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R. Guthke · SciRah

Researcher profile · Semantic Scholar

R. Guthke

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R. Guthke — researcher profile on SciRah

h-index: 49
Works: 215
Citations: 8,391

Most-cited papers

Impaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
K. Zarse, S. Schmeisser, Marco Groth, Steffen Priebe +6 more
2012Cell Metabolism436 citations Open access
Semantic Scholar
Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation
D. Woetzel, René Huber, P. Kupfer, D. Pohlers +7 more
2014Arthritis Research & Therapy268 citations Open access
Semantic Scholar
D-Glucosamine supplementation extends life span of nematodes and of ageing mice
Sandra Weimer, J. Priebs, Doreen Kuhlow, Marco Groth +12 more
2014Nature Communications227 citations Open access
Semantic Scholar
Role of Sirtuins in Lifespan Regulation is Linked to Methylation of Nicotinamide
Kathrin Schmeisser, Johannes Mansfeld, Doreen Kuhlow, Sandra Weimer +17 more
2013Nature Chemical Biology224 citations Open access
Semantic Scholar
FungiFun2: a comprehensive online resource for systematic analysis of gene lists from fungal species
Steffen Priebe, Christian Kreisel, F. Horn, R. Guthke +1 more
2014Bioinform.214 citations Open access
Semantic Scholar
RNA-seq of the aging brain in the short-lived fish N. furzeri – conserved pathways and novel genes associated with neurogenesis
M. Baumgart, Marco Groth, Steffen Priebe, A. Savino +10 more
2014Aging Cell152 citations Open access
Semantic Scholar
Branched-chain amino acid catabolism is a conserved regulator of physiological ageing
Johannes Mansfeld, N. Urban, Steffen Priebe, Marco Groth +20 more
2015Nature Communications150 citations Open access
Semantic Scholar
Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension.
S. Schmeisser, Steffen Priebe, Marco Groth, S. Monajembashi +4 more
2013Molecular Metabolism149 citations Open access
Semantic Scholar
Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension
S. Schmeisser, Kathrin Schmeisser, Sandra Weimer, Marco Groth +9 more
2013Aging Cell144 citations Open access
Semantic Scholar
Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.
M. Baumgart, Steffen Priebe, Marco Groth, N. Hartmann +9 more
2016Cell Systems136 citations Open access
Semantic Scholar
An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells
L. Tierney, J. Linde, Sebastian Müller, S. Brunke +5 more
2012Front. Microbio.131 citations Open access
Semantic Scholar
Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
Peer Aramillo Irizar, Sascha Schäuble, D. Esser, Marco Groth +24 more
2018Nature Communications123 citations Open access
Semantic Scholar
Integrated metabolic spatial‐temporal model for the prediction of ammonia detoxification during liver damage and regeneration
F. Schliess, S. Hoehme, Sebastian Henkel, A. Ghallab +9 more
2014Hepatology113 citations Open access
Semantic Scholar
A review on computational systems biology of pathogen–host interactions
Saliha Durmuş, Tunahan Çakır, Arzucan Özgür, R. Guthke
2015Frontiers in Microbiology111 citations Open access
Semantic Scholar
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue
P. Godoy, Agata Widera, W. Schmidt-Heck, G. Campos +28 more
2016Archives of Toxicology109 citations Open access
Semantic Scholar
Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq
Shiva Marthandan, M. Baumgart, Steffen Priebe, Marco Groth +7 more
2016PLoS ONE87 citations Open access
Semantic Scholar
Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant
Anja Wartenberg, J. Linde, Ronny Martin, Maria Schreiner +11 more
2014PLoS Genetics86 citations Open access
Semantic Scholar
Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis
M. Matz-Soja, Christiane Rennert, K. Schönefeld, Susanne Aleithe +10 more
2016eLife78 citations Open access
Semantic Scholar
Defining the transcriptomic landscape of Candida glabrata by RNA-Seq
J. Linde, Seána Duggan, Michael Weber, F. Horn +7 more
2015Nucleic Acids Research77 citations Open access
Semantic Scholar
Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.
Meenakshi Ravichandran, Steffen Priebe, Giovanna Grigolon, L. Rozanov +6 more
2018Cell Metabolism75 citations Open access
Semantic Scholar
ModuleDiscoverer: Identification of regulatory modules in protein-protein interaction networks
S. Vlaic, T. Conrad, Christian Tokarski-Schnelle, M. Gustafsson +3 more
2017Scientific Reports72 citations Open access
Semantic Scholar
Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus
Robert Altwasser, Clara Baldin, J. Weber, R. Guthke +4 more
2015PLoS ONE67 citations Open access
Semantic Scholar
Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0
Michael Weber, Sebastian Henkel, S. Vlaic, R. Guthke +2 more
2013BMC Systems Biology63 citations Open access
Semantic Scholar
Regulatory Networks Controlling Nitrogen Sensing and Uptake in Candida albicans
Shruthi Ramachandra, J. Linde, M. Brock, R. Guthke +2 more
2014PLoS ONE62 citations Open access
Semantic Scholar
Computational prediction of molecular pathogen-host interactions based on dual transcriptome data
Sylvie Schulze, Sebastian Henkel, D. Driesch, R. Guthke +1 more
2015Frontiers in Microbiology57 citations Open access
Semantic Scholar
Data- and knowledge-based modeling of gene regulatory networks: an update
J. Linde, Sylvie Schulze, Sebastian Henkel, R. Guthke
2015EXCLI Journal : Experimental and Clinical Sciences54 citations
Semantic Scholar
Use of systems biology to decipher host-pathogen interaction networks and predict biomarkers.
A. Dix, S. Vlaic, R. Guthke, J. Linde
2016Clinical Microbiology and Infection53 citations Open access
Semantic Scholar
Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts
Shiva Marthandan, Steffen Priebe, M. Baumgart, Marco Groth +4 more
2015BioMed Research International52 citations Open access
Semantic Scholar
Age-dependent regulation of tumor-related microRNAs in the brain of the annual fish Nothobranchius furzeri.
M. Baumgart, Marco Groth, Steffen Priebe, J. Appelt +3 more
2012Mechanisms of Ageing and Development51 citations
Semantic Scholar
Batch correction of microarray data substantially improves the identification of genes differentially expressed in Rheumatoid Arthritis and Osteoarthritis
P. Kupfer, R. Guthke, D. Pohlers, René Huber +2 more
2012BMC Medical Genomics49 citations Open access
Semantic Scholar
Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach
J. Linde, P. Hortschansky, Eugen Fazius, A. Brakhage +2 more
2012BMC Systems Biology47 citations Open access
Semantic Scholar
Survival Strategies of Pathogenic Candida Species in Human Blood Show Independent and Specific Adaptations
Philipp Kämmer, Sylvie McNamara, Thomas Wolf, T. Conrad +8 more
2020mBio46 citations Open access
Semantic Scholar
A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease.
Jana Schleicher, R. Guthke, U. Dahmen, O. Dirsch +2 more
2014Biochimica et Biophysica Acta45 citations
Semantic Scholar
Increased Expression of RUNX1 in Liver Correlates with NASH Activity Score in Patients with Non-Alcoholic Steatohepatitis (NASH)
S. Kaur, P. Rawal, Hamda Siddiqui, Sumati Rohilla +11 more
2019Cells42 citations Open access
Semantic Scholar
Candida albicans infection leads to barrier breakdown and a MAPK/NF‐κB mediated stress response in the intestinal epithelial cell line C2BBe1
M. Böhringer, Susann Pohlers, Sylvie Schulze, D. Albrecht-Eckardt +7 more
2016Cellular Microbiology42 citations Open access
Semantic Scholar
Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study
A. Dix, Kerstin Hünniger, Michael Weber, R. Guthke +2 more
2015Frontiers in Microbiology40 citations Open access
Semantic Scholar
Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence
Shiva Marthandan, U. Menzel, Steffen Priebe, Marco Groth +5 more
2016Biological Research36 citations Open access
Semantic Scholar
Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression
Mario M. Müller, Roland Lehmann, Tilman E. Klassert, Stella Reifenstein +7 more
2017Scientific Reports35 citations Open access
Semantic Scholar
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
G. Campos, W. Schmidt-Heck, J. De Smedt, Agata Widera +21 more
2020Archives of Toxicology34 citations Open access
Semantic Scholar
Proteomics of Aspergillus fumigatus Conidia-containing Phagolysosomes Identifies Processes Governing Immune Evasion*
Hella Schmidt, S. Vlaic, Thomas Krüger, Franziska Schmidt +6 more
2018Molecular & Cellular Proteomics33 citations Open access
Semantic Scholar
Verticillium dahliae-Arabidopsis Interaction Causes Changes in Gene Expression Profiles and Jasmonate Levels on Different Time Scales
Sandra S. Scholz, W. Schmidt-Heck, R. Guthke, A. Furch +3 more
2018Frontiers in Microbiology33 citations Open access
Semantic Scholar
Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells
A. Dix, Kristin Czakai, I. Leonhardt, Karin Schäferhoff +6 more
2017Frontiers in Microbiology33 citations Open access
Semantic Scholar
Within-host influenza dynamics: A small-scale mathematical modeling approach
Himanshu Manchanda, Nora Seidel, A. Krumbholz, A. Sauerbrei +2 more
2014Biosyst.30 citations
Semantic Scholar
Zonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake
Jana Schleicher, U. Dahmen, R. Guthke, S. Schuster
2017Journal of the Royal Society Interface28 citations Open access
Semantic Scholar
Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy
Amelia E. Barber, Michael Weber, Kerstin Kaerger, J. Linde +6 more
2018Antimicrobial Agents and Chemotherapy27 citations Open access
Semantic Scholar
Hormetic effect of rotenone in primary human fibroblasts
Shiva Marthandan, Steffen Priebe, Marco Groth, R. Guthke +3 more
2015Immunity & Ageing27 citations Open access
Semantic Scholar
Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells
Roland Lehmann, Mario M. Müller, Tilman E. Klassert, D. Driesch +7 more
2018Mucosal Immunology26 citations Open access
Semantic Scholar
How to Predict Molecular Interactions between Species?
Sylvie Schulze, Jana Schleicher, R. Guthke, J. Linde
2016Frontiers in Microbiology26 citations Open access
Semantic Scholar
The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus
F. Hillmann, J. Linde, N. Beckmann, Michael Cyrulies +6 more
2014Molecular Microbiology26 citations
Semantic Scholar
Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus.
V. Valiante, D. Mattern, A. Schüffler, F. Horn +9 more
2017ACS Chemical Biology22 citations
Semantic Scholar

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