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L. Clarke · SciRah

Researcher profile · Semantic Scholar

L. Clarke

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L. Clarke — researcher profile on SciRah

h-index: 21
Works: 53
Citations: 1,415

Most-cited papers

Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei
D. Zink, M. Amaral, Andreas Englmann, Susanne Lang +8 more
2004Journal of Cell Biology286 citations Open access
Semantic Scholar
Magnetic field-assisted DNA hybridisation and simultaneous detection using micron-sized spin-valve sensors and magnetic nanoparticles
Daniel B. Graham, H. Ferreira, N. Feliciano, P. Freitas +2 more
200591 citations
Semantic Scholar
Correction of a Cystic Fibrosis Splicing Mutation by Antisense Oligonucleotides
S. Igreja, L. Clarke, H. Botelho, Luís Marques +1 more
2016Human Mutation77 citations Open access
Semantic Scholar
Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis
Nikhil T. Awatade, Inna Uliyakina, C. Farinha, L. Clarke +5 more
2014EBioMedicine76 citations Open access
Semantic Scholar
Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies
L. Clarke, L. Sousa, C. Barreto, M. Amaral
2013Respiratory Research70 citations Open access
Semantic Scholar
BO-LSTM: classifying relations via long short-term memory networks along biomedical ontologies
Andre Lamurias, Diana Sousa, L. Clarke, Francisco M. Couto
2018BMC Bioinformatics65 citations Open access
Semantic Scholar
Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic Fibrosis.
B. Nagy, L. Fila, L. Clarke, Ferenc Gönczy +15 more
2016Chest64 citations Open access
Semantic Scholar
High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.
J. Almaça, Diana Faria, M. Sousa, Inna Uliyakina +11 more
2013Cell54 citations Open access
Semantic Scholar
Magnetoresistive DNA chips
P. Freitas, H. Ferreira, D. Graham, L. Clarke +4 more
200450 citations
Semantic Scholar
Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition
Margarida C Quaresma, Ines Pankonien, L. Clarke, Luís Sousa +5 more
2020Cell Death and Disease48 citations Open access
Semantic Scholar
Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts.
A. Ramalho, S. Beck, C. Farinha, L. Clarke +7 more
2004Journal of Cystic Fibrosis46 citations Open access
Semantic Scholar
F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis.
Joana R. Martins, Patthara Kongsuphol, E. Sammels, S. Dahimène +6 more
2011Biochimica et Biophysica Acta44 citations Open access
Semantic Scholar
Extracting microRNA-gene relations from biomedical literature using distant supervision
Andre Lamurias, L. Clarke, Francisco M. Couto
2017PLoS ONE43 citations Open access
Semantic Scholar
Rapid DNA hybridization based on ac field focusing of magnetically labeled target DNA
H. Ferreira, N. Feliciano, Daniel B. Graham, L. Clarke +2 more
200542 citations
Semantic Scholar
Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators.
L. Clarke, H. Botelho, L. Sousa, A. O. Falcão +1 more
2015Genomics41 citations Open access
Semantic Scholar
Detection of cystic fibrosis related DNA targets using AC field focusing of magnetic labels and spin-valve sensors
H. Ferreira, D. L. Graham, N. Feliciano, L. Clarke +2 more
2005INTERMAG Asia 2005. Digests of the IEEE International Magnetics Conference, 2005.40 citations
Semantic Scholar
Magnetic biosensors for genetic screening of cystic fibrosis
L. Lagae, R. Wirix-Speetjens, Cheng-Xun Liu, W. Laureyn +8 more
200530 citations
Semantic Scholar
TMEM16A chloride channel does not drive mucus production
F. Simões, Margarida C Quaresma, L. Clarke, Iris Al Silva +4 more
2019Life Science Alliance27 citations Open access
Semantic Scholar
Comparative ex vivo, in vitro and in silico analyses of a CFTR splicing mutation: Importance of functional studies to establish disease liability of mutations.
A. Ramalho, L. Clarke, M. Sousa, Verónica Felício +3 more
2016Journal of Cystic Fibrosis24 citations Open access
Semantic Scholar
The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read‐through therapies in cystic fibrosis
L. Clarke, Nikhil T. Awatade, Verónica Felício, I. Silva +9 more
2018Human Mutation23 citations Open access
Semantic Scholar
Microarray analysis in cystic fibrosis.
P. Galvin, L. Clarke, S. Harvey, M. Amaral
2004Journal of Cystic Fibrosis22 citations
Semantic Scholar
Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells
Zsolt Bene, Z. Fejes, T. Szanto, F. Fenyvesi +7 more
2021Frontiers in Pharmacology17 citations Open access
Semantic Scholar
Quantitative methods for the analysis of CFTR transcripts/splicing variants.
M. Amaral, L. Clarke, A. Ramalho, S. Beck +15 more
2004Journal of Cystic Fibrosis17 citations Open access
Semantic Scholar
Organoids as a Personalized Medicine Tool for Ultra-Rare Mutations in Cystic Fibrosis: the Case of S955P and 1717–2A>G
Iris al Silva, T. Doušová, S. Ramalho, R. Centeio +10 more
2020Biochimica et Biophysica Acta - Molecular Basis of Disease15 citations Open access
Semantic Scholar
KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway
Luís Sousa, Ines Pankonien, L. Clarke, I. Silva +2 more
2020Cells12 citations Open access
Semantic Scholar
Microarray mRNA expression profiling to study cystic fibrosis.
S. Ramachandran, L. Clarke, T. Scheetz, M. Amaral +1 more
2011Methods in molecular biology12 citations
Semantic Scholar
Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis
L. Clarke, Vanessa C. C. Luz, Szymon Targowski, S. Ramalho +2 more
2021Genes10 citations Open access
Semantic Scholar
Generating a Tolerogenic Cell Therapy Knowledge Graph from Literature
Andre Lamurias, J. Ferreira, L. Clarke, Francisco M. Couto
2017Frontiers in Immunology10 citations Open access
Semantic Scholar
What Can RNA-Based Therapy Do for Monogenic Diseases?
L. Clarke, M. Amaral
2023Pharmaceutics9 citations Open access
Semantic Scholar
The replication timing of CFTR and adjacent genes
Andreas Englmann, L. Clarke, Susanne Christan, M. Amaral +2 more
2005Chromosome Research8 citations
Semantic Scholar
GRYFUN: A Web Application for GO Term Annotation Visualization and Analysis in Protein Sets
Hugo P. Bastos, L. Sousa, L. Clarke, Francisco M. Couto
2015PLoS ONE7 citations Open access
Semantic Scholar
Annotation extension through protein family annotation coherence metrics
Hugo P. Bastos, L. Clarke, Francisco M. Couto
2013Frontiers in Genetics7 citations Open access
Semantic Scholar
Quantification of CFTR transcripts.
A. Ramalho, L. Clarke, M. Amaral
2011Methods in molecular biology6 citations
Semantic Scholar
Magnetoresistive biochips
P. P. Freitas, H. Ferreira, D. Graham, L. Clarke +4 more
20086 citations Open access
Semantic Scholar
Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators
H. Botelho, M. Lopes-Pacheco, Madalena C Pinto, Violeta Railean +11 more
2025iScience4 citations Open access
Semantic Scholar
Nanotechnology and the Detection of Biomolecular Recognition Using Magnetoresistive Transducers
P. Freitas, H. Ferreira, F. Cardoso, S. Cardoso +15 more
20074 citations
Semantic Scholar
ULISBOA at SemEval-2017 Task 12: Extraction and classification of temporal expressions and events
Andre Lamurias, Diana Sousa, Sofia Cardoso Pereira, L. Clarke +1 more
2017International Workshop on Semantic Evaluation2 citations Open access
Semantic Scholar
Extraction of Regulatory Events using Kernel-based Classifiers and Distant Supervision
Andre Lamurias, M. J. Rodrigues, L. Clarke, Francisco M. Couto
2016Workshop on Biomedical Natural Language Processing2 citations Open access
Semantic Scholar
Human epididymis protein 4 (HE4): a novel serum inflammatory biomarker in cystic fibrosis
B. Nagy, L. Fila, L. Clarke, Ferenc Gönczy +18 more
20161 citations
Semantic Scholar
Identifying chemical entities in patents using brown clustering and semantic similarity
Andre Lamurias, Manuel Lobo, M. Antunes, L. Clarke +1 more
20151 citations
Semantic Scholar
Annotating biomedical ontology terms in electronic health records using crowd-sourcing
Andre Lamurias, V. Pedro, L. Clarke, Francisco M. Couto
2015International Conference on Biomedical Ontology1 citations
Semantic Scholar
Detection of cystic fibrosis related DNA targets using AC field focusing of magnetic labels and spin-valve sensors
H. Ferreira, D. L. Graham, N. Feliciano, L. Clarke +2 more
2005IEEE transactions on magnetics1 citations
Semantic Scholar
Nucleic acid-based therapeutic strategies for modulator-refractory cystic fibrosis-causing variants.
Mark Leahy, I. Zollo, L. Clarke, C. M. Farinha
2026Human Molecular Genetics0 citations
Semantic Scholar
WS03-2 Modulation of CFTR alters human epididymis protein 4 (HE4) expression in cystic fibrosis bronchial epithelial cells via NF-κB pathway
Zsolt Bene, Z. Fejes, F. Fenyvesi, Judit Váradi +5 more
2019Journal of Cystic Fibrosis0 citations Open access
Semantic Scholar
WS02.5 Human epididymis protein 4 (HE4) level positively correlates with pulmonary inflammation in cystic fibrosis
B. Nagy, L. Fila, L. Clarke, Z. Fejes +5 more
20170 citations Open access
Semantic Scholar
Functional coherence metrics in protein families
Hugo P. Bastos, L. Sousa, L. Clarke, Francisco M. Couto
2016Journal of Biomedical Semantics0 citations Open access
Semantic Scholar
IICE: Web Tool for Automatic Identification of Chemical Entities and Interactions
Andre Lamurias, L. Clarke, Francisco M. Couto
2015ECML/PKDD0 citations
Semantic Scholar
161 E3 ubiquitin ligases: A potential role in regulating the inflammatory phenotype of cystic fibrosis?
Sara Canato, M. Telhada, M. Amaral, L. Clarke
20130 citations Open access
Semantic Scholar
WS20.3 Transcriptomics of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies
L. Clarke, L. Sousa, M. Amaral
20130 citations Open access
Semantic Scholar
WS22.5 Effect of the Burkholderia cenocepacia exoproteome on CFTR protein expression in human cystic fibrosis lung epithelial cell models
Sara Canato, M. Telhada, M. Amaral, L. Clarke
20130 citations Open access
Semantic Scholar

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