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S. Sakkiah · SciRah

Researcher profile · Semantic Scholar

S. Sakkiah

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S. Sakkiah — researcher profile on SciRah

h-index: 28
Works: 84
Citations: 2,632

Most-cited papers

Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods
Wenjing Guo, Bohu Pan, S. Sakkiah, Gökhan Yavaş +4 more
2019International Journal of Environmental Research and Public Health348 citations Open access
Semantic Scholar
CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity
K. Mansouri, N. Kleinstreuer, A. Abdelaziz, Domenico Alberga +68 more
2020Environmental Health Perspectives147 citations Open access
Semantic Scholar
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
Bing-chen Han, Ying Qu, Yan-Li Jin, Yi-Chu Yu +20 more
2015Cell Reports138 citations Open access
Semantic Scholar
3D QSAR pharmacophore based virtual screening and molecular docking for identification of potential HSP90 inhibitors.
S. Sakkiah, S. Thangapandian, Shalini John, Yong Jung Kwon +1 more
2010European journal of medicinal chemistry127 citations
Semantic Scholar
Homology modeling, molecular dynamics, e-pharmacophore mapping and docking study of Chikungunya virus nsP2 protease
Kh. Dhanachandra Singh, P. Kirubakaran, S. Nagarajan, S. Sakkiah +3 more
2011Journal of Molecular Modeling101 citations
Semantic Scholar
Identification of Inhibitor Binding Site in Human Sirtuin 2 Using Molecular Docking and Dynamics Simulations
S. Sakkiah, M. Arooj, M. Kumar, S. Eom +1 more
2013PLoS ONE87 citations Open access
Semantic Scholar
Ligand and structure based pharmacophore modeling to facilitate novel histone deacetylase 8 inhibitor design.
S. Thangapandian, Shalini John, S. Sakkiah, K. Lee
2010European journal of medicinal chemistry85 citations
Semantic Scholar
Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
Shalini John, S. Thangapandian, S. Sakkiah, K. Lee
2011BMC Bioinformatics77 citations Open access
Semantic Scholar
Pharmacophore-based virtual screening and density functional theory approach to identifying novel butyrylcholinesterase inhibitors
S. Sakkiah, K. Lee
2012Acta Pharmacologica Sinica74 citations Open access
Semantic Scholar
Molecular dynamics simulations and applications in computational toxicology and nanotoxicology.
C. Selvaraj, S. Sakkiah, W. Tong, H. Hong
2017Food and Chemical Toxicology70 citations Open access
Semantic Scholar
Machine Learning Models for Predicting Cytotoxicity of Nanomaterials.
Zuowei Ji, Wenjing Guo, Erin Wood, Jie Liu +4 more
2022Chemical Research in Toxicology68 citations
Semantic Scholar
A Combination of Receptor-Based Pharmacophore Modeling & QM Techniques for Identification of Human Chymase Inhibitors
M. Arooj, S. Sakkiah, Songmi Kim, Venkatesh Arulalapperumal +1 more
2013PLoS ONE59 citations Open access
Semantic Scholar
Pharmacophore based virtual screening, molecular docking studies to design potent heat shock protein 90 inhibitors.
S. Sakkiah, S. Thangapandian, Shalini John, K. Lee
2011European journal of medicinal chemistry57 citations
Semantic Scholar
An Innovative Strategy for Dual Inhibitor Design and Its Application in Dual Inhibition of Human Thymidylate Synthase and Dihydrofolate Reductase Enzymes
M. Arooj, S. Sakkiah, G. Cao, K. Lee
2013PLoS ONE50 citations Open access
Semantic Scholar
Potential virtual lead identification in the discovery of renin inhibitors: application of ligand and structure-based pharmacophore modeling approaches.
S. Thangapandian, Shalini John, S. Sakkiah, K. Lee
2011European journal of medicinal chemistry43 citations Open access
Semantic Scholar
Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A
H. Hong, B. Harvey, G. Palmese, J. Stanzione +4 more
2016International Journal of Environmental Research and Public Health41 citations Open access
Semantic Scholar
Insight the C-Site Pocket Conformational Changes Responsible for Sirtuin 2 Activity Using Molecular Dynamics Simulations
S. Sakkiah, M. Arooj, G. Cao, K. Lee
2013PLoS ONE40 citations Open access
Semantic Scholar
BPA Replacement Compounds: Current Status and Perspectives
Zuowei Ji, Jie Liu, S. Sakkiah, Wenjing Guo +1 more
202137 citations
Semantic Scholar
Nanomaterial Databases: Data Sources for Promoting Design and Risk Assessment of Nanomaterials
Zuowei Ji, Wenjing Guo, S. Sakkiah, Jie Liu +2 more
2021Nanomaterials36 citations Open access
Semantic Scholar
Molecular Docking and Pharmacophore Filtering in the Discovery of Dual-Inhibitors for Human Leukotriene A4 Hydrolase and Leukotriene C4 Synthase
S. Thangapandian, Shalini John, S. Sakkiah, K. Lee
2011Journal of Chemical Information and Modeling36 citations
Semantic Scholar
Correction to: Similarities and differences between variants called with human reference genome HG19 or HG38
Bohu Pan, Rebecca Kusko, W. Xiao, Yuan-Ting Zheng +10 more
2019BMC Bioinformatics34 citations Open access
Semantic Scholar
Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory
S. Sakkiah, C. Meganathan, Young-sik Sohn, Sundaraganesan Namadevan +1 more
2012International Journal of Molecular Sciences34 citations Open access
Semantic Scholar
Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations
S. Sakkiah, Wenjing Guo, Bohu Pan, Zuowei Ji +5 more
2021Frontiers in Chemistry32 citations Open access
Semantic Scholar
Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations
S. Sakkiah, Rebecca Kusko, Bohu Pan, Wenjing Guo +3 more
2018Frontiers in Pharmacology32 citations Open access
Semantic Scholar
Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery
S. Sakkiah, Hui W. Ng, W. Tong, H. Hong
2016Expert opinion on therapeutic targets30 citations
Semantic Scholar
Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies.
Shalini John, S. Thangapandian, S. Sakkiah, K. Lee
2010European journal of medicinal chemistry30 citations Open access
Semantic Scholar
Exploration of Virtual Candidates for Human HMG-CoA Reductase Inhibitors Using Pharmacophore Modeling and Molecular Dynamics Simulations
Minky Son, Ayoung Baek, S. Sakkiah, Chanin Park +2 more
2013PLoS ONE29 citations Open access
Semantic Scholar
Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
S. Sakkiah, Tony Wang, Wen Zou, Yuping Wang +3 more
2017International Journal of Environmental Research and Public Health28 citations Open access
Semantic Scholar
Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model
R. Waldron, Hsin-Yuan Su, H. Piplani, Joseph R. Capri +10 more
2018Cellular and Molecular Gastroenterology and Hepatology27 citations Open access
Semantic Scholar
The Aquila Digital Community The Aquila Digital Community
Bohu Pan, Rebecca Kusko, Wenming Xiao, Yuan-Ting Zheng +10 more
27 citations
Semantic Scholar
Computational prediction models for assessing endocrine disrupting potential of chemicals
S. Sakkiah, Wenjing Guo, Bohu Pan, Rebecca Kusko +2 more
2018Journal of Environmental Science And Health Part C - Environmental Carcinogenesis & Ecotoxicology Reviews26 citations
Semantic Scholar
Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors.
S. Thangapandian, Shalini John, S. Sakkiah, K. Lee
2011European journal of medicinal chemistry26 citations Open access
Semantic Scholar
Development of estrogen receptor beta binding prediction model using large sets of chemicals
S. Sakkiah, C. Selvaraj, Ping Gong, Chao-Yang Zhang +2 more
2017OncoTarget25 citations Open access
Semantic Scholar
Consensus Modeling for Prediction of Estrogenic Activity of Ingredients Commonly Used in Sunscreen Products
H. Hong, D. Rua, S. Sakkiah, C. Selvaraj +2 more
2016International Journal of Environmental Research and Public Health24 citations Open access
Semantic Scholar
Binding Mode Investigation of Polyphenols from Scrophularia Targeting Human Aldose Reductase Using Molecular Docking and Molecular Dynamics Simulations
A. Manivannan, P. Soundararajan, Y. Park, S. Sakkiah +1 more
201522 citations Open access
Semantic Scholar
Discovery of potential pancreatic cholesterol esterase inhibitors using pharmacophore modelling, virtual screening, and optimization studies
Shalini John, S. Thangapandian, S. Sakkiah, K. Lee
2011Journal of Enzyme Inhibition and Medicinal Chemistry22 citations Open access
Semantic Scholar
Molecular Modeling Study for Inhibition Mechanism of Human Chymase and Its Application in Inhibitor Design
M. Arooj, Songmi Kim, S. Sakkiah, G. Cao +2 more
2013PLoS ONE21 citations Open access
Semantic Scholar
Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding
S. Sakkiah, M. Chandrasekaran, Yuno Lee, Songmi Kim +1 more
2012Journal of Biomolecular Structure and Dynamics21 citations
Semantic Scholar
Pharmacophore Mapping and Virtual Screening for SIRT1 Activators
S. Sakkiah, N. Krishnamoorthy, P. Gajendrarao, S. Thangapandian +5 more
200921 citations Open access
Semantic Scholar
Finding off‐targets, biological pathways, and target diseases for chymase inhibitors via structure‐based systems biology approach
M. Arooj, S. Sakkiah, G. Cao, Songmi Kim +2 more
2015Proteins: Structure, Function, and Bioinformatics20 citations
Semantic Scholar
Identification of critical chemical features for Aurora kinase-B inhibitors using Hip-Hop, virtual screening and molecular docking
S. Sakkiah, S. Thangapandian, Shalini John, K. Lee
201120 citations
Semantic Scholar
sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides
Heng Luo, Hao Ye, Hui W. Ng, S. Sakkiah +2 more
2016Scientific Reports19 citations Open access
Semantic Scholar
Ligand-based pharmacophore modeling and Bayesian approaches to identify c-Src inhibitors
S. Sakkiah, Venkatesh Arullaperumal, Swan Hwang, K. Lee
2014Journal of Enzyme Inhibition and Medicinal Chemistry18 citations Open access
Semantic Scholar
Pharmacophore modeling, molecular docking, and molecular dynamics simulation approaches for identifying new lead compounds for inhibiting aldose reductase 2
S. Sakkiah, S. Thangapandian, K. Lee
2012Journal of Molecular Modeling18 citations
Semantic Scholar
A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals
H. Hong, Jie Shen, Hui W. Ng, S. Sakkiah +5 more
2016International Journal of Environmental Research and Public Health17 citations Open access
Semantic Scholar
Molecular Docking and Dynamics Simulation, Receptor‐based Hypothesis: Application to Identify Novel Sirtuin 2 Inhibitors
S. Sakkiah, S. Thangapandian, Chanin Park, Minky Son +1 more
2012Chemical Biology and Drug Design17 citations
Semantic Scholar
Elucidation of Agonist and Antagonist Dynamic Binding Patterns in ER-α by Integration of Molecular Docking, Molecular Dynamics Simulations and Quantum Mechanical Calculations
S. Sakkiah, C. Selvaraj, Wenjing Guo, Jie Liu +3 more
2021International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
Ligand‐Based Virtual Screening and Molecular Docking Studies to Identify the Critical Chemical Features of Potent Cathepsin D Inhibitors
S. Sakkiah, S. Thangapandian, K. W. Lee
2012Chemical Biology and Drug Design16 citations Open access
Semantic Scholar
Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations.
Swan Hwang, S. Thangapandian, Yuno Lee, S. Sakkiah +2 more
2011Journal of Bioinformatics and Computational Biology15 citations
Semantic Scholar
Macromolecular Docking Simulation to Identify Binding Site of FGB1 for Antifungal Compounds
P. Soundararajan, S. Sakkiah, I. Sivanesan, K. Lee +1 more
201115 citations Open access
Semantic Scholar

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