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J. Frangos · SciRah

Researcher profile · Semantic Scholar

J. Frangos

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J. Frangos — researcher profile on SciRah

h-index: 59
Works: 178
Citations: 13K

Most-cited papers

G protein-coupled receptors sense fluid shear stress in endothelial cells
M. Chachisvilis, Yan‐Liang Zhang, J. Frangos
2006Proceedings of the National Academy of Sciences of the United States of America487 citations Open access
Semantic Scholar
The shear stress of it all: the cell membrane and mechanochemical transduction
C. R. White, J. Frangos
2007Philosophical Transactions of the Royal Society B: Biological Sciences266 citations Open access
Semantic Scholar
Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria
I. Gramaglia, P. Sobolewski, D. Meays, R. Contreras +4 more
2006Nature Medicine222 citations
Semantic Scholar
Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion.
Amy G. Tsai, C. Acero, P. Nance, P. Cabrales +3 more
2005American Journal of Physiology. Heart and Circulatory Physiology210 citations
Semantic Scholar
Nongenomic Thyroid Hormone Signaling Occurs Through a Plasma Membrane Receptor
Hema Kalyanaraman, R. Schwappacher, Jisha Joshua, Shunhui Zhuang +7 more
2014Science Signaling128 citations Open access
Semantic Scholar
PECAM-1 Mediates NO-Dependent Dilation of Arterioles to High Temporal Gradients of Shear Stress
Z. Bagi, J. Frangos, J. Yeh, C. R. White +2 more
2005Arteriosclerosis, Thrombosis and Vascular Biology121 citations Open access
Semantic Scholar
Paradoxical hypotension following increased hematocrit and blood viscosity.
J. Martini, B. Carpentier, A. C. Negrete, J. Frangos +1 more
2005American Journal of Physiology. Heart and Circulatory Physiology117 citations
Semantic Scholar
Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.
P. Cabrales, G. Zanini, D. Meays, J. Frangos +1 more
2011Journal of Infectious Diseases107 citations Open access
Semantic Scholar
Type II cGMP-dependent Protein Kinase Mediates Osteoblast Mechanotransduction*
Hema Rangaswami, Nisha Marathe, Shunhui Zhuang, Yongchang Chen +4 more
2009Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Microfluidic Enhancement of Intramedullary Pressure Increases Interstitial Fluid Flow and Inhibits Bone Loss in Hindlimb Suspended Mice
R. Kwon, D. Meays, W. J. Tang, J. Frangos
2010Journal of Bone and Mineral Research90 citations Open access
Semantic Scholar
PECAM-1 Interacts With Nitric Oxide Synthase in Human Endothelial Cells: Implication for Flow-Induced Nitric Oxide Synthase Activation
N. Dusserre, N. L'Heureux, K. Bell, Hazel Y. Stevens +4 more
2004Arteriosclerosis, Thrombosis and Vascular Biology90 citations Open access
Semantic Scholar
Laurdan fluorescence senses mechanical strain in the lipid bilayer membrane.
Yan‐Liang Zhang, J. Frangos, M. Chachisvilis
2006Biochemical and Biophysical Research Communications - BBRC89 citations
Semantic Scholar
Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells.
Yan‐Liang Zhang, J. Frangos, M. Chachisvilis
2009American Journal of Physiology - Cell Physiology75 citations Open access
Semantic Scholar
Artemether and Artesunate Show the Highest Efficacies in Rescuing Mice with Late-Stage Cerebral Malaria and Rapidly Decrease Leukocyte Accumulation in the Brain
L. Clemmer, Y. C. Martins, G. Zanini, J. Frangos +1 more
2011Antimicrobial Agents and Chemotherapy72 citations Open access
Semantic Scholar
Nitric oxide bioavailability in malaria.
P. Sobolewski, I. Gramaglia, J. Frangos, M. Intaglietta +1 more
2005Trends in Parasitology72 citations
Semantic Scholar
Immunopathology and Infectious Diseases Murine Cerebral Malaria Is Associated with a Vasospasm-Like Microcirculatory Dysfunction , and Survival upon Rescue Treatment Is Markedly Increased by Nimodipine
P. Cabrales, G. Zanini, D. Meays, J. Frangos +1 more
201071 citations
Semantic Scholar
Role of endothelial nitric oxide in microvascular oxygen delivery and consumption.
P. Cabrales, Amy G. Tsai, J. Frangos, M. Intaglietta
2005Free Radical Biology & Medicine70 citations
Semantic Scholar
Involvement of ras activation in toxic hair cell damage of the mammalian cochlea.
Alessandra Battaglia, Kwang K. Pak, D. Brors, Daniel Bodmer +2 more
2003Neuroscience68 citations Open access
Semantic Scholar
Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria
Kai-Ong Peng, B. Melchior, Y. C. Martins, A. Hofer +5 more
2013PLoS Pathogens61 citations Open access
Semantic Scholar
Reactive oxygen species inhibited by titanium oxide coatings.
Richard K. Suzuki, J. Muyco, J. McKittrick, J. Frangos
2003Journal of Biomedical Materials Research. Part A60 citations
Semantic Scholar
Pressure gradients and transport in the murine femur upon hindlimb suspension.
H. Stevens, D. Meays, J. Frangos
2006Bone58 citations
Semantic Scholar
Shear-induced endothelial cell-cell junction inclination.
B. Melchior, J. Frangos
2010American Journal of Physiology - Cell Physiology57 citations Open access
Semantic Scholar
Rapid Activation of Ras by Fluid Flow Is Mediated by G&agr;q and G&bgr;&ggr; Subunits of Heterotrimeric G Proteins in Human Endothelial Cells
S. Gudi, I. Huvar, C. R. White, Nathan L. McKnight +3 more
200356 citations Open access
Semantic Scholar
Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice
G. Zanini, P. Cabrales, Wisam Barkho, J. Frangos +1 more
2011Journal of Neuroinflammation51 citations Open access
Semantic Scholar
Plasmodium berghei Resists Killing by Reactive Oxygen Species
P. Sobolewski, I. Gramaglia, J. Frangos, M. Intaglietta +1 more
2005Infection and Immunity48 citations Open access
Semantic Scholar
Protein kinase C mediates flow-induced prostaglandin E2 production in osteoblasts
K. M. Reich, J. Frangos
2004Calcified Tissue International48 citations
Semantic Scholar
Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells.
C. R. White, H. Stevens, M. Haidekker, J. Frangos
2005American Journal of Physiology. Heart and Circulatory Physiology47 citations
Semantic Scholar
Skeletal Adaptation to Intramedullary Pressure-Induced Interstitial Fluid Flow Is Enhanced in Mice Subjected to Targeted Osteocyte Ablation
R. Kwon, D. Meays, Alexander S. Meilan, Jeremiah Jones +4 more
2012PLoS ONE44 citations Open access
Semantic Scholar
Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow
M. V. Hillsley, J. Frangos
2009Calcified Tissue International44 citations
Semantic Scholar
Strain‐induced fetal type II epithelial cell differentiation is mediated via cAMP‐PKA‐dependent signaling pathway
Yu-Lian Wang, Benjamin S. Maciejewski, Nicole K. L. Lee, Ophira Silbert +3 more
2006American Journal of Physiology - Lung cellular and Molecular Physiology43 citations
Semantic Scholar
Efficacy of Different Nitric Oxide-Based Strategies in Preventing Experimental Cerebral Malaria by Plasmodium berghei ANKA
Y. C. Martins, G. Zanini, J. Frangos, L. Carvalho
2012PLoS ONE42 citations Open access
Semantic Scholar
Strain Rate Mechanotransduction in Aligned Human Vascular Smooth Muscle Cells
Nathan L. McKnight, J. Frangos
2003Annals of Biomedical Engineering41 citations
Semantic Scholar
Shear stress induces Gαq/11 activation independently of G protein-coupled receptor activation in endothelial cells.
Nathaniel G. Dela Paz, B. Melchior, J. Frangos
2017American Journal of Physiology - Cell Physiology40 citations Open access
Semantic Scholar
Heparan Sulfates Mediate the Interaction between Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and the Gαq/11 Subunits of Heterotrimeric G Proteins*
Nathaniel G. Dela Paz, B. Melchior, Francisca Y Shayo, J. Frangos
2014Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Extracellular signal‐regulated kinase activation and endothelin‐1 production in human endothelial cells exposed to vibration
C. R. White, Mark A. Haidekker, H. Stevens, J. Frangos
2004Journal of Physiology39 citations Open access
Semantic Scholar
Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols.
D. H. Kim, J. Frangos
2008Biophysical Journal37 citations Open access
Semantic Scholar
Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons.
P. Cabrales, Amy G. Tsai, J. Frangos, J. C. Briceño +1 more
2004American Journal of Physiology. Heart and Circulatory Physiology37 citations
Semantic Scholar
Titanate biomaterials with enhanced antiinflammatory properties.
R. Contreras, H. Sahlin, J. Frangos
2007Journal of Biomedical Materials Research. Part A36 citations
Semantic Scholar
Evidence for the role of G-proteins in flow stimulation of dinoflagellate bioluminescence.
Antony K. Chen, M. Latz, P. Sobolewski, J. Frangos
2007American Journal of Physiology. Regulatory Integrative and Comparative Physiology36 citations
Semantic Scholar
Anti-inflammatory properties of micropatterned titanium coatings.
H. Sahlin, R. Contreras, D. Gaskill, L. Bjursten +1 more
2006Journal of Biomedical Materials Research. Part A36 citations
Semantic Scholar
Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells.
S. Gudi, I. Huvar, C. R. White, Nathan L. McKnight +3 more
2003Arteriosclerosis, Thrombosis and Vascular Biology34 citations
Semantic Scholar
Computerized methods for X-ray-based small bone densitometry
M. Haidekker, H. Stevens, J. Frangos
2004Comput. Methods Programs Biomed.32 citations
Semantic Scholar
Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons
P. Cabrales, Amy G. Tsai, J. Frangos, J. C. Briceño +1 more
200432 citations
Semantic Scholar
Derivation of an occupational exposure limit for an inhalation analgesic methoxyflurane (Penthrox(®)).
J. Frangos, Antti T. Mikkonen, Christin Down
2016Regulatory toxicology and pharmacology : RTP31 citations Open access
Semantic Scholar
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.
P. Cabrales, G. Zanini, D. Meays, J. Frangos +1 more
2010American Journal of Pathology31 citations Open access
Semantic Scholar
S-nitrosoglutathione prevents experimental cerebral malaria
G. Zanini, Y. C. Martins, P. Cabrales, J. Frangos +1 more
2012Journal of Neuroimmune Pharmacology30 citations Open access
Semantic Scholar
NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers.
H. Sakai, Atsushi Sato, P. Sobolewski, S. Takeoka +4 more
2008Biochimica et Biophysica Acta30 citations
Semantic Scholar
Bone marrow niches orchestrate stem cell hierarchy and immune tolerance
K. Furuhashi, Miwako Kakiuchi, Ryosuke Ueda, Hiroko Oda +19 more
2025Nature28 citations Open access
Semantic Scholar
The Concentration of No Toxicological Concern (CoNTC): A Risk Assessment Screening Tool for Air Toxics
R. Drew, J. Frangos
2007Journal of Toxicology and Environmental Health, Part A25 citations
Semantic Scholar
Cell- Rather Than Antibody-Mediated Immunity Leads to the Development of Profound Thrombocytopenia during Experimental Plasmodium berghei Malaria1
I. Gramaglia, H. Sahlin, J. Nolan, J. Frangos +2 more
2005Journal of Immunology25 citations
Semantic Scholar

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