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J. Pocock · SciRah

Researcher profile · Semantic Scholar

J. Pocock

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J. Pocock — researcher profile on SciRah

h-index: 34
Works: 86
Citations: 6,728

Most-cited papers

TREM2 Variants in Alzheimer's Disease
R. Guerreiro, Aleksandra M. Wojtas, J. Bras, M. Carrasquillo +20 more
2012New England Journal of Medicine2,762 citations Open access
Semantic Scholar
Neurotransmitter receptors on microglia.
J. Pocock, H. Kettenmann
2007Trends in Neurosciences347 citations
Semantic Scholar
Stimulation of Microglial Metabotropic Glutamate Receptor mGlu2 Triggers Tumor Necrosis Factor α-Induced Neurotoxicity in Concert with Microglial-Derived Fas Ligand
Deanna L. Taylor, F. Jones, Eva S F Chen Seho Kubota, J. Pocock
2005Journal of Neuroscience311 citations Open access
Semantic Scholar
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
Claudio Villegas-Llerena, Alexandra E. M. Phillips, P. Garcia-Reitboeck, John Hardy +1 more
2016Current Opinion in Neurobiology263 citations
Semantic Scholar
Activation of Microglial Group III Metabotropic Glutamate Receptors Protects Neurons against Microglial Neurotoxicity
Deanna L. Taylor, L. Diemel, J. Pocock
2002Journal of Neuroscience207 citations Open access
Semantic Scholar
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
Wenfei Liu, O. Taso, Rui Wang, Sevinc Bayram +11 more
2018bioRxiv181 citations Open access
Semantic Scholar
Insights into TREM2 biology by network analysis of human brain gene expression data
P. Forabosco, Adaikalavan Ramasamy, D. Trabzuni, Robert Walker +8 more
2013Neurobiology of Aging181 citations Open access
Semantic Scholar
Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis
P. Garcia-Reitboeck, Alexandra E. M. Phillips, T. Piers, Claudio Villegas-Llerena +11 more
2018Cell Reports152 citations Open access
Semantic Scholar
Apoptotic Pathways Mobilized in Microglia and Neurones as a Consequence of Chromogranin A‐Induced Microglial Activation
P. Kingham, M. Cuzner, J. Pocock
1999Journal of Neurochemistry152 citations
Semantic Scholar
Complement receptor 1 (CR1) and Alzheimer's disease.
H. Crehan, P. Holton, Selina Wray, J. Pocock +2 more
2012Immunobiology143 citations
Semantic Scholar
The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
X. Xiang, T. Piers, B. Wefers, Kai-Chuan Zhu +9 more
2018Molecular Neurodegeneration132 citations Open access
Semantic Scholar
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia
T. Piers, K. Cosker, Anna Mallach, Gabriel Johnson +3 more
2019bioRxiv122 citations Open access
Semantic Scholar
Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease.
R. Dale, P. Candler, A. Church, R. Wait +2 more
2006Journal of Neuroimmunology116 citations
Semantic Scholar
Wnt3a induces exosome secretion from primary cultured rat microglia
C. Hooper, R. Sáinz-Fuertes, S. Lynham, A. Hye +5 more
2012BMC Neuroscience103 citations Open access
Semantic Scholar
Microglia, Alzheimer's Disease, and Complement
H. Crehan, John Hardy, J. Pocock
2012International Journal of Alzheimer's Disease100 citations Open access
Semantic Scholar
Blockage of CR1 prevents activation of rodent microglia.
H. Crehan, John Hardy, J. Pocock
2013Neurobiology of Disease97 citations Open access
Semantic Scholar
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene
N. Magusali, A. C. Graham, T. Piers, Pantila Panichnantakul +16 more
2021Brain : a journal of neurology93 citations Open access
Semantic Scholar
Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.
D. Morsali, David A. Bechtold, Woo-Jin Lee, Summen Chauhdry +8 more
2013Brain : a journal of neurology82 citations Open access
Semantic Scholar
Inhibiting p53 pathways in microglia attenuates microglial‐evoked neurotoxicity following exposure to Alzheimer peptides
C. Davenport, I. Sevastou, C. Hooper, J. Pocock
2010Journal of Neurochemistry71 citations
Semantic Scholar
Kainic Acid Inhibits the Synaptosomal Plasma Membrane Glutamate Carrier and Allows Glutamate Leakage from the Cytoplasm but Does Not Affect Glutamate Exocytosis
J. Pocock, Helen M. Murphie, David G. Nicholls
1988Journal of Neurochemistry68 citations
Semantic Scholar
Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood–brain barrier damage
C. Hooper, Fleur Pinteaux-Jones, V. Fry, I. Sevastou +3 more
2009Journal of Neurochemistry67 citations
Semantic Scholar
Exocytotic and Nonexocytotic Modes of Glutamate Release from Cultured Cerebellar Granule Cells During Chemical Ischaemia
J. Pocock, D. Nicholls
1998Journal of Neurochemistry59 citations Open access
Semantic Scholar
Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis
Jenny Lange, Luke J. Haslett, Emyr Lloyd-Evans, J. Pocock +3 more
2018Acta Neuropathologica Communications54 citations Open access
Semantic Scholar
Modelling microglial function with induced pluripotent stem cells: an update
J. Pocock, T. Piers
2018Nature Reviews Neuroscience50 citations Open access
Semantic Scholar
Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome
K. Cosker, Anna Mallach, Janhavi Limaye, T. Piers +4 more
2021Scientific Reports49 citations Open access
Semantic Scholar
Modulation of neurotransmitter release by dihydropyridine‐sensitive calcium channels involves tyrosine phosphorylation
G. Evans, J. Pocock
1999European Journal of Neuroscience49 citations
Semantic Scholar
Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study.
C. Russell, A. Heslegrave, V. Mitra, H. Zetterberg +3 more
2017Rapid Communications in Mass Spectrometry48 citations Open access
Semantic Scholar
A toxin (Aga-GI) from the venom of the spider Agelenopsis aperta inhibits the mammalian presynaptic Ca2+ channel coupled to glutamate exocytosis.
J. Pocock, D. Nicholls
1992European Journal of Pharmacology48 citations
Semantic Scholar
Phorbol ester translocation of protein kinase C in guinea-pig synaptosomes and the potentiation of calcium-dependent glutamate release.
M. Díaz-Guerra, J. Sánchez-Prieto, L. Boscá, J. Pocock +2 more
1988Biochimica et Biophysica Acta47 citations Open access
Semantic Scholar
Neuroprotection by safinamide in the 6‐hydroxydopamine model of Parkinson's disease
Mona Sadeghian, Gizem Mullali, J. Pocock, T. Piers +2 more
2016Neuropathology and Applied Neurobiology46 citations
Semantic Scholar
Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration.
J. Jebelli, C. Hooper, J. Pocock
2014Neuroscience Letters46 citations
Semantic Scholar
Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss
Alma S. Popescu, C. Butler, David H. Allendorf, T. Piers +10 more
2022Glia44 citations Open access
Semantic Scholar
Glutamate induces release of glutathione from cultured rat astrocytes – a possible neuroprotective mechanism?
João Frade, S. Pope, Maike M. Schmidt, R. Dringen +4 more
2008Journal of Neurochemistry41 citations
Semantic Scholar
Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species
Grace C. O'Regan, Sahar H. Farag, C. Casey, A. Wood‐Kaczmar +3 more
2021Journal of Neuroinflammation37 citations Open access
Semantic Scholar
Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection.
T. Piers, S. Heales, J. Pocock
2011Neuroscience Letters34 citations
Semantic Scholar
Phosphorylation of synapsin I and MARCKS in nerve terminals is mediated by Ca2+ entry via an Aga‐GI sensitive Ca2+ channel which is coupled to glutamate exocytosis
E. Coffey, T. Sihra, D. Nicholls, J. Pocock
1994FEBS Letters34 citations
Semantic Scholar
Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia.
C. Hooper, J. Pocock
2007Neuroscience Letters28 citations
Semantic Scholar
Pathways linking Alzheimer’s disease risk genes expressed highly in microglia
A. Hodges, T. Piers, David Collier, Oliver Cousins +1 more
2021Neuroimmunology and Neuroinflammation27 citations Open access
Semantic Scholar
Glia: guardians, gluttons, or guides for the maintenance of neuronal connectivity?
J. Jebelli, W. Su, S. Hopkins, J. Pocock +1 more
2015Annals of the New York Academy of Sciences26 citations Open access
Semantic Scholar
Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells
Iqra Nazish, C. Arber, T. Piers, T. Warner +4 more
2021Neurochemistry International24 citations Open access
Semantic Scholar
Scavenger receptor control of chromogranin A‐induced microglial stress and neurotoxic cascades
C. Hooper, V. Fry, I. Sevastou, J. Pocock
2009FEBS Letters23 citations
Semantic Scholar
Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity
T. Piers, E. East, Claudio Villegas-Llerena, I. Sevastou +3 more
2018Frontiers in Cellular Neuroscience21 citations Open access
Semantic Scholar
Endothelin-1 inhibits voltage-sensitive Ca2+ channels in cultured rat cerebellar granule neurones via the ET-A receptor
B. Held, J. Pocock, H. Pearson
1998Pflügers Archiv20 citations
Semantic Scholar
Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout
C. Arber, Claudio Villegas-Llerena, J. Toombs, J. Pocock +5 more
2019Brain Communications19 citations Open access
Semantic Scholar
Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons
Anna Mallach, J. Gobom, C. Arber, T. Piers +4 more
2021bioRxiv16 citations Open access
Semantic Scholar
The Plant-Derived Chalcone 2,2′,5′-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia
M. Jiwrajka, Alexandra E. M. Phillips, M. Butler, M. Rossi +1 more
2015Oxidative Medicine and Cellular Longevity16 citations Open access
Semantic Scholar
The influence of the R47H TREM2 variant on microglial exosome profiles
Anna Mallach, J. Gobom, H. Zetterberg, John Hardy +3 more
202115 citations Open access
Semantic Scholar
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells
Christophe Boudesco, Annelies Nonneman, A. Cinti, Paola Picardi +14 more
2022Glia14 citations Open access
Semantic Scholar
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester.
J. Jebelli, T. Piers, J. Pocock
2015Journal of Visualized Experiments12 citations Open access
Semantic Scholar
Glycolytic enzymes on neuronal membranes are candidate autoantigens in post-streptococcal neuropsychiatric disorders
R. Dale, P. Candler, A. Church, R. Wait +2 more
200410 citations
Semantic Scholar

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