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J. Ambati · SciRah

Researcher profile · Semantic Scholar

J. Ambati

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J. Ambati — researcher profile on SciRah

h-index: 50
Works: 295
Citations: 15K

Most-cited papers

LINE-1 derepression in senescent cells triggers interferon and inflammaging
M. De Cecco, Takahiro Ito, Anna P. Petrashen, Amy E. Elias +17 more
2019Nature958 citations Open access
Semantic Scholar
Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19
Joseph Magagnoli, S. Narendran, Felipe Pereira, Tammy H. Cummings +3 more
2020medRxiv663 citations Open access
Semantic Scholar
cGAS drives non-canonical inflammasome activation in age-related macular degeneration
N. Kerur, S. Fukuda, Daipayan Banerjee, Young-hee Kim +34 more
2017Nature Medicine214 citations Open access
Semantic Scholar
Pharmacology of Corticosteroids for Diabetic Macular Edema
S. Whitcup, J. Cidlowski, K. Csaky, J. Ambati
2018Investigative Ophthalmology and Visual Science122 citations Open access
Semantic Scholar
Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome
B. Gelfand, Charles B. Wright, Young-hee Kim, T. Yasuma +14 more
2015Cell Reports87 citations Open access
Semantic Scholar
A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling
Daipayan Banerjee, Kurt A. Langberg, S. Abbas, E. Odermatt +10 more
2021Nature Communications77 citations Open access
Semantic Scholar
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration
S. Fukuda, Akhil Varshney, B. Fowler, Shao-bin Wang +55 more
2021Proceedings of the National Academy of Sciences of the United States of America62 citations Open access
Semantic Scholar
Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
J. Ambati, Joseph Magagnoli, Hannah Leung, Shao-bin Wang +25 more
2020Nature Communications60 citations Open access
Semantic Scholar
A Revised Hemodynamic Theory of Age-Related Macular Degeneration
B. Gelfand, J. Ambati
2016Trends in Molecular Medicine59 citations Open access
Semantic Scholar
Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression
F. Di Ruocco, V. Basso, Michel Rivoire, P. Mehlen +3 more
2017Oncogene56 citations Open access
Semantic Scholar
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs
Shao-bin Wang, S. Narendran, Shuichiro Hirahara, Akhil Varshney +20 more
2021Science immunology46 citations Open access
Semantic Scholar
Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy
H. Uehara, Xiao-Hui Zhang, Felipe Pereira, S. Narendran +13 more
2020bioRxiv46 citations Open access
Semantic Scholar
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity
S. Fukuda, S. Narendran, Akhil Varshney, Yosuke Nagasaka +35 more
2021Science Advances41 citations Open access
Semantic Scholar
Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice.
Takeshi Mizutani, B. Fowler, Young-hee Kim, Reo Yasuma +3 more
2015Investigative Ophthalmology and Visual Science37 citations Open access
Semantic Scholar
Human IgG1 antibodies suppress angiogenesis in a target-independent manner
S. Bogdanovich, Young-hee Kim, Takeshi Mizutani, Reo Yasuma +32 more
2016Signal Transduction and Targeted Therapy35 citations Open access
Semantic Scholar
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice
Charles B. Wright, H. Uehara, Young-hee Kim, T. Yasuma +18 more
2020Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism
R. Al-khalidi, C. Panicucci, P. Cox, Natalia Chira +10 more
2018Acta Neuropathologica Communications32 citations Open access
Semantic Scholar
Phagocytosis in the retina promotes local insulin production in the eye
J. I. Etchegaray, Shannon M Kelley, Kristen K. Penberthy, Laura Karvelyte +18 more
2023Nature Metabolism30 citations Open access
Semantic Scholar
Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration
S. Narendran, Felipe Pereira, P. Yerramothu, Ivana Apicella +16 more
2021Signal Transduction and Targeted Therapy28 citations Open access
Semantic Scholar
Intravenous immune globulin suppresses angiogenesis in mice and humans
Reo Yasuma, Valeria Cicatiello, Takeshi Mizutani, L. Tudisco +22 more
2016Signal Transduction and Targeted Therapy25 citations Open access
Semantic Scholar
Compartmentalized citrullination in Muller glial endfeet during retinal degeneration
S. Palko, Nicholas J. Saba, Elias M. Mullane, B. Nicholas +6 more
2022Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
Association of nucleoside reverse transcriptase inhibitor use with reduced risk of Alzheimer's disease risk
Joseph Magagnoli, Meenakshi Ambati, Tammy H. Cummings, Joseph Nguyen +5 more
2025Alzheimer's & Dementia21 citations Open access
Semantic Scholar
RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes
R. Makin, Ivana Apicella, Yosuke Nagasaka, H. Kaneko +4 more
2018Investigative Ophthalmology and Visual Science21 citations Open access
Semantic Scholar
Dry Age-Related Macular Degeneration Pharmacology
Charles B. Wright, J. Ambati
2016Handbook of Experimental Pharmacology21 citations Open access
Semantic Scholar
Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation
M. De Cecco, Takahiro Ito, Anna P. Petrashen, Amy E. Elias +17 more
2019Nature20 citations Open access
Semantic Scholar
Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization
Shao-bin Wang, Yosuke Nagasaka, Dionne Argyle, Ayami Nagasaka +3 more
2023Signal Transduction and Targeted Therapy17 citations Open access
Semantic Scholar
Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration.
S. Sutton, Joseph Magagnoli, Tammy H. Cummings, James W. Hardin +1 more
2024JAMA ophthalmology16 citations
Semantic Scholar
A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration
S. Narendran, Felipe Pereira, P. Yerramothu, Ivana Apicella +10 more
2020Investigative Ophthalmology and Visual Science16 citations Open access
Semantic Scholar
Subretinal injection in mice to study retinal physiology and disease
Pei-Rong Huang, S. Narendran, Felipe Pereira, S. Fukuda +8 more
2022Nature Protocols14 citations Open access
Semantic Scholar
Cancer-derived exosomal Alu RNA promotes colorectal cancer progression
Sara Magliacane Trotta, A. Adinolfi, Luca D’Orsi, Sonia Panico +5 more
2024Experimental and Molecular Medicine13 citations Open access
Semantic Scholar
Macular Hemorrhage Due to Age-Related Macular Degeneration or Retinal Arterial Macroaneurysm: Predictive Factors of Surgical Outcome
Mitta Pierre, A. Mainguy, I. Chatziralli, Kaivon Pakzad-Vaezi +7 more
2021Journal of Clinical Medicine13 citations Open access
Semantic Scholar
Voluntary Exercise Suppresses Choroidal Neovascularization in Mice
R. Makin, Dionne Argyle, Shuichiro Hirahara, Yosuke Nagasaka +5 more
2020Investigative Ophthalmology and Visual Science12 citations
Semantic Scholar
NLRP3 Inflammasome Inhibition
S. Narendran, Felipe Pereira, J. Ambati
2020JACC: Basic to Translational Science12 citations Open access
Semantic Scholar
Association between Fluoxetine Use and Overall Survival among Patients with Cancer Treated with PD-1/L1 Immunotherapy
Joseph Magagnoli, S. Narendran, Felipe Pereira, Tammy H. Cummings +3 more
2023Pharmaceuticals11 citations Open access
Semantic Scholar
The Learning Curve of Murine Subretinal Injection Among Clinically Trained Ophthalmic Surgeons
Pei-Rong Huang, S. Narendran, Felipe Pereira, S. Fukuda +8 more
2021bioRxiv10 citations Open access
Semantic Scholar
Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy
N. Kerur, Young-hee Kim, S. Fukuda, Reo Yasuma +6 more
201610 citations
Semantic Scholar
Kamuvudine-9 Protects Retinal Structure and Function in a Novel Model of Experimental Rhegmatogenous Retinal Detachment
Pei-Rong Huang, Claire C. Thomas, Kameshwari Ambati, Roshni Dholkawala +14 more
2023Investigative Ophthalmology and Visual Science9 citations Open access
Semantic Scholar
Reduction of human Alzheimer’s disease risk and reversal of mouse model cognitive deficit with nucleoside analog use
Joseph Magagnoli, P. Yerramothu, Kameshwari Ambati, Tammy H. Cummings +14 more
2023medRxiv8 citations Open access
Semantic Scholar
Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris
Sen-You An, H. Yu, M. D. Mahfuzul Islam, Xiaoyu Zhang +5 more
2023Scientific Reports8 citations Open access
Semantic Scholar
Complement Activation and Inhibition in Retinal Diseases
M. Kleinman, J. Ambati
2015Developments in ophthalmology8 citations Open access
Semantic Scholar
Inflammasome activation aggravates choroidal neovascularization
R. Makin, Ivana Apicella, Roshni Dholkawala, Shinichi Fukuda +11 more
2024Angiogenesis5 citations Open access
Semantic Scholar
Are intravitreal injections essential during the COVID-19 pandemic? Global preferred practice patterns and practical recommendations
A. Tan, R. Schwartz, D. Anaya, I. Chatziralli +16 more
2022International Journal of Retina and Vitreous5 citations Open access
Semantic Scholar
Expert opinion on the management and follow-up of uveitis patients during SARS-CoV-2 outbreak
D. Stanescu-Segall, Thomas Sales de Gauzy, R. Reynolds, L. Faes +9 more
2020Expert Review of Clinical Immunology5 citations Open access
Semantic Scholar
Allopurinol and the risk of diabetic macular edema among U.S. veterans with type 2 diabetes
S. Sutton, Joseph Magagnoli, Tammy H. Cummings, James W. Hardin +1 more
2023Ocular immunology and inflammation4 citations
Semantic Scholar
Anti-HIV Drugs Reduce Risk of Prediabetes and Progression to Type 2 Diabetes in HIV-Infected Patients
Joseph Magagnoli, Felipe Pereira, S. Narendran, Pei-Rong Huang +5 more
2023MedComm – Future Medicine4 citations Open access
Semantic Scholar
Modulation of Angiogenesis
B. Ambati, J. Ambati
20184 citations
Semantic Scholar
Oral lamivudine in diabetic macular edema: a randomized, double-blind, placebo-controlled clinical trial
Felipe Pereira, Joseph Magagnoli, Meenakshi Ambati, Talita Fernandes de Oliveira +10 more
2025i Medicina3 citations Open access
Semantic Scholar
TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis
Jing Li, Yosuke Nagasaka, Hong-Tao Shen, Xin-Yu Zhou +6 more
2025Molecular Therapy: Nucleic Acids3 citations Open access
Semantic Scholar
Targeting the cholinergic anti‐inflammatory pathway for type 2 diabetes prevention: A retrospective cohort study
Joseph Magagnoli, Tammy H. Cummings, James W. Hardin, J. Ambati +1 more
2024Diabetes, obesity and metabolism3 citations
Semantic Scholar
Y chromosome proteins in female tissues
B. Gelfand, J. Ambati
2023Science3 citations Open access
Semantic Scholar

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B. Gelfand — researcher profile on SciRah
S. Narendran×16
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S. Narendran — researcher profile on SciRah
Felipe Pereira×16
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Felipe Pereira — researcher profile on SciRah
Yosuke Nagasaka×15
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Ivana Apicella — researcher profile on SciRah

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N. Kerur — researcher profile on SciRah

Kameshwari Ambati×12

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Kameshwari Ambati — researcher profile on SciRah

Joseph Magagnoli×12

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Joseph Magagnoli — researcher profile on SciRah

P. Yerramothu×11

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P. Yerramothu — researcher profile on SciRah

Tammy H. Cummings×10

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B. Fowler — researcher profile on SciRah

Meenakshi Ambati×10

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Meenakshi Ambati — researcher profile on SciRah