal of Immunology94 citations Open access
Semantic Scholar
Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities
T. Otsuka, D. Villaret, T. Yokota, Y. Takebe +3 more
1987Nucleic Acids Res.77 citations Open access
Semantic Scholar
The combination of polymorphisms within interferon‐γ receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus
H. Nakashima, H. Inoue, M. Akahoshi, Yosuke Tanaka +7 more
1999FEBS Letters67 citations
Semantic Scholar
A Phase I-II Trial of Autologous Peripheral Blood Stem Cell Transplantation in the Treatment of Refractory Autoimmune Disease
H. Tsukamoto, K. Nagafuji, T. Horiuchi, T. Miyamoto +13 more
200565 citations
Semantic Scholar
Effect of IL-10 on collagen-induced arthritis in mice
Yoshihiro Tanaka, T. Otsuka, T. Hotokebuchi, H. Miyahara +5 more
1996Inflammation Research63 citations
Semantic Scholar
Role of IL-10 in the Crossregulation of Prostaglandins and Cytokines in Monocytes
Y. Niho, H. Niiro, Yosuke Tanaka, H. Nakashima +1 more
1998Acta Haematologica57 citations
Semantic Scholar
Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines.
S. Nagano, T. Otsuka, H. Niiro, K. Yamaoka +8 more
2002International Immunology55 citations Open access
Semantic Scholar
Impact of interferon-gamma and interleukin-4 gene polymorphisms on development and progression of IgA nephropathy in Japanese patients.
Kohsuke Masutani, K. Miyake, H. Nakashima, T. Hirano +8 more
2003American Journal of Kidney Diseases54 citations
Semantic Scholar
Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate
Y. Nakashima, M. Kondo, H. Harada, T. Horiuchi +13 more
2010Modern Rheumatology51 citations
Semantic Scholar
Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis.
Takeo Sato, S. Inokuma, A. Sagawa, T. Matsuda +5 more
2009Rheumatology45 citations
Semantic Scholar
Complete nucleotide sequence of the 26S rRNA gene of Physarum polycephalum: its significance in gene evolution.
T. Otsuka, Hisayuki Nomiyama, Hideaki Yoshida, T. Kukita +2 more
1983Proceedings of the National Academy of Sciences of the United States of America44 citations Open access
Semantic Scholar
Levels of human serum granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor under pathological conditions
Fusayuki Omori, S. Okamura, K. Shimoda, T. Otsuka +2 more
1992Biotherapy43 citations
Semantic Scholar
MPO-ANCA-positive Wegener’s granulomatosis presenting with hypertrophic cranial pachymeningitis: case report and review of the literature
M. Akahoshi, Goichi Yoshimoto, H. Nakashima, K. Miyake +6 more
2004Modern Rheumatology39 citations Open access
Semantic Scholar
Nucleotide sequence of the ribosomal RNA gene of Physarum polycephalum: intron 2 and its flanking regions of the 26S rRNA gene.
Hisayuki Nomiyama, S. Kuhara, T. Kukita, T. Otsuka +1 more
1981Nucleic Acids Research32 citations Open access
Semantic Scholar
Novel Regulatory Mechanisms of CD40-Induced Prostanoid Synthesis by IL-4 and IL-10 in Human Monocytes
Y. Inoue, T. Otsuka, H. Niiro, S. Nagano +8 more
2004Journal of Immunology31 citations
Semantic Scholar
Remission in patients with active rheumatoid arthritis by tocilizumab treatment in routine clinical practice: results from 3 years of prospectively registered data
Y. Nakashima, M. Kondo, T. Fukuda, H. Harada +18 more
2014Modern Rheumatology21 citations
Semantic Scholar
Usefulness of Endoscopic Managements in Patients with Ceftriaxone-Induced Pseudolithiasis Causing Biliary Obstruction
Yasuhiro Doi, Yasushi Takii, Hiroyuki Ito, Norihiko Jingu +7 more
2017Case Reports in Medicine10 citations Open access
Semantic Scholar
Detection of polymorphisms within the human IL10 receptor cDNA gene sequence by RT-PCR RFLP
Yosuke Tanaka, H. Nakashima, T. Otsuka, Y. Nemoto +7 more
1997Immunogenetics10 citations
Semantic Scholar
Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease
T. Otsuka, Takako Koyama, Ryoko Ohtani, H. Niiro +3 more
2008Modern Rheumatology9 citations
Semantic Scholar
Expression of the c‐kit ligand and interleukin 6 genes in mouse bone marrow stromal cell lines
T. Otsuka, Tomonori Ogo, T. Nakano, H. Niiro +5 more
1994Stem Cells7 citations
Semantic Scholar
Reconstitution of HLA-A*2402-Restricted Cytomegalovirus-Specific T-Cells Following Stem Cell Transplantation
H. Gondo, D. Himeji, K. Kamezaki, A. Numata +22 more
2004International journal of hematology6 citations
Semantic Scholar
Systemic vasculitis associated with α1-antitrypsin deficiency
Yasushi Takii, H. Inoue, Eiji Karashima, M. Akahoshi +11 more
20035 citations Open access
Semantic Scholar
Nucleotide sequence of Physarum polycephalum 5.8S rRNA gene and its flanking regions.
T. Otsuka, Hisayuki Nomiyania, Yoshiyuki Sakaki, Yasuyuki Takagi
1982Nucleic Acids Research5 citations Open access
Semantic Scholar
Structure around the 3' terminus of the 26S ribosomal RNA gene of Physarum polycephalum.
Kukita Toshio, Yoshiyuki Sakaki, Nomiyama Hisayuki, T. Otsuka +2 more
19815 citations
Semantic Scholar
Association between IFNA genotype and the risk of systemic lupus erythematosus
H. Nakashima, Sawa Matsuno, M. Akahoshi, K. Miyake +8 more
2005Clinical Rheumatology4 citations
Semantic Scholar
Suppression of joint destruction with subcutaneous tocilizumab for Japanese patients with rheumatoid arthritis in clinical practice
Y. Nakashima, M. Kondo, Eisuke Shono, T. Ishinishi +19 more
2020Modern Rheumatology3 citations
Semantic Scholar
Remission in patients with active rheumatoid arthritis by tocilizumab treatment in routine clinical practice: results from 3 years of prospectively registered data
Y. Nakashima, M. Kondo, T. Fukuda, H. Harada +18 more
2013Modern Rheumatology3 citations
Semantic Scholar
Isolation and characterization of mouse and human interleukin il 4 genes that express b cell t cell and mast cell stimulating activities
T. Yokota, T. Otsuka, Y. Takebe, T. Mosmann +5 more
19873 citations
Semantic Scholar
Isolation and Characterization of Mouse and Human cDNA Clones Encoding IL-4 and IgA-Enhancing Factor/Eosinophil CSF (IL-5)
T. Yokota, H. Hagiwara, Y. Takebe, T. Otsuka +13 more
19873 citations
Semantic Scholar
Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production
Hisakata Yamada, T. Tsuru, T. Otsuka, M. Maekawa +11 more
2020Immunological Medicine2 citations Open access
Semantic Scholar
Systemic vasculitis associated with alphal-antitrypsin deficiency.
Yasushi Takii, H. Inoue, Eiji Karashima, M. Akahoshi +11 more
2003Internal medicine2 citations
Semantic Scholar
Characterization of proliferating cells in transient abnormal myelopoiesis: ultrastructural and immunocytochemical study.
Akira Shibata, Tadashi Koike, Sadao Aoki, Souichi Maruyama +2 more
1987The Keio Journal of Medicine2 citations Open access
Semantic Scholar
Th1/Th2 balance of the peripheral helper T cells in systemic lupus erythematosus
M. Akahoshi, H. Nakashima, Yosuke Tanaka, S. Nagano +11 more
19991 citations
Semantic Scholar
MonocytesColony-Stimulating Factor Production in Human Through Granulocyte-Macrophage Activation of STAT5 by Lipopolysaccharide
K. Yamaoka, T. Otsuka, H. Niiro, Y. Arinobu +3 more
19981 citations
Semantic Scholar
[Immunodeficiency and carcinogenesis in patients with chronic active Epstein-Barr virus infection].
S. Nagafuchi, T. Fujisaki, K. Ohshima, K. Anzai +6 more
1997Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases1 citations Open access
Semantic Scholar
High incidence of a polymorphic variant of erythrocyte membrane protein, Band 3-Memphis, on a western Japanese island
K. Izuhara, H. Ideguchi, T. Otsuka, K. Okubo +3 more
1995The Japanese Journal of Human Genetics1 citations
Semantic Scholar

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Y. Niho×14
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K. Miyake — researcher profile on SciRah

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