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L. Zhong · SciRah

Researcher profile · Semantic Scholar

L. Zhong

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L. Zhong — researcher profile on SciRah

h-index: 20
Works: 38
Citations: 2,600

Most-cited papers

Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence.
L. Zhong, Elias S. J. Arnér, A. Holmgren
2000Proceedings of the National Academy of Sciences of the United States of America502 citations Open access
Semantic Scholar
Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations*
L. Zhong, A. Holmgren
2000Journal of Biological Chemistry427 citations Open access
Semantic Scholar
Preparation and assay of mammalian thioredoxin and thioredoxin reductase.
Elias S. J. Arnér, L. Zhong, A. Holmgren
1999Methods in Enzymology329 citations
Semantic Scholar
Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme
T. Sandalova, L. Zhong, Y. Lindqvist, A. Holmgren +1 more
2001Proceedings of the National Academy of Sciences of the United States of America325 citations Open access
Semantic Scholar
Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue*
L. Zhong, Elias S. J. Arnér, J. Ljung, F. Åslund +1 more
1998Journal of Biological Chemistry265 citations Open access
Semantic Scholar
Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue*
J. Nordberg, L. Zhong, A. Holmgren, Elias S. J. Arnér
1998Journal of Biological Chemistry200 citations Open access
Semantic Scholar
Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium‐deficient rat liver
Jun Lu, L. Zhong, M. Lönn, Raymond F. Burk +2 more
2009The FASEB Journal79 citations Open access
Semantic Scholar
Thioredoxin and Thioredoxin Reductase Control Tissue Factor Activity by Thiol Redox-dependent Mechanism*
Pei Wang, Yun-Fei Wu, Xiaoming Li, Xiaofeng Ma +1 more
2012Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.
Huihui Zhang, Dong Cao, Wei Cui, Mingjuan Ji +2 more
2010Free Radical Biology & Medicine41 citations
Semantic Scholar
Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity.
Yun-Fei Wu, Lijuan Yang, L. Zhong
2010Atherosclerosis39 citations
Semantic Scholar
Systematic characterization of the covalent interactions between (-)-epigallocatechin gallate and peptides under physiological conditions by mass spectrometry.
Dong Cao, Yang-Jun Zhang, Huihui Zhang, L. Zhong +1 more
2009Rapid Communications in Mass Spectrometry35 citations
Semantic Scholar
A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance
Xiao-lin Zhang, Jin-ying Tian, Juan Li, Li-Wei Huang +5 more
2016British Journal of Pharmacology31 citations Open access
Semantic Scholar
Ebselen: A thioredoxin reductase-dependent catalyst for α-tocopherol quinone reduction
Jian-Guo Fang, L. Zhong, Rong Zhao, A. Holmgren
200531 citations
Semantic Scholar
Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions.
Yatao Du, Yun-Fei Wu, Xue-Li Cao, Wei Cui +5 more
2009Biochimie30 citations
Semantic Scholar
Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.
Yan Wang, Huihui Zhang, A. Holmgren, Wei-Xi Tian +1 more
2008Oncology Report29 citations Open access
Semantic Scholar
Effect of selenium‐supplement on the calcium signaling in human endothelial cells
Yi Zheng, L. Zhong, Xun Shen
2005Journal of Cellular Physiology26 citations
Semantic Scholar
Bacterial thioredoxin and thioredoxin reductase as mediators for epigallocatechin 3‐gallate‐induced antimicrobial action
W. Liang, A. Fernandes, A. Holmgren, Xiaoming Li +1 more
2016The FEBS Journal25 citations Open access
Semantic Scholar
Mammalian thioredoxin reductases as hydroperoxide reductases.
L. Zhong, A. Holmgren
2002Methods in Enzymology25 citations
Semantic Scholar
A thioredoxin reductase and/or thioredoxin system-based mechanism for antioxidant effects of ambroxol.
Jin Huang, Jianying Xu, Lin Tian, L. Zhong
2014Biochimie22 citations
Semantic Scholar
High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance
H. Qin, Xiao-lin Zhang, Fei Ye, L. Zhong
2014FEBS Open Bio20 citations Open access
Semantic Scholar
Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction.
Jian-Guo Fang, L. Zhong, Rong Zhao, A. Holmgren
2005Toxicology and Applied Pharmacology15 citations
Semantic Scholar
Role and mechanism of homocysteine in affecting hepatic protein-tyrosine phosphatase 1B.
Ping Liu, Jin Huang, L. Zhong
2019Biochimica et Biophysica Acta - General Subjects10 citations
Semantic Scholar
Mechanistic insights into the inhibitory effects of palmitoylation on cytosolic thioredoxin reductase and thioredoxin.
H. Qin, W. Liang, Zhiyu Xu, Fei Ye +2 more
2015Biochimie9 citations
Semantic Scholar
New insights into the posttranslational regulation of human cytosolic thioredoxin by S-palmitoylation.
Zhiyu Xu, L. Zhong
2015Biochemical and Biophysical Research Communications - BBRC8 citations
Semantic Scholar
Purification, crystallization and preliminary crystallographic data for rat cytosolic selenocysteine 498 to cysteine mutant thioredoxin reductase.
L. Zhong, K. Persson, T. Sandalova, Gunter Schneider +1 more
2000Acta Crystallographica Section D: Biological Crystallography8 citations
Semantic Scholar
Elevated serum 4HNE plus decreased serum thioredoxin: Unique feature and implications for acute exacerbation of chronic obstructive pulmonary disease
Jia Liu, Jin Huang, Hu Liu, Chang Chen +2 more
2021PLoS ONE6 citations Open access
Semantic Scholar
Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status.
Huihui Zhang, L. Zhong
2010European Journal of Pharmacology6 citations
Semantic Scholar
New insights into serum/extracellular thioredoxin in regulating hepatic insulin receptor activation.
Yun-Qing Bai, Jia Liu, Lijuan Yang, L. Zhong
2020Biochimica et Biophysica Acta - General Subjects4 citations
Semantic Scholar
A reciprocal inhibitory relationship between adiponectin and mammalian cytosolic thioredoxin
Jin-Sheng Liu, Jianying Xu, Jin Huang, Yong Zhao +2 more
20164 citations
Semantic Scholar
Unique association of adiponectin isoforms with serum cytokines and redox molecules in patients with chronic obstructive pulmonary disease
Hu Liu, Jin-Sheng Liu, Jin Huang, L. Zhong +1 more
2013Chinese Medical Journal4 citations Open access
Semantic Scholar
Mammalian thioredoxin reductase
T. Sandalova, L. Zhong, Y. Lindqvist, A. Holmgren +1 more
20014 citations
Semantic Scholar
Serum thioredoxin activity: a promising biomarker for assessment of coronary stenosis severity in patients with coronary artery disease.
Jin-Ling Li, Pei Wang, Li-zhong Xiao, Jian-Min Yu +2 more
2017Science Bulletin3 citations
Semantic Scholar
The C-terminal selenenylsulfide of extracellular/non-reduced thioredoxin reductase endows this protein with selectivity to small-molecule electrophilic reagents under oxidative conditions
H. Qin, Chenchen Guo, Bozhen Chen, Hui Huang +2 more
2024Frontiers in Molecular Biosciences0 citations Open access
Semantic Scholar
Compound magaldrate chewable tablets in treatment of symptoms of gastric acid-related diseases: a multicenter, randomized, double-blind, double-dummy, controlled trial
Xiang-Yi He, F. Ji, Jian-Ting Cai, Yi-Bin Jiang +2 more
20170 citations
Semantic Scholar
アディポネクチンおよびほ乳類サイトゾルのチオレドキシンの間の相互抑制関係【Powered by NICT】
Jin-Sheng Liu, Jianying Xu, Jin Huang, Yong Zhao +2 more
20160 citations
Semantic Scholar
Redox-dependent Mechanism Control Tissue Factor Activity by Thiol Thioredoxin and Thioredoxin Reductase Molecular Bases of Disease :
Pei Wang, Yun-Fei Wu, Xiaoming Li, Xiaofeng Ma +1 more
20130 citations
Semantic Scholar
Insulin resistance and altered protein-expression profiles in mouse liver
H. Qin, L. Zhong
20110 citations
Semantic Scholar
Selenium in mammalian thioredoxin reductase
L. Zhong
20000 citations
Semantic Scholar

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