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Valerie Daggett · SciRah

Researcher profile · Semantic Scholar

Valerie Daggett

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Valerie Daggett — researcher profile on SciRah

h-index: 68
Works: 249
Citations: 16K

Most-cited papers

Distance restraints from crosslinking mass spectrometry: Mining a molecular dynamics simulation database to evaluate lysine–lysine distances
E. Merkley, Steven J. Rysavy, A. Kahraman, Ryan P. Hafen +2 more
2014Protein Science297 citations Open access
Semantic Scholar
Insights from molecular dynamics simulations for computational protein design
M. Childers, Valerie Daggett
2017Molecular Systems Design & Engineering206 citations Open access
Semantic Scholar
A Comparison of Multiscale Methods for the Analysis of Molecular Dynamics Simulations
N. Benson, Valerie Daggett
2012Journal of Physical Chemistry B135 citations Open access
Semantic Scholar
α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease
Dylan Shea, Cheng-Chieh Hsu, Timothy Bi, Natasha Paranjapye +10 more
2019Proceedings of the National Academy of Sciences of the United States of America125 citations Open access
Semantic Scholar
Validating Molecular Dynamics Simulations Against Experimental Observables in Light of Underlying Conformational Ensembles
M. Childers, Valerie Daggett
2018Journal of Physical Chemistry B116 citations Open access
Semantic Scholar
The dynameomics rotamer library: Amino acid side chain conformations and dynamics from comprehensive molecular dynamics simulations in water
Alexander D. Scouras, Valerie Daggett
2011Protein Science114 citations Open access
Semantic Scholar
Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations.
M. W. van der Kamp, Valerie Daggett
2011Topics in current chemistry108 citations Open access
Semantic Scholar
Influence of pH on the human prion protein: insights into the early steps of misfolding.
M. W. van der Kamp, Valerie Daggett
2010Biophysical Journal84 citations Open access
Semantic Scholar
Protein folds and protein folding.
R. D. Schaeffer, Valerie Daggett
2011Protein engineering, design & selection : PEDS79 citations Open access
Semantic Scholar
Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers
Gene Hopping, Jackson Kellock, R. Barnwal, Peter B. Law +4 more
2014eLife72 citations Open access
Semantic Scholar
USING SIMULATIONS TO PROVIDE THE FRAMEWORK FOR EXPERIMENTAL PROTEIN FOLDING STUDIES
B. Rizzuti, Valerie Daggett
2012Archives of Biochemistry and Biophysics58 citations Open access
Semantic Scholar
Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms
Alissa Bleem, G. Christiansen, D. J. Madsen, Hans M Maric +5 more
2018Journal of Molecular Biology53 citations Open access
Semantic Scholar
Peptides Comprised of Alternating L- and D- Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence
Jackson Kellock, Gene Hopping, B. Caughey, Valerie Daggett
2016Journal of Molecular Biology51 citations Open access
Semantic Scholar
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers
Dylan Shea, E. Colasurdo, Alec S. T. Smith, C. Paschall +7 more
2022Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Structural and functional consequences of the cardiac troponin C L48Q Ca2+-sensitizing mutation
Dan D. Wang, I. M. Robertson, Monica X. Li, M. McCully +6 more
2012Biochemistry46 citations Open access
Semantic Scholar
The Denatured State Dictates the Topology of Two Proteins with Almost Identical Sequence but Different Native Structure and Function*
Angela Morrone, M. McCully, P. Bryan, M. Brunori +3 more
2010Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Temperature dependence of the flexibility of thermophilic and mesophilic flavoenzymes of the nitroreductase fold.
E. Merkley, W. W. Parson, Valerie Daggett
2010Protein engineering, design & selection : PEDS44 citations Open access
Semantic Scholar
Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain
Sara Calhoun, Valerie Daggett
2011Biochemistry43 citations Open access
Semantic Scholar
New Dynamic Rotamer Libraries: Data-Driven Analysis of Side-Chain Conformational Propensities
Clare-Louise Towse, Steven J. Rysavy, Ivan Vulovic, Valerie Daggett
2016Structure42 citations Open access
Semantic Scholar
Visualizing Protein Folding and Unfolding.
J. Ferina, Valerie Daggett
2019Journal of Molecular Biology41 citations
Semantic Scholar
Nature versus design: the conformational propensities of D-amino acids and the importance of side chain chirality.
Clare-Louise Towse, Gene Hopping, Ivan Vulovic, Valerie Daggett
2014Protein engineering, design & selection : PEDS41 citations Open access
Semantic Scholar
Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
Alissa Bleem, Robyn Francisco, J. Bryers, Valerie Daggett
2017npj Biofilms and Microbiomes39 citations Open access
Semantic Scholar
DIVE: A Graph-based Visual Analytics Framework for Big Data
Steven J. Rysavy, D. Bromley, Valerie Daggett
2014IEEE Computer Graphics and Applications38 citations Open access
Semantic Scholar
GB1 is not a two-state folder: identification and characterization of an on-pathway intermediate.
Angela Morrone, Rajanish Giri, Rudesh D. Toofanny, C. Travaglini-Allocatelli +3 more
2011Biophysical Journal37 citations Open access
Semantic Scholar
Structural and functional diversity among amyloid proteins: Agents of disease, building blocks of biology, and implications for molecular engineering
Alissa Bleem, Valerie Daggett
2017Biotechnology and Bioengineering36 citations
Semantic Scholar
Structural and dynamic properties of the human prion protein.
Wei Chen, M. W. van der Kamp, Valerie Daggett
2014Biophysical Journal36 citations Open access
Semantic Scholar
Amyloid- β Oligomers: Multiple Moving Targets
Dylan Shea, Valerie Daggett
202234 citations
Semantic Scholar
Understanding protein unfolding from molecular simulations
Rudesh D. Toofanny, Valerie Daggett
201234 citations
Semantic Scholar
Structural and Functional Consequences of Cardiac Troponin C L57Q and I61Q Ca2+-Desensitizing Variants
Dan D. Wang, M. McCully, Zhao-Xiong Luo, Jonathan McMichael +3 more
2013Archives of Biochemistry and Biophysics33 citations Open access
Semantic Scholar
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin
J. Powers, C. Yuan, Kimberly J. McCabe, J. Murray +11 more
2019Proceedings of the National Academy of Sciences of the United States of America31 citations Open access
Semantic Scholar
Structural Consequences of Mutations to the α-Tocopherol Transfer Protein Associated with the Neurodegenerative Disease Ataxia with Vitamin E Deficiency
D. Bromley, P. C. Anderson, Valerie Daggett
2013Biochemistry31 citations Open access
Semantic Scholar
A comprehensive multidimensional-embedded, one-dimensional reaction coordinate for protein unfolding/folding.
Rudesh D. Toofanny, Amanda L. Jonsson, Valerie Daggett
2010Biophysical Journal29 citations Open access
Semantic Scholar
Molecular Dynamics Simulations Capture the Misfolding of the Bovine Prion Protein at Acidic pH
Chin J. Ung Cheng, Valerie Daggett
2014Biomolecules28 citations Open access
Semantic Scholar
Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2’-deoxy-ATP
Weikang Ma, M. Childers, J. Murray, F. Moussavi-Harami +5 more
2020Journal of Physiology27 citations Open access
Semantic Scholar
Chemical and Physical Variability in Structural Isomers of an L/D α-Sheet Peptide Designed To Inhibit Amyloidogenesis
N. Maris, Dylan Shea, Alissa Bleem, J. Bryers +1 more
2017Biochemistry27 citations Open access
Semantic Scholar
Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems.
Gene Hopping, Jackson Kellock, B. Caughey, Valerie Daggett
2013ACS Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
De novo designed alpha-sheet peptides inhibit functional amyloid formation of Streptococcus mutans biofilms
Natasha Paranjapye, Valerie Daggett
2018Journal of Molecular Biology24 citations Open access
Semantic Scholar
Malleability of folding intermediates in the homeodomain superfamily
Wiktor Banachewicz, T. Religa, R. D. Schaeffer, Valerie Daggett +1 more
2011Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
Refolding the engrailed homeodomain: structural basis for the accumulation of a folding intermediate.
M. McCully, D. Beck, A. Fersht, Valerie Daggett
2010Biophysical Journal24 citations Open access
Semantic Scholar
The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design.
M. Childers, Clare-Louise Towse, Valerie Daggett
2016Protein engineering, design & selection : PEDS22 citations Open access
Semantic Scholar
A Chemical Group Graph Representation for Efficient High-Throughput Analysis of Atomistic Protein Simulations
N. Benson, Valerie Daggett
2012J. Bioinform. Comput. Biol.20 citations Open access
Semantic Scholar
Manifestations of Native Topology in the Denatured State Ensemble of Rhodopseudomonas palustris Cytochrome c′
T. Dar, R. D. Schaeffer, Valerie Daggett, B. Bowler
2011Biochemistry20 citations Open access
Semantic Scholar
Early steps in thermal unfolding of superoxide dismutase 1 are similar to the conformational changes associated with the ALS-associated A4V mutation.
Tom Schmidlin, K. Ploeger, Amanda L. Jonsson, Valerie Daggett
2013Protein engineering, design & selection : PEDS19 citations Open access
Semantic Scholar
The Dynameomics Entropy Dictionary: A Large-Scale Assessment of Conformational Entropy across Protein Fold Space.
Clare-Louise Towse, M. Akke, Valerie Daggett
2017Journal of Physical Chemistry B18 citations Open access
Semantic Scholar
DIVE: a data intensive visualization engine
D. Bromley, Steven J. Rysavy, Robert Su, Rudesh D. Toofanny +2 more
2014Bioinform.18 citations Open access
Semantic Scholar
Different misfolding mechanisms converge on common conformational changes
Chin-Jung Cheng, Valerie Daggett
2014Prion18 citations Open access
Semantic Scholar
Edge strand dissociation and conformational changes in transthyretin under amyloidogenic conditions.
M. Childers, Valerie Daggett
2020Biophysical Journal16 citations Open access
Semantic Scholar
An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein.
D. Bromley, M. Bauer, A. Fersht, Valerie Daggett
2016Protein engineering, design & selection : PEDS16 citations Open access
Semantic Scholar
Multimolecule test-tube simulations of protein unfolding and aggregation
M. McCully, D. Beck, Valerie Daggett
2012Proceedings of the National Academy of Sciences of the United States of America15 citations Open access
Semantic Scholar
Drivers of α-sheet formation in transthyretin under amyloidogenic conditions.
M. Childers, Valerie Daggett
2019Biochemistry14 citations
Semantic Scholar

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