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M. Lockley · SciRah

Researcher profile · Semantic Scholar

M. Lockley

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M. Lockley — researcher profile on SciRah

h-index: 28
Works: 110
Citations: 3,132

Most-cited papers

Copy-number signatures and mutational processes in ovarian carcinoma
G. Macintyre, T. Goranova, D. De Silva, D. Ennis +35 more
2017Nature Genetics407 citations Open access
Semantic Scholar
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers
O. Pearce, Robin M. Delaine-Smith, E. Maniati, S. Nichols +21 more
2017Cancer Discovery299 citations Open access
Semantic Scholar
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Steffen Böhm, A. Faruqi, I. Said, M. Lockley +11 more
2015Journal of Clinical Oncology268 citations
Semantic Scholar
CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma
J. Walton, J. Blagih, D. Ennis, E. Leung +13 more
2016Cancer Research203 citations Open access
Semantic Scholar
A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases
A. Montfort, O. Pearce, E. Maniati, B. Vincent +12 more
2016Clinical Cancer Research203 citations Open access
Semantic Scholar
Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma
Steffen Böhm, A. Montfort, O. Pearce, J. Topping +15 more
2016Clinical Cancer Research143 citations
Semantic Scholar
Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data.
P. Cohen, A. Powell, Steffen Böhm, C. Gilks +86 more
2019Gynecologic Oncology110 citations Open access
Semantic Scholar
Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis
E. H. Puttock, E. Tyler, M. Manni, E. Maniati +16 more
2023Nature Communications93 citations Open access
Semantic Scholar
A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice
C. Newton, K. Murali, A. Ahmad, H. Hockings +9 more
2019European Journal of Cancer63 citations Open access
Semantic Scholar
The peritoneal tumour microenvironment of high-grade serous ovarian cancer
D. Andrew Leinster, H. Kulbe, Gemma Everitt, Richard G. Thompson +9 more
2012Journal of Pathology58 citations Open access
Semantic Scholar
The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma
Philip Smith, T. Bradley, Lena Morrill Gavarró, T. Goranova +32 more
2023Nature Communications55 citations Open access
Semantic Scholar
Mainstreamed genetic testing for women with ovarian cancer: first-year experience
B. Rahman, A. Lanceley, R. Kristeleit, J. Ledermann +4 more
2018Journal of Medical Genetics54 citations Open access
Semantic Scholar
Adaptive immunity in cancer immunology and therapeutics
Emma Spurrell, M. Lockley
2014ecancermedicalscience54 citations Open access
Semantic Scholar
Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials.
R. Brais, S. Davies, M. O'Donovan, B. Simpson +15 more
2012Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]54 citations
Semantic Scholar
Objective responses to first-line neoadjuvant carboplatin−paclitaxel regimens for ovarian, fallopian tube, or primary peritoneal carcinoma (ICON8): post-hoc exploratory analysis of a randomised, phase 3 trial
R. Morgan, I. McNeish, A. Cook, E. James +22 more
2020The Lancet Oncology53 citations Open access
Semantic Scholar
Implementation of Multigene Germline and Parallel Somatic Genetic Testing in Epithelial Ovarian Cancer: SIGNPOST Study
D. Chandrasekaran, Monika Sobočan, O. Blyuss, Rowan E. Miller +30 more
2021Cancers51 citations Open access
Semantic Scholar
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
Abbie E. Fearon, Edward P. Carter, N. Clayton, E. Wilkes +15 more
2018Cell Reports48 citations Open access
Semantic Scholar
The genomic landscape of early stage ovarian high grade serous carcinoma
Z. Cheng, H. Mirza, D. Ennis, P. Smith +16 more
2021bioRxiv43 citations Open access
Semantic Scholar
Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in vitro and in vivo.
A. Young, Kyra M. Archibald, L. Tookman, Alexandra Pool +7 more
2012Molecular Therapy39 citations Open access
Semantic Scholar
A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion
Beatrice Malacrida, S. Nichols, E. Maniati, R. Jones +10 more
2021iScience35 citations Open access
Semantic Scholar
Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.
C. Connell, A. Shibata, L. Tookman, Kyra M. Archibald +5 more
2011Journal of Clinical Investigation35 citations Open access
Semantic Scholar
Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control
Carin K. Ingemarsdotter, L. Tookman, Ashley K. Browne, K. Pirlo +13 more
2015Molecular Oncology33 citations Open access
Semantic Scholar
Adolescent and Young Adult Germ Cell Tumors: Epidemiology, Genomics, Treatment, and Survivorship
L. B. Travis, D. Feldman, C. Fung, J. Poynter +2 more
2023Journal of Clinical Oncology32 citations
Semantic Scholar
Histopathologic response to neoadjuvant chemotherapy as a prognostic biomarker in tubo-ovarian high-grade serous carcinoma: updated Chemotherapy Response Score (CRS) results
Steffen Böhm, N. Le, M. Lockley, E. Brockbank +6 more
2019International Journal of Gynecologic Cancer32 citations Open access
Semantic Scholar
Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer
D. A. Leinster, B. Colom, J. Whiteford, D. Ennis +7 more
2013The FASEB Journal28 citations Open access
Semantic Scholar
Ovarian cancer in adolescents and young adults
M. Lockley, S. Stoneham, T. Olson
2018Pediatric Blood & Cancer27 citations
Semantic Scholar
Ovarian germ cell tumour classification: views from the testis
D. Berney, S. Stoneham, R. Arora, J. Shamash +1 more
2020Histopathology25 citations
Semantic Scholar
Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
H. Hockings, Eszter Lakatos, Wei-Ni Huang, M. Mossner +7 more
2025Cancer Research23 citations Open access
Semantic Scholar
Single-agent carboplatin AUC10 in metastatic seminoma: A multi-centre UK study of 216 patients.
C. Alifrangis, Anand Sharma, Shafi Chowdhury, S. Duncan +12 more
2020European Journal of Cancer23 citations
Semantic Scholar
A comparison of p53 and WT1 immunohistochemical expression patterns in tubo‐ovarian high‐grade serous carcinoma before and after neoadjuvant chemotherapy
Laura Casey, M. Köbel, R. Ganesan, Simone Tam +8 more
2017Histopathology23 citations
Semantic Scholar
Inhibition of the inflammatory cytokine TNF-α increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression.
Michael A. Salako, H. Kulbe, Carin K. Ingemarsdotter, K. Pirlo +4 more
2011Molecular Therapy23 citations Open access
Semantic Scholar
Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference.
F. Pashankar, Krisztina Z. Hanley, M. Lockley, S. Stoneham +15 more
2022European Journal of Cancer21 citations
Semantic Scholar
Venous thromboembolism in women with ovarian cancer undergoing neoadjuvant chemotherapy prior to cytoreductive surgery: A retrospective study
S. Oxley, Y. Achampong, N. Sambandan, D. Hughes +3 more
2021Acta Obstetricia et Gynecologica Scandinavica19 citations Open access
Semantic Scholar
Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma—experience of the BriTROC consortium
T. Goranova, D. Ennis, A. Piskorz, G. Macintyre +23 more
2017British Journal of Cancer19 citations Open access
Semantic Scholar
RAD51 and BRCA2 enhance oncolytic adenovirus type 5 activity in ovarian cancer
L. Tookman, Ashley K. Browne, C. Connell, Gemma Bridge +6 more
2015Molecular Cancer Research18 citations Open access
Semantic Scholar
The avoiding late diagnosis of ovarian cancer (ALDO) project; a pilot national surveillance programme for women with pathogenic germline variants in BRCA1 and BRCA2
S. Philpott, M. Raikou, R. Manchanda, M. Lockley +22 more
2022Journal of Medical Genetics17 citations Open access
Semantic Scholar
Adaptive therapy achieves long-term control of chemotherapy resistance in high grade ovarian cancer
H. Hockings, Eszter Lakatos, Wei-Ni Huang, M. Mossner +7 more
2023bioRxiv16 citations Open access
Semantic Scholar
Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium
A. Fonseca, J. Lobo, F. Hazard, J. Gell +10 more
2022British Journal of Cancer15 citations Open access
Semantic Scholar
The impact of a supranetwork multidisciplinary team (SMDT) on decision-making in testicular cancers: a 10-year overview of the Anglian Germ Cell Cancer Collaborative Group (AGCCCG)
J. Shamash, W. Ansell, C. Alifrangis, A. Sahdev +11 more
2019British Journal of Cancer15 citations Open access
Semantic Scholar
LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations
Eszter Lakatos, H. Hockings, M. Mossner, Wei-Ni Huang +2 more
2021bioRxiv13 citations Open access
Semantic Scholar
Pharmacological inhibition of β3 integrin reduces the inflammatory toxicities caused by oncolytic adenovirus without compromising anticancer activity
Ashley K. Browne, L. Tookman, Carin K. Ingemarsdotter, R. Bouwman +4 more
2015Cancer Research13 citations Open access
Semantic Scholar
Surgical management and outcomes for stage 1 malignant ovarian germ cell tumours: A UK multicentre retrospective cohort study.
Radha Graham, N. Macdonald, M. Lockley, Rowan E. Miller +9 more
2022European Journal of Obstetrics, Gynecology, and Reproductive Biology11 citations
Semantic Scholar
A novel cell line panel reveals non-genetic mediators of platinum resistance and phenotypic diversity in high grade serous ovarian cancer.
J. I. Hoare, H. Hockings, J. Saxena, V. Silva +9 more
2022Gynecologic Oncology11 citations Open access
Semantic Scholar
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer
V. Silva, J. Saxena, Francesco Nicolini, J. I. Hoare +3 more
2021Cell Death and Disease9 citations Open access
Semantic Scholar
Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapy
J. I. Hoare, Bleona Osmani, Emily A. O’Sullivan, Ashley K. Browne +6 more
2022Communications Biology7 citations Open access
Semantic Scholar
The genomic landscape of early-stage ovarian high grade serous carcinoma
Z. Cheng, H. Mirza, D. Ennis, Philip Smith +16 more
2022Clinical Cancer Research4 citations Open access
Semantic Scholar
Re: 'Can we replace adjuvant chemotherapy with surveillance for stage IA-C immature ovarian teratomas of any grade? An international multicenter analysis'.
M. Lockley, S. Stoneham, J. Shamash, F. Pashankar +1 more
2021European Journal of Cancer4 citations
Semantic Scholar
Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancer
J. I. Hoare, H. Hockings, J. Saxena, V. Silva +8 more
2020bioRxiv4 citations Open access
Semantic Scholar
Patient decision aids in mainstreaming genetic testing for women with ovarian cancer: A prospective cohort study
Monika Sobocan, D. Chandrasekaran, Michail Sideris, O. Blyuss +22 more
2023BJOG: an International Journal of Obstetrics and Gynaecology3 citations Open access
Semantic Scholar
Pathological Chemotherapy Response Score Predicts Survival in Patients with Advanced Ovarian Cancer Receiving Neoadjuvant Chemotherapy: Systematic Review and Meta-Analysis of Individual Patient Data
P. Cohen, A. Powell, Steffen Böhm, C. Gilks +25 more
20183 citations Open access
Semantic Scholar

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