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S. Gupte · SciRah

Researcher profile · Semantic Scholar

S. Gupte

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S. Gupte — researcher profile on SciRah

h-index: 38
Works: 200
Citations: 4,521

Most-cited papers

Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.
P. Hecker, J. Leopold, S. Gupte, F. Recchia +1 more
2013American Journal of Physiology. Heart and Circulatory Physiology121 citations Open access
Semantic Scholar
Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
A. D'Alessandro, K. El Kasmi, L. Plecitá-Hlavatá, P. Ježek +4 more
2018Antioxidants and Redox Signaling102 citations Open access
Semantic Scholar
Increased Reactive Oxygen Species, Metabolic Maladaptation, and Autophagy Contribute to Pulmonary Arterial Hypertension–Induced Ventricular Hypertrophy and Diastolic Heart Failure
Dhawjbahadur K Rawat, Abdallah Alzoubi, Rakhee S. Gupte, Sukrutha Chettimada +5 more
2014HYPERTENSION96 citations Open access
Semantic Scholar
Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension.
Sukrutha Chettimada, Rakhee S. Gupte, Dhwajbahadur K. Rawat, S. Gebb +2 more
2015American Journal of Physiology - Lung cellular and Molecular Physiology84 citations Open access
Semantic Scholar
Glucose 6-Phosphate Dehydrogenase Deficiency Increases Redox Stress and Moderately Accelerates the Development of Heart Failure
P. Hecker, Vincenzo Lionetti, Rogerio F. Ribeiro, S. Rastogi +10 more
2013Circulation: Heart Failure76 citations Open access
Semantic Scholar
Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity.
M. Mitry, D. Laurent, Britny L Keith, E. Sira +5 more
2020American Journal of Physiology - Cell Physiology74 citations Open access
Semantic Scholar
MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.
S. Joshi, V. Dhagia, S. Gairhe, J. Edwards +2 more
2016American Journal of Physiology. Heart and Circulatory Physiology60 citations Open access
Semantic Scholar
Glc-6-PD and PKG contribute to hypoxia-induced decrease in smooth muscle cell contractile phenotype proteins in pulmonary artery.
Sukrutha Chettimada, Dhwajbahadur K. Rawat, Nupur B. Dey, Robert Kobelja +4 more
2012American Journal of Physiology - Lung cellular and Molecular Physiology46 citations Open access
Semantic Scholar
Contractile protein expression is upregulated by reactive oxygen species in aorta of Goto-Kakizaki rat.
Sukrutha Chettimada, Hirotaka Ata, Dhwajbahadur K. Rawat, S. Gulati +3 more
2014American Journal of Physiology. Heart and Circulatory Physiology38 citations Open access
Semantic Scholar
20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
Anand Lakhkar, V. Dhagia, S. Joshi, K. Gotlinger +5 more
2016American Journal of Physiology. Heart and Circulatory Physiology37 citations Open access
Semantic Scholar
Hypoxic Activation of G6PD Controls the Expression of Genes Involved in the Pathogenesis of Pulmonary Hypertension Through the Regulation of DNA Methylation.
S. Joshi, Atushi Kitagawa, C. Jacob, Ryota Hashimoto +12 more
2020American Journal of Physiology - Lung cellular and Molecular Physiology36 citations Open access
Semantic Scholar
Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats.
Sukrutha Chettimada, S. Joshi, Abdallah Alzoubi, S. Gebb +3 more
2014American Journal of Physiology - Lung cellular and Molecular Physiology34 citations Open access
Semantic Scholar
Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart.
C. Vimercati, K. Qanud, Gianfranco Mitacchione, D. Sosnowska +8 more
2014American Journal of Physiology. Heart and Circulatory Physiology31 citations Open access
Semantic Scholar
Glucose-6-Phosphate Dehydrogenase and NADPH Redox Regulates Cardiac Myocyte L-Type Calcium Channel Activity and Myocardial Contractile Function
Dhwajbahadur K. Rawat, P. Hecker, Makino Watanabe, Sukrutha Chettimada +4 more
2012PLoS ONE29 citations Open access
Semantic Scholar
G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
V. Dhagia, A. Kitagawa, C. Jacob, Connie Zheng +5 more
2021American Journal of Physiology. Heart and Circulatory Physiology28 citations Open access
Semantic Scholar
Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency.
Sukrutha Chettimada, S. Joshi, V. Dhagia, Alessandro Aiezza +4 more
2016American Journal of Physiology. Heart and Circulatory Physiology26 citations Open access
Semantic Scholar
CRISPR-Mediated SNP Modeling in Rats Reveals Insight into Reduced Cardiovascular Risk Associated with Mediterranean G6PD Variant
A. Kitagawa, I. Kizub, C. Jacob, Kevin Michael +8 more
2020HYPERTENSION25 citations Open access
Semantic Scholar
Elevated 20-HETE in Metabolic Syndrome Regulates Arterial Stiffness and Systolic Hypertension via MMP12 Activation
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca L. Hutcheson +12 more
2018Journal of Molecular and Cellular Cardiology24 citations Open access
Semantic Scholar
Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca2+ current in A7r5 aortic smooth muscle cells.
R. Ochi, V. Dhagia, Anand Lakhkar, Dhara P. Patel +2 more
2016American Journal of Physiology. Heart and Circulatory Physiology24 citations Open access
Semantic Scholar
Potential role of mitochondrial superoxide decreasing ferrochelatase and heme in coronary artery soluble guanylate cyclase depletion by angiotensin II.
Dhara P. Patel, Raed Alhawaj, M. Kelly, J. Accarino +4 more
2016American Journal of Physiology. Heart and Circulatory Physiology24 citations Open access
Semantic Scholar
CRISPR-Cas9 Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin
Qing R. Lyu, V. Dhagia, Yu Han, B. Guo +8 more
2018Arteriosclerosis, Thrombosis and Vascular Biology22 citations Open access
Semantic Scholar
Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia
A. Kitagawa, C. Jacob, A. Jordan, I. Waddell +2 more
2021Journal of Pharmacology and Experimental Therapeutics19 citations Open access
Semantic Scholar
Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE.
I. Kizub, Anand Lakhkar, V. Dhagia, S. Joshi +8 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology17 citations Open access
Semantic Scholar
Mitochondria in Cardiovascular Physiology and Disease Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat
S. Hicks, N. Labinskyy, B. Piteo, D. Laurent +3 more
201316 citations
Semantic Scholar
Relationships between Vascular Oxygen Sensing Mechanisms and Hypertensive Disease Processes
S. Gupte, M. Wolin
2012HYPERTENSION15 citations Open access
Semantic Scholar
Cyp2c44 Gene Disruption Exacerbated Pulmonary Hypertension and Heart Failure in Female but Not Male Mice
S. Joshi, Anand Lakhkar, V. Dhagia, Ariadne L. Zias +8 more
2016Pulmonary Circulation14 citations Open access
Semantic Scholar
High Sugar Intake Does Not Exacerbate Metabolic Abnormalities or Cardiac Dysfunction in Genetic Cardiomyopathy
P. Hecker, Tatiana F. G. Galvão, Karen M. O'Shea, Bethany H. Brown +4 more
2012Nutrition (Burbank, Los Angeles County, Calif.)13 citations Open access
Semantic Scholar
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension
Catherine D'addario, Shun Matsumura, A. Kitagawa, Gregg M. Lainer +8 more
2023Vascular pharmacology12 citations Open access
Semantic Scholar
G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation.
Ryota Hashimoto, S. Gupte
2022Vascular pharmacology11 citations Open access
Semantic Scholar
Differences in the expression of DNA methyltransferases and demethylases in leukocytes and the severity of pulmonary arterial hypertension between ethnic groups
Catherine D'addario, G. Lanier, C. Jacob, Natalie Bauer +3 more
2022Physiological Reports11 citations Open access
Semantic Scholar
Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.
Ryota Hashimoto, S. Joshi, Houli Jiang, J. Capdevila +3 more
2017American Journal of Physiology. Heart and Circulatory Physiology11 citations Open access
Semantic Scholar
Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats
Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat-Ider Tumenbayar +10 more
2024Journal of Biological Chemistry10 citations Open access
Semantic Scholar
The severity of SARS-CoV-2 infection in K18-hACE2 mice is attenuated by a novel steroid-derivative in a gender-specific manner
S. Gupte, C. S. Bakshi, Emma E. Blackham, G. Duhamel +6 more
2023British Journal of Pharmacology10 citations
Semantic Scholar
Blockade of 20-HETE Receptor Lowers Blood Pressure and Alters Vascular Function in Mice with Smooth Muscle-Specific Overexpression of CYP4A12-20-HETE Synthase
Kevin Agostinucci, Rebecca L. Hutcheson, Sakib Hossain, Jonathan V. Pascale +7 more
2022Journal of Hypertension10 citations Open access
Semantic Scholar
Glucose-6-phosphate dehydrogenase increases Ca2+ currents by interacting with Cav1.2 and reducing intrinsic inactivation of the L-type calcium channel.
Rakhee S. Gupte, V. Dhagia, Petra Ročić, R. Ochi +1 more
2020American Journal of Physiology. Heart and Circulatory Physiology10 citations Open access
Semantic Scholar
Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cells
Amanda Krajnik, Erik Nimmer, Joseph A. Brazzo, John C. Biber +13 more
2023APL Bioengineering9 citations Open access
Semantic Scholar
Effects of laparoscopic Roux-en-Y gastric bypass on glucose-6 phosphate dehydrogenase activity in obese type 2 diabetics
Andrew Schneider, Dhwajbahadur K. Rawat, L. Weinstein, S. Gupte +1 more
2012Surgical Endoscopy9 citations
Semantic Scholar
Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension
C. Jacob, A. Kitagawa, Christina Signoretti, Monika Dzieciatkowska +6 more
2022Journal of Biological Chemistry8 citations Open access
Semantic Scholar
Pluripotent hematopoietic stem cells augment (cid:2) -adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension
Ryota Hashimoto, G. Lanier, V. Dhagia, S. Joshi +7 more
20208 citations
Semantic Scholar
Dehydroepiandrosterone inhibits ICa,L and its window current in voltage-dependent and -independent mechanisms in arterial smooth muscle cells.
R. Ochi, Sukrutha Chettimada, I. Kizub, S. Gupte
2018American Journal of Physiology. Heart and Circulatory Physiology8 citations Open access
Semantic Scholar
Poly(Ethylene Glycol)-Cholesterol Inhibits L-Type Ca2+ Channel Currents and Augments Voltage-Dependent Inactivation in A7r5 Cells
R. Ochi, Sukrutha Chettimada, S. Gupte
2014PLoS ONE8 citations Open access
Semantic Scholar
G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall
Christina Signoretti, S. Gupte
2023International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness
Shun Matsumura, Catherine D'Addiaro, Orazio J. Slivano, C. De Miguel +4 more
2022Vascular pharmacology7 citations Open access
Semantic Scholar
Pluripotent HSCs Augment a-Adrenergic Receptor-Mediated Contraction of Pulmonary Artery and Contribute to the Pathogenesis of Pulmonary Hypertension.
Ryota Hashimoto, G. Lanier, V. Dhagia, S. Joshi +7 more
2020American Journal of Physiology - Lung cellular and Molecular Physiology7 citations Open access
Semantic Scholar
G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker‐Induced Pulmonary Vascular Disease
Christina Signoretti, Shun Matsumura, Samuel Fatehi, M. D’silva +7 more
2024Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease6 citations Open access
Semantic Scholar
Mitochondrial Calcium Transport: A Potentially Prominent, Therapeutically Targetable Contributor to Pulmonary Arterial Hypertension Progression.
S. Gupte, M. Wolin
2017American Journal of Respiratory and Critical Care Medicine4 citations Open access
Semantic Scholar
Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension.
Ryota Hashimoto, S. Gupte
2017Advances in Experimental Medicine and Biology4 citations Open access
Semantic Scholar
Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell
A. Kitagawa, C. Jacob, S. Gupte
2022Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi3 citations Open access
Semantic Scholar
Cyp 2 c 44 gene disruption is associated with increased hematopoietic stem cells : implication in chronic hypoxia-induced pulmonary hypertension
Ryota Hashimoto, S. Joshi, Houli Jiang, J. Capdevila +3 more
20172 citations
Semantic Scholar
Iron Metabolism and Vascular Remodeling: Novel Insights Provided by Transferrin-1 Receptor Depletion in Mice With Pulmonary Hypertension.
M. Wolin, Dhara P. Patel, Raed Alhawaj, S. Gupte +1 more
2016American Journal of Hypertension2 citations Open access
Semantic Scholar

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S. Joshi×13
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S. Joshi — researcher profile on SciRah
V. Dhagia×12
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V. Dhagia — researcher profile on SciRah
Rakhee S. Gupte×10
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Rakhee S. Gupte — researcher profile on SciRah
I. Mcmurtry×10
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M. Wolin — researcher profile on SciRah

Sukrutha Chettimada×9

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C. Jacob — researcher profile on SciRah

Ryota Hashimoto×7

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Ryota Hashimoto — researcher profile on SciRah

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M. Schwartzman×6

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M. Schwartzman — researcher profile on SciRah

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A. Kitagawa — researcher profile on SciRah

Dhwajbahadur K. Rawat×5

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Dhwajbahadur K. Rawat — researcher profile on SciRah