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I. Hollander · SciRah

Researcher profile · Semantic Scholar

I. Hollander

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I. Hollander — researcher profile on SciRah

h-index: 29
Works: 54
Citations: 2,798

Most-cited papers

Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia.
P. Hamann, L. Hinman, I. Hollander, C. Beyer +9 more
2002Bioconjugate chemistry559 citations
Semantic Scholar
Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.
A. Venkatesan, Christoph M. Dehnhardt, Efren Delos-Santos, Ze-Cheng Chen +13 more
2010Journal of Medicinal Chemistry215 citations Open access
Semantic Scholar
Adenomyoepithelioma of the Breast: A Spectrum of Biologic Behavior
J. Loose, A. Patchefsky, I. Hollander, Linda Lavin +2 more
1992American Journal of Surgical Pathology188 citations
Semantic Scholar
Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor
Robert Mallon, Larry R. Feldberg, J. Lucas, I. Chaudhary +7 more
2011Clinical Cancer Research178 citations Open access
Semantic Scholar
Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis.
Frédéric Marion, David E. Williams, B. Patrick, I. Hollander +6 more
2006Organic Letters134 citations
Semantic Scholar
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785).
Carolyn M. Discafani, M. L. Carroll, M. Floyd, I. Hollander +11 more
1999Biochemical Pharmacology101 citations
Semantic Scholar
ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines.
A. Zask, J. Verheijen, K. Curran, Joshua A. Kaplan +15 more
2009Journal of Medicinal Chemistry94 citations Open access
Semantic Scholar
Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors.
A. Zask, Joshua A. Kaplan, J. Verheijen, David J. Richard +7 more
2009Journal of Medicinal Chemistry90 citations Open access
Semantic Scholar
Matrix-assisted UV-laser desorption/ionization mass spectrometric analysis of monoclonal antibodies for the determination of carbohydrate, conjugated chelator, and conjugated drug content.
M. Siegel, I. Hollander, P. Hamann, J. P. James +6 more
1991Analytical Chemistry75 citations
Semantic Scholar
Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.
Christoph M. Dehnhardt, A. Venkatesan, Efren Delos-Santos, Ze-Cheng Chen +12 more
2010Journal of Medicinal Chemistry72 citations Open access
Semantic Scholar
Selection of reaction additives used in the preparation of monomeric antibody-calicheamicin conjugates.
I. Hollander, Arthur Kunz, P. Hamann
2008Bioconjugate chemistry71 citations
Semantic Scholar
Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor
Robert Mallon, I. Hollander, Larry R. Feldberg, J. Lucas +8 more
2010Molecular Cancer Therapeutics67 citations Open access
Semantic Scholar
PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.
A. Venkatesan, Ze-Cheng Chen, O. dos Santos, Christoph M. Dehnhardt +9 more
2010Bioorganic & Medicinal Chemistry Letters65 citations Open access
Semantic Scholar
Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent.
K. Curran, J. Verheijen, Joshua A. Kaplan, David J. Richard +6 more
2010Bioorganic & Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
Calicheamicin derivatives conjugated to monoclonal antibodies: determination of loading values and distributions by infrared and UV matrix-assisted laser desorption/ionization mass spectrometry and electrospray ionization mass spectrometry.
M. Siegel, K. Tabei, A. Kunz, I. Hollander +4 more
1997Analytical Chemistry56 citations
Semantic Scholar
Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.
J. Verheijen, David J. Richard, K. Curran, Joshua A. Kaplan +12 more
2009Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors.
Ze-Cheng Chen, A. Venkatesan, Christoph M. Dehnhardt, S. Ayral-Kaloustian +8 more
2010Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.
P. Nowak, D. Cole, N. Brooijmans, M. Bursavich +12 more
2009Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Joshua A. Kaplan, J. Verheijen, N. Brooijmans, L. Toral‐Barza +3 more
2010Bioorganic & Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal.
Albán R. Pereira, W. Strangman, Frédéric Marion, Larry R. Feldberg +4 more
2010Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: discovery of highly potent and selective analogs with improved human microsomal stability.
David J. Richard, J. Verheijen, K. Curran, Joshua A. Kaplan +5 more
2009Bioorganic & Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Hwei-Ru Tsou, G. Macewan, G. Birnberg, G. Grosu +8 more
2010Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides.
I. Hollander, Eileen Frommer, Robert Mallon
2000Analytical Biochemistry39 citations
Semantic Scholar
Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors.
A. Zask, J. Verheijen, David J. Richard, Joshua A. Kaplan +5 more
2010Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
A. Gilbert, P. Nowak, N. Brooijmans, M. Bursavich +9 more
2010Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.
J. Verheijen, Ker Yu, L. Toral‐Barza, I. Hollander +1 more
2010Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.
Christoph M. Dehnhardt, A. Venkatesan, Ze-Cheng Chen, Efren Delos-Santos +7 more
2011Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Novel sesterterpenoid and norsesterterpenoid RCE-protease inhibitors isolated from the marine sponge Hippospongia sp.
Kyle S. Craig, David E. Williams, I. Hollander, Eileen Frommer +6 more
200233 citations
Semantic Scholar
Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.
David E. Williams, I. Hollander, Larry R. Feldberg, Eileen Frommer +4 more
2009Journal of Natural Products32 citations Open access
Semantic Scholar
Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies.
M. Bursavich, N. Brooijmans, Larry R. Feldberg, I. Hollander +5 more
2010Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.
A. Zask, Joshua A. Kaplan, L. Toral‐Barza, I. Hollander +6 more
2008Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.
A. Venkatesan, Christoph M. Dehnhardt, Ze-Cheng Chen, E. D. Santos +15 more
2010Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
An enzyme-linked immunosorbent assay for the Raf/MEK1/MAPK signaling cascade.
Robert Mallon, Larry R. Feldberg, Steven C. Kim, Karen C. Collins +4 more
2001Analytical Biochemistry23 citations
Semantic Scholar
5-ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer.
N. Zhang, S. Ayral-Kaloustian, James T. Anderson, Thai Nguyen +7 more
2010Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Hwei-Ru Tsou, G. Macewan, G. Birnberg, Nan Zhang +5 more
2010Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Enzymatic Synthesis of a Sulfur-Analog of Penicillin Using the “cyclase” of Cephalosporium Acremonium
S. Wolfe, I. Hollander, A. Demain
1984Bio/Technology18 citations
Semantic Scholar
Liphagal, a Selective Inhibitor of PI3 Kinase ά Isolated from the Sponge Aka coralliphaga: Structure Elucidation and Biomimetic Synthesis
Frédéric Marion, David E. Williams, B. Patrick, I. Hollander +6 more
200614 citations
Semantic Scholar
Liquid secondary ion mass spectrometric analysis of natural and recombinant proteins and monoclonal antibody light chains with molecular weights between 16 000 and 25 000
M. Siegel, R. Tsao, V. Doelling, I. Hollander
199013 citations
Semantic Scholar
Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides.
I. Hollander, Eileen Frommer, A. Aulabaugh, Robert Mallon
2003Biochimica et Biophysica Acta12 citations
Semantic Scholar
Determination of the loading values for high levels of drugs and sugars conjugated to proteins by matrix‐assisted ultraviolet laser desorption/ionization mass spectrometry
M. Siegel, Hwei-Ru Tsou, Bai-Wei Lin, I. Hollander +4 more
199311 citations
Semantic Scholar
A directly labeled TR-FRET assay for monitoring phosphoinositide-3-kinase activity.
Xiaoke Yang, Puyao Li, Larry R. Feldberg, Steven C. Kim +4 more
2006Combinatorial chemistry & high throughput screening10 citations
Semantic Scholar
Delivery of Tenofovir to the Brain by Novel Nano-Vesicles for the Treatment of Neuro-HIV (S10.003)
E. Heldman, C. Linder, S. Grinberg, M. Popov +1 more
2014Neurology2 citations
Semantic Scholar
Abstract B145: Highly selective pyrazolopyrimidine mTOR inhibitors with profound in vivo antitumor activity
A. Zask, Joshua A. Kaplan, K. Curran, J. Verheijen +11 more
20092 citations
Semantic Scholar
Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor
A. Venkatesan, Christoph M. Dehnhardt, E. D. Santos, Ze-Cheng Chen +12 more
20101 citations
Semantic Scholar
Liphagal, a new meroterpenoid from the Caribbean sponge Aka coralliphaga that shows potent and selective inhibition of P13 kinase alpha.
I. Hollander, Frédéric Marion, David E. Williams, Robert Mallon +5 more
20061 citations
Semantic Scholar
Delivery of GDNF to the Brain by Novel Nanovesicles for the Treatment of Parkinson’s Disease (P6.082)
E. Heldman, S. Grinberg, C. Linder, M. Popov +1 more
2014Neurology0 citations
Semantic Scholar
Cancer Therapy : Preclinical Antitumor Efficacy of PKI-587 , a Highly Potent Dual PI 3 K / mTOR Kinase Inhibitor
Robert Mallon, Larry R. Feldberg, J. Lucas, I. Chaudhary +7 more
20110 citations
Semantic Scholar
165 POSTER Furan ring-opened 17-hydroxywortmannin analogs as phcsphoinositide 3-kinase inhibitors active in human tumor xenograft models
A. Zask, Joshua A. Kaplan, J. Lucas, I. Hollander +4 more
20060 citations
Semantic Scholar
Methods for preparing monomeric calicheamicin derivative conjugates / carrier.
M. Kunstmann, I. Hollander, P. Hamann, Arthur Kunz
19960 citations
Semantic Scholar
Conjugates of methyltrithio antitumor agents and intermediates for their preparation
P. Hamann, L. Hinman, I. Hollander, Ryan C. Holcomb +3 more
19950 citations
Semantic Scholar

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Robert Mallon — researcher profile on SciRah
Ker Yu×21
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Ker Yu — researcher profile on SciRah
S. Ayral-Kaloustian×19
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S. Ayral-Kaloustian — researcher profile on SciRah
Larry R. Feldberg×19
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J. Lucas — researcher profile on SciRah

N. Brooijmans×17

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N. Brooijmans — researcher profile on SciRah

L. Toral‐Barza×13

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L. Toral‐Barza — researcher profile on SciRah

A. Venkatesan×12

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A. Venkatesan — researcher profile on SciRah

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A. Zask — researcher profile on SciRah

Christoph M. Dehnhardt×11

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Christoph M. Dehnhardt — researcher profile on SciRah

Joshua A. Kaplan×11

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Joshua A. Kaplan — researcher profile on SciRah

Ze-Cheng Chen×10

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Ze-Cheng Chen — researcher profile on SciRah